This systematic review focuses on the therapeutic properties of the Ipomoea genus by examining its bioactive components and ethnobotanical uses. The review was conducted using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. The project compiles indigenous information from many regions worldwide regarding the medicinal uses of Ipomoea species, serving as a basis for future research and the advancement of pharmaceutical endeavors. Among the 4297 studies identified in the study, only 152 met the criteria for inclusion. The species that was most commonly employed was Ipomoea batatas (L.) Lam; it was utilized for the treatment of diabetes, along with other medical ailments. The genus encompasses a diverse array of ailments, including cancer, diabetes, dermatological disorders, and gastrointestinal disorders. Ipomoea species possess bioactive compounds that have anti-inflammatory, antibacterial, antioxidant, and anticancer properties. Further investigation is necessary to scientifically validate the medicinal capabilities of these plants and their bioactive constituents. This study should encompass clinical trials and complete pharmacological assessments while also upholding appropriate consumption practices and respecting indigenous knowledge.