The trends in the production of special equipment for mass production are analyzed and the prospects for the use of multi-tool blocks for such equipment are established. The questions of synthesis of variants of multi-tool machining for parts with a large number of machined sides and machining surfaces are considered. Three groups of factors of a technological, geometrical and technical nature are established, which have a dominant influence on the compatibility of machining with tools in one tool block. Their allowable values and the proposed matrix of compatibility of technological operations performed are established. Based on the research carried out, a refined method for the synthesis of multi-tool blocks of special machine tools is proposed, the layout of which is based on the maximum use of unified modules and assemblies. This approach does not depend on the technological operations performed and on which modules can be used for the design implementation of the proposed tool block layout. The proposed method is focused on the use of computer-aided design systems in the process of creating machine tools with an aggregate-modular layout for mass production. It is based on the wide use of the knowledge base of the technical characteristics and technological capabilities of the modules used and makes it possible to initially configure the synthesis system for specific tasks solved at the enterprise by establishing admissible boundary parameters.