Abstract Being situated in the estuary of the flood-dominated Hooghly River system, the macrotidal Indian Sundarban Delta (ISD) has become one of the most complex, dynamic, and rapidly changing landforms on Earth’s surface. To study the horizontal areal shifting of shoreline and its impact on mangrove cover in the region, the U.S. Geological Survey (USGS) satellite data of 1980, 1990, 2000, 2010, and 2021 were used. Remote sensing and geographic information system (GIS) techniques were employed in the investigation. Simultaneous prograding and retrograding shoreline shifting was distinguished almost in all the parts, although sediment-starved eastern and macrotidally more active southern lobes experienced dominantly retreating shift, and the sediment-engorged western lobe was demonstrated to be more dynamic. Net areal change over north–south tracks followed the trend of decreasing accretion to increasing erosion while going from west to east, whereas that over west–east tracks followed the trend of exponentially increasing erosion while going from north to south. Overall accretion of ∼91 km2 in the ISD accounted for the augmentation of sparse vegetation of ∼13 km2, whereas ∼243 km2 erosion called for the depletion of sparse and moderate vegetation of ∼18 and ∼174 km2, respectively, over the 41-yr period. Various oceanographic and riparian forces and actions, episodic natural events, etc., vis-a-vis several anthropogenic interventions—all together contributed to such changes. The findings may help the coastal environmentalists, professionals, planners, decision-makers, and implementers in formulating and taking up of suitable strategic measures for integrated and effective coastal zone management in this estuarine wetland forest.