Introduction. The beginning of the patient-physician relationship often involves the delivery of bad news. The work of rheumatologists is unique in that they have to form strong relationships with their patients while delivering bad news. Many rheumatology patients stay with their doctors for their entire lives, which makes it essential to create a positive and caring experience for them. This depends on the physician's professional skills, ability to understand the patient, and engage in respectful and understandable communication when discussing complicated information. Currently, no specific recommendations exist for constructing an appropriate approach for every patient, especially in the case of rheumatology patients. This paper will adapt the SPIKES protocol for rheumatology practice. Methods. The literature search was done via MEDLINE/PubMed, Scopus, and Google Scholar. Search terms included “Ethics”, “Rheumatology”, “Bad news”, “SPIKES” and “Difficult patient”. These keywords were used in different combinations, using a filter box with an option for the recent 5 years. Firstly, articles’ abstracts were analyzed, and only articles that met inclusion criteria were included. Also, references from the selected articles were analyzed, except for the older publications and those irrelevant to the specific topic. Since there was not enough information for these requests, we tried to narrow the search by combining the names of various (most common) rheumatological diseases and using them along with the main purpose of the search. Then, we focused on the publications that met criteria and analyzed the sources cited in them. The 'Related Citations' function was also used in the search strategy. In the literature review process, we included 10 MEDLINE/PubMed articles, 4 Scopus articles, and 2 Google Scholar articles. Aim. This paper analyzes utilization of the SPIKES protocol in rheumatology practice. Results. Currently, no studies have been conducted on the utilization of these approaches in rheumatology practice. There is insufficient data regarding comparison of the effectiveness of different protocols in enhancing communication between the healthcare provider (physician or nurse) and the patient. Effective communication between physicians and patients can be achieved by following the six-step SPIKES approach, which involves specific communication skills. Conclusion. Delivering bad news requires different approaches, but none of them have been specifically tailored for rheumatic disease patients. These patients have unique behavior patterns due to the nature of their illnesses, which can lead to a decrease in their quality of life, limited activity, and painful symptoms. As a result, they often turn to their doctors in a state of personal and mental suffering. Thus, the SPIKES protocol is a useful tool for rheumatology practice