In the present study, a Wave Finite Element-based method is introduced to estimate the Sound Transmission Loss (STL) of periodic structures with contrasting properties. This method addresses the precision and computational speed limitations of existing methodologies. It calculates the wave STL by applying a plane wave excitation from the ambient medium to a Unit Cell (UC), which is representative of the periodic structure. The STL under Diffuse Acoustic Field (DAF) is then computed by integrating the wave STL over all possible incidence angle ranges. The advantages of this methodology are demonstrated through various configurations, ranging from simple plates to complex laminated structures. Additionally, the study investigates the Mass Law of STL.