The unit commitment (UC) is highly complex to solve the increasing integrations of wind farm due to intermittent wind power fluctuation in nature. This paper presents a hybrid methodology to solve the stochastic unit commitment (SUC) problem depending on binary mixed integer generator combination with renewable energy sources (RESs). In this combination, ON/OFF tasks of the generators are likewise included to satisfy the load requirement as for the system constraints. The proposed hybrid methodology is the consolidation of grey wolf optimization algorithm (GWOA) and artificial neural network (ANN), hence it is called the hybrid GWOANN (HGWOANN) technique. Here, the GWOA algorithm is used to optimizing the best combination of thermal generators depending on uncertain wind power, minimum operating cost and system constraints – that is, thermal generators limits, start-up cost, ramp-up time, ramp-down time, etc. ANN is utilized to capture the uncertain wind power events, therefore the system ensures maximal application of wind power. The combination of HGWOANN technique guarantees the prominent use of sustainable power sources to diminish the thermal generators unit operating cost. The proposed technique is implemented in MATLAB/Simulink site and the efficiency is assessed with different existing methods. The comparative analysis demonstrates that the proposed HGWOANN approach is proficient to solve unit commitment problems and wind integration. Here, the HGWOANN method is compared with existing techniques such as PSO, BPSO, IGSA to assess the overall performance using various metrics viz. RMSE, MAPE, MBE under 50 and 100 count of trials. In the proposed approach, the range of RMSE achieves 9.26%, MAPE achieves 0.95%, MBE achieves 1% in 50 count of trials. Moreover, in 100 count of trials, the range of RMSE achieves 7.38%, MAPE achieves 1.91%, MBE achieves 2.87%.