The air source heat pumps (ASHPs) for winter heating have the advantages of high efficiency and environmental protection. However, the outside evaporator’s frosting negatively impacts the performance of heat pump systems in low-temperature and high-humidity environments. In this paper, we fabricated the superhydrophobic evaporator and mounted it on a commercial ASHP unit, expanding the use of superhydrophobic surface modification technology from heat exchangers in the laboratory to the ASHP units. Then we investigated the operating characteristics of two ASHP units equipped with hydrophilic and superhydrophobic evaporators respectively under six distinct outdoor and indoor environmental conditions experimentally. In the non-frosting conditions, film condensation formed on the surface of the hydrophilic evaporator and the evaporation temperature decreased with the formation of water film, resulting in a decrease in heat production and COP. In the frosting conditions, the time of forming the frost layers with the same thickness on the superhydrophobic surface was more than 4 times longer than that on the hydrophilic surface. The COP of the superhydrophobic evaporator unit was improved by 2.9% to 8.2% under the non-frosting conditions, by 11.5% under the continuous heating conditions and by 14.28% when the hydrophilic unit performed two defrosting cycles, respectively. During the period in which the hydrophilic evaporator unit completed two frosting/defrosting cycles, the energy loss coefficient caused by the defrosting process was 31.65% compared to the superhydrophobic evaporator unit. This work extended the experimental method of superhydrophobic heat exchanger, contributing to the application of superhydrophobic finned-tube evaporators in ASHP units.