In the constantly changing field of architectural design and meeting the evolving demands of the space tourism industry, this study presents a case study focused on the design of a space tourism building in Sharjah, United Arab Emirates (UAE). The main objective of this study is to showcase the integration of simulation-driven and optimization-based methodologies in architectural design to anticipate forthcoming challenges and resolve design-related issues or constraints. This study employs a range of computational tools to optimize various design parameters, including sun path, radiation, shadow, outdoor comfort, and wind simulation, to conduct a more thorough assessment in the process of choosing the best-optimized design. In addition, a finite element analysis (FEA) was carried out to gain insights into the structural behavior of the chosen design under diverse physical conditions. This integration marks a paradigm shift in how architectural projects are conceptualized, developed, and realized by addressing complex challenges and enhancing the functionality, sustainability, and performance of architectural buildings. The findings of this case study demonstrate and prove the potential of simulation-driven and optimization-based design approaches in determining the future of architectural designs. As the UAE strives to become a center for space-related activities, this research helps to drive the realization of cutting-edge, sustainable, and user-centric architectural solutions, paving the way for the next generation of space tourism facilities.