Conferences are often organized within specialty disciplines, compartmentalizing information exchange by field of specialty. In the midst of these successful conferences there remains a niche for unifying, cross-cutting, interdisciplinary gatherings, where specialists can have exposure to diverse fields, a chance to meet new people in or near their individual areas of research, and participate in special sessions different from their own field. The proposed meeting of the 2nd International Conference on Mathematical Modelling and Computational Methods in Science and Engineering (ICMMCMSE-2020), has this purpose, to serve as a catalyst for computational mathematics among cutting edge applications in science and engineering.The fields of Mathematical Modelling and Computational Methods and their applications to major areas such as Fluid Dynamics, Structural Mechanics, Semiconductor Modelling, Electromagnetics and CAD/CAM. Multidisciplinary applications of these fields to critical societal and technological problems encountered in sectors like Aerospace, Car and Ship Industry, Electronics, Energy, Finance, Chemistry, Medicine, Biosciences, Environmental sciences, Graph theory are of particular interest.Computational mathematics, science and engineering are rapidly growing multidisciplinary areas with connections to business, economics, engineering, and mathematics and computer science through academia as well as industry. There is furthermore a constant need in these fields for the quick and efficient advancement of information exchange with an expert audience.Altogether, the intent of this conference is to exchange information and to promote the transfer between the research community and industry consistent with the development and applications of computational methods in science and technology. So, the conference theme provides opportunity to initiate and develop such activities among the researchers, scientists and engineers from all over the world.The overwhelming response to our call-for-papers indicates the popularity of this conference and confirms that the 2nd ICMMCMSE-2020 has become the world-wide forum for all aspects of Mathematics and Computer Science in science and technology. There are totally 575 participants have been registered for the conference. Out of this, 315 have been registered and presented their research findings in the “Contributed Talk” sessions and rest of the 260 participants have been registered themselves as a Listener for the conference. Thanks to this response, all important fields of the 2nd ICMMCMSE-2020 techniques, technology and exploitation are covered by their contributions. To our pleasure several Keynote and Invited sessions has been organised by eminent professors from USA, Turkey, Romania, UK, Thailand, New Zealand, UAE, Australia, some of the leading institutions in India like IIT’s and IIST.I would like to express my sincere thanks to all the authors for their outstanding contributions, sponsors for our conference RUSA 2.0, Elsevier Publishing Company, IOP Publishing Company, MDPI, AIMS Press and Hindawi Publishing House and in particular the members of the program board for their competent evaluation of the large number of submissions. Likewise, I would also like to express my appreciation to all the invited chairs for their careful preparation of the invited sessions. Dr. R. Raja Convener 2nd ICMMCMSE-2020