To explore hepatitis C risk, knowledge, and stigma among individuals who inject substances in South Central Indiana. A cross-sectional study design was employed using a community-based participatory research approach. The community partner was a grassroots harm reduction organization. Participants in this study were at least 18 years of age, current residents of Indiana, and self-identified as injection substance users (n=179). The survey measured hepatitis C risk, knowledge, and stigma, as well as differences in hepatitis C risk scores among key demographic characteristics. Most participants identified as male (n=106, 59%), White (n=139, 78%), and straight (n=143, 80%). People of color reported lower hepatitis C knowledge than White participants. Women had significantly lower hepatitis C knowledge compared with men. LGBTQ participants reported increased hepatitis C risk compared with straight participants. Increased frequency of substance use was associated with decreased stigma. Unhoused participants demonstrated significantly lower hepatitis C knowledge compared with housing-secure participants. Our findings increase understanding that knowledge and risk around hepatitis C are associated with demographic characteristics. Results underscore the need for tailored public health interventions to increase hepatitis C knowledge, reduce stigma, and improve testing and treatment among vulnerable populations.
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