Spearman Rank-order Correlation Test Research Articles

Basic coagulation parameters and platelet count among malaria patients attending at Addis Zemen Primary Hospital, Northwest Ethiopia.

Malaria is an intravascular parasitic-related blood disease that causes bleeding, coagulopathy, and thrombocytopenia. However, limited data shows the effect of Plasmodium species infection on basic coagulation parameters and platelet count. Thus, this study aimed to assess basic coagulation parameters and platelet count among malaria patients. A cross-sectional study was conducted among 240 study participants (120 cases and 120 controls) from June 1, 2021, to February 30, 2022. A convenient sampling technique was employed to select study participants. The blood sample was collected by a trained laboratory technologist for platelet counts, prothrombin time (PT), partial thromboplastin time (PTT), international normalization ratio (INR), blood film, and serological testing. The collected data were analyzed in SPSS version 23. Data were analyzed by the Mann-Whitney U test, Kruskal Wallis H, and Spearman's rank-order correlation tests. Descriptive findings were presented through median, tables, and chart. In all cases, a P-value < 0.05 was considered statistically significant. The percentage of mild, moderate, and high malaria parasitemia levels per microliter of blood was 21.7%, 20%, and 58.3%, respectively. The overall median malaria parasitemia was 10,304 per microliter of blood. Among malaria patients, 77.5%, 61.7%, and 51.7% had prolonged PT, INR, and APTT, respectively as compared to control. Moreover, 26.7% of Plasmodium-infected participants had mild thrombocytopenia as compared to the control group (P < 0.001). The value of PT, APTT, and INR were significantly elevated, whereas the level of platelet count was inversely reduced when the malaria parasitemia level increased as compared to controls (p < 0.001).

Evaluating trends in groundwater quality of coastal alluvial aquifers of Eastern India for sustainable groundwater management.

Groundwater is a precious natural element which ensures global water, food, and environmental security in the twenty-first century. Systematic monitoring, sustainable utilization, preservation and remediation are critical aspects of efficient groundwater resource management. This study deals with the analysis of spatial variability and trend in groundwater chemistry as well as identification of possible contamination sources in a coastal alluvial basin of eastern India. Pre-monsoon season data of 14 groundwater-quality variables measured in 'leaky confined' and 'confined' aquifers were analyzed for ten years (2012-2021). Mann-Kendall (M-K) test with the Sen's Slope Estimator, Spearman Rank Order Correlation (SROC) and Innovative Trend Analysis (ITA) tests were employed to assess decadal (2012-2021) trends. The analysis of the results indicated that the 'critical' water-quality parameters exceeding the acceptable limits for drinking are TDS, EC, TH, pH, Mg2+, Na+, K+, Fe2+, HCO3-, Cl- and NO3-. Weak negative correlations between rainfall and groundwater elevation for both the aquifers reveal poor rainfall recharge into the aquifers. Therefore, a reduction in groundwater abstraction and augmentation of groundwater recharge is recommended. Trend analysis results indicated that the concentrations of TH, Mg2+ and Fe2+ exhibit significant increasing trends in the 'leaky confined aquifer'. In contrast, significant rising trends in TH, Mg2+, Na+, Fe2+, HCO3- and NO3- concentrations are identified in the 'confined aquifer'. Further, the SROC test could not detect the trends in groundwater quality in most blocks and for many parameters. On the other hand, the ITA test revealed significant trends in most of the parameters of the two aquifers in almost all the blocks. Trend magnitudes of the groundwater-quality parameters based on the Sen's Slope Estimator and the ITA test vary from -63.7 to 58.65mg/L/year for TDS, -14 to 39.07mg/L/year for TH, -1.49 to 4.83mg/L/year for Mg2+, -7.14 to 22.96mg/L/year for Na+, -0.32 to 0.44mg/L/year for Fe2+, -8.33 to 20.75mg/L/year for HCO3-, -26.52 to 31.01mg/L/year for Cl- and 1.29 to 3.76mg/L/year for NO3- over the study area. The results of M-K and ITA tests were found in agreement in all the blocks for both the aquifers. Groundwater contamination in both the aquifers can be attributed to weathering, geogenic processes, mineral dissolution, seawater intrusion, poor recharge pattern and injudicious anthropogenic activities. It is strongly recommended that concerned authorities urgently formulate efficient strategies for managing groundwater quality in the 'leaky confined' and 'confined' aquifers which serve as vital sources of drinking and irrigationwater suppliesin the study area.

Health-associated changes of the fecal microbiota in dairy heifer calves during the pre-weaning period.

Neonatal calf diarrhea is a multifactorial condition that occurs in early life when calves are particularly susceptible to enteric infection and dysbiosis of the gut microbiome. Good calf health is dependent on successful passive transfer of immunity from the dam through colostrum. There are limited studies on the developing gut microbiota from birth to weaning in calves. Therefore, the objective of this study was to examine the effect of immune status and diarrheal incidence on the development of the fecal microbiota in Jersey (n = 22) and Holstein (n = 29) heifer calves throughout the pre-weaning period. Calves were hand-fed a colostrum volume equivalent to 8.5% of their birthweight, from either the calf's dam (n = 28) or re-heated mixed colostrum (≤2 cows, ≤1d; n = 23) within 2 h of birth. All calves were clinically assessed using a modified Wisconsin-Madison calf health scoring system and rectal temperature at day (d) 0, d7, d21, or disease manifestation (DM) and weaning (d83). Weights were recorded at d0, d21, and d83. Calf blood samples were collected at d7 for the determination of calf serum IgG (sIgG). Fecal samples were obtained at d7, d21/DM [mean d22 (SE 0.70)], and at weaning for 16S rRNA amplicon sequencing of the fecal microbiota. Data were processed in R using DADA2; taxonomy was assigned using the SILVA database and further analyzed using Phyloseq and MaAsLin 2. Significant amplicon sequence variants (ASVs) and calf performance data underwent a Spearman rank-order correlation test. There was no effect (p > 0.05) of colostrum source or calf breed on serum total protein. An effect of calf breed (p < 0.05) was observed on sIgG concentrations such that Holstein calves had 6.49 (SE 2.99) mg/ml higher sIgG than Jersey calves. Colostrum source and calf breed had no effect (p > 0.05) on health status or the alpha diversity of the fecal microbiota. There was a relationship between health status and time interaction (p < 0.001), whereby alpha diversity increased with time; however, diarrheic calves had reduced microbial diversity at DM. No difference (p > 0.05) in beta diversity of the microbiota was detected at d7 or d83. At the genus level, 33 ASVs were associated (adj.p < 0.05) with health status over the pre-weaning period.

A Comparison of CT Perfusion Output of RapidAI and Viz.ai Software in the Evaluation of Acute Ischemic Stroke.

Automated CTP postprocessing packages have been developed for managing acute ischemic stroke. These packages use image processing techniques to identify the ischemic core and penumbra. This study aimed to investigate the agreement of decision-making rules and output derived from RapidAI and Viz.ai software packages in early and late time windows and to identify predictors of inadequate quality CTP studies. One hundred twenty-nine patients with acute ischemic stroke who had CTP performed on presentation were analyzed by RapidAI and Viz.ai. Volumetric outputs were compared between packages by performing Spearman rank-order correlation and Wilcoxon signed-rank tests with subanalysis performed at early (<6 hours) and extended (>6 hours) time windows. The concordance of selecting patients on the basis of DAWN and DEFUSE 3 eligibility criteria was assessed using the McNemar test. One hundred eight of 129 patients were found to have adequate-quality studies. Spearman rank-order correlation coefficients were calculated on time-to-maximum >6-second volume, time-to-maximum >10-second volume, CBF <30% volume, mismatch volume, and mismatch ratio between both software packages with correlation coefficients of 0.82, 0.65, 0.77, 0.78, 0.59, respectively. The Wilcoxon signed-rank test was also performed on time-to-maximum >6-second volume, time-to-maximum >10-second volume, CBF <30% volume, mismatch volume, and mismatch ratio with P values of .30, .016, <.001, .03, <.001, respectively. In a 1-sided test, CBF <30% was greater in Viz.ai (P < .001). Although this finding resulted in statistically significant differences, it did not cause clinically significant differences when applied to the DAWN and DEFUSE 3 criteria. A lower ejection fraction predicted an inadequate study in both software packages (P = .018; 95% CI, 0.01-0.113) and (P = .024; 95% CI, 0.008-0.109) for RapidAI and Viz.ai, respectively. Penumbra and infarct core predictions between Rapid and Viz.ai correlated but were statistically different and resulted in equivalent triage using DAWN and DEFUSE3 criteria. Viz.ai predicted higher ischemic core volumes than RapidAI. Viz.ai predicted lower combined core and penumbra values than RapidAI at lower volumes and higher estimates than RapidAI at higher volumes. Clinicians should be cautious when using different software packages for clinical decision-making.

Comparison of performances of SIREN or MFSRS in stroke risk prediction in an African environment

BackgroundThe Modified Framingham Stroke Risk Score (MFSRS) is a widely utilized stroke risk assessment algorithm usually applied in international comparison. The Stroke Investigative Research and Educational Network (SIREN) is the only known African-specific stroke risk assessment algorithm.Aims and objectivesTo compare stroke risk estimates from the SIREN and the MFSRS in an African community.MethodsThis was a population-based cross-sectional survey involving consecutively recruited 310 consenting adult residents (mean age = 37.21 ± 15.84 years) of a Nigerian community. Risk factors of stroke were assessed among the participants and were utilized in calculating stroke risk estimates on the MFSRS and the SIREN. The obtained data were analyzed using descriptive statistics and the Spearman-rank order correlation test at an alpha level of 0.05.ResultsThe percentage stroke risk scores estimated by the SIREN and the MFSRS were 34.5% and 6.79% respectively. The most prevalent risk factors among the participants were hypertriglyceridemia (100.0%), raised waist-hip ratio (50.6%), hypercholesterolemia (45.5), physical inactivity (43.2%), psychological stress (41.3%), and hypertension (37.7%). Only two (hypertriglyceridemia and high blood pressure) out of the six factors considered in the MFSRS were rated among the first 10 most impactful risks by the SIREN. There was a weak correlation between the total scores on the MFSRS and the SIREN (rho = 0.39; p < 0.01) suggesting that the two ratings were discordant.ConclusionThere were disagreements between the risk estimates on the SIREN and MFSRS with SIREN having a higher estimate that corresponded with the literature; this may be suggesting a poorer estimation of stroke risks by the MFSRS in an African environment. There is a need for large African-based quality control studies to determine and address these lapses.

Trans Woman Voice Questionnaire Scores Highlight Specific Benefits of Adjunctive Glottoplasty With Voice Therapy in Treating Voice Feminization.

Treatment options to assist patients to produce a more perceptually feminine voice include voice therapy (VT) and surgeries to elevate pitch such as the Wendler glottoplasty (WG). The Trans Woman Voice Questionnaire (TWVQ) is a validated quality of life measure for trans women's self-reported perceptions of their voice and is frequently administered before and after such interventions. The 30 statements broadly pertain to how feminine a patient feels their voice is, how effortful it is to produce their voice, and how their voice impacts them psychosocially, making it a useful and specific outcome measure when treating trans females for voice concerns. To compare quality of life outcomes between VT and VT with adjunct WG (VT+WG) based on changes in ratings of individual statements on the TWVQ. A retrospective case series of 31 trans female patients treated was completed. A total of 17 patients underwent VT and 14 underwent VT with adjunctive WG. Ratings for each of the 30 TWVQ statements were compared before and after treatment for each group. Wilcoxon rank-sum tests were used to compare rating changes before and after treatment. Spearman rank-order correlation tests were used to assess the association between total TWVQ score and "current voice" rating. WG was associated with statistically significantly improved ratings for every statement on the TWVQ except one. In contrast, VT was associated with statistically significant improvements in 16 of the 30 statements, which largely pertained to patient emotions surrounding their voice rather than physical aspects such as pitch and dysphonia. Furthermore, while both WG+VT and VT improved the "current voice" rating significantly, WG improved the score by nearly 1 unit more. Lastly, we found a positive association between the total TWVQ score and current voice rating, indicating that lower scores were associated with more self-perceived feminine-sounding voices (P < 0.01). Both VT and VT+WG result in improvements in the TWVQ. The specific statements on the TWVQ offer insight into specific quality of life treatment outcomes, with VT associated with improvements in mostly psychosocial aspects of voice production and VT+WG with both psychosocial and physical aspects.

Landscape of the Radiosensitizing Properties of Targeted Agents from the NCI CTEP Portfolio across Genomically Diverse 3D Tumor Models

Clinical translation of molecular targeted radiosensitizers remains challenging. To improve the robustness of preclinical data, we sought to broadly examine across a wide spectrum of genomic cancer features the radiosensitizing properties of targeted drugs from the NCI Cancer Therapy Evaluation Program (CTEP). As part of a U01 Consortium, we adapted a robotic high-throughput platform for testing ionizing radiation (IR) plus drug combinations in 3D cultures derived from non-small cell lung carcinoma (NSCLC), head/neck (HNSCC), and pancreatic cancers. All cell lines were annotated, mycoplasma free, and re-authenticated. Signal windows were established for all 3D growth formats. CTEP drugs were added in four concentrations 24 hours prior to IR exposure of 384-well plates. Five days after IR, cell viability was assessed, an endpoint previously benchmarked using colony formation. Each data point was based on 4-6 technical replicates with 2 biological repeats. A multistep statistical method combining Wilcoxon signed-rank and Spearman rank-order correlation tests together with adjusted Benjamini-Hochberg corrections for multiple comparisons was used to identify radiosensitization hits. Select validation experiments of hits were carried out. We screened 73 3D tumor models with 34-42 CTEP drugs each plus IR (n = 10,744 cell line/drug concentration combinations). IR/drug patterns were comparable for the three cancer types. DNA damage response (DDR) inhibitors constituted the most active class of radiosensitizers with DNA-PKcs, PARP, and ATR being the top targets. In contrast, the majority of the other agents radiosensitized only a minority of models. Highlighting NSCLC, out of 1,120 cell line/drug combinations, 328 (29.3%) were associated with statistically significant radiosensitization. PARP inhibitors, of particular interest for clinical translation in this space, demonstrated relatively broad radiosensitization for talazoparib (62%) and olaparib (44%) but less so for veliparib (28%), which correlated with differential PARP trapping potentials. Radiosensitization was evident even for tumor genotypes associated with radioresistance such as mutant KRAS, KEAP1, and STK11. Interestingly, single-agent activity of olaparib was more pronounced in 11/30 3D cultures compared to 2D growth conditions but with only 2/11 having known homologous recombination defects. Lastly, for HPV negative HNSCC (735 combinations), there was radiosensitization in subsets of models for IAP, ATR, and AKT targets, which are under clinical investigation. We present a unique resource for examining radiosensitizing drug properties in 3D cultures. The observed radiosensitization patterns strongly argue for the use of larger panels of clinically relevant tumor models rather than a few non-representative cell lines. Our data highlight the urgent need for predictive biomarkers to guide IR/drug combinations, even for some DDR inhibitors.

Detections of organophosphate and pyrethroid insecticide metabolites in urine and sweat obtained from women during infrared sauna and exercise: A pilot crossover study.

Synthetic pesticides such as organophosphates and pyrethroids are commonly used worldwide yet the metabolic and long-term human health effects of these environmental exposures are unclear. Urinary detections of metabolites involving both classes of insecticides have been documented in various global populations. However, reports documenting similar detections in human sweat are sparse. In this study, the concentrations of four insecticide metabolites were measured using liquid chromatography coupled with tandem mass spectrometry in repeated sweat and urine collections (n=85) from 10 women undergoing three interventions (control, infrared sauna and indoor bicycling) within a single-blinded randomised crossover trial. The Friedman test with post-hoc two-way analysis of variance, the related-samples Wilcoxon signed rank test and the Spearman's rank-order correlation test were used to analyse the results. Organophosphate metabolites were detected in 84.6% (22/26) and pyrethroids in 26.9% (7/26) of the collected sweat samples (pooled per individual, per intervention). Urinary concentrations of three of the four metabolites marginally increased after infrared sauna bathing: 3,5,6-trichloro-2-pyridinol (z=2.395, p=0.017); 3-phenoxybenzoic acid (z=2.599, p=0.009); and trans-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropane-1-carboxylic acid (z=2.090, p=0.037). Urinary 3-phenoxybenzoic acid also increased after exercise (z=2.073, p=0.038) and demonstrated the most temporal variability (days to weeks) of any of the urinary metabolites. Definitive sweat/urine correlations were not demonstrated. These results indicate metabolites from organophosphate and pyrethroid pesticides can be detected in human sweat and this raises intriguing questions about perspiration and its role in the metabolism and excretion of synthetic pesticides.

Association between Intelligence Quotient Dental Anxiety and Oral Health-related Quality of Life in Children: A Cross-sectional Study.

Determining the intelligence quotient (IQ) grades of children help in managing dental anxiety (DA) and maintaining the good oral health-related quality of life (OHRQoL). To assess the association between IQ, DA, and OHRQoL in children aged 10-11 years. This cross-sectional study was carried out among 202 children aged 10-11 years in the Southern part of Tamil Nadu, India. The IQ level, DA, and OHRQoL were measured using Raven's Coloured Progressive Matrices (RCPM), Children's Fear Survey Schedule-Dental Subscale (CFSS-DS), and Child Oral Health Impact Profile Short Form (COHIP-SF) 19, respectively. Chi-squared test and Spearman rank order correlation test were used for analysis. The results revealed a significant negative correlation (p < 0.05; r = -0.239) between IQ and OHRQoL. DA was negatively correlated with IQ (r = -0.093) and OHRQoL (r = -0.065), but it was not statistically significant. The gender-based comparison revealed no significant difference in the distribution of girls and boys within different grades of IQ levels (p = 0.74), DA (p = 0.29), and OHRQoL (p = 0.85). Children with higher IQ showed low OHRQoL scores. DA was negatively correlated with IQ and OHRQoL. Asokan S, PR GP, Mathiazhagan T, et al. Association between Intelligence Quotient Dental Anxiety and Oral Health-related Quality of Life in Children: A Cross-sectional Study. Int J Clin Pediatr Dent 2022;15(6):745-749.

Analysis of Trend in Groundwater-Quality Parameters: A Case Study

In the 21st century, groundwater has a pivotal role in ensuring water, food, and environmental securities worldwide. Systematic observation, protection and restoration are essential for sustainable management of water resources. Regular monitoring is key to investigate temporal changes in groundwater quality, and statistical trend tests define whether these changes are significant or not. This study focuses on investigating trend in seasonal groundwater quality in an alluvial coastal basin of West Bengal, India. The seasonal groundwater-quality data (pH, TH, TDS, Fe2+ and HCO3ˉ) of pre-monsoon and post-monsoon seasons were collected for 2011–2018 period and analyzed using three non-parametric statistical trend detection tests, namely: (i) Original Mann-Kendall (M-K) test, (ii) Modified Mann-Kendall (mM-K) test, and (iii) Spearman Rank Order Correlation (SROC) test. The trend magnitudes were estimated by using the Sen’s slope estimation test. Statistical analyses revealed that seasonal concentrations of all five groundwater-quality parameters have large spatial (block-wise) variation within the study area. The results of trend analyses indicated that seasonal TH and TDS concentrations mainly have significant decreasing trends (α = 5% or 1%), whereas seasonal HCO3ˉ and Fe2+ concentrations mostly show significant increasing trends (α = 5% or 1%) in different blocks. However, seasonal pH concentrations exhibited no trend. The mM-K test was found to be over-sensitive in finding trends than M-K and SROC tests. The SROC test was found to be less sensitive in detecting trends than M-K and mM-K tests. Trend magnitudes of seasonal pH, TH, TDS, HCO3ˉ and Fe2+ concentrations varied from –0.03/year to 0.23/year, –57.44 mg/L/year to 25.88 mg/L/year, –172.98 mg/L/year to 92.58 mg/L/year, –15.81 mg/L/year to 27.88 mg/L/year, and –0.05 mg/L/year to 0.61 mg/L/year, respectively. Continuous and proper groundwater-quality monitoring is critically required in all aquifer systems. The outcomes of this study will aid policy-makers in appropriately monitoring and managing groundwater quality.

Victimisation, Depression and Suicidal Ideation among Lesbian, Gay and Bisexual Adults in Malaysia.

BackgroundLesbian, gay and bisexual (LGB) individuals have been found to experience a high prevalence of psychological conditions. The present study aims to examine the relationship between victimisation, depression and suicidal ideation among LGB adults in Malaysia.MethodsThis study used a cross-sectional design. We distributed the questionnaire online using snowball sampling and self-identified LGB adults responded to the survey. Scales on sexual minority-specific victimisation, depression and suicidal ideation were employed. The data were analysed using Spearman rank order correlation and Kruskal-Wallis tests.ResultsThe study included 220 adults in Malaysia (156 males and 64 females; 58 lesbian, 112 gays and 50 bisexuals). Ninety-two participants (41.8%) reported experiencing sexual minority-specific victimisation; 29 participants (13.2%), 35 participants (15.9%) and 23 participants (10.5%) were mildly, moderately and severely depressed, respectively and 44.0% participants were experiencing current suicidal ideation. The correlations were fair (rs = 0.30) between victimisation and depression, poor (rs = 0.16) between victimisation and suicidal ideation, and moderate (rs = 0.60) between depression and suicidal ideation. There were no differences between homosexual and bisexual participants in victimisation, depression and suicidal ideation.ConclusionThis study contributes to a better understanding of the relationship between victimisation, depression and suicidal ideation among LGB adults in Malaysia.

Safe Working Cycle: Is It a Panacea to Combat Construction Site Safety Accidents in Hong Kong?

In Hong Kong, the accident statistics of the construction industry is still comparatively higher than other industries. However, accident rates within the industry have significantly decreased, starting from the implementation of diverse safety initiatives, including the Safe Working Cycle (SWC). In this study, a post-positivist philosophical stance was adopted, and a questionnaire survey was launched to gather empirical data on the application of SWC in construction projects, the effectiveness of the safety initiative, and the benefits thereof. The data gathered from 197 construction participants were analysed using descriptive statistics, mean score, Mann–Whitney U-Test, Kendall’s concordance analysis, Chi-square value, Spearman rank-order correlation test and exploratory factor analysis. The findings revealed significant adoption of SWC in the Hong Kong construction industry. Furthermore, daily, weekly, and monthly inspections and supervisions and safety committee meetings are effective items of this safety initiative. The benefits of adopting SWC can be grouped into the safety of frontline workers and increase in the organisation’s safety commitment and reputation. This study has created an excellent theoretical platform for future research work on the usefulness of the SWC in the construction industry at large.

Impact of COVID-19 on Online Interest in Urologic Conditions: An Analysis of Google Trends.

BackgroundWith COVID-19 leading to several isolation measures for preventative care, health care utilization, especially within urology, decreased substantially. The impact of COVID-19 on the population’s interests in urologic conditions remains to be established. By using the platform of Google Trends, which allows search behaviors and interest in healthcare topics to be quantified over time, we investigated the impact of COVID-19 on online search behaviors relating to common urologic conditions in the US.MethodsThe platform of Google Trends was utilized to analyze online interest in twelve common urologic conditions in the US from October 1, 2018 to August 1, 2021 (divided into “pre-COVID” and “COVID” periods at March 1, 2020). Search volume index (SVI), a measure of relative search volume on Google, data sets for the US, top queried and populated states, rising queries, and top queries were retrieved and analyzed for all conditions. Pre-COVID and COVID median SVIs were compared using the Mann Whitney U test, and correlations were analyzed using Spearman’s rank-order correlation test.ResultsFor all twelve urologic conditions, rising and top queries were often related to symptoms, treatments, and COVID-19. COVID showed higher SVIs for erectile dysfunction (p=0.04) and lower SVIs for bladder cancer (p<0.01), hematuria (p<0.01), kidney cancer (p<0.01), kidney stones (p=0.03), and prostate cancer (p<0.01). Correlations to COVID-19 searches were seen for bladder cancer (RS=-0.36, p<0.01), erectile dysfunction (RS=0.20, p=0.04), hematuria (RS=-0.31, p<0.01), overactive bladder (RS=-0.23, p=0.04), and prostate cancer (RS=-0.33, p<0.01). No correlations were found for benign prostatic hyperplasia, interstitial cystitis, low testosterone, urinary incontinence, and urinary tract infections.ConclusionsOnline interest in many urologic conditions, especially cancers, decreased during COVID. Given the internet’s increasing role in healthcare, a reduced interest could translate to delayed diagnosis and treatment of these conditions. Only erectile dysfunction showed increasing interest, potentially due to research or misinformation linking it to COVID-19.

Expression of CXCR4 and CXCR7 in papillary thyroid carcinoma and adjacent tissues and their relationship with pathologic indicators of tumor aggressiveness

The receptors of chemokines play a significance role in the aggressiveness of tumor. CXCR4/CXCR7 promote metastasis of papillary thyroid carcinoma (PTC). This study examined the expresssion of chemokine receptors CXCR4/CXCR7 in human tissue specimens of PTC and peritumoral nonmalignant tissues. The correlation between CXCR4/CXCR7 and the clinicopathological factors in PTC was also determined. CXCR4/CXCR7 were examined in 115 PTC tissues from 115 patients using immunohistochemistry. Staining intensity was compared with patients and tumor characteristics including gender, age, tumor size, capsule invasion, multifocality, lymph node metastasis, and nature of paracancerous tissue. [Statistics: rank sum test, Spearman rank order correlation test; p < 0.05]. Higher expression rates of CXCR4/CXCR7 exhibited in PTC compared with peritumoral nonmalignant tissues. The expression of them was correlated in cancer and paracancerous specimens. A trend toward higher CXCR4/CXCR7 expression was found among tumors showing positive lymph nodes and capsule invasion, while no association with sex, age, tumor size, and nature of paracancerous tissue. Number of lymph nodes was associated with higher intensity IHC staining for CXCR4/CXCR7. Intense staining for CXCR4 was also associated with multifocality. Expression of CXCR4/CXCR7 by PTCs was correlated with lymph node metastasis and capsule invasion. Although multiple bias, they were thought to play a significance role in the aggressiveness of PTC, which provides potential targets for therapeutic interventions.

Investigation of the Relationship between Academic Competencies and Social Information Processing of 60–72 Month-Old Children

Starting from the preschool period, children need to grow up as individuals with high academic skills, academic enablers and respond positively to their social situations. Academic skills and academic enablers together constitute academic competence. The positive reaction of children to the problems they face constitutes social information processing. This study aimed to examine the relationship between the academic competencies of 60–72-month-old children and their social information processing. The study was designed with the relational survey method. The study group consisted of 132 children aged 60–72 months with normal development who attend preschool education. The data collection tools of the study are as follows: Personal Information Form, The Social Information Processing Interview–Preschool Version, and Teacher Rating Scales of Early Academic Competence. Spearman's rank-order correlation test was used to evaluate the relationship between the scales. The findings of the study revealed that there is a relationship between the interpretation of cues and response decision, which are subdimensions of the social information processing model, academic skills (numeracy, early literacy, thinking skills, and comprehension) and academic enablers (social-emotional competence, approaches to learning, and communication).

Social Information Processing in Preschool Children: Relations to Social Interaction

The Social Information Processing Process Model consists of organizing the social adaptation and behavior of children in line with their responses to the social situations they encounter with their peers in their daily lives. The Social Information Processing Model affects children's ability to interact with their peers, their level of interaction, and provides information about the structure of interaction. In this direction, it was aimed to examine the relationship between social information processing and social interaction skills of 60-72 month-old children. The study was designed in relational screening model. The study group of the research consisted of 250 children, between 60 - 72 months, with normal development in the fall semester of the 2020-2021 academic year. The Social Information Processing Interview–Preschool Version and Children's Interaction Rating Scale were used as data collection tools in the study. The data were collected by reading stories with children, asking questions about the story and observation. Since no normal distribution was observed in the analysis of the data, Spearman's Rank-Order Correlation Test was used. As a result of the study, there was a statistically significant and positive relationship between "interpretation, response diversification, response decision", which were sub-dimensions of Social Information Processing Interview and "cooperation, self-control, assertiveness”, sub-dimensions of the Interaction Rating Scale for Children. This situation can be evaluated as children who make positive comments in social situations they encounter, who create positive reactions and react positively, are more cooperative in the context of social interaction, have a strong sense of self-control, and their assertiveness skills are high.

The Unintended Consequence of Novel Coronavirus (COVID-19) Pandemic on Racial Inequities Associated With Adverse Childhood Experiences (ACEs): Findings From a Population-Based Study.

A rising concern is the COVID-19 pandemic effect on adverse childhood experiences (ACEs) due to increased parental stress and social/physical isolation. These pandemic effects are likely to be higher in already marginalized communities. The objective of this ecological study was to examine the relationship between COVID-19 cases and deaths, race/ethnicity, and the estimated number of adults with ACEs using data from South Carolina (SC). COVID-19 reported cases and death data were obtained from the SC Department of Health and Environmental Control. ACE data was used from the 2014–2016 SC Behavioral Risk Factor Surveillance System. Census data were used to obtain county population data. To measure the relationship between these variables, the Spearman rank-order correlation test was used because the data distribution was non-normal. There was a moderate relationship between the estimated number of adults with one or more ACEs and deaths (ρ = 0.89) and race/ethnicity-specific COVID-19 case counts by county (Black: ρ = 0.76; =White: ρ = 0.96; Hispanic: ρ = 0.89). Further, the Spearman correlation test showed the strongest relationship between COVID-19 deaths and race-ethnicity-specific county populations was with the Black adult population (ρ = 0.90). Given the known link between existing health inequities and exposure to COVID-19, these results demonstrate that the current pandemic could have unintended consequences on the well-being of children and caregivers. Response efforts should consider promoting protective factors for children and families and advocating for equitable policies and systems that serve children.

Assessment of precipitation trends and its implications in the semi-arid region of Southern India

Rainfall is a complex meteorological phenomenon with high spatio-temporal variability. These variations in hydrologic time series can be better analyzed using homogeneity and trend tests. In this paper, three homogeneity tests were applied to the annual rainfall series of 1980–2013 from 30 raingauge stations over the study area. The rainfall stations with homogeneous time series were subjected to cluster analysis (Agglomerative Hierarchical Clustering technique) and thereafter traditional trend tests (Mann-Kendall test and Spearman Rank-order Correlation test) and one emerging trend test (called ‘Innovative Trend test’) were applied to individual clusters. Based on the homogeneity test results, 27 rainfall stations with homogeneous time series were classified under six clusters. The results of the trend analysis revealed that a distinct pattern of increasing (decreasing) rainfall trend exists in the northern (southern) part of the study area. Although the traditional tests detected insignificant trends, the Innovative Trend (IT) test indicated the trends to be significant in all the clusters. However, the magnitude of trends detected by the traditional trend tests and non-traditional trend tests is similar for all the clusters. It is concluded that the emerging IT test is highly sensitive to the changes in the rainfall time series. The findings of this study suggest that the orography, population density, industrialization and agricultural intensity lead to a precipitation gradient in the study area.

Impaired Exercise Tolerance in Repaired Tetralogy of Fallot Is Associated With Impaired Biventricular Contractile Reserve: An Exercise-Stress Real-Time Cardiovascular Magnetic Resonance Study.

Correction of tetralogy of Fallot (cTOF) often results in pulmonary valve pathology and right ventricular (RV) dysfunction. Reduced exercise capacity in cTOF patients cannot be explained by these findings alone. We aimed to explore why cTOF patients exhibit impaired exercise capacity with the aid of a comprehensive cardiopulmonary exercise testing (CPET) and real-time cardiovascular magnetic resonance exercise testing (CMR-ET) protocol. Thirty three cTOF patients and 35 matched healthy controls underwent CPET and CMR-ET in a prospective case-control study. Real-time steady-state free precession cine and phase-contrast sequences were obtained during incremental supine in-scanner cycling at 50, 70, and 90 W. RV and left ventricle (LV) volumes and pulmonary blood flow (Qp) were calculated. Differences of CPET and CMR-ET between cTOF versus controls and correlations between CPET and CMR-ET parameters in cTOF were evaluated statistically for all CMR exercise levels using Mann-Whitney U and Spearman rank-order correlation tests. CPET capacity was significantly lower in cTOF than in controls. cTOF patients exhibited not only significantly reduced Qp and RV function but also lower LV function on CMR-ET. Higher CPET values in cTOF correlated with higher Qp (Qp 90 W versus carbon dioxide ventilatory equivalent %: R=-0.519, P<0.05), higher LV-end-diastolic volume indexed to body surface area (LV-end-diastolic volume indexed to body surface area at 50 W versus oxygen uptake in % at maximum exercise on CPET R=0.452, P<0.05), and change in LV ejection fraction (EF; LV-EF at 90 W versus Watt %: r=-0.463, P<0.05). No correlation was found with regard to RV-EF. Significant RV-LV interaction was observed during CMR-ET (RV-EF versus LV-EF at 50 W and 70 W: r=0.66, P<0.02 and r=0.52, P<0.05, respectively). Impaired exercise capacity in cTOF resulted from a reduction in not only RV, but also LV function. cTOF with good exercise capacity on CPET demonstrated higher LV reserve and pulmonary blood flow during incremental CMR-ET. Apart from RV parameters, CMR-ET-derived LV function could be a valuable tool to stratify cTOF patients for pulmonary valve replacement.

The relatively higher concentrations of trace elements to arsenic may have influenced on methylation process of inorg- As in humans

The relatively higher concentrations of trace elements to arsenic may have influenced on methylation process of inorg- As in humans