Background and aim: Lactating adenoma is one of the benign tumors of breast that is frequently associated with pregnancy and lactation. Its size ranged from 1cm to 4 cm; however, rare cases with rapid postpartum enlargement up to 25 cm have been reported. Surgical removal of small lactating adenoma usually postponed till weaning, waiting for spontaneous regression and to avoid wound complications. The aim of this study was to assess the safety of surgical removal of giant (more than 5 cm) lactating adenomas during lactation, regarding wound complication specially milk fistula, with maintenance of breast feeding and its benefit. Patients and methods: The present study was conducted on 12 patients with giant lactating breast adenoma in Surgical Oncology unit at General Surgery Department, Tanta University Hospital from March 2013 to July 2016. The patients included in the study were lactating, had solitary breast mass more than 5 cm in size, had subjected to surgical removal through a cosmetic circumareolar or curvilinear incision. The patients resumed breast feeding within 24 hours, then followed-up for wound haematoma, wound seroma, wound infection, milk fistula, psychic and pain relief. Results: The patients' age ranged from 18 to 38 years with a mean age of 27 ± 3.6 years. In all patients; the chief complaint was cosmetically discomforting mass, asymmetry between the two breasts and fear of malignancy, pain was a presenting symptom in 6 patients. The size of the adenoma by ultrasound ranged from 8-18 cm with a mean of 12.6 cm. No wound complications were recorded. Conclusion: Giant lactating adenoma could be safely removed during lactation to alleviate pain, heaviness, and anxiety, to rule out malignancy or coexisting carcinoma with no wound complication, no milk fistula and good aesthetic outcome with maintenance of the breast feeding and its benefits.