The examination of the spatiotemporal characteristics and developmental trends of drought is crucial for enhancing water resource management, bolstering drought resistance, and improving disaster prevention capabilities. This study employs the Standardized Precipitation Evapotranspiration Index (SPEI) and grain yield data across various time scales, in conjunction with methodologies such as Run Theory, Mann-Kendall, and Standardized Yield Residual Series, to conduct an in-depth investigation into the spatiotemporal variation characteristics of meteorological drought in Hunan Province and its impact on grain yield. The findings suggest that: (1) Since 1960, the likelihood of seasonal drought occurrence in Hunan Province has been ranked as autumn > winter > spring > summer, with mild drought occurring most frequently, followed by moderate drought, while the frequency of severe and extreme drought remains low. (2) Meteorological drought in Hunan Province exhibits spatial differences at the seasonal scale, with the overall drought changes in spring and summer displaying a non-significant upward trend; the western and southern regions exhibit a trend of aridification in autumn; and in winter, the Zhangjiajie and Xiangxi regions show an insignificant downward trend. (3) From 1960 to 2022, grain production in Hunan Province has demonstrated a pattern of fluctuation and increase. The meteorological yield of grain crops displays a high-low-high spatial distribution from south to north. Concurrently, there is a positive correlation between short-term climate change and meteorological output, while long-term climate change is not evident. (4) El Niño Southern Oscillation (ENSO) is a significant circulation factor affecting meteorological drought in Hunan Province, and the meteorological drought in autumn and winter in Hunan Province is significantly influenced by ENSO. The research findings can provide reference significance and a scientific basis for drought research and comprehensive management in Hunan Province, and offer data and theoretical support for promoting economic development.