Space Radiation Effects Research Articles

Space-Like Irradiation Exacerbated Cognitive Deficits and Amyloid Pathology in CRND8 Mouse Model of Alzheimer's Disease.

Space radiation was linked to neurological damage and behavioral deficits which raised concerns of increased degenerative risk on the brain and development of Alzheimer's disease following space travel. In this study, we investigated the effects of irradiation by 56Fe and 28Si in CRND8 mice, an Alzheimer's disease mouse model. Six-month-old CRND8 mice were exposed to whole body irradiation by 56Fe and 28Si at 0.5 Gy and 2 Gy doses. Behavior tests were administered 1-month to 3-months post-irradiation. Amyloid deposition and other pathological changes were analyzed 3-months and/or 6-months post-irradiation. The Novel Object Recognition test showed some decline in 8-month-old mice compared to non-irradiated CRND8 mice. Male mice also showed a loss of freezing behavior in the fear conditioning contextual test following irradiation. Golgi staining revealed a loss of spines in hippocampal neurons after irradiation. Total amyloid immunohistochemistry showed a robust increase in 3-months post-irradiation 56Fe groups which became normalized to non-irradiated group by 6-months post-irradiation. However, 2 Gy 28Si caused a trend towards increased plaque load at 3-months post-irradiation which became significant at 6-months post irradiation only in male CRND8 mice. While 0.5 Gy Fe did not induce obvious changes in the total number of iba-1 positive microglia, more hippocampal microglia were found to express PCNA after 0.5 Gy Fe treatment, suggesting potential involvement of microglial dysfunction. Overall, our study provides new evidence of gender-specific and ion-dependent effects of space radiation on cognition and amyloid pathology in AD models.

Photoelectric property degradation of graded barrier InAs/GaSb type II superlattice long-wave infrared detectors under 1 MeV electron irradiation.

Amid rapid advancements in aerospace science and technology, studying the effects of space radiation on an infrared detector is crucial for enhancing their reliability in radiation environments, particularly against electrons-one of the most damaging charged particles. Barrier structures significantly reduce dark current without any substantial degradation in the optical performance of the devices. Consequently, they are being investigated for use in extreme environments. This paper presents a study on the performance degradation of InAs/GaSb type II superlattice (T2SLs) long-wave infrared (LWIR) detectors with a graded barrier structure under 1 MeV electron irradiation and analyzes potential damage mechanisms. The findings indicate that 1 MeV electron irradiation causes both ionization and displacement damage to the graded barrier InAs/GaSb T2SL LWIR detectors. After irradiation with a fluence of 2 × 1015 e/cm2, the device's dark current density has increased by approximately two orders of magnitude, while the quantum efficiency has decreased by approximately one order of magnitude. As the device mesa shrinks, the sensitivity of dark current to radiation exposure increases. Electron irradiation notably exacerbates surface leakage and bulk dark current, with a pronounced increase in surface leakage current. The study also reveals that electron irradiation primarily enhances the dark current by introducing defect states, thereby leading to device performance degradation.

NASA’s Galactic Cosmic Ray Simulator - Studying the Effects of Space Radiation on Earth

NASA’s Galactic Cosmic Ray Simulator - Studying the Effects of Space Radiation on Earth

Analysis of the influence of microgravity and space radiation on astronauts’ gene expression: An approach using quantum simulations and fuzzy logic

<img src=” https://s3.amazonaws.com/production.scholastica/article/117460/large/prnano_1292024ga.jpg?1715201784”> An analysis of the effects of microgravity and space radiation on astronauts’ RNA expression has been developed, utilizing data from NASA’s “Cell-Free RNA Analysis of Plasma Samples Collected from Six Astronauts in JAXA Cell-Free Epigenome (CFE) Study.” The project aims to deepen our understanding of how the space environment affects gene expression, particularly in key genes such as ACTB and ACTG1, by employing quantum simulations and unconventional logic, including quantum and fuzzy logic. The results suggest that specific genes like ACTB and ACTG1 undergo significant changes in their expression under these unique conditions. This in-terdisciplinary approach allows for a detailed analysis of gene expression data and explores the potential of emerging technologies in space research and bioinformatics.

Outstanding Conference Paper Award: 2023 IEEE Nuclear and Space Radiation Effects Conference

Outstanding Conference Paper Award: 2023 IEEE Nuclear and Space Radiation Effects Conference

2023 IEEE Nuclear and Space Radiation Effects Conference Awards: Comments by the Chair

2023 IEEE Nuclear and Space Radiation Effects Conference Awards: Comments by the Chair

WormSpace μ-TAS enabling automated on-chip multi-strain culturing and multi-function imaging of Caenorhabditis elegans at the single-worm level on the China Space Station.

As a model organism for space biology experiments, Caenorhabditis elegans (C. elegans) has low demand for life support and strong resistance to unfavorable environments, making experimentation with C. elegans relatively easy and cost-effective. Previously, C. elegans has been flown in several spaceflight investigations, but there is still an urgent need for analytical platforms enabling on-orbit automated monitoring of multiple phenotypes of worms, such as growth and development, movement, changes of biomarkers, etc. To solve this problem, we presented a fully integrated microfluidic system (WormSpace μ-TAS) with an arrayed microfluidic chip (WormChip-4.8.1) and a replaceable microfluidic module (WormChip cartridge), which was compatible with the experimental facility on the China Space Station (CSS). By adopting technologies of programmed fluid control based on liquid medium CeMM as well as multi-function imaging with a camera mounted on a three-dimensional (3D) transportation stage, automated and long-term experimentation can be performed for on-chip multi-strain culturing and bright-field and fluorescence imaging of C. elegans at the single-worm level. The presented WormSpace μ-TAS enabled its successful application on the CSS, achieving flight launch of the sample unit (WormChip cartridge) at low temperature (controlled by a passive thermal case at 12 °C), automated 30-day cultivation of 4 strains of C. elegans, on-orbit monitoring of multiple phenotypes (growth and development, movement, and changes of fluorescent protein expression) at the single worm-level, on-chip fixation of animals at the end of the experiment and returning the fixed samples to earth. In summary, this study presented a verified microfluidic system and experimental protocols for automated on-chip multi-strain culturing and multi-function imaging of C. elegans at the single-worm level on the CSS. The WormSpace μ-TAS will provide a novel experimental platform for the study of biological effects of space radiation and microgravity, and for the development of protective drugs.

Simulated galactic cosmic ray exposure activates dose-dependent DNA repair response and down regulates glucosinolate pathways in arabidopsis seedlings.

Outside the protection of Earth's magnetic field, organisms are constantly exposed to space radiation consisting of energetic protons and other heavier charged particles. With the goal of crewed Mars exploration, the production of fresh food during long duration space missions is critical for meeting astronauts' nutritional and psychological needs. However, the biological effects of space radiation on plants have not been sufficiently investigated and characterized. To that end, 10-day-old Arabidopsis seedlings were exposed to simulated Galactic Cosmic Rays (GCR) and assessed for transcriptomic changes. The simulated GCR irradiation was carried out in the NASA Space Radiation Laboratory (NSRL) at Brookhaven National Lab (BNL). The exposures were conducted acutely for two dose points at 40 cGy or 80 cGy, with sequential delivery of proton, helium, oxygen, silicon, and iron ions. Control and irradiated seedlings were then harvested and preserved in RNAlater at 3 hrs post irradiation. Total RNA was isolated for transcriptomic analyses using RNAseq. The data revealed that the transcriptomic responses were dose-dependent, with significant upregulation of DNA repair pathways and downregulation of glucosinolate biosynthetic pathways. Glucosinolates are important for plant pathogen defense and for the taste of a plant, which are both relevant to growing plants for spaceflight. These findings fill in knowledge gaps of how plants respond to radiation in beyond-Earth environments.

Radiation Epidemiology: Keeping Space Travelers Safe

Did you know that millions of people are exposed to radiation on Earth as part of their jobs or during helpful medical procedures? The branch of medicine that studies the health effects of radiation exposure on large groups of people is called radiation epidemiology. Radiation also exists in space! But how do we study the ways that radiation impacts the body in space when there are so few space travelers? In this article, we will define radiation epidemiology, give some examples of studies that evaluate how radiation on Earth effects people’s health, and explain how we use the information from studies on Earth to better understand the health effects of radiation in space.

Space Radiation Effects on Surface and Bulk Resistivity of Polymeric Materials

Space Radiation Effects on Surface and Bulk Resistivity of Polymeric Materials

Radiation cataract in Heterogeneous Stock mice after γ-ray or HZE ion exposure

Health effects of space radiation are a serious concern for astronauts on long-duration missions. The lens of the eye is one of the most radiosensitive tissues in the body and, therefore, ocular health risks for astronauts is a significant concern. Studies in humans and animals indicate that ionizing radiation exposure to the eye produces characteristic lens changes, termed “radiation cataract,” that can affect visual function. Animal models of radiation cataractogenesis have previously utilized inbred mouse or rat strains. These studies were essential for determining morphological changes and dose-response relationships between radiation exposure and cataract. However, the relevance of these studies to human radiosensitivity is limited by the narrow phenotypic range of genetically homogeneous animal models. To model radiation cataract in genetically diverse populations, longitudinal cataract phenotyping was nested within a lifetime carcinogenesis study in male and female heterogeneous stock (HS/Npt) mice exposed to 0.4 Gy HZE ions (n = 609) or 3.0 Gy γ-rays (n = 602) and in unirradiated controls (n = 603). Cataractous change was quantified in each eye for up to 2 years using Merriam-Focht grading criteria by dilated slit lamp examination. Virtual Optomotry™ measurement of visual acuity and contrast sensitivity was utilized to assess visual function in a subgroup of mice. Prevalence and severity of posterior lens opacifications were 2.6-fold higher in HZE ion and 2.3-fold higher in γ-ray irradiated mice compared to unirradiated controls. Male mice were at greater risk for spontaneous and radiation associated cataracts. Risk for cataractogenesis was associated with family structure, demonstrating that HS/Npt mice are well-suited to evaluate genetic determinants of ocular radiosensitivity. Last, mice were extensively evaluated for cataract and tumor formation, which revealed an overlap between individual susceptibility to both cancer and cataract.

Loss of Cognitive Flexibility Practice Effects in Female Rats Exposed to Simulated Space Radiation.

During the planned missions to Mars, astronauts will be faced with many potential health hazards including prolonged exposure to space radiation. Ground-based studies have shown that exposure to space radiation impairs the performance of male rats in cognitive flexibility tasks which involve processes that are essential to rapidly and efficiently adapting to different situations. However, there is presently a paucity of information on the effects of space radiation on cognitive flexibility in female rodents. This study has determined the impact that exposure to a low (10 cGy) dose of ions from the simplified 5-ion galactic cosmic ray simulation [https://www.bnl.gov/nsrl/userguide/SimGCRSim.php (07/2023)] (GCRSim) beam or 250 MeV/n 4He ions has on the ability of female Wistar rats to perform in constrained [attentional set shifting (ATSET)] and unconstrained cognitive flexibility (UCFlex) tasks. Female rats exposed to GCRSim exhibited multiple decrements in ATSET performance. Firstly, GCRSim exposure impaired performance in the compound discrimination (CD) stage of the ATSET task. While the ability of rats to identify the rewarded cue was not compromised, the time the rats required to do so significantly increased. Secondly, both 4He and GCRSim exposure reduced the ability of rats to reach criterion in the compound discrimination reversal (CDR) stage. Approximately 20% of the irradiated rats were unable to complete the CDR task; furthermore, the irradiated rats that did reach criterion took more attempts to do so than did the sham-treated animals. Radiation exposure also altered the magnitude and/or nature of practice effects. A comparison of performance metrics from the pre-screen and post-exposure ATSET task revealed that while the sham-treated rats completed the post-exposure CD stage of the ATSET task in 30% less time than for completion of the pre-screen ATSET task, the irradiated rats took 30-50% longer to do so. Similarly, while sham-treated rats completed the CDR stage in ∼10% fewer attempts in the post-exposure task compared to the pre-screen task, in contrast, the 4He- and GCRSim-exposed cohorts took more (∼2-fold) attempts to reach criterion in the post-exposure task than in the pre-screen task. In conclusion, this study demonstrates that female rats are susceptible to radiation-induced loss of performance in the constrained ATSET cognitive flexibility task. Moreover, exposure to radiation leads to multiple performance decrements, including loss of practice effects, an increase in anterograde interference and reduced ability or unwillingness to switch attention. Should similar effects occur in humans, astronauts may have a compromised ability to perform complex tasks.

Self-healing polymers for space: A study on autonomous repair performance and response to space radiation

One of the main challenges of space exploration is to properly protect astronauts from the hazards of the space environment. Space suits were hence created to protect crewmembers during extravehicular activities, but they are currently unable to properly withstand damage after, for example, impacts with micrometeoroids and orbital debris (MMOD), and they would depressurize and collapse if punctured, with catastrophic consequences. In this context, the possibility of integrating self-healing materials into spacesuits has drawn the attention of the scientific community, as it would lead to autonomous damage restoration and subsequently increased safety and operational life. Nevertheless, the effects of space environment on these materials are still to be determined and could lead to a significant decrease of their overall performance.The here presented study focuses on a first example of application to a space suit, analyzing the healing performance of a set of candidate self-healing polymers before and after exposure to simulated space radiation. A comparison of bilayers and nanocomposites having these polymers as matrices is also made in the non-irradiated case. This research also aims at filling the gap between standard characterization of self-healing materials (e.g.: scratch, impact, and puncture tests) and assessment of the effects of space radiation on them by combining these two aspects. Understanding if and how radiation can affect damage recovery performance is in fact fundamental to determine whether a given self-healing material can actually be used for space applications.The self-healing response is assessed through in-situ flow rate measurements after puncture damage. Maximum and minimum flow rate, the time between them and the air volume lost within the 3 min following puncture are collected as healing performance parameters. For the neat materials, the same tests are then repeated on gamma-ray irradiated samples to study the variation in self-repairing performance after exposure to simulated space radiation. Results show that the healing performance is higher in systems with lower viscous response and that it decreases after irradiation. A further analysis of the effects of space environment on the presented materials is hence required.The NASA HZETRN2015 (High Z and Energy TRaNsport, 2015 version) software is also used to simulate the action of galactic cosmic rays on the space suit during extravehicular activity. The classic suit multilayer is compared with configurations in which the standard bladder is replaced with a layer of each analyzed material to identify the most promising candidates and determine whether the addition of nanofillers significantly increases the shielding ability.

Nanotechnology enabled radioprotectants to reduce space radiation-induced reactive oxidative species.

Interest in space exploration has seen substantial growth following recent launch and operation of modern space technologies. In particular, the possibility of travel beyond low earth orbit is seeing sustained support. However, future deep space travel requires addressing health concerns for crews under continuous, longer-term exposure to adverse environmental conditions. Among these challenges, radiation-induced health issues are a major concern. Their potential to induce chronic illness is further potentiated by the microgravity environment. While investigations into the physiological effects of space radiation are still under investigation, studies on model ionizing radiation conditions, in earth and micro-gravity conditions, can provide needed insight into relevant processes. Substantial formation of high, sustained reactive oxygen species (ROS) evolution during radiation exposure is a clear threat to physiological health of space travelers, producing indirect damage to various cell structures and requiring therapeutic address. Radioprotection toward the skeletal system components is essential to astronaut health, due to the high radio-absorption cross-section of bone mineral and local hematopoiesis. Nanotechnology can potentially function as radioprotectant and radiomitigating agents toward ROS and direct radiation damage. Nanoparticle compositions such as gold, silver, platinum, carbon-based materials, silica, transition metal dichalcogenides, and ceria have all shown potential as viable radioprotectants to mitigate space radiation effects with nanoceria further showing the ability to protect genetic material from oxidative damage in several studies. As research into space radiation-induced health problems develops, this review intends to provide insights into the nanomaterial design to ameliorate pathological effects from ionizing radiation exposure. This article is categorized under: Therapeutic Approaches and Drug Discovery > Emerging Technologies Nanotechnology Approaches to Biology > Nanoscale Systems in Biology Nanotechnology Approaches to Biology > Cells at the Nanoscale Therapeutic Approaches and Drug Discovery > Nanomedicine for Oncologic Disease.

Radiation environment and effect detection based on global navigation constellation

Abstract Combining the anomalies and environmental monitoring data of the early stage Beidou satellites, the space radiation environment spatial/temporal distribution and space radiation effect risk characteristics are analyzed, and the dynamic characteristics of space environmental factors, such as hot plasma, high-energy electron and solar proton are summarized. The systematic joint monitoring for surface charging, internal charging, single event effect and total dose effect with corresponding space environment factors is proposed. The detector types, measurement parameters range and engineering constraints are allocated, and the engineering application and scientific research of detection data are prospected.

Special NSREC 2022 Issue of the IEEE Transactions on Nuclear Science Editor Comments

The April 2023 Special Issue of the IEEE Transactions on Nuclear Science (TNS) contains selected papers from the 59th annual IEEE International Nuclear and Space Radiation Effects Conference (NSREC), which after two years of virtual conferences, was held in person from July 18 through July 22, 2022, in Provo, UT, USA. The 2022 IEEE NSREC was sponsored by the IEEE Nuclear and Plasma Sciences Society. More than 40 of the papers presented at NSREC are included in this year’s Special Issue. This issue is neither a conference proceeding nor a conference record. The papers that appear in this issue successfully completed the regular journal review process before the Special Issue deadline. A few other papers presented during the conference are likely to appear in subsequent issues of IEEE TNS.

Editorial Conference Comments by the General Chair

The 59th IEEE Nuclear and Space Radiation Effects Conference (NSREC) was held from July 18 to 22, 2022, at the Utah Valley Convention Center in Provo, UT, USA. The conference was a wonderful return to the inperson format for the first time since 2019. The 2022 NSREC was attended by 522 engineers, scientists, managers, students, and exhibitors. International participation was also strong, with 76 non-U.S. attendees from Australia, Belgium, Canada, China, the Czech Republic, Finland, France, Germany, Italy, Japan, Korea, Netherlands, Spain, Sweden, Switzerland, and the United Kingdom.

Outstanding Conference Paper Award: 2022 IEEE Nuclear and Space Radiation Effects Conference

Outstanding Conference Paper Award: 2022 IEEE Nuclear and Space Radiation Effects Conference

2022 IEEE Nuclear and Space Radiation Effects Conference Awards: Comments by the Chair

On Behalf of the Committee, I am pleased to announce the 2022 IEEE Nuclear and Space Radiation Effects Conference (NSREC) awards. In a strong field of candidate papers, one paper stood out in terms of relative ranking and scoring, and a second paper received evaluations well above those of the remaining papers. Accordingly, it was decided to award a best paper and a meritorious paper for NSREC 2022. The Outstanding Student Paper was the highest-ranking finalist paper first authored and presented by a student. The Outstanding Data Workshop paper was judged on the basis of the quality and impact of the poster at NSREC. The award recipients include:

Effects of Simulated 5-Ion Galactic Cosmic Radiation on Function and Structure of the Mouse Heart.

Missions into deep space will expose astronauts to the harsh space environment, and the degenerative tissue effects of space radiation are largely unknown. To assess the risks, in this study, male BALB/c mice were exposed to 500 mGy 5-ion simulated GCR (GCRsim) at the NASA Space Radiation Laboratory. In addition, male and female CD1 mice were exposed to GCRsim and administered a diet containing Transforming Growth Factor-beta (TGF-β)RI kinase (ALK5) inhibitor IPW-5371 as a potential countermeasure. An ultrasound was performed to investigate cardiac function. Cardiac tissue was collected to determine collagen deposition, the density of the capillary network, and the expression of the immune mediator toll-like receptor 4 (TLR4) and immune cell markers CD2, CD4, and CD45. In male BALB/c mice, the only significant effects of GCRsim were an increase in the CD2 and TLR4 markers. In male CD1 mice, GCRsim caused a significant increase in total collagens and a decrease in the expression of TLR4, both of which were mitigated by the TGF-β inhibitor diet. In female CD1 mice, GCRsim caused an increase in the number of capillaries per tissue area in the ventricles, which may be explained by the decrease in the left ventricular mass. However, this increase was not mitigated by TGF-β inhibition. In both male and female CD1 mice, the combination of GCRsim and TGF-β inhibition caused changes in left ventricular immune cell markers that were not seen with GCRsim alone. These data suggest that GCRsim results in minor changes to cardiac tissue in both an inbred and outbred mouse strain. While there were few GCRsim effects to be mitigated, results from the combination of GCRsim and the TGF-β inhibitor do point to a role for TGF-β in maintaining markers of immune cells in the heart after exposure to GCR.