Spaces Of Esophageal Epithelium Research Articles

95 Luminal Nitric Oxide Provoked Dilated Intercellular Spaces in Esophageal Epithelium of Rats

95 Luminal Nitric Oxide Provoked Dilated Intercellular Spaces in Esophageal Epithelium of Rats

T1964 Dilation of Intercellular Spaces in Esophageal Epithelium in Non-Erosive and Erosive Reflux Disease Patients and Appropriate Controls

and pH recordings. c) sleep stages using standardized EEG, EOG and EMG recording. Results: A total of 96 EPR were recorded only three of which occurred during sleep, therefore, data regarding the remaining 93 episodes were pooled. Of these refluxates, 10 were fluid, 78 were gas and 5 were mixed. UES and esophageal pressure behavior for refluxates of different physical properties were similar and this data was pooled. Two types of UES pressures were identified during pharyngeal reflux. The UES nadir pressure for complete UES relaxation (cUES-R) averaged -2.1±3.0 mmHg. UES nadir pressure for partial relaxation (pUES-R) averaged 9.4±4.0 mmHg. Complete relaxation occurred in 26/93 (28%) of EPR while incomplete relaxation occurred in 67/93(72%). Pharyngeal reflux events occurred within 1-2 seconds of or as late as 10s after GE reflux (GER) (table). Reflux-induced CC pressure was either equal to or significantly greater than UES residual pressure (p<0.01, table). This was also true for the three pharyngeal reflux events during sleep. GER events not associated with EPR had an average CC pressure of 7.5±3.7 mmHg and a UES pressure of 54±27 mmHg. Conclusions: 1) EPR during sleep is rare. 2) EPR is accompanied by either complete or partial relaxation of UES. 3) Reflux-induced CC pressure equals or exceeds UES nadir pressure.

Changes of intercellular spaces of esophageal epithelium in patients with gastroesophageal reflux disease before and after esomeprazole treatment

To observe the changes of dilated intercellular space (DIS) of esophageal epithelium in different subtypes of gastroesophageal reflux disease (GERD) before and after esomeprazole treatment. Nineteen patients with GERD, 6 with erosive esophagitis (EE), 7 with NERD with abnormal acid exposure (NERD pH+), and 6 with NERD with normal acid exposure (NERD pH-), were treated with esomeprazole 40 mg daily for two months. During endoscopy before and after treatment, six biopsy specimens were taken from the apparently normal mucosa 3 - 5 cm above the dentate line in the esophagus to undergo HE staining and histological examination and transmission electron microscopy (TEM). Fifteen normal subjects were used as controls. Two months after the treatment 5 cases (83.33%) in the EE group, 6 cases (85.57%) in the NERD pH+ group, and 5 cases (83.33%) in the NERD pH- group showed a complete recovery of DIS and complete disappearance of the symptom of heartburn. Two of the left three patients who showed incomplete recovery of DIS still had heartburn. A complete recovery of DIS 2 months after treatment of esomeprazole is always accompanied by resolution of heartburn symptom. No significant difference in complete recovery of DIS can be found among different GERD subgroups.