At the northwestern end of the India–Asia collision zone, in the eastern Pamir interior, the Kongur Shan extensional system extends for ∼250 km as a composite system of normal faults. As the southernmost segment of the extensional system, the Tashkurgan fault can be divided into a northern and southern segment by the intersection of the Tahman and Tashkurgan faults. To evaluate the tectonic activity along the Tashkurgan fault and explore the extensional characteristics of the southern Kongur Shan extensional system, we integrate geomorphologic analysis with thermochronologic data and modeling. Geomorphic indices, including local relief, normalized channel steepness index (ksn), and river χ-plots, show that the southern Tashkurgan fault is more active than the northern Tashkurgan fault. On the footwall of the northern Tashkurgan fault, most thermochronologic data, which include biotite 40Ar/39Ar (Arbt), zircon (U-Th)/He (ZHe), apatite fission track (AFT), and apatite (U-Th-Sm)/He (AHe) dates, record emplacement-related cooling, and only a few AHe dates possibly record exhumation of <2 km since ∼7 Ma ago. On the footwall of the southern Tashkurgan fault, almost all of the ZHe, AFT, and AHe dates record significant late Miocene to present exhumation; thus, we perform three-dimensional thermokinematic modeling for the normal slip along this fault segment. Modeling results indicate a probably constant slip rate on the southern Tashkurgan fault at a value of 1.4–1.5 mm/a, which corresponds to 6–7 km of both horizontal extension and footwall uplift since 6.5 Ma ago. All together, the geomorphic and thermochronologic evidences imply that the southern Tashkurgan fault is responsible for the ∼E–W extension along the southernmost portion of the Kongur Shan extensional system, while the northern fault segment plays a minor role in the extension. This result, combined with the previously published magnitude of extension along the southern Kongur Shan fault, indicates that the extension at any site along the southern Kongur Shan extensional system can be primarily attributed to normal faulting along a single border fault, which is a typical characteristic of an interbasin transfer zone with a transfer fault.