Spatial Orientation Behavior Research Articles

Improving wayfinding in hospitals for people with diverse needs and abilities: An exploratory approach based on multi-criteria decision making

Hospital wayfinding systems that are based solely on signage do not provide adequate solutions for wayfinding needs, especially for users with impairments. Moreover, the interaction between user characteristics and the inner space of the building also determines wayfinding efficiency. The aims of this study, therefore, were to identify architectural features that affect spatial orientation and wayfinding behaviors; demonstrate the implementation of a multi-criteria decision-making (MCDM) approach for improving wayfinding in a diverse range of users; and produce a set of quantitative values (i.e., weights) for each selected architectural feature, based on the individual's preferences. Doing so could enable the formulating of practical design guidelines for hospital buildings, tailored to the needs and abilities of the users, to minimize disorientation and confusion – as demonstrated in this paper through a case study. The MCDM approach was chosen as it is based on observations whereby wayfinding resembles a continuous decision-making process, throughout which, users continuously select those architectural features that they perceive as having the greatest wayfinding value.

Expanding through the Emerald Isle: exploration and spatial orientation of non-native bank voles in Ireland.

Whether introduced into a completely novel habitat or slowly expanding their current range, the degree to which animals can efficiently explore and navigate new environments can be key to survival, ultimately determining population establishment and colonization success. We tested whether spatial orientation and exploratory behavior are associated with non-native spread in free-living bank voles (Myodes glareolus, N = 43) from a population accidentally introduced to Ireland a century ago. We measured spatial orientation and navigation in a radial arm maze, and behaviors associated to exploratory tendencies and risk-taking in repeated open-field tests, at the expansion edge and in the source population. Bank voles at the expansion edge re-visited unrewarded arms of the maze more, waited longer before leaving it, took longer to start exploring both the radial arm maze and the open field, and were more risk-averse compared to conspecifics in the source population. Taken together, results suggest that for this small mammal under heavy predation pressure, a careful and thorough exploration strategy might be favored when expanding into novel environments.

Comparative biology of spatial navigation in three arachnid orders (Amblypygi, Araneae, and Scorpiones).

From both comparative biology and translational research perspectives, there is escalating interest in understanding how animals navigate their environments. Considerable work is being directed towards understanding the sensory transduction and neural processing of environmental stimuli that guide animals to, for example, food and shelter. While much has been learned about the spatial orientation behavior, sensory cues, and neurophysiology of champion navigators such as bees and ants, many other, often overlooked animal species possess extraordinary sensory and spatial capabilities that can broaden our understanding of the behavioral and neural mechanisms of animal navigation. For example, arachnids are predators that often return to retreats after hunting excursions. Many of these arachnid central-place foragers are large and highly conducive to scientific investigation. In this review we highlight research on three orders within the Class Arachnida: Amblypygi (whip spiders), Araneae (spiders), and Scorpiones (scorpions). For each, we describe (I) their natural history and spatial navigation, (II) how they sense the world, (III) what information they use to navigate, and (IV) how they process information for navigation. We discuss similarities and differences among the groups and highlight potential avenues for future research.

3D escape: an alternative paradigm for spatial orientation studies in insects

Arthropods and in particular insects show a great variety of different exoskeletal sensors. For most arthropods, spatial orientation and gravity perception is not fully understood. In particular, the interaction of the different sensors is still a subject of ongoing research. A disadvantage of most of the experimental methods used to date to study the spatial orientation of arthropods in behavioral experiments is that the body or individual body parts are fixed partly in a non-natural manner. Therefore, often only the movement of individual body segments can be used to evaluate the experiments. We here present a novel experimental method to easily study 3D-escape movements in insects and analyze whole-body reaction. The animals are placed in a transparent container, filled with a lightweight substrate and rotating around two axes. To verify our setup, house crickets (Acheta domesticus) with selectively manipulated gravity-perceiving structures were analyzed. The spatial orientation behavior was quantified by measuring the time individuals took to escape toward the surface and the angular deviation toward the gravitational vector. These experiments confirm earlier results and therefore validated our experimental setup. Our new approach thus allows to investigate several comprehensive questions regarding the spatial orientation of insects and other animals.

Types, Aspects, and Impact of Relocation Initiatives Deployed within and between Long-Term Care Facilities: A Scoping Review.

Relocation of residents within or between long-term care facilities occurs regularly. To mitigate potential negative consequences, supportive relocation initiatives have been developed. This scoping review addresses types, aspects, and impact of relocation initiatives developed to relocate residents between or within long-term care facilities. A total of 704 articles were identified in a systematic literature search of 11 databases between April and July 2021. Using predefined eligibility criteria, two researchers independently screened titles and abstracts, resulting in 36 articles for full-text screening. Finally, six articles were included. Analysis was performed using thematic coding. Three types of relocation initiatives were identified, namely, interventions (n = 3), guidelines (n = 2), and a plan (n = 1). These initiatives described specific aspects of relocation, namely, spatial orientation (n = 3), practical assistance (n = 3), psychological support (n = 3), staff preparation (n = 2), and client engagement (n = 2). Only three intervention studies reported the impact of relocation initiatives on residents, namely, improved mental health (n = 3), spatial orientation (n = 2), self-reliance (n = 2), and social behavior (n = 1). The scope of the found relocation initiatives was often limited as they focused on specific designs, aspects, and residents. Therefore, the complexity of relocation processes is often overlooked, and more comprehensive relocation initiatives should be developed.

Assessing Similarities and Differences between Males and Females in Visual Behaviors in Spatial Orientation Tasks

Spatial orientation is an important task in human wayfinding. Existing research indicates sex-related similarities and differences in performance and strategies when executing spatial orientation behaviors, but few studies have investigated the similarities and differences in visual behaviors between males and females. To address this research gap, we explored visual behavior similarities and differences between males and females using an eye-tracking method. We recruited 40 participants to perform spatial orientation tasks in a desktop environment and recorded their eye-tracking data during these tasks. The results indicate that there are no significant differences between sexes in efficiency and accuracy of spatial orientation. In terms of visual behaviors, we found that males fixated significantly longer than females on roads. Males and females had similar fixation counts in building, signpost, map, and other objects. Males and females performed similarly in fixation duration for all five classes. Moreover, fixation duration was well fitted to an exponential function for both males and females. The base of the exponential function fitted by males’ fixation duration was significantly lower than that of females, and the coefficient difference of exponential function was not found. Females were more effective in switching from maps to signposts, but differences of switches from map to other classes were not found. The newfound similarities and differences between males and females in visual behavior may aid in the design of better human-centered outdoor navigation applications.

Gonadotropin-releasing hormone receptor (Gnrhr) gene knock out: Normal growth and development of sensory, motor and spatial orientation behavior but altered metabolism in neonatal and prepubertal mice.

Gonadotropin-releasing hormone (GnRH) is important in the control of reproduction, but its actions in non-reproductive processes are less well known. In this study we examined the effect of disrupting the GnRH receptor in mice to determine if growth, metabolism or behaviors that are not associated with reproduction were affected. To minimize the effects of other hormones such as FSH, LH and sex steroids, the neonatal-prepubertal period of 2 to 28 days of age was selected. The study shows that regardless of sex or phenotype in the Gnrhr gene knockout line, there was no significant difference in the daily development of motor control, sensory detection or spatial orientation among the wildtype, heterozygous or null mice. This included a series of behavioral tests for touch, vision, hearing, spatial orientation, locomotory behavior and muscle strength. Neither the daily body weight nor the final weight on day 28 of the kidney, liver and thymus relative to body weight varied significantly in any group. However by day 28, metabolic changes in the GnRH null females compared with wildtype females showed a significant reduction in inguinal fat pad weight normalized to body weight; this was accompanied by an increase in glucose compared with wildtype females shown by Student-Newman-Keuls Multiple Comparison test and Student's unpaired t tests. Our studies show that the GnRH-GnRHR system is not essential for growth or motor/sensory/orientation behavior during the first month of life prior to puberty onset. The lack of the GnRH-GnRHR axis, however, did affect females resulting in reduced subcutaneous inguinal fat pad weight and increased glucose with possible insulin resistance; the loss of the normal rise of estradiol at postnatal days 15–28 may account for the altered metabolism in the prepubertal female pups.

Tetrahydroxy Stilbene Glucoside improved the behavioral disorders of APP695V717I transgenic mice by inhibiting the expression of Beclin-1 and LC3-II

ObjectiveTo observe the effect of tetrahydroxy stilbene glucoside (TSG) on the behavior of APP695V717I transgenic mouse models and the expression of autophagy-associated proteins Beclin-1 and LC3-II. MethodsForty 3-month-old APP695V717I transgenic mice were randomized equally into either a TSG group (n = 20) or a model group (n = 20). A normal control group consisted of C57BL/6J mice of the same age and background (n = 20). The TSG group received TSG intragastric administration for 1 month. Behavior was measured using the Morris water maze and the Y-maze tests. Changes in protein expression and mRNA of autophagy-associated Beclin-1 and LC3-II in mice hippocampus were detected by western blot and Reverse Transcription-Polymerase Chain Reaction (RT-PCR) analyses. ResultsThe number of electric-stimulus escapes significantly increased and the Morris water maze test showed prolonged escape latency, greater swimming distance, less time taken to cross the exact former platform location in the model group, and increased mRNA and protein expressions of Beclin-1 and LC3-II compared with the control group (P < 0.05). The TSG group showed a decrease in the number of electric-stimulus escapes, shorter escape latency and swimming distance, greater time taken to cross the exact former platform location, and decreased mRNA and protein expressions of Beclin-1 and LC3-II compared with the model group (P < 0.05). ConclusionThese results indicate that tetrahydroxy stilbene glucoside can decrease expressions of Beclin-1 and LC3-II in the autophagy pathway. It can attenuate injury to endoplasmic reticulum functions caused by Ab neurotoxicity, improving learning, memorizing, and spatial orientation behavior in mice.

Visual navigation in the Neotropical ant Odontomachus hastatus (Formicidae, Ponerinae), a predominantly nocturnal, canopy-dwelling predator of the Atlantic rainforest

The arboreal ant Odontomachus hastatus nests among roots of epiphytic bromeliads in the sandy forest at Cardoso Island (Brazil). Crepuscular and nocturnal foragers travel up to 8m to search for arthropod prey in the canopy, where silhouettes of leaves and branches potentially provide directional information. We investigated the relevance of visual cues (canopy, horizon patterns) during navigation in O. hastatus. Laboratory experiments using a captive ant colony and a round foraging arena revealed that an artificial canopy pattern above the ants and horizon visual marks are effective orientation cues for homing O. hastatus. On the other hand, foragers that were only given a tridimensional landmark (cylinder) or chemical marks were unable to home correctly. Navigation by visual cues in O. hastatus is in accordance with other diurnal arboreal ants. Nocturnal luminosity (moon, stars) is apparently sufficient to produce contrasting silhouettes from the canopy and surrounding vegetation, thus providing orientation cues. Contrary to the plain floor of the round arena, chemical cues may be important for marking bifurcated arboreal routes. This experimental demonstration of the use of visual cues by a predominantly nocturnal arboreal ant provides important information for comparative studies on the evolution of spatial orientation behavior in ants.“This article is part of a Special Issue entitled: Neotropical Behaviour”.

Vestibular activity and cognitive development in children: perspectives

Vestibular signals play an essential role in oculomotor and static and dynamic posturomotor functions. Increasing attention is now focusing on their impact on spatial and non-spatial cognitive functions. Movements of the head in space evoke vestibular signals that make important contributions during the development of brain representations of body parts relative to one another as well as representations of body orientation and position within the environment. A central nervous system pathway relays signals from the vestibular nuclei to the hippocampal system where this input is indispensable for neuronal responses selective for the position and orientation of the head in space. One aspect of the hippocampal systems’ processing to create episodic and contextual memories is its role in spatial orientation and navigation behaviors that require processing of relations between background cues. These are also impaired in adult patients with vestibular deficits. However little is known about the impact of vestibular loss on cognitive development in children. This is investigated here with a particular emphasis upon the hypothetical mechanisms and potential impact of vestibular loss at critical ages on the development of respective spatial and non-spatial cognitive processes and their brain substrates.

Microfluidic Devices for Analysis of Spatial Orientation Behaviors in Semi-Restrained Caenorhabditis elegans

This article describes the fabrication and use of microfluidic devices for investigating spatial orientation behaviors in nematode worms (Caenorhabditis elegans). Until now, spatial orientation has been studied in freely moving nematodes in which the frequency and nature of encounters with the gradient are uncontrolled experimental variables. In the new devices, the nematode is held in place by a restraint that aligns the longitudinal axis of the body with the border between two laminar fluid streams, leaving the animal's head and tail free to move. The content of the fluid streams can be manipulated to deliver step gradients in space or time. We demonstrate the utility of the device by identifying previously uncharacterized aspects of the behavioral mechanisms underlying chemotaxis, osmotic avoidance, and thermotaxis in this organism. The new devices are readily adaptable to behavioral and imaging studies involving fluid borne stimuli in a wide range of sensory modalities.

Evolution and Analysis of Minimal Neural Circuits for Klinotaxis inCaenorhabditis elegans

Chemotaxis during sinusoidal locomotion in nematodes captures in simplified form the general problem of how dynamical interactions between the nervous system, body, and environment are exploited in the generation of adaptive behavior. We used an evolutionary algorithm to generate neural networks that exhibit klinotaxis, a common form of chemotaxis in which the direction of locomotion in a chemical gradient closely follows the line of steepest ascent. Sensory inputs and motor outputs of the model networks were constrained to match the inputs and outputs of the Caenorhabditis elegans klinotaxis network. We found that a minimalistic neural network, comprised of an ON-OFF pair of chemosensory neurons and a pair of neck muscle motor neurons, is sufficient to generate realistic klinotaxis behavior. Importantly, emergent properties of model networks reproduced two key experimental observations that they were not designed to fit, suggesting that the model may be operating according to principles similar to those of the biological network. A dynamical systems analysis of 77 evolved networks revealed a novel neural mechanism for spatial orientation behavior. This mechanism provides a testable hypothesis that is likely to accelerate the discovery and analysis of the biological circuitry for chemotaxis in C. elegans.

Distinct Retinal Pathways Drive Spatial Orientation Behaviors in Zebrafish Navigation

Navigation requires animals to adjust ongoing movements in response to pertinent features of the environment and select between competing target cues. The neurobiological basis of navigational behavior in vertebrates is hard to analyze, partly because underlying neural circuits are experience dependent. Phototaxis in zebrafish is a hardwired navigational behavior, performed at a stage when larvae swim by using a small repertoire of stereotyped movements. We established conditions to elicit robust phototaxis behavior and found that zebrafish larvae deploy directional orienting maneuvers and regulate forward swimming speed to navigate toward a target light. Using genetic analysis and targeted laser ablations, we show that retinal ON and OFF pathways play distinct roles during phototaxis. The retinal OFF pathway controls turn movements via retinotectal projections and establishes correct orientation by causing larvae to turn away from nontarget areas. In contrast, the retinal ON pathway activates the serotonergic system to trigger rapid forward swimming toward the target. Computational simulation of phototaxis with an OFF-turn, ON-approach algorithm verifies that our model accounts for key features of phototaxis and provides a simple and robust mechanism for behavioral choice between competing targets.

Digit ratio (2D:4D) is associated with traffic violations for male frequent car drivers

Digit ratio (2D:4D) is a putative marker of prenatal hormone exposure. A lower digit ratio has been suggested as an index of higher testosterone relative to estrogen exposure during prenatal development. Digit ratio has been associated with a variety of psychological sex-dimorphic variables, including spatial orientation, aggression, or risk-taking behavior. The present study aimed to relate digit ratio to traffic violations for a male sample ( N = 77) of frequent car drivers. Digit ratio was assessed via printout scans of the hand, and traffic offense behavior was assessed via self-reported penalty points as registered by the Central Register of Traffic Offenders in Germany. In addition, social desirability and sensation seeking were recorded. Results showed that digit ratio was inversely related to penalty point entries, suggesting more traffic violations for individuals with higher prenatal testosterone exposure. Sensation seeking was positively associated with traffic violations, but there was no relationship between sensation seeking and digit ratio, proposing additive effects of both variables. The results suggest that prenatal androgen exposure might be related to traffic violations for frequent car drivers.

Six-week postpartum maternal depressive symptoms and 4-month mother-infant self- and interactive contingency.

Associations of 6-week maternal depressive symptoms [Center for Epidemiological Studies Depression Scale (CES-D)] with 4-month mother-infant self- and interactive contingency patterns during face-to-face play were investigated in 132 dyads. Self- and interactive contingency (auto- and lagged cross-correlation, respectively) were assessed by multilevel time-series analysis. Infant and mother gaze, facial and vocal affect, touch, and spatial orientation behaviors were coded second-by-second from split-screen videotape, and a multimodal measure of facial-visual "engagement" was constructed, generating nine modality pairings. With higher CES-D, the self-contingency of both partners was lowered in most modalities. With higher CES-D, interactive contingency values were both heightened (in some modalities) and lowered (in others), varying by partner. These results are consistent with an optimal midrange model. With higher CES-D, interactive contingency showed the following patterns: (a) Mothers and their infants had a reciprocal orientational sensitivity; (b) mothers and infants manifested a reciprocal intermodal discordance in attention versus affect coordination, lowering gaze coordination, but heightening affective coordination; (c) infants heightened, but mothers lowered, touch coordination with partner touch-an "infant approach-mother withdraw" touch pattern. Nonlinear analyses indicated that altered self- and interactive contingency were similar at both the low ("denial") as well as the high ("endorsement") poles of depressive symptoms, in half the findings. These complex, multimodal findings define different aspects of communication disturbance, with relevance for therapeutic intervention.

Circuit Motifs for Spatial Orientation Behaviors Identified by Neural Network Optimization

Spatial orientation behavior is universal among animals, but its neuronal basis is poorly understood. The main objective of the present study was to identify candidate patterns of neuronal connectivity (motifs) for two widely recognized classes of spatial orientation behaviors: hill climbing, in which the organism seeks the highest point in a spatial gradient, and goal seeking, in which the organism seeks an intermediate point in the gradient. Focusing on simple networks of graded processing neurons characteristic of Caenorhabditis elegans and other nematodes, we used an unbiased optimization algorithm to seek values of neuronal time constants, resting potentials, and synaptic strengths sufficient for each type of behavior. We found many different hill-climbing and goal-seeking networks that performed equally well in the two tasks. Surprisingly, however, each hill-climbing network represented one of just three fundamental circuit motifs, and each goal-seeking network comprised two of these motifs acting in concert. These motifs are likely to inform the search for the real circuits that underlie these behaviors in nematodes and other organisms.

Wayfinding in an Unfamiliar Environment

The purpose of this article is to explore spatial orientation and wayfinding behavior of newcomers in an unfamiliar environment and to emphasize the importance of landmarks and spatial differentiation in the acquisition of environmental knowledge. One setting with a symmetrical layout and regularly organized, monotonous units on different floors and another setting with an asymmetrical layout and repetitive units along one side of a linear corridor of one floor were used to explore different strategies for learning about large-scale spatial environments. Wayfinding performance was found to correlate with performances in sketch-map tasks and the answers of a questionnaire about each building. Most of the participants of the asymmetrical setting could complete a sketch map with a minimum of errors. In the symmetrical setting, however, some participants drew incomplete sketch maps but could find their way through the building with a minimum of errors.

Evidence for anatomical but not functional asymmetry in the hemidecorticate rat.

Rats with unilateral ablation of the left or right cerebral neocortex or left or right hippocampus were studied in a battery of tests of spatial orientation, motor coordination, and social behavior, including Morris water task, radial arm maze, feeding, narrow beam traversing, puzzle latches, hoarding, grooming, nest building, running wheel activity, male--male interaction, and shock-induced aggression. Comparison of the brains of operated and control rats confirmed previous suggestions that the right hemisphere of the rat is bigger and may have different connections than the left hemisphere. Despite the morphological asymmetries, comparison of the behavior of rats with right hemidecortication with that of rats with left hemidecortication, and of rats with right and of those with left hippocampal lesions, failed to show a single instance of functional asymmetry in the rat brain. These behavioral results stand in marked contrast to previous reports of functional asymmetry in the control of activity, orientation, and rotation.

Organization of retina of the mudpuppy, Necturus maculosus. I. Synaptic structure.

Organization of retina of the mudpuppy, Necturus maculosus. I. Synaptic structure.