Solid Rod Research Articles

Peculiarities of flexural wave propagation in a notched bar

The results of numerical modeling and experimental studies of the propagation of flexural elastic waves in a metal notched bar approximates the effect of an acoustic black hole are presented. The sample is a bar with notches, the depth of which increases according to the power law with an exponent equal to (4/3). It has been confirmed experimentally and with the simulation results, that such bars slow down the propagation of an elastic wave to the end of the bar. It is shown in such structures flexural waves have dispersion and their localization at the end of the bar is higher for some natural frequencies than that of a solid rod. The natural oscillations of the whole and notched bars are compared, i.e. the shape of the amplitude of the flexural wave along the rods. The dependence of the flexural wave length in a notched bar on the frequency is investigated as a wave propagates to the end of the bar.

Artificial electron snorkels reduce CH4 emissions in paddy soil: Regulation of the electron transfer pathway and microbial community ecology

Climate science has focused on reducing emissions of atmospheric CH4 from paddy soils, as CH4 has stronger infrared absorption characteristics than CO2. Like cable bacteria, artificial electron snorkels (made of solid graphite rods) have been proposed in this study to provide potential remote electron acceptors for soil anaerobic metabolism to compete with methanogenic processes. A systematic investigation was conducted on the modulation of the CH4 emission dynamics by electron snorkels at different densities, as well as the associated metabolism of C/N/Fe in paddy soil. During 124 days of operation, the electron snorkels suppressed CH4 emissions by 7–31% over ten sampling periods, and the high-density setting exhibited stronger performance. The electron snorkels accelerated the early mineralization of soil organic matter, increasing the content of dissolved organic matter by 20–236%. These organics were utilized by microorganisms, where O2, NO3−, and Fe3+ acted as electron acceptors, enhancing soil alternative respiration and producing CO2. Metagenomic and 16S rRNA gene sequencing revealed that microbial abundance and diversity were increased by 4–71% in the soil bottom layer (7 cm–8 cm depth) driven by electron snorkels. Moreover, electron snorkels potentially prevented CH4 escape by either improving soil permeability or electrically stimulating the abundance of methanotrophs (e.g., Methylocystis). The ratio of methanogenic to methane-oxidizing gene abundances was reduced by 22–66% under the electron snorkels. Our results indicate that the applied electron snorkels have significant potential in enriching the soil microbial community involved in methane cycling to mitigate CH4 emissions from paddy fields.

Acoustic energy harvesting using phononic crystal fiber with conical input

In this paper, a novel phononic crystal fiber with conical input is introduced for coupling environmental acoustic waves to the fiber core. Environmental acoustic waves can be focused and coupled to the core through conical input. In the first step, a cone shape coupler has been considered for coupling the incident acoustic waves to the core region. This initial idea has a significant acoustic energy loss. This disadvantage encourages us to design a new phononic crystal fiber without it. Designed structure includes a phononic crystal fiber with conical input meaning solid rods have been shaped in conical way at the input section of fiber. By using this structure, environmental acoustic waves can be properly coupled to the core region of the fiber. Acoustic wave leakage to outside of the Phononic crystal fiber has been extremely decreased in comparison with initial coupler. Experimental results indicate that environmental acoustic waves can be focused and coupled to the core region by phononic crystal fiber with conical input.

3D-printed bioinspired spicules: Strengthening and toughening via stereolithography

Recently, the replication of biological microstructures has garnered significant attention due to their superior flexural strength and toughness, coupled with lightweight structures. Among the most intriguing biological microstructures renowned for their flexural strength are those found in the Euplectella Aspergillum (EA) marine sponges. The remarkable strength of this sponge is attributed to its complex microstructure, which consists of concentric cylindrical layers known as spicules with organic interlayers. These features effectively impede large crack propagation, imparting extraordinary mechanical properties. However, there have been limited studies aimed at mimicking the spicule microstructure. In this study, structures inspired by spicules were designed and fabricated using the stereolithography (SLA) 3D printing technique. The mechanical properties of concentric cylindrical structures (CCSs) inspired by the spicule microstructure were evaluated, considering factors such as the wall thickness of the cylinders, the number of layers, and core diameter, all of which significantly affect the mechanical response. These results were compared with those obtained from solid rods used as solid samples. The findings indicated that CCSs with five layers or fewer exhibited a flexural strength close to or higher than that of solid rods. Particularly, samples with 4 and 5 cylindrical layers displayed architecture similar to natural spicules. Moreover, in all CCSs, the absorbed energy was at least 3–4 times higher than solid rods. Conversely, CCSs with a cylinder wall thickness of 0.65 mm exhibited a more brittle behavior under the 3-point bending test than those with 0.35 mm and 0.5 mm wall thicknesses. CCSs demonstrated greater resistance to failure, displaying different crack propagation patterns and shear stress distributions under the bending test compared to solid rods. These results underscore that replicating the structure of spicules and producing structures with concentric cylindrical layers can transform a brittle structure into a more flexible one, particularly in load-bearing applications.

Numerical Investigation of Heat Exchanger Enhancement for a Staggered Arrangement with Corrugated Rods in Front

The heat exchanger is used in many industrial and engineering activities.Where, numerous applications confirms on a large heat transfer rate. However, the twisted tube is one of heat transfer rate enhancement methods. Also, the turbulent flows are often used instead of laminar for enhancement heat transfer rate. Therefore, the tube arrangement can be used in a suitable way for utilized this purpose. The shape features of tubes in the heat exchangers are very important for enhancing their performance. As well, the pressure drop and heat transfer rate have a remarkable effect on the thermal efficiency of the heat exchanger. In this research, a numerical investigation with a new way for heat exchanger tube staggered arrangement is presented. Where new solid spiral rods with oval sections are inserted in front of main tubes to induce high turbulent flow intensity as well as redistribution airflow over exchanger tubes. However, the new air distribution will help the airflow pressure over all the tubes to push the thermal boundary symmetrically behind the tubes. Therefore, two different sectional tubes were presented (circular and elliptical). These cross-sectional areas for both types have the same values. The main tubes have no twisted to prevent decreases in pressure. The numerical analysis used the K- ε model at a low Reynolds number to the simulation of this situation. Where, the eddy will generate in the vicinity region to pipe walls due to twisted pipe as well as the obstruction the cross flow. However, there are a good improvement of heat transfer rate without spend any energy depending on the control the shape and arrangement of pipes. The results show that the corrugated rod will increase the Nusselt number at different values of Reynolds. However, the elliptic tube gives the best results for heat transfer rate and maximum Nusselt number. The results compared with others works and give a good agreement.

Effect of initial heat treatment of A390 alloy on microstructure and tribological behavior of friction surfaced coating

In this study, the effect of the A390 alloy consumable rod's three preprocessing heat treatment conditions (homogenization, solid solution, and artificial aging treatment) on the microstructural evolution, mechanical properties, and wear resistance of the friction surfaced coating applied on a commercially pure aluminum alloy substrate was investigated. The results showed that friction surfacing using artificially aged and solid solution-treated consumable rods results in minimum (3.45 ± 0.35 μm) and maximum (5.63 ± 0.25 μm) coating grain sizes, respectively. Friction surfacing using artificially aged treated consumable rods results in smaller, more uniformly distributed Si particles in the coating microstructure. The [111] and [101] directions of most grains in the consumable rod and coating are parallel to the consumable rod axial axis and surfacing direction, respectively. Recrystallization texture components, including Goss and Cube-Twin, are observed in coatings. Compared to the other consumable rods, the coatings fabricated using artificially aged treated consumable rod result in highest hardness (117.62 ± 9.58 HV0.1), maximum bond strength (13.98 ± 1.02 kN), and lowest wear rate (5.6 ± 0.8 μg/m).

Physical and mathematical model of friction welding

The physical and mathematical model of the friction welding process in the form of a system of differential nonlinear heat conduction equation and a variational problem to determine the pressure distribution and shortening of the rods is proposed. The computer model of the friction welding process of solid cross-section rods on its basis is created. Computer simulation reproduces the main effects observed in the friction welding process: equalization of heat generation intensity in the joint plane; stabilization of the joint temperature when the plastic state of the metal is reached; characteristic sequence of increase, decrease and stabilization of torque during welding.

Effect of preprocessing heat treatment of the Al-16Si-4Cu alloy on microstructure and tribological behavior of friction-surfaced coating

This study investigated the simultaneous effect of the consumable rod's preprocessing heat treatment conditions (homogenization, solid solution, and artificial aging treatment) and severe plastic deformation on the properties of Al-Si-Cu alloy friction surfaced on a commercially pure aluminum alloy substrate. The friction-surfaced coating's microstructural evolution, mechanical properties, and wear resistance were evaluated. The results showed that coatings fabricated using artificially aging (T6)-treated consumable rods resulted in the highest coating width (17.02±0.83 mm) and maximum efficiency (39.78 ± 1.23 %). Friction surfacing using artificially aged and solid solution-treated consumable rods results in minimum (2.78 ± 0.28 µm) and maximum (6.32±0.34 µm) coating grain sizes, respectively. Friction surfacing using T6-treated consumable rods results in smaller, more uniformly distributed Si particles in the coating microstructure. Compared to the other consumable rods, the coatings fabricated using T6-treated consumable rods result in the highest hardness (110.54±10.29 HV0.1), maximum bond strength (14.15±0.75 kN), and lowest wear rate (0.20±0.03 µg/Nm).

Guided Acoustic Waves in Polymer Rods with Varying Immersion Depth in Liquid.

Monitoring tanks and vessels play an important part in public infrastructure and several industrial processes. The goal of this work is to propose a new kind of guided acoustic wave sensor for measuring immersion depth. Common sensor types such as pressure sensors and airborne ultrasonic sensors are often limited to non-corrosive media, and can fail to distinguish between the media they reflect on or are submerged in. Motivated by this limitation, we developed a guided acoustic wave sensor made from polyethylene using piezoceramics. In contrast to existing sensors, low-frequency Hanning-windowed sine bursts were used to excite the L(0,1) mode within a solid polyethylene rod. The acoustic velocity within these rods changes with the immersion depth in the surrounding fluid. Thus, it is possible to detect changes in the surrounding media by measuring the time shifts of zero crossings through the rod after being reflected on the opposite end. The change in time of zero crossings is monotonically related to the immersion depth. This relative measurement method can be used in different kinds of liquids, including strong acids or bases.

Assessment of Reactor Physics Characteristics of Prismatic Fuel Concepts With a Hydrogen-Based Moderator for Use in a Fluoride Salt-Cooled Small Modular Reactor

Abstract Fluoride-salt-cooled high temperature reactor (FHR) effectively combines the solid fuel and moderator design of high-temperature gas-cooled reactor (HTGR) technology with the fluoride salt coolant (LiF-BeF2, FLiBe) of molten salt reactor (MSR) technology, enabling low-pressure (∼1 atm, 101.325 kPa), and high-temperature (∼700 °C) operations. The design and operational features of the FHR make it a potentially attractive option for a small modular reactor (SMR), provided that it can be modified and made physically small and operate at a low-enough power level (<350 MWth/<150 MWel). Most FHR-SMR designs use high-assay low enriched uranium (HALEU) fuel in the form of tri-structural isotropic (TRISO) fuel particles, combined with the use of a graphite moderator. However, there are alternative design concepts for an FHR-SMR that may offer superior performance characteristics, while utilizing an alternative fissile fuel supply option. In this exploratory study, lattice physics calculations were performed with Serpent to evaluate an alternative FHR-SMR prismatic fuel block design concept using coated annular fuel pellets instead of TRISO-particle fuel compacts, along with the use of hydrogen-based solid moderator rods made of 7LiH. In initial studies, it was found that fuel blocks with 120 moderator rods made of 7LiH tended to have large positive temperature reactivity coefficients (TRCs), which is undesirable for safety reasons. However, reducing the number of moderator rods to 90 or 54, while increasing the number of fuel rods and coolant holes led to low or negative temperature coefficients. For a prismatic fuel block design with 54-7LiH moderator rods, the isothermal temperature coefficient of reactivity (Isothermal TRC), with simultaneous changes in the fuel (F), graphite (G), hydrogen (H), and coolant (C) temperatures, ranges between −0.159 mk/K and −0.054 mk/K, depending on the operating temperature and fuel burnup. Such alternative FHR-SMR fuels could achieve a single-batch core life of ∼10 years with low enriched uranium (LEU) fuel, and ∼45 years with HALEU, in a 350-MWth reactor core.

Generation of magnetosonic waves by electrical explosion of conductors driven by mega-ampere current pulses

An experimental study of the explosion of cylindrical copper rods in the current skinning mode was performed using the GIT-12 high-current pulse generator with currents of amplitude up to 5 MA and rise time about 2 μs. It was observed that the waveforms of the electrical impedance of the exploded rods exhibited low-frequency oscillations with a period of several hundreds of nanoseconds. The results of the experiment with exploded solid copper rods carried out on the GIT-12 facility were interpreted by performing a series of magnetohydrodynamic calculations. It was shown that the experimentally observed low-frequency oscillations of the rod impedance were associated with a fast magnetosonic wave excited in the material of the rod.

Investigating the effect of input parameters on tool wear in incremental sheet metal forming

Abstract Over the years incremental sheet metal forming (ISMF) has developed as a futuristic technique in which the metal sheets are transformed into the final product with the use of a solid metallic rod having a designed end, rather than a dedicated die. The production lead time is quite high in this process as compared to the conventional sheet forming methods. ISMF is most suitable for developing model for the purpose of research and development, manufacturing of the customized part and for low-volume production. Tool life is an important criterion for determining feasibility of any manufacturing process. The sliding of the forming tool over the clamped metal worksheet during the ISMF is another important aspect for understanding the tool-wearing behaviour. The present study has investigated the wearing of the 440C grade steel forming tool during the ISMF of aluminum grade AA3003-O. It has examined the process statistically to establish that the step downsize (P = 0.021) and sheet metal thickness (P = 0.005) significantly influence the wearing of 440C steel tool. The coefficient of performance, i.e., R 2 has been reported as 92.0 % with an adjusted R 2 of 81.9 %.

Hardness prediction in the upsetting process of Al%ZrO2—an approach to machine learning using regression and classification models

The current study focuses on the prediction of metal hardness distribution in upsetting tests for different compositions of ZrO2 embedded with an aluminum matrix using machine learning algorithms and finite element (FE) analysis. The mass fraction of the ZrO2 particles varied from 4% to 8%, and three sets of solid cylindrical rods with Al4%ZrO2, Al6%ZrO2, and Al8%ZrO2 were prepared using the stir casting method. The upsetting process was simulated, and an equation for predicting hardness was developed from the equivalent strain distributions. Artificial neural networks (ANNs), multilinear regression (MLR) along with equations developed from FE analysis were used to train the model for regression analysis, considering the principal stresses, friction factor, anisotropy ratio, effective strain, and hoop strain as input and the magnitude of hardness as output parameters. Regression analysis reveals that ANN (tri-layer network), XGBoost, and MLR algorithms are the best suitable for the given data sets with a root mean square ( R2) greater than 0.95. XGBoost, ANN (narrow), and SVM are linear and are the most recommendable classifier algorithms for the current investigation. Hardness data from ring compression tests were used to validate the results obtained from the trained models with the test results.

Construction of Al-Mg-Si-Cu(p) composite coating on aluminum alloy 1050 substrate

The AA6061 aluminum alloy matrix composite reinforced by copper particles was applied to the AA1050 aluminum substrate using a friction surfacing process. The effect of reinforcement content and pre-coating heat treatment condition of the consumable rod on the microstructure and mechanical properties was investigated. The results showed that coating with T6 treated consumable rod and increasing the mass fraction of copper powder resulted in higher temperature during friction surfacing. With increasing the mass fraction of copper powder, the average grain size of the coatings created with T6 and solid solutionized rods decreased. The average grain size of the coating in the samples created with the solid solutionized rod was 16% finer than that in the samples created with T6 rods. By increasing the mass fraction of copper to 20%, the wear resistance in coatings created with T6 and solid solutionized rods is increased by 28% and 24%, respectively, compared to that of the AA1050 substrate. Furthermore, by using a T6 rod and 20 wt.% copper, the shear strength, hardness, and wear resistance of the coating were 4%, 8%, and 5%, respectively, higher than those of the coating created with the solution-treated rod.

Investigation on the Irradiation-thermal–mechanical coupling behaviors of the solid Microencapsulated fuel rod

Solid Microencapsulated Fuel (SMF) is a kind of new accident-tolerant fuel (ATF), where the TRISO coated fuel particles are dispersed directly into a type of matrix in the form of a solid rod. SMF is expected to provide improved performance because of the elimination of cladding tube and associated failure mechanisms. This study aims to investigate the irradiation-thermal–mechanical coupling behavior of SMF rod under normal operation of the 200 MW Nuclear Heating Reactor (NHR200-II) using finite element method (FEM). Two kinds of SMFs have been evaluated and compared -with the fuel particles dispersed into a silicon carbide matrix or a zirconium matrix. The finite element models, considering comprehensive coupling behavior (including irradiation-induced dimensional change, irradiation-induced creep, thermal expansion, fission gas pressure, heat generation and conduction, elasticity and plasticity, etc.), were developed based on the ABAQUS platform and accurately verified. The study also investigated the impacts of key parameters on the coupling behavior of SMF, including particle kernel diameter, non-fuel zone width, extent of particle aggregation, and operational conditions. The results revealed that SMFs exhibit excellent heat transfer capability, resistance to deformation, and a stress-relaxed state under normal operation. Specifically, SMF-Zr exhibited a higher centerline temperature but lower levels of deformation and stress compared to SMF-SiC. The effects of fuel kernel diameter and non-fuel zone width were found to be limited, whereas higher particle aggregation and harsher operational conditions indeed increase temperature, deformation, and stress, particularly during the initial irradiation stage. Moreover, a higher creep coefficient of pyrolytic carbon leads to a more relaxed stress state. This study lays a fundamental basis for the design and optimization of this kind of solid particle-dispersed fuel.

Turbidity Removal from a Model Solution by Continuous Mode Electrocoagulation and Evaluation of Energy Consumption

The purpose of the research has been the construction of a new electrocoagulation (EC) equipment and its technical evaluation in the treatment of a model solution with a high level of turbidity. The EC system contains six cells installed in series, coupled to a flocculator and a clarifier (sludge decanter), each cell unit is composed of a cylindrical aluminum (Al) anode and a solid stainless-steel rod as cathode in connection with a DC power supply, the aluminum anodes are replaced by iron (Fe) according to the proposed tests. The influence of two factors, such as the applied electric potential and the type of electrode used, on turbidity removal performance, total dissolved solids (TDS) and electrical energy consumption were examined. The tests were carried out using a two-factor factorial design, electrical potential at (0, 3, 6 and 9 V) and type of anode (aluminum and iron). The investigation of the operating parameters was carried out in continuous mode. The initial turbidity of the water to be treated was set at 84.5 NTU, a value generally found in surface water. The results showed that the best conditions for turbidity removal were at an electrical potential of nine volts reaching a removal of 82.29 % and an energy consumption for aluminum electrodes of 0.7142 kWh/m3. It is also observed that the value of total dissolved solids after treatment is still slightly high. In conclusion, electrocoagulation with Al/steel electrodes proved to be an appropriate technology for water treatment due to its turbidity removal efficiency and low electrical energy consumption.

Fabrication and Evaluation of YBa2Cu3O7-δ Probe for Scanning Probe Microscopy

We proposed, fabricated, and evaluated a high-temperature superconducting probe made of YBa <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> Cu <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sub> O <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">7-δ</sub> (YBCO) for scanning probe microscopy. A c-axis-oriented bulk was cut into a rectangular solid rod (0.5 × 0.5 × 10 mm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sup> ) using a fine cutter machine. The transition temperature of the rod was approximately 90 K, which was almost the same as that of the original bulk, indicating no critical damage to the superconductivity owing to the cutting process. One end of the rod was polished to a pyramid shape with <100-μm radius of curvature, and the apex was further sharpened to ∼1 μm using a focused Ga ion beam. The penetration depth of Ga ions from the YBCO surface was much less than 1 μm at an acceleration voltage of 40 kV, suggesting that the chemical composition was conserved inside the rod. An YBCO probe was installed in an atomic force microscope (AFM), where the probe temperature was set at 300 K at the time. Depending on the tip radius, a clear AFM image was obtained by gluing the probe to a quartz-tuning fork.

Pragmatic modelling of axial flow-induced vibration (FIV) for nuclear fuel rods

Flow-induced vibration (FIV) at the spacer grid in the fuel assembly of a Light Water Reactor (LWR) is the leading cause of fuel failure. This project aims to produce a simulation benchmark on the experimental campaign at MACE on axial FIV of a cantilever beam in an annular tube, that mimics the configuration and environment of a typical LWR. The nuclear fuel rod, which consists of fuel pellets filled in Zirconium alloy cladding is modelled in the experiment as a steel rod filled with lead shots that closely approximates the filling density of the fuel pellet. To reduce the complexity and increase the efficiency of the simulation, further simplification is applied by on the geometry and assuming the solid domain as a single material instead of multiple materials. The first mode of frequency of the rod vibrating in quiescent water, which had been validated via the Euler-Bernoulli beam theory against experimental measurements, was used to design the single-material solid domain. Two models were proposed, firstly a solid rod with lower density and stiffness (SLE), and secondly an empty cladding with high density and low stiffness (EHD). Both solid and fluid domains were discretised using the cell-centred finite volume (FV) method and coupled with strong two-way fluid-structure interaction (FSI). Results on the frequency of vibration in quiescent water and in axial flow showed good agreement with experimental measurement, and the computational efficiency is analyzed for different rod models and changes in parameters of the solid domains.

Ultrasonic synthesis of controllable thin sheet-like BiPO4 assisted by ionic liquid and Bi-MOF with enhanced visible-light photocatalytic activity

Raw materials and synthesis strategies have great influence on the morphologies and optical properties of materials. In this study, ultrasonic synthesis of controllable thin sheet-like BiPO4 with an excessive visible-light response was synthesized, using Bi-based metal-organic frameworks (CAU-17) and ionic liquid [Omim]H2PO4 as raw materials. Compared with BiPO4-H (hydrothermal, solid rod shape) synthesized using inorganic salt, BiPO4-A (agitation, thin rod-like) and BiPO4-U (ultrasonic, thin sheet-like) have better visible-light absorption capacity and narrower band gap. Under visible-light, they could degrade 27.7 % (BiPO4-H), 73.0 % (BiPO4-A), and 76.3 % (BiPO4-U) tetracycline hydrochloride at 30 min, respectively. The speedy charge transfer at the photogenerated carrier interface, large specific surface areas, and improved light adsorption greatly enhance the photocatalytic performance. Cyclic experiments exhibit that the material has good photostability and repeatability. Finally, the feasible degradation mechanism of the material was proposed via a capture experiment. This paper provides a new technique for synthesizing BiPO4 or other photocatalysts, which can be used for high-efficiency wastewater purification under visible-light.

75 Tranexamic Acid Reduces Burn Wound Conversion and Lung Inflammation in a Murine Comb Burn Model

Abstract Introduction Burn wound conversion is a process where superficial partial thickness burns convert into deep partial and even full thickness burn injuries. Unfortunately, the pathophysiology of this phenomenon is poorly understood. A therapeutic intervention that may prevent secondary progression and cell death in burn-injured tissue is desirable. Recent work by our group has established that tranexamic acid (TXA) has significant anti-inflammatory properties in addition to its well-known anti-fibrinolytic effects. This study investigates tranexamic acid as a novel therapeutic treatment to mitigate burn wound conversion and reduce systemic inflammation. Methods Sprague-Dawley rats were subjected to a hot comb burn contact injury using a 150-g brass comb preheated to 100°C, to create four rectangular burns, separated by three unburned interspaces. A subset of animals underwent the comb burn injury with an adjacent 30% TBSA contact injury using solid brass rods. The interspaces represent the ischemic zones simulating the zone of stasis. The treatment group received IP injection of TXA (100mg/kg) immediately after injury and once daily until sacrifice. Sham animals underwent an identical procedure, with application of a room temperature comb. Animals were sacrificed at 6hrs and 7-day time points post-injury. Photo images were obtained of the comb burn injury. Full-thickness biopsies from the ischemic zones and lung tissue were assessed with established histological and immunohistochemical (IHC) techniques. Results At 7-days post injury, the percentage of ischemic zones with necrosis was significantly reduced in the treatment group when compared with untreated burn controls by photographic image analysis. When compared with controls, the treatment groups had significantly less progression of ischemic zones to necrosis when assessed by standard microscopy. These findings were consistent in both the comb burn only and comb burn + 30%TBSA injury models. The TXA treatment group demonstrated significantly more expression of the regeneration marker (CTHRC-1) and a trend toward increased expression of the Ki-67 proliferation marker when compared to untreated burn group. At 6 hours post-injury, TXA significantly decreased infiltration of neutrophils in the lungs for the 30%TBSA burn injury model. Furthermore, systemic levels of mitochondrial DNA, IL-1α and TNFα were significantly lower in TXA treated animals when compared to untreated burn controls. Conclusions Animals treated with tranexamic acid demonstrated reduced burn wound conversion and decreased burn-induced SIRS response. Lung inflammation was also significantly reduced by administration of TXA after injury. Applicability of Research to Practice Tranexamic acid and agents with similar mechanisms of action may provide a treatment to reduce burn wound conversion. This therapy could be easily incorporated into standard acute burn care practices.