Abstract The health needs of the population are increasingly difficult to plan and predict. Technological progress, artificial intelligence, new medicines, but also ecological disasters, humanitarian crises, energy crisis and other challenges (as a Covid 19 pandemic) represent the image of our time. New design of hospitals should be able to respond to the challenges of the future: comprehensive provision of health services taking into account the patient’s needs, working conditions taking into account the hospital staff, energy efficiency and construction in accordance with high standards and reduction of CO2 emissions (green hospitals), to ensure alternative sources of electricity and water supply bearing in mind potential emergencies. The big challenge of long-term construction in which advanced technologies and new procedures cannot simply fit into a rigid building structure that is several decades old (example Serbia), so it is necessary to apply precise planning and efficient and high-quality construction in the next generation hospitals, taking into account current modern equipment and that which will appear in the future. Designing hospitals involves anticipating future healthcare challenges, technological advancements, demographic shifts, and changes in patient expectations. Hospitals emphasis on patient-centered design principles, creating environments that prioritize comfort, privacy, and dignity for patients and their families, accessibility and inclusivity, infection control and prevention, sustainability and resilience. Modern hospitals should create collaborative spaces for interdisciplinary teamwork and communication among healthcare providers, research and innovation units, but also community engagement and health promotion activities. Future hospital design requires strong multidisciplinary and cross-sectional cooperation, in which priority is given to architects dedicated to this field and their cooperation with public health and health management experts.