Specific Messages Research Articles

From the genome's perspective: Bearing somatic retrotransposition to leverage the regulatory potential of L1 RNAs.

Transposable elements (TEs) are mobile genomic elements constituting a big fraction of eukaryotic genomes. They ignite an evolutionary arms race with host genomes, which in turn evolve strategies to restrict their activity. Despite being tightly repressed, TEs display precisely regulated expression patterns during specific stages of mammalian development, suggesting potential benefits for the host. Among TEs, the long interspersed nuclear element (LINE-1 or L1) has been found to be active in neurons. This activity prompted extensive research into its possible role in cognition. So far, no specific cause-effect relationship between L1 retrotransposition and brain functions has been conclusively identified. Nevertheless, accumulating evidence suggests that interactions between L1 RNAs and RNA/DNA binding proteins encode specific messages that cells utilize to activate or repress entire transcriptional programs. We summarize recent findings highlighting the activity of L1 RNAs at the non-coding level during early embryonic and brain development. We propose a hypothesis suggesting a mutualistic relationship between L1 mRNAs and the host cell. In this scenario, cells tolerate a certain rate of retrotransposition to leverage the regulatory effects of L1s as non-coding RNAs on potentiating their mitotic potential. In turn, L1s benefit from the cell's proliferative state to increase their chance to mobilize.

Extracellular vesicles from microglial cells activated by abnormal heparan sulfate oligosaccharides from Sanfilippo patients impair neuronal dendritic arborization

BackgroundIn mucopolysaccharidosis type III (MPS III, also known as Sanfilippo syndrome), a pediatric neurodegenerative disorder, accumulation of abnormal glycosaminoglycans (GAGs) induces severe neuroinflammation by triggering the microglial pro-inflammatory cytokines production via a TLR4-dependent pathway. But the extent of the microglia contribution to the MPS III neuropathology remains unclear. Extracellular vesicles (EVs) mediate intercellular communication and are known to participate in the pathogenesis of adult neurodegenerative diseases. However, characterization of the molecular profiles of EVs released by MPS III microglia and their effects on neuronal functions have not been described.MethodsHere, we isolated EVs secreted by the microglial cells after treatment with GAGs purified from urines of Sanfilippo patients (sfGAGs-EVs) or from age-matched healthy subjects (nGAGs-EVs) to explore the EVs’ proteins and small RNA profiles using LC–MS/MS and RNA sequencing. We next performed a functional assay by immunofluorescence following nGAGs- or sfGAGs-EVs uptake by WT primary cortical neurons and analyzed their extensions metrics after staining of βIII-tubulin and MAP2 by confocal microscopy.ResultsFunctional enrichment analysis for both proteomics and RNA sequencing data from sfGAGs-EVs revealed a specific content involved in neuroinflammation and neurodevelopment pathways. Treatment of cortical neurons with sfGAGs-EVs induced a disease-associated phenotype demonstrated by a lower total neurite surface area, an impaired somatodendritic compartment, and a higher number of immature dendritic spines.ConclusionsThis study shows, for the first time, that GAGs from patients with Sanfilippo syndrome can induce microglial secretion of EVs that deliver a specific molecular message to recipient naive neurons, while promoting the neuroinflammation, and depriving neurons of neurodevelopmental factors. This work provides a framework for further studies of biomarkers to evaluate efficiency of emerging therapies.Graphical

Interrogating the environmental and social correlates of health risk behaviours in West Africa

Abstract Background Despite the high incidences of health risk behaviors (HRBs) in sub-Saharan Africa, studies on the contextual determinants of HRBs across countries are generally lacking, concentrated on isolated countries and often focus solely on specific health behaviors. Thus, this study investigated the environmental and social correlates of HRBs in West Africa. Methods Data was from post-2015 Demographic and Health Surveys in three West African countries of Benin, Mali and Nigeria. A composite outcome variable of health risk behaviors (HRBs) was derived from variables of tobacco smoking, intimate partner violence, overweight/obesity and risky sexual behaviors. The contextual variables were normalized difference vegetation index, precipitation, maximum and minimum temperatures, region of residence and population Density. Data analysis involved descriptive statistics, chi square test, geographical mapping, and multilevel logistic regression. Results The engagement in HRBs varied from 42.65% in Nigeria to 42.88% in Benin and 51.06% in Mali as there are spatial variations in the engagement in HRBs within different regions of these countries. There also existed significant variations in HRBs regarding age, education, employment status, wealth index, household size, place of residence, and region of residence in the three countries. In the contextual models of environmental and social factors, population density significantly increased odds of HRBs in the three countries, maximum temperature significantly increased odds of HRBs in Benin and Mali, while precipitation significantly increased odds of HRBs in Nigeria and Mali. Other factors which significantly increased odds of HRBs across the three countries were increase in age, wealth index, households with 9+ persons, and regions of residence. Conclusions These findings suggest that among other things, changes in lifestyles regarding the different HRBs should be emphasized in specific contextual situations Key messages • There are variations in engagement in health risk behaviours across the countries. • Cliamte variables influence engagement in health risk behaviours.

Time-Encoded Information Encryption with pH Clock Guided Broad-Spectrum Emission by Dynamic Assemblies.

With growing threats from counterfeiting-based security breaches, multi-level and specific stimuli-responsive anti-counterfeiting devices and message encryption methods have attracted immense research interest. Fluorescence-based encryption from aggregation-induced emission (AIE)-based materials solves the problems to a considerable extent. However, the development of smarter patterns with hierarchical security levels alongside dynamic display is still challenging. To screen out this complication, we bring forward a pH-switchable fluorescent assembly of an AIEgen and an aliphatic acid. We later temporally direct the molecular assembly with the aid of a chemical trigger-regulated pH clock, generating a transitory multicolor emission, including transient white light generation. The pH-dependent emissions were further implemented in constructing smart multi-input fluorescent chemical AND gates. Subsequently, we integrate the time-gated emissive system to develop an advanced multi-dimensionally secure data encryption strategy. This novel approach enhances anti-counterfeiting measures by introducing an additional layer of security based on temporal characteristics.

5099 Capturing the Patient Voice for Diabetes Eye Exams

Abstract Disclosure: S. Du: None. S. Lambrechts: None. M. Freeby: None. M. Han: None. Background: Diabetic retinopathy (DR) is a leading cause of blindness among adults 20-74 years old. Ophthalmic exams are recommended every 1-2 years for type 2 diabetes patients with minimal to no DR. The 50th percentile Integrated Healthcare Association benchmark for DR screening is 49%, but at our academic medical center, the completion rate is 30%. Potential barriers to screening noted in the literature include lower levels of education, lack of knowledge about DR, and financial barriers. Objective: To understand motivating factors and barriers to DR screening among patients in our health system. Methods: We utilized the Patient Voice qualitative research method to uncover themes and identify interventions to improve care delivery. The literature was synthesized to develop a structured interview guide. From our urban academic health system, 15 patients were randomly selected for interview, six of whom had completed the “Diabetes Eye Exam” care gap and nine that had not. Interviews were transcribed and coded for thematic analysis. Results: Six opportunity areas were identified. 1) There are currently only six retinal cameras located across primary and specialty care clinics serving more than 38,000 diabetes patients. 67% of patients felt the current clinic locations were inconvenient, with distant locations and long travel times. 2) 20% of patients expressed that they would like increased flexibility of appointments offered, such as evening, weekend, and same day appointments. 3) Patients were motivated by automated diabetes eye exam specific reminder messages and appreciated the ability to self-schedule within the patient portal. 47% of patients wanted yearly reminder messages, while 40% had no preference. 4) 53% of patients expressed that they did not fully understand DR or were confused about the difference between an optometrist exam and diabetes eye exam. 5) 40% of patients completed their eye exam with their local optometrist and found this to be a more convenient option. One patient expressed that she wished her doctor had informed her that she could complete her diabetes eye exam at a local optometry clinic. 6) If patients do choose to complete their exam with their local optometrist, they would like reminders to send their records to their primary care physician or endocrinologist. A more streamlined processes to upload outside records through the patient portal would decrease this barrier. Conclusion: It is important to engage patient stakeholders and understand their needs to improve overall experience and close care gaps. Through the Patient Voice, we learned that factors such as driving distance, traffic, scheduling, and issues with uploading records are major barriers to care gap completion. Convenient clinic locations, education, and reminder messages are motivating factors. Future work will focus on developing and implementing solutions in each opportunity area. Presentation: 6/1/2024

Evaluation of the 'A walk can work wonders' mass media campaign in South Australia.

Few population-wide efforts have targeted physical activity in Australia. Mass media campaigns are used to promote physical activity and walking, and World Health Organisation recommends their linkage to broader cross-government initiatives. This project evaluates a South Australian (SA) walking mass media campaign linked to the overall SA Walking Strategy. Between January and June 2022, Wellbeing SA (a SA government agency) conducted two waves of a mass media campaign, 'A walk can work wonders', to promote walking. The campaign was part of the SA Walking Strategy, targeting the goal to change the 'community culture towards recognising walking' as convenient, affordable and health-promoting. Evaluation was formative (pre-campaign), process (campaign implementation and delivery) and impact. Formative evaluation comprised concept and tagline testing with adult SAs to develop the campaign messages and theme. Process evaluation was comprised of media monitoring of social media, mainstream media and other media monitoring metrics. The process evaluation was dominated by social media marketing in Wave 1, with substantially more paid TV media and radio in Wave 2. The impact evaluation comprised two independent sample surveys of adult SAs (n = 800 each) following each wave of the campaign. Measures included generic and prompted campaign recall and attitudes to physical activity. An independent South Australian Population Health Survey (SAPHS) tracked walking and physical activity behaviours from 2021 to the end of 2022. Process evaluation showed intensive social media usage in Wave 1, and through increased paid television and radio in Wave 2. Generic recall of any walking message (23.9%) and prompted recall of the specific campaign message (27.8%) reached most socio-demographic groups, especially those with chronic health problems. Increases in intention to increase activity and increased self-reported activity were seen between the campaign Wave 1 and Wave 2 notable as the Wave 2 increase followed substantial television advertising. The SAPHS data showed increased population walking following the campaign waves, compared to the same period in 2021. Detailed and structured evaluation of a comprehensive mass media campaign showed good reach, and population changes in intentions and walking behaviour amongst SAs. SO WHAT?: It is likely that comprehensive approaches are needed to support mass media campaigns and amplify their effects. Serial, sustained campaigns are needed to monitor ongoing effects.

DYNAMICS OF THE EU STRATEGIC COMMUNICATIONS REGARDING THE EUROPEAN INTEGRATION OF UKRAINE

This research covers the analysis of changes in the strategic communications of the European Union regarding the European integration of Ukraine during 2000-2023. Specifically, it pays attention to the reactions of key EU officials to significant political events and foreign policy challenges. Having used the semantic analysis of official documents and speeches, the study presents the evolution of approaches and perspectives, revealing the hidden strategies, intentions, and ideological influences that shape the EU policy. The analysis emphasizes the growing importance of Ukraine in the strategic plans of the EU, while the geopolitical context significantly affects the European integration process. Examining the communication activity of the main EU institutions since 2022, the study has revealed specific messages regarding Ukraine's prospects for becoming a member of the EU, recognizing the successes in carrying out reforms and the country’s efforts to achieve the goals underlying its status as a candidate for membership.

Eating frequency, timing of meals, and sleep duration before and after a randomized controlled weight loss trial for breast cancer survivors.

To examine eating frequency, timing of meals, and sleep duration before and after a weight loss intervention for breast cancer survivors. Female breast cancer survivors (n = 159; 55 ± 9years; 31.4 ± 5.0 kg/m2; stage I-III, median [IQR] 9.5 [5.5] months post-diagnosis) participated in a randomized controlled trial of a 12-month weight loss intervention versus usual care. Eating frequency, proportion of daily calories consumed after 5 PM, eating after 8 PM, nightly fasting duration, and sleep duration were estimated and categorized based on existing associations with factors influencing breast cancer prognosis and breast cancer outcomes. These behaviors at baseline were compared to women from an Australian national survey with similar age and BMI range. Mixed-effects linear regression models were used to examine the changes in health behaviors from baseline to 18months between intervention and usual care groups. Before the trial, eating after 8 PM (67%) was higher, and short nightly fasting duration (< 13h, 83%) and long sleep duration (> 9h/day, 26%) were marginally higher, in breast cancer survivors than women in the national survey (52%, 75%, and 17%, respectively). "Less optimal" eating behaviors and sleep duration tended to co-occur. Behaviors remained unchanged over the 18-month follow-up, irrespective of the study group (p > 0.05; Cohen's effect sizes < 0.3). Later timing of eating and long sleep duration were prevalent in breast cancer survivors and continued following a weight loss intervention. Future multi-behavior interventions in breast cancer survivors should consider specific messages to target eating timing behaviors and sleep.

Statistically optimal firstorder algorithms: a proof via orthogonalization

Abstract We consider a class of statistical estimation problems in which we are given a random data matrix ${\boldsymbol{X}}\in{\mathbb{R}}^{n\times d}$ (and possibly some labels ${\boldsymbol{y}}\in{\mathbb{R}}^{n}$) and would like to estimate a coefficient vector ${\boldsymbol{\theta }}\in{\mathbb{R}}^{d}$ (or possibly a constant number of such vectors). Special cases include low-rank matrix estimation and regularized estimation in generalized linear models (e.g. sparse regression). Firstorder methods proceed by iteratively multiplying current estimates by ${\boldsymbol{X}}$ or its transpose. Examples include gradient descent or its accelerated variants. Under the assumption that the data matrix ${\boldsymbol{X}}$ is standard Gaussian, Celentano, Montanari, Wu (2020, Conference on Learning Theory, pp. 1078–1141. PMLR) proved that for any constant number of iterations (matrix vector multiplications), the optimal firstorder algorithm is a specific approximate message passing algorithm (known as ‘Bayes AMP’). The error of this estimator can be characterized in the high-dimensional asymptotics $n,d\to \infty $, $n/d\to \delta $, and provides a lower bound to the estimation error of any firstorder algorithm. Here we present a simpler proof of the same result, and generalize it to broader classes of data distributions and of firstorder algorithms, including algorithms with non-separable nonlinearities. Most importantly, the new proof is simpler, does not require to construct an equivalent tree-structured estimation problem, and is therefore susceptible of a broader range of applications.

Employing targeted outreach to improve community involvement in detecting invasive Nile monitors (Varanus niloticus) in Florida

We successfully employed targeted outreach to communities in Palm Beach County, Florida, to enhance detection of invasive reptiles. We defined targeted outreach as delivering a specific message to a specific audience, at a specific location, to obtain a specific result. These efforts improved our ability to solicit community involvement focused on target species of interest in locations at risk of potential establishment of incipient populations. From 2018 through 2020, we reached over 112,000 individuals who reported over 50 nonnative lizard sightings to EDDMapS, a web-based mapping system for documenting invasive species, and the State-managed IVE-GOT1 reporting hotline. We considered reports to be directly attributed to our outreach efforts when the reporter indicated our outreach method as the source from which they obtained information on reporting large invasive lizards. We found print media elicited the most reports, while social media reached the largest audience both in direct shares and spillover to additional communities outside our target area. We concluded that to help improve invasive species management programs, three tactics could be employed: (1) using multiple forms of media, (2) additional educational support to improve the accuracy of public reports, and (3) rapid, dedicated capability to respond to reported sightings.

Effect of various active reminders via mobile phone on cooperation of orthodontic teenage patients regarding oral hygiene and ClassII elastics use : Athree-month follow-up prospective cohort study.

The purpose of this prospective cohort study was to assess the impact of reminders via mobile phone, such as text messages or video/multimedia images, on orthodontic patients' cooperation with regard to oral hygiene and the use of ClassII intermaxillary elastics. The study included 124 orthodontic patients aged 12-20years (mean age14.06 ± 2.0 years, 63females and 61males). The patients were divided into two groups: group1 (n = 56) was evaluated for oral hygiene, while group2 (n = 68) was evaluated for the use of ClassII intermaxillary elastics. Each main group was divided into three subgroups: text message group, video message group, and control group. Specific messages were sent to the participants in the study groups twice aweek for 12weeks. Data were collected at the beginning of the study (T0), after 6weeks (T1), and 12weeks (T2) and compared to determine the impact of the reminders. Oral hygiene was evaluated using plaque and gingival index scores, and the use of ClassII elastics was evaluated using digital model measurements. Between-subject comparisons were performed using Kruskal-Wallis or one-way analysis of variance (ANOVA). For within-subject comparisons (T0-T1, T1-T2, and T0-T2 time intervals), one-way repeated measures ANOVA or Friedman test was performed. There was no significant difference between the control group (1.49 ± 0.22) and the message groups (video: 1.58 ± 0.34 and text: 1.51 ± 0.28) in terms of plaque index scores and gingival index (control: 1.56 ± 0.26, text: 1.51 ± 0.36, video: 1.52 ± 0.26) scores. However, in the intragroup comparison, it was observed that both plaque index scores and gingival index scores at T0, T1, and T2 increased for both the study and control groups. While there was no difference between the subgroups in overjet measurement at T0 (control: 3.46 ± 1.20, video: 3.34 ± 1.20, text: 2.73 ± 1.03; p = 0.51), there was asignificant difference at T2 (control: 2.62 ± 0.85, video: 2.32 ± 1.41, text: 1.48 ± 0.72, p < 0.01). Mobile active reminders had no effect on improving oral hygiene. Despite repeated reminders, hygiene worsened over time. The use of ClassII elastics seemed to have increased as aresult of the mobile reminders.

Compositional Elements of Photographic Coverage of the Westgate Mall Terrorist Attack

Purpose: Terrorism is a global threat that has prompted extensive research, with mass media playing a crucial role in reporting such events. This study investigated the compositional elements of photographic coverage of the Westgate Mall terrorist attack in Nairobi, Kenya, on September 21, 2013. Methodology: Photographs from the Daily Nation, Standard, and New York Times were analysed. Using qualitative descriptive research and content analysis through MaxQDA software, the study identified patterns and themes in the images, focusing on denotative, stylistic-semiotic, connotative, and ideological representations. Findings: It was found that camera angles, shot proximity, and image sizes were strategically used by photojournalists to convey messages and emotions. Large images on front pages provided visual appeal, while medium and small images added content and facilitated sensationalized storytelling. Shot proximity varied to deliver specific messages, with few close-ups used to avoid evoking sombre emotions or aiding terrorist propaganda. Unique Contribution to Theory, Practice and Policy: The study contributes to the existing mass media research by highlighting the importance of thoughtful image selection and composition in responsible photojournalism to balance accurate reporting with mitigating potential harm.

Communicative Competence in the Select Speech of Shri Narendra Modi: A Linguistic Analysis

The close connection between language and ideology has long been a recurring subject of study among linguists. Politicians often rely on language manipulation to convey specific messages, discussing topics that seem familiar but may not be fully understood by the audience. This study uses critical discourse analysis to identify the presuppositions and entailments, and thus the ideology, in a speech delivered by the Prime Minister of India, Shri Narendra Modi. The speech is an appeal from Modi to the people of India. A closer examination reveals that Prime Minister Modi employed various persuasive strategies to achieve political and ideological goals. The analysis of the selected speech of Shri Narendra Modi for Swachh Bharat mission on Independence Day establishes the social practises followed and the text that influences the people to bring changes in our society. The level of text and the level of context is analysed for linguistic analysis in six categories like phonology, syntax, semantics, conceptual, belief and para linguistics.

Exploring perceptions of anti-vaping message themes: A qualitative study of Australian adolescents and adults.

Minimising electronic cigarette (e-cigarette) uptake and encouraging vaping cessation have become important components of public health agendas. Given the success of well-designed anti-smoking campaigns, attention has turned to developing health communications that target vaping. Although prior work has identified a range of potentially effective campaign messages, several gaps in the literature remain. We aimed to (i) identify message themes perceived to be effective at minimising e-cigarette use and (ii) elicit opinion on how these message themes could be optimised in terms of message execution and delivery. Focus groups (n = 16) were conducted with adolescents (14-15 and 16-17 year olds), young adults (18-24 year olds), and adults (25-39 year olds). The groups reported on message themes they believed would assist with minimising e-cigarette use. They then provided feedback on 14 message themes developed by the research team. Data were analysed using reflexive thematic analysis. Groups discussed a range of message themes they believed would be effective. These included themes focused on the health harms associated with vaping, the chemical ingredients in e-cigarettes, use dependence, and social attitudes to use. Groups discussed the importance of using evidence-based personal testimonies, and reported that messages would be most effectively communicated via social media, in public places, and at point of sale. Results build on existing research by identifying message themes perceived to be most effective, and how these would best be executed. Results have the potential to inform the development of co-designed health communication campaigns addressing youth vaping. Using a stratified focus group methodology, we collected rich and detailed qualitative data on Australians' perceptions of anti-vaping message themes. Themes considered most effective were those that addressed the health harms of vaping, the chemical ingredients in e-cigarettes, social consequences of use and the impacts of dependence. We recommend further work to develop and trial a range of specific anti-vaping messages based on the themes identified as having the most potential. This process should include iterative co-design with the target audience to optimise future health communication campaigns.

Communication Strategy of BPBD of East Java Province in Reducing Disaster Risk: Case Study of Disaster Prevention Socialization

This study focuses on the effectiveness of the communication strategy of the East Java Provincial Disaster Management Agency (BPBD) in disaster socialization. Using a qualitative approach and case study method, this study evaluates the selection of communicators, target setting, messages, and communication media used. The results of the study indicate that selecting the right communicator, including collaboration with the Regency/City BPBD and experts, significantly increases public understanding of disaster risk. In addition, adjusting messages according to local characteristics and disaster vulnerability levels is effective in clarifying information to the public. Social media and innovations such as the Disaster Management Education Car (MOSIPENA) and the Disaster Education Tent (TEMPINA) have been proven to expand reach and increase community involvement. The novelty of this study includes an in-depth analysis of the strategy for selecting communicators and cross-sectoral collaboration in disaster communication, as well as the adjustment of innovative and specific messages according to the characteristics of disaster-prone areas. This study also highlights the use of technology and social media to improve the effectiveness of socialization, as well as the implementation of innovative methods in delivering disaster information. These findings offer a practical model for more effective disaster socialization and open up opportunities for further research in the development of disaster communication methods.

Impact éloquent des mots empruntés et arabisés dans la traduction: Analyse des emprunts lexicaux dans les œuvres d’Al-Ghazāli «Al-munqid Min Addalâl (Erreur et Délivrance)» et «Le livre des Bons Usages en Matière de Mariage»

Eloquent Impact of Borrowed and Arabicized Words in Translation: Analysis of loanwords in Al- Ghazāli’s work «'Al-munqid min addalâl (Erreur et Délivrance)» and «Le livre des Bons Usages en Matière de Mariage» The Arabisation of words is a common practice in Arabic translation. It involves borrowing words from other languages and adjusting their phonetics to fit Arabic phonology. Sometimes, these words undergo semantic adaptations to fit into specific contexts, enriching the Arabic lexicon with essential terms. Such linguistic borrowings have seamlessly integrated into Arabic over time, serving both specialised and everyday functions. In the French translation of two works by Al-Ghazāli, "Al-munqid Min Addalâl (The Deliverance from Error)" and "Le livre des Bons Usages en Matière de Mariage (The Book of Good Practices in Marriage)," it is noteworthy that several Arabised words have been retained without translation. Instead, they are presented alongside their equivalents or with explanatory notes. The translator’decision to preserve these Arabised words by the translator reflects a desire to convey the original author's specific messages. It underlines a commitment to maintain the semantic depth of the original texts while honoring the cultural and linguistic richness of Arabic. These words imbue the analysed texts with profound meaning, adding a semantic dimension that enhances the works in both Arabic and French. This approach caters to a French readership interested in exploring the nuances of Al-Ghazāli's works, ensuring the integrity of his writings is preserved. It guarantees an authentic and comprehensive reading experience that captures the richness and subtleties of the original texts.

Revocable identity-based designated verifier proxy re-signature with signature evolution

Identity-based proxy re-signature (IDPRS) enables a semi-trusted proxy to convert one user’s signature to another user’s for the same message without revealing any secret information of both users’ signing keys. In IDPRS, user revocation is a necessary problem arising from privilege expiry or private key compromise. A revoked user cannot produce new signatures including re-signatures from the proxy. There is a need for some applications like a contract management system to keep expired message and signature pairs valid in the next period. The conventional solution is to require the unrevoked users to sign these messages again, which burdens users heavily. Therefore, establishing an IDPRS system with revocation and efficient signature updating is crucial. This paper introduces the concept of revocable IDPRS with signature evolution, facilitating efficient signature updating. The signature evolution enables the proxy to batch update non-revoked users’ signatures from old ones to new ones, while also offering precise execution of signature updates on specific messages. Moreover, to further protect the privacy of signature validity, we employ designated verifier in our scheme. Formal security proofs are provided, and performance evaluation demonstrates our scheme’s lower computation costs for signature updating and its comprehensive security attributes.

Bone health education in individuals with spinal cord injury or disease-the Bare Bones Podcast Series: plan it, produce it, post it!

The Consortium for Spinal Cord Medicine's inaugural Clinical Practice Guideline for Bone Health and Osteoporosis Management for Individuals with Spinal Cord Injury or Disease (CSCM-CPG) was published in 2022 for a clinician audience. The aim of this project was to develop a podcast series to ensure people with lived experience with Spinal Cord Injury or Disease (PLEX) understand the CSCM-CPG content and know how to act to reduce their fracture risk. The "Bare Bones Podcast Series" consists of nine episodes; one related to each CSCM-CPG chapter. The podcast content and the questions asked in each podcast were co-developed by PLEX partners (PLEX-P) and the project team. Two PLEX-P acted as co-hosts for the series. The invited speaker(s) were CSCM-CPG expert panel members who participated in an informal dialogue with the hosts. Each podcast closes with a specific action a listener can do to advance their bone health. The related Educational Action Planning Tool (EAT) handouts contain text and infographic information specific to each podcast episode and include key concepts and a specific actionable take-home message. Local PLEX reviewers (PLEX-R) were invited to review podcast episodes and EATs and provide their feedback through focus group participation or one-on-one (1:1) interviews. The project team revised the podcast episodes and the EATs based on feedback from the PLEX-R prior to releasing them online. Nine podcast episodes and related EATs were designed and created collaboratively with 3 PLEX-P, 22 PLEX-R, 11 CSCM-CPG expert panel members, and the project team. The episodes were titled: "Introduction to the Bare Bones of Bone Health"; "Fracture 101"; "Blood Tests-a Window into You"; "I See Your Skeleton"; "Vitamin D for all, Calcium for Some"; "Get Moving and Loading"; "Pills or Poisons & Atomic Habits"; "Snap and Crack"; and "Directions for Research". The Bare Bones Podcast Series was shared through the project website. The podcasts will aid PLEX and their family caregivers to advocate for ongoing bone health assessments and to promote an ongoing dialogue with care team members regarding how to prevent fractures and fracture-related morbidity and mortality.

Primary somatosensory cortical processing in tactile communication.

Touch is an essential form of non-verbal communication. While language and its neural basis are widely studied, tactile communication is less well understood. We used fMRI and multivariate pattern analyses in pairs of emotionally close adults to examine the neural basis of human-to-human tactile communication. In each pair, a participant was designated either as sender or as receiver. The sender was instructed to communicate specific messages by touching only the arm of the receiver, who was inside the scanner. The receiver then identified the message based on the touch expression alone. We designed two multivariate decoder algorithms-one based on the sender's intent (sender-decoder), and another based on the receiver's response (receiver-decoder). We identified several brain areas that significantly predicted behavioural accuracy of the receiver. Regarding our a priori region of interest, the receiver's primary somatosensory cortex (S1), both decoders were able to accurately differentiate the messages based on neural activity patterns here. The receiver-decoder, which relied on the receivers' interpretations of the touch expressions, outperformed the sender-decoder, which relied on the sender's intent. Our results identified a network of brain areas involved in human-to-human tactile communication and supported the notion of non-sensory factors being represented in S1. This article is part of the theme issue 'Sensing and feeling: an integrative approach to sensory processing and emotional experience'.

A Linguistic Analysis of Idiomatic Expressions in Town Bemba: A Systematic Functional Linguistic

Idioms, as linguistic expressions, convey meanings that go beyond the literal interpretation of words. They are deeply rooted in historical and cultural contexts and are widely utilized by language speakers to effectively communicate specific messages. These expressions have diverse origins, including historical events, folklore, mythology, and popular culture, and they form an integral part of daily communication among Bemba speakers. In recent times, urban speakers of Town Bemba have developed idioms that reflect modern life and are associated with multilingual practices and shared experiences. This study aims to examine the nature of Town Bemba idioms as spoken in the Copperbelt province in Zambia. The study is guided by aspects of the Systemic Functional Linguistics (SFL) model and the concept of recontextualization in analyzing the nature of idiomatic expressions used in Town Bemba. The study collected idioms from 20 purposively selected speakers of Town Bemba for oral interviews. The data were descriptively examined to unpack the conveyed meanings and the nature and form of the idioms in Town Bemba. The findings suggest several linguistic processes that give rise to idiomatic expressions, including linguistic coining, blending, and recontextualization of meaning. Additionally, the study demonstrates how multilingualism is used as a resource in forming non-traditional idiomatic expressions, incorporating linguistic features from different language sources. The study further shows how socio-cultural context and shared experiences of the speakers play a key role in determining the meaning associated with idioms.