Improvements in thermal transference rate and minimization of entropy generation are critical issues in many industrial and engineering applications where heat transfer coefficient is essential to achieve optimal performance and minimal energy consumption. In the present investigation, a computational analysis has been conducted to analyze the impact of magnetic field on magneto-free convection and entropy generation inside a vertical wavy cabinet filled by Cu-Al2O3/H2O hybrid nanosuspension. In the geometry of this model, vertical boundaries of the chamber are designed as wavy and kept as cooled temperature (Tc), whereas the horizontal boundaries are modeled as square and are designed to be thermally adiabatic, except the centrally heated portion on the bottom wall. The centered bottom heated section is supposed to be isothermal with linearly changing temperature, and it changes linearly from Th1 to Th2, whereas it is modelled as a non-isothermal condition. The main focus, in this investigation, is on the entire chamber filled with the combination of hybrid nanoparticles regarded the volumetric concentration of copper and alumina nanoparticles (Cu-50 %+Al2O3-50 %) along with base liquid (H2O). The transformed dimensionless partial differential equations were solved by using finite volume method (FVM) with power law differencing scheme. The simulated flow and temperature fields are scrutinized by streamlines, isotherms, entropy formations, total entropy generation and average convective Nusselt number associated with varying number of undulations (0 ≤ N≤3) volume fraction of hybrid nano liquid (0 ≤ φ ≤ 0.04) magnetic orientation angles (0° ≤ ς ≤ 135°), Hartmann number (Ha = 0 and 50), and dimensionless temperature drop (Ω = 0.001–0.1). From this study, it is found that the average Nusselt number and entropy generation increase as the solid volume fraction of hybrid nanoadditives increases, while opposite trend is observed when the values of Hartmann number rises. The findings show that growth of undulation number (N) causes the reduction of convective heat transfer rate as well as average entropy production intensity. The obtained outcomes concluded that hybrid nano liquid is more effective and finest choice for the improvement of cooling of heat transfer process and minimal energy loss than single nanoliquid. According to the new proposed criterion (TPC), the results show that square-shaped enclosure (N=0) manifests the better cooling performance among the considered governing parameters. The novelty of this study is to scrutinize the flat/ vertical wavy boundaries of the cabinet which can be represented as a model of heat transfer controller, in which it manages the thermal and flow field characteristics. Predominantly, the isothermal line source is used to boost the overall convective heat transfer which is applied in buildings and fluid-mounted heaters. Additionally, many investigators have focused only on the enhancement of heat transfer. As it is known, to increase the thermodynamic efficiency of a system, optimization of entropy generation is an excellent tool which reduces the loss of energy. Hence, it recently does a good engineering sense to highlight an entropy irreversibility.