Solid Water Phantom Research Articles

Characterization of novel 3D-printed metal shielding for brachytherapy applicators.

To characterize 3D-printed stainless steel metal samples in the presence of an Iridium-192 source for organ-at-risk sparing in gynecologic brachytherapy. Samples of 3D-printed stainless steel (5.5×5.5 cm2, thickness range 1-5mm) were embedded in a solid water phantom at varying distances from source catheters. An Ir-192 brachytherapy source was passed through the phantom and the dose was measured using EBT3 Gafchromic film. The film was initially positioned in the sagittal plane 2cm away from the catheters, with the metal directly below and then 1cm from the film. A uniform dose was delivered at the film plane. A second setup measured a depth dose curve in solid water with film in the transverse plane directly above the metal samples. This setup was recreated using Monte Carlo simulations (EGSnrc egs_brachy). Validation between methods was performed with unshielded (solid water only) measurements. The planar dose passing through the metal samples (thickness 1-5mm) at the midpoint between the film and catheters, decreased compared to solid water by 7.4%±6.9% to 26.5%±5.5%. Dose enhancement on the order of 5% was noted when metal was directly adjacent to the film. The average decrease in depth dose from a single dwell position ranged from 10.0%±5.9% (1mm) to 21.1%±5.3% (5mm) as measured with film, and from 3.8%±0.9% (1mm) to 16.3%±0.9% (5mm) using MC simulation. The average depth dose values were measured using a line width of 2.5mm for film, and 3mm for MC simulation, and the measurements generally agree within standard error. The 3D-printed metal samples show potential for personalized applicators. Maximum dose reduction of 26.5%±5.5% compared to solid water was measured at 2cm from the source using the 5mm sample. An outer layer of solid water could potentially be used to reduce dose enhancement due to increased scatter near the metal.

Comprehensive analysis of peripheral dose in electron beam therapy with a Varian TrueBeam Linac

ObjectiveTo investigate the characteristics of peripheral doses outside electron-beam applicators in Varian TrueBeam linacs. MethodPeripheral doses outside the electron applicator were measured for 6-, 9- and 12-MeV beams at the maximum dose depth (Dmax) for each energy source and at a source-to-surface distance of 100 cm. Measurements were performed using EBT3 films in solid water phantoms. The impact of field size on the penumbra width and peripheral doses was studied using various cutouts, including 3 cm × 3 cm, 6 cm × 6 cm, and 10 cm × 10 cm in a 10 cm × 10 cm applicator with the gantry and collimator at 0°. The influence of the applicator size was investigated using a circular cutout of 5 cm in diameter for various applicator sizes, including 6 cm × 6 cm, 10 cm × 10 cm, 15 cm × 15 cm, 20 × 20 cm, and 25 cm × 25 cm, at Dmax for each energy, while keeping the gantry and collimator angle at 0°. The measured dose profiles were compared with the Eclipse treatment planning system (TPS) predicted dose profiles. The effect of varying gantry angles (0°, 90°, and 270°) for a 3 cm × 3 cm cutout in a 10 cm × 10 cm applicator for each energy source and varying collimator angles (0°, 90°, and 270°) for a 10 cm × 10 cm field were investigated to determine their effects on the penumbra widths and peripheral doses. ResultsBoth the penumbra width and peripheral dose values increased with energy across different field sizes, gantry angles, collimator angles, and applicator sizes. Root Mean Square Deviation (RMSD) analysis indicated minimal differences between the measured profiles and TPS data. Peripheral doses remained below 5% of the maximum dose approximately 10–15 mm away from the field edges, suggesting the potential for implementing additional shielding where required. ConclusionsThis study highlights the importance of considering peripheral doses in electron radiotherapy. It is important to note the impact on healthy tissues beyond the treatment area to ensure patient safety and prevent the long-term side effects of treatment. These findings emphasize the necessity of implementing appropriate measures to minimize peripheral doses.

Verification of mean dose in a tumor using 3D-printed tumor-model scintillators in anthropomorphic phantoms and a spherical phantom

To enhance treatment outcomes of radiotherapy, accurate verification of dosimetric parameters such as the mean, minimum, and maximum doses is essential. This study aimed to measure the mean absorbed dose in a tumor-shaped target and compare the results with the calculated value of the treatment planning system. Tumor model scintillators (TMSs) mimicking brain tumors were fabricated with a commercial 3D printer based on stereolithography files of tumors. The TMSs were irradiated following treatment plans made with the Leksell Gamma Plan® (Elekta AB, Stockholm, Sweden), and the mean dose in each TMS was measured three times and compared with the calculated value. Eleven TMSs were set at the center of a spherical solid water phantom. Two additional TMSs were fabricated according to images of vestibular schwannomas and were set at the tumor location in head model phantoms following each patient's head shape. The mean relative differences between the measured and calculated mean doses were less than one percent. This method provides an independent parameter for evaluating the accuracy of the treatment planning system.

Validation of GAMOS Monte Carlo simulation for 131Cs brachytherapy source in water and dosimetric characterization of solid water, bone, and brain tissues

PurposeThe treatment of brain tumours using permanently implanted 131Cs has become more frequent since GammaTile brachytherapy platform was cleared by the U.S. Food and Drug Administration (FDA). Current treatment planning systems (TPS) (BrachyVision v11.0.47, Varian Medical Systems, Palo Alto, CA, USA) used clinically do not account for anatomical heterogeneities. GAMOS Monte Carlo simulation was validated for the dose deposited by 131Cs in water and used to accurately determine the dose deposited in simulated human tissues, including bone and brain tissue, as well as in Solid Water (SW) phantom material. MethodGAMOS was validated and benchmarked for dose deposited by 131Cs (CS-1 Rev2) in water. The evaluation performed included air-kerma strength, radial dose function, anisotropy function, and dose rate constant based on the recommendation of TG-43U1S2 protocol. Dosimetric simulation of the 131Cs brachytherapy source was also performed in SW, bone, and brain tissue using GAMOS. Conversion factors were calculated by the ratio of the dose rate constant from water to SW, bone, and brain tissue, respectively. ResultResults for dose in water were benchmarked with MCNP simulation and experiential data published in the TG-43U1S2. The dose rate constant in water was 1.039 ± 0.017 cGy h−1 U−1 which is consistent with the results used to determine the TG-43U1S2 consensus data. The conversion factor of water to SW, water to the bone, and water to brain tissue were 0.936, 1.15, and 0.964, respectively. ConclusionOther Monte Carlo (MC) simulation codes, such as MCNP, have been previously used in the literature to determine the dose deposited by 131Cs. In this work, doses deposited by 131Cs radioactive sources were successfully simulated using GAMOS MC simulation. To our knowledge, this is the first time that GAMOS was used to simulate the dose deposited by 131Cs seed. MC simulation of dose for brachytherapy sources is especially important to accurately estimate the dose deposited in high Z materials such as skull bone, which may be widely different than the dose calculated by the TG-43U1S2 formalism.

Technical Note: Investigating of dosimetric leaf gap and leaf transmission factor variations across gantry and collimator angles in volumetric modulation arc therapy.

This study investigates the influence of gantry and collimator angles on the dosimetric leaf gap (DLG) and leaf transmission factor (LTF) in a Varian LINAC equipped with rounded-end multi-leaf collimators (MLCs). While Varian guidelines recommend DLG measurements at zero degrees for both gantry and collimator, this research aims to address the knowledge gap by assessing DLG and LTF variations at different gantry and collimator angles. Measurements were conducted using a Varian TrueBeam LINAC with a Millennium 120-leaf MLC and Eclipse TPS version 16.1. The beams utilized in this study had energies of 6 MV, 10 MV, 6 FFF, and 10 FFF. LTF and DLG were determined using ionization chambers in solid water phantoms at various gantry angles (0°, 45°, 90°, 135°, 180°, 225°, 270°, and 315°). For each gantry angle, measurements were also taken at various collimator angles (0°, 45°, 90°, and 315°). Dosimetric impacts were evaluated through VMAT Picket Fence tests and patient-specific verification using portal dosimetry for 10 clinical VMAT plans. LTF values showed no significant variation across gantry and collimator angles. However, DLG values exhibited notable differences depending on the gantry angle and were independent of the collimator angle. The highest DLG value was observed at a gantry angle of 270 degrees, while the lowest was at 90 degrees. The AXB DLGAverage (averaging seven measurements of DLGs at different gantry angles) model demonstrated the best agreement between measured and calculated dose distributions, indicating the importance of considering averaged DLG values across multiple gantry angles for accurate dose calculations. Our study highlights the variability of DLG with gantry angle alterations, contrary to Varian guidelines recommending DLG measurements at zero gantry angle only. We advocate for utilizing an averaged DLG value from measurements across multiple gantry angles, as outlined in our methodology.

The accuracy of Eclipse AXB and AAA dose algorithms with dental amalgam.

High-density materials used for dental restorations are poorly defined in CT imaging due to scanner limitations. Studies have established that Eclipse offers poor agreement with delivered dose in situations involving high-density material. Defining the accuracy of dose algorithms in situations involving high-density overrides would improve clinical outcomes both for target coverage and OAR sparing. Dental amalgam was placed within a solid water phantom and measurements were taken at 1cm increments beneath the amalgam down to a depth of 6cm. Exposed film was compared with Eclipse Treatment Planning system (TPS) calculations on a CT of the experimental setup. The amalgam was overridden with a range of HU values and material selections for dose calculation. AXB performs poorly at describing depth dose downstream of Amalgam, regardless of the override material selected. Query ID="Q2" Text="Please confirm the section headings are correctly identified." Applying the known mass density with the Anisotropic Analytical Algorithm (AAA) predicts an average of 1.8% and 2.8% for 6 MV and 10 MV beams. The closest agreement achieved using the Acuros XB (AXB) was overriding with stainless steel, which predicted approximately 1.1% and 1.8% above measured dose for 6 MV and 10 MV respectively. Without overriding the density of amalgam, AAA and AXB return depth dose predictions of 7.3% and 5.8% above film measurement for a 6 MV and 7.6% and 6.5% for 10 MV static beams. Applying override options to a clinical case using an anthropomorphic phantom showed using AXB with Stainless Steel as amalgam override returns the same results as AAA with mass density applied for amalgam. Both of these were in close agreement to the TPS.

Evaluating the Kerma coefficients relevant to various water-equivalent materials at different photon energies

To investigate the water equivalency of some solid phantoms, relevant Kerma coefficients were determined through both Monte Carlo (MC) simulation and analytical approaches over a wide range of photon energies ranging from 1 keV to 20 MeV.MCNPX MC Code was employed to simulate the Kerma coefficients for A-150, PMMA, Polystyrene, Solid Water (RMI 457), Solid Phantom (RW3), Virtual water, Solid Water (WT1), and Water Equivalent (Wte) solid phantoms. Kerma coefficients were also theoretically calculated using the mass energy absorption coefficients at different photon energies ranging from 1 keV to 20 MeV. Obtained Kerma coefficients for considered solid phantoms were also compared with those of water to find which material shows the best water-equivalency.Calculated Kerma coefficients by MC simulation were in a good agreement with those calculated via an analytical method which no statistically significant differences were observed among simulated and analytically calculated Kerma coefficients (p-value>0.05). Solid water (RMI 457) showed the best water-equivalency among studied plastic phantoms for radiology and radiotherapy quality assurance purposes. From the results, the Kerma coefficients for solid phantoms are highly dependent on photon energy.

Design, construction, and dosimetry of 3D printed heterogeneous phantoms for synchrotron brain cancer radiation therapy quality assurance

Objective. This study aims to design, manufacture, and test 3D printed quality assurance (QA) dosimetry phantoms for synchrotron brain cancer radiation therapy at the Australian synchrotron. Approach. Fabricated 3D printed phantoms from simple slab phantoms, a preclinical rat phantom, and an anthropomorphic head phantom were fabricated and characterized. Attenuation measurements of various polymers, ceramics and metals were acquired using synchrotron monochromatic micro-computed tomography (CT) imaging. Polylactic acid plus, VeroClear, Durable resin, and tricalcium phosphate were used in constructing the phantoms. Furthermore, 3D printed bone equivalent materials were compared relative to ICRU bone and hemihydrate plaster. Homogeneous and heterogeneous rat phantoms were designed and fabricated using tissue-equivalent materials. Geometric accuracy, CT imaging, and consistency were considered. Moreover, synchrotron broad-beam x-rays were delivered using a 3 Tesla superconducting multipole wiggler field for four sets of synchrotron radiation beam qualities. Dose measurements were acquired using a PinPoint ionization chamber and compared relative to a water phantom and a RMI457 Solid Water phantom. Experimental depth doses were compared relative to calculated doses using a Geant4 Monte Carlo simulation. Main results. Polylactic acid (PLA+) shows to have a good match with the attenuation coefficient of ICRU water, while both tricalcium phosphate and hydroxyapatite have good attenuation similarity with ICRU bone cortical. PLA+ material can be used as substitute to RMI457 slabs for reference dosimetry with a maximum difference of 1.84%. Percent depth dose measurement also shows that PLA+ has the best match with water and RMI457 within ±2.2% and ±1.6%, respectively. Overall, PLA+ phantoms match with RMI457 phantoms within ±3%. Significance and conclusion. The fabricated phantoms are excellent tissue equivalent equipment for synchrotron radiation dosimetry QA measurement. Both the rat and the anthropomorphic head phantoms are useful in synchrotron brain cancer radiotherapy dosimetry, experiments, and future clinical translation of synchrotron radiotherapy and imaging.

Radiochromic film EBT3 calibration for linear accelerator in 10 MV

Radiochromic film is used to applications in dosimetry have become increasingly significant for studies on radiotherapy. Due to sensitivity to exposure to ionizing radiation, radiochromic films are commonly used to obtain dose distribution maps and for calibration curves. The calibration curves in the radiochromic films can be use radiochromic films as a dosimetry method and then seek the generation of images with lower dose deposition and higher diagnostic quality. When ionizing radiation interacts with matter it generates energy deposition. Radiation dosimetry is important for medical applications of ionizing radiation due to the increasing demand for diagnostic radiology and radiotherapy. The film is a dose measurement method that records the energy deposition by the darkening of its emulsion. Radiochromic films have a little visible light sensitivity and respond better to ionizing radiation exposure. The aim of this study is to obtain the resulting calibration curve by the irradiation of radiochromic film strips, making it possible to relate the darkening of the film with the absorbed dose, to measure doses in experiments with X-ray beam of 10 MeV in Linear Accelerator. The objective of this study is to obtain the calibration curves of the radiographic film for exposure with X-ray beam in Linear Accelerator scanner for realize measures of typical doses found in radiotherapy. It was used Gafchromic EBT Radiochromic Film, which shows little sensitivity to visible light and a response in the range of 0.1 to 10 Gy for X-ray beam. In the experiments, a Solid Water Phantom, with a 30x30x2.0 cm³. The strips were scanned and processed using the ImageJ software to obtain the intensity values resulting from the absorbed radiation by grayscale. The darkening responses on film strips according to the doses were observed and they allowed obtaining the corresponding numeric values to the darkening for each specific dose value. From the numerical values of darkening, a calibration curve was obtained.

A Comparison Study of the Solid Phantom and Water Phantom Using 6 MV and 15 MV Photon Energies, Depending on the Depth

Water is such an environmental element that is considered the best human body tissue equivalent. In the field of dosimetry studies, water is frequently used. This comparison study is conducted by a solid phantom and a water phantom with 6 MV and 15 MV photon energies, respectively. A cylindrical-type ionization chamber is used to collect charge when beams are on. The distance between the ray source and the surface of the phantom was fixed at 100 cm i.e. to SSD (Source to Surface Distance) of during the experiment. Chamber travels 1 cm to 20 cm in both phantoms and an electrometer is attached in the experimental set-up to measure the charge. The field size was 10x10 cm2. The relative deviation ratio of the solid phantom to the water phantom was calculated. In the result, the maximum deviation was 0.64%, while the minimum deviation was 0%, corresponding to the depths of 1 cm and 2.5 cm, respectively, for 6 MV and at 15 MV, maximum deviation and minimum deviation were 1.90% and 0.167% respectively, corresponding to the depths of 1.5 cm and 13 cm. Therefore, it can be said that the solid phantom can overcome the disadvantages of installation time required for the water phantom and problems while water level changing for depth measurement, simultaneously can used to measure the radiological dose precisely. Bangladesh J. Nuclear Med. 27(1): 34-38, 2024

Evaluation of cutout factors with small and narrow fields using various dosimetry detectors in electron beam keloid radiotherapy.

The inherent problems in the existence of electron equilibrium and steep dose fall-off pose difficulties for small- and narrow-field dosimetry. To investigate the cutout factors for keloid electron radiotherapy using various dosimetry detectors for small and narrow fields. The measurements were performed in a solid water phantom with nine different cutout shapes. Five dosimetry detectors were used in the study: pinpoint 3D ionization chamber, Farmer chamber, semiflex chamber, Classic Markus parallel plate chamber, and EBT3 film. The results demonstrated good agreement between the semiflex and pinpoint chambers. Furthermore, there was no difference between the Farmer and pinpoint chambers for large cutouts. For the EBT3 film, half of the cases had differences greater than 1%, and the maximum discrepancy compared with the reference chamber was greater than 2% for the narrow field. The parallel plate, semiflex chamber and EBT3 film are suitable dosimeters that are comparable with pinpoint 3D chambers in small and narrow electron fields. Notably, a semiflex chamber could be an alternative option to a pinpoint 3D chamber for cutout widths≥3 cm. It is very important to perform patient-specific cutout factor calibration with an appropriate dosimeter for keloid radiotherapy.

Graphite foils as potential skin and epithelium dosimeters at therapeutic photon energies

This work builds upon a prior study, examining the dosimetric utility of pencil lead and thin graphitic sheets, focusing upon the measurement of skin doses within the mammographic regime. In recognizing the near soft-tissue equivalence of graphite and the earlier-observed favourable thermoluminescence yield of thin sheets of graphite, this has led to present study of 50 μm thick graphite for parameters typical of external beam fractionated radiotherapy and skin dose evaluations. The graphite layers were annealed and then stacked to form an assembly of 0.5 mm nominal thickness. Using a 6 MV photon beam and delivering doses from 2- to 60 Gy, irradiations were conducted, the assembly first forming a superficial layer to a solid water phantom and subsequently underlying a 1.5 cm bolus, seeking to circumvent the build-up to electronic equilibrium for skin treatments. Investigations were made of several dosimetric properties arising from the thermoluminescence yield of the 50 μm thick graphite slabs, in particular proportionality and sensitivity to dose. The results show excellent sensitivity within the dose range of interest, the thermoluminescence response varying with increasing depth through the stacked graphite layers, obtaining a coefficient of determination of 90%. Acknowledging there to be considerable challenge in accurately matching skin thickness with dose, the graphite sheets have nevertheless shown considerable promise as dosimeters of skin, sensitive in determination of dose from the surface of the graphite through to sub-dermal depth thicknesses.

Operational Radiation Safety Considerations During Equine Superficial Radiation Treatment Using Portable X-Ray Devices

Abstract Veterinary personnel exposure due to scattered x rays, when present during superficial radiation treatment (SRT), was evaluated. Veterinary personnel presence is needed during SRT to minimize the degree of required aesthesia to horses. Animal treatment was simulated, and exposure rates determined for 50, 70, and 100 kV x rays using eight different SRT applicators. Exposure rates at the surface of a solid water phantom (SWP) phantom ranged from 3.9 mR h−1 to 396 mR h−1 for 50 kV, from 41 mR h−1 to 2,880 mR h−1 for 70 kV, and from 235 mR h−1 to 7,500 mR h−1, for 100 kV, respectively. A horse phantom was used to mimic SRT equine ocular treatment creating a spatial exposure field where the directional scatter was measured at 1 m. The minimum distance away from the source to reach < 2 mR h−1 varied with angular position and energy and was lowest for all energies directly behind the x-ray tube. The closest distance before exceeding 2 mR h−1 at 50 kVp was determined to 1.96 m. A worker could stand 1 m behind the x-ray tube at 50 kVp with 0.25 mm lead for 15,106 hours. Typical SRT treatment times for horse eyelid squamous cell carcinoma are less than 5 minutes, and radiation doses to practitioners are expected to be well below local administrative ALARA limits.

The development of a cylindrical phantom for nanoDotTM calibration with multiple beam angles

Background: The nanoDotTM dosimeter, an optically stimulated luminescent dosimeter (OSLD), is compact and precise, ideal for various applications like radiation dosimetry. The nanoDotTM requires calibration before use with the detector alignment perpendicular to the central beam axis. It exhibits angular dependence that may impact the calibration factor, requiring the fabrication of a specific cylindrical phantom for the calibration procedure. Objective: This study aimed to develop a cylindrical phantom for nanoDotTM calibration to facilitate dose measurements in composite fields with various beam angles and to evaluate the nanoDotTM calibration factors for different plans. Materials and methods: The cylindrical phantom was constructed using cast nylon material to accommodate the nanoDotTM or a cylindrical ionization chamber (IC). The novel phantom underwent validation for physical characteristics, including dimensions, density, and uniformity. Validation for the calibration factor, using cylindrical phantom (CF cylin) under standard conditions with a 10x10 cm² field size at 10 cm depth was conducted with 6 MV X-rays, comparing it with calibration factor using slab solid water phantoms (CFsolid). The CFcylin for different numbers of beams were determined and validated against a reference IC in various planning conditions. Furthermore, angular correction factors were determined for their application in the single-beam calibration factor. Results: The cylindrical phantom had dimensions of 20 cm in diameter and 30 cm in length, a density of 1.145 g/cm³ and good uniformity. As a result of single beam, the CF cylin, agreed well with CFsolid, showing a difference of -0.069%. The CFcylin increased with the number of beams, ranging between 1.179 and 1.242. Additionally, the angular correction factor increased as the number of beams increased, peaking at 1.058 with 9 beams. When comparing the results to the IC, it was observed that with an increase in the number of beams to 4 beams, the single-beam calibration factor exhibited a variation of more than 2%. However, when applying the CF cylin specific to the number of beams or correcting for the angular correction factor, the dose differences between nanoDotTM and IC measurements were within 2%. Conclusion: The developed cylindrical phantom is suitable for nanoDotTM calibration under single beam angle and in composite fields with various beam angles. The new calibration factors for specific numbers of beams allow for accurate dose measurements using nanoDotTM, thus reducing the dose difference from the IC to acceptable levels. Further studies should investigate its application in clinical situations.

Electron streaming dose measurements and calculations on a 1.5 T MR-Linac.

To evaluate the accuracy of different dosimeters and the treatment planning system (TPS) for assessing the skin dose due to the electron streaming effect (ESE) on a 1.5 T magnetic resonance (MR)-linac. Skin dose due to the ESE on an MR-linac (Unity, Elekta) was investigated using a solid water phantom rotated 45° in the x-y plane (IEC61217) and centered at the isocenter. The phantom was irradiated with 1 × 1, 3 × 3, 5 × 5, 10 × 10, and 22 × 22cm2 fields, gantry at 90°. Out-of-field doses (OFDs) deposited by electron streams generated at the entry and exit surface of the angled phantom were measured on the surface of solid water slabs placed±20.0cm from the isocenter along the x-direction. A high-resolution MOSkin™ detector served as a benchmark due to its shallower depth of measurement that matches the International Commission on Radiological Protection (ICRP) recommended depth for skin dose assessment (0.07mm). MOSkin™ doses were compared to EBT3 film, OSLDs, a diamond detector, and the TPS where the experimental setup was modeled using two separate calculation parameters settings: a 0.1cm dose grid with 0.2% statistical uncertainty (0.1cm, 0.2%) and a 0.2cm dose grid with 3.0% statistical uncertainty (0.2cm, 3.0%). OSLD, film, the 0.1cm, 0.2%, and 0.2cm, 3.0% TPS ESE doses, underestimated skin doses measured by the MOSkin™ by as much as -75.3%, -7.0%, -24.7%, and -41.9%, respectively. Film results were most similar to MOSkin™ skin dose measurements. These results show that electron streams can deposit significant doses outside the primary field and that dosimeter choice and TPS calculation settings greatly influence the reported readings. Due to the steep dose gradient of the ESE, EBT3 film remains the choice for accurate skin dose assessment in this challenging environment.

Study of PRESAGE® dosimeter for end-to-end 3D radiotherapy verification using an anthropomorphic phantom with bespoke dosimeter insert.

Modern radiotherapy techniques have advanced and become more sophisticated. End-to-end 3D verification of the complex radiotherapy dose distribution in an anthropomorphic phantom can ensure the accuracy of the treatment delivery. The phantoms commonly used for dosimetry are homogeneous solid water phantom which lacks the capability to measure the 3D dose distribution for heterogeneous tissues necessary for advanced radiotherapy techniques. Therefore, we developed an end-to-end 3D radiotherapy dose verification system based on MAX-HD anthropomorphic phantom (Integrated Medical Technologies Inc., Troy, New York) with bespoke intracranial insert for PRESAGE® dosimeter. In this study, several advanced radiotherapy treatment techniques of various levels of complexity; 3D-CRT, IMRT and VMAT treatment, were planned for a 20mm diameter of a spherical target in the brain region and delivered to the phantom. The dosimeters were read out using an in-house developed optical computed tomography (OCT) imaging system known as 3DmicroHD-OCT. It was found that the measured dose distribution of the PRESAGE® when compared with the measured dose distribution of EBT film and Monaco TPS has a maximum difference of less than 3% for 3D-CRT, IMRT and VMAT treatment plans. The gamma analysis results of PRESAGE® in comparison to EBT film and Monaco TPS show pass rates of more than 95% for the criteria of 3% dose difference and 3mm distance-to-agreement. This study proves the capability of PRESAGE® and bespoke MAX-HD phantom in conjunction with the 3DmicroHD-OCT system to measure 3D dose distribution for end-to-end dosimetry verification.

Evaluation of Ion Recombination Correction for Indigenously Developed Farmer Ion Chamber in Flattening Filter-Free Photon Beams.

Modern generation linear accelerator (linac) either generates X-rays with a flattening filter (WFF beam) or without flattening filter free (FFF beam). The FFF beams are associated with a significantly higher dose per pulse compared to WFF beams due to the absence of a flattening filter and the corresponding attenuation caused by it. This results in increased ion recombination and a larger saturation correction factor (ks). In accordance with the IAEA TRS 398 dosimetry protocol, ks is necessary for the accurate measurement of absorbed dose at a point in water. The objective of this study was to evaluate the ks for the indigenous FAR 65-GB ion chamber (IC) for the FFF X-rays. The study was carried out on TrueBeam linac (Varian, A Siemens Healthineers company) which offers 6 MV WFF, 6 MV FFF, 10 MV WFF and 10 MV FFF beams. The two-voltage method was employed to measure ks in a solid water phantom at a depth of 10 cm for a FAR 65-GB and SNC 600c and 0.6cc PTW 30013 Farmer chambers at 100 cm and 150 cm source-to-chamber distances for a 10 cm × 10 cm field size. The ks values for the FAR 65-GB, PTW 30,013, and SNC 600c were 1.0055 (1.0113), 1.0051 (1.0071), and 1.0033 (1.0066) for the 6 MV WFF (FFF) beams, respectively, and 1.0066 (1.0178), 1.0061 (1.0137), and 1.0035 (1.0119) for the 10MV WFF (FFF) beams, respectively. The ks values calculated by two-voltage method matches with ks values obtained from Jaffe's plot. The chamber exhibited a linear dose-response up to 3000 cGy, beyond which a saturation effect was observed. Our study reveals that this chamber is suitable for the reference dosimetry for the FFF beams.

Resolving signal drift in the wall-mounted camera of the RGSC system.

To present a modified calibration method to reduce signal drift due to table sagging in Respiratory Gating for Scanner (RGSC) systems with a wall-mounted camera. Approximately 70kg of solid water phantoms were evenly distributed on the CT couch, mimicking the patient's weight. New calibration measurements were performed at 9 points at the combination of three lateral positions, the CT isocenter and±10cm laterally from the isocenter, and three longitudinal locations, the CT isocenter and±30cm or±40cm from the isocenter. The new calibration was tested in two hospitals. Implementing the new weighed calibration method at the extended distance yielded improved results during the DIBH scan, reducing the drift to within 1 from 3mm. The extended calibration positions exhibited similarly reduced drift in both hospitals, reinforcing the method's robustness and its potential applicability across all centers. This proposed solution aims to minimize the systematic error in radiation delivery for patients undergoing motion management with wall-mounted camera RGSC systems, especially in conjunction with a bariatric CT couchtop.

Technical note: A small animal irradiation platform for investigating the dependence of the FLASH effect on electron beam parameters.

The recent rediscovery of the FLASH effect, a normal tissue sparing phenomenon observed in ultra-high dose rate (UHDR) irradiations, has instigated a surge of research endeavors aiming to close the gap between experimental observation and clinical treatment. However, the dependences of the FLASH effect and its underpinning mechanisms on beam parameters are not well known, and large-scale in vivo studies using murine models of human cancer are needed for these investigations. To commission a high-throughput, variable dose rate platform providing uniform electron fields(≥15cm diameter) at conventional (CONV) and UHDRs for in vivo investigations of the FLASH effect and its dependences on pulsed electron beam parameters. A murine whole-thoracic lung irradiation (WTLI) platform was constructed using a 1.3cm thick Cerrobend collimator forming a 15 × 1.6 cm2 slit. Control of dose and dose rate were realized by adjusting the number of monitor units and couch vertical position, respectively. Achievable doses and dose rates were investigated using Gafchromic EBT-XD film at 1cm depth in solid water and lung-density phantoms. Percent depth dose (PDD) and dose profiles at CONV and various UHDRs were also measured at depths from 0 to 2cm. A radiation survey was performed to assess radioactivation of the Cerrobend collimator by the UHDR electron beam in comparison to a precision-machined copper alternative. This platform allows for the simultaneous thoracic irradiation of at least three mice. A linear relationship between dose and number of monitor units at a given UHDR was established to guide the selection of dose, and an inverse-square relationship between dose rate and source distance was established to guide the selection of dose rate between 20 and 120Gy·s-1 . At depths of 0.5 to 1.5cm, the depth range relevant to murine lung irradiation, measured PDDs varied within±1.5%. Similar lateral dose profiles were observed at CONV and UHDRs with the dose penumbrae widening from 0.3mm at 0cm depth to 5.1mm at 2.0cm. The presence of lung-density plastic slabs had minimal effect on dose distributions as compared to measurements made with only solid water slabs. Instantaneous dose rate measurements of the activated copper collimator were up to two orders of magnitude higher than that of the Cerrobend collimator. A high-throughput, variable dose rate platform has been developed and commissioned for murine WTLI electron FLASH radiotherapy. The wide field of our UHDR-enabled linac allows for the simultaneous WTLI of at least three mice, and for the average dose rate to be modified by changing the source distance, without affecting dose distribution. The platform exhibits uniform, and comparable dose distributions at CONV and UHDRs up to 120Gy·s-1 , owing to matched and flattened 16 MeV CONV and UHDR electron beams. Considering radioactivation and exposure to staff, Cerrobend collimators are recommended above copper alternatives for electron FLASH research. This platform enables high-throughput animal irradiation, which is preferred for experiments using a large number of animals, which are required to effectively determine UHDR treatment efficacies.

Feasibility of Synchrotron-Based Ultra-High Dose Rate (UHDR) Proton Irradiation with Pencil Beam Scanning for FLASH Research.

This study aims to present the feasibility of developing a synchrotron-based proton ultra-high dose rate (UHDR) pencil beam scanning (PBS) system. The RF extraction power in the synchrotron system was increased to generate 142.4 MeV pulsed proton beams for UHDR irradiation at ~100 nA beam current. The charge per spill was measured using a Faraday cup. The spill length and microscopic time structure of each spill was measured with a 2D strip transmission ion chamber. The measured UHDR beam fluence was used to derive the spot dwell time for pencil beam scanning. Absolute dose distributions at various depths and spot spacings were measured using Gafchromic films in a solid-water phantom. For proton UHDR beams at 142.4 MeV, the maximum charge per spill is 4.96 ± 0.10 nC with a maximum spill length of 50 ms. This translates to an average beam current of approximately 100 nA during each spill. Using a 2 × 2 spot delivery pattern, the delivered dose per spill at 5 cm and 13.5 cm depth is 36.3 Gy (726.3 Gy/s) and 56.2 Gy (1124.0 Gy/s), respectively. The synchrotron-based proton therapy system has the capability to deliver pulsed proton UHDR PBS beams. The maximum deliverable dose and field size per pulse are limited by the spill length and extraction charge.