Statistical energy analysis (SEA) was performed on models of International Space Station (ISS) truss segments. These segments are large truss structures built up from I-beam members. The purpose of this analytical program is to determine the random vibration environment for equipment mounted on these segments. The equipment is mounted to secondary structural built-up plates in most instances. In general, the secondary structure is more rigid than typical aerospace structures because of the large spans between the primary truss members. This presents a challenge to the SEA methodology because of the low modal density of both the primary and the secondary structure, and novel approaches to the problem were identified. The need to test verify these modeling approaches was apparent. On the previous Space Station Freedom program, a developmental vibroacoustic test of a space station-like truss segment was conducted. The development test specimen was modeled in a similar manner to the ISS segments and predicted responses were compared with test data. This paper discusses the modeling methods determined to be effective for these structures