Background & Objective: Wireless technologies like Wi-Fi, WiMAX, and LTE are using Multiple Input, Multiple Output (MIMO) communications that play an important role in achieving high data rates. Bit Error Rate (BER) is one of the most important performance parameters in multipath channels for data communication. Methods: This research proposes a new method based on Reed Solomon (RS) coding to improve the efficacy of a Space-Time Block Coded (STBC) MIMO System concatenated with M-ary Phase Shift Keying (MPSK) and M-ary Quadrature Amplitude Modulation (MQAM) in reducing BER in Rayleigh, Rician and Nakagami channels. It is based on the error detection and correction properties intrinsic to RS coding processes. Binary data is coded using an RS encoder and the modulated signal STBC encoded and transmitted through Rayleigh, Rician and Nakagami channels. Signals received by two antennas are STBC decoded, demodulated, RS decoded and tested for BER. Results & Conclusion: Results show lower BER rates for RS Coded systems as compared for uncoded systems in all three channels. In addition, it was found that reduction in BER is greater for high Signal to Noise Ratio (SNR) but deteriorates for low SNR. Furthermore, this research observed that RS coding gives 63% to 98% improvement in BER in the Rayleigh as compared to Rician and Nakagami channels. This research has been able to successfully incorporate the BER reduction of STBC MIMO to further enhance the efficacy of an STBC MIMO system.