Solid-phase Synthesis Of Peptide Amides Research Articles

An improved and practical synthesis of Fmoc Rink linker

Fmoc Rink linker is a widely used peptide-resin linker in the solid-phase synthesis of peptide-amides. This paper describes an improved and practical eight-step synthetic approach for this compound in a 50% overall yield, using p-hydroxybenzaldehyde as the starting material. The procedure is operationally simple and amenable to scale-up synthesis.

Improved Synthesis of 4-[(R,S)-1-[1-(9H-Fluoren-9yl)-methoxycarbonylamino]-(2ʹ,4ʹ-dimethoxybenzyl]phenoxyacetic Acid as a Peptide-resin Linker in the Solid-phase Synthesis of Peptide-amides

Improved Synthesis of 4-[(<i>R,S</i>)-1-[1-(9<i>H</i>-Fluoren-9yl)-methoxycarbonylamino]-(2ʹ,4ʹ-dimethoxybenzyl]phenoxyacetic Acid as a Peptide-resin Linker in the Solid-phase Synthesis of Peptide-amides

Solid-phase synthesis of peptide amides on a polystyrene support using fluorenylmethoxycarbonyl protecting groups

Solid-phase synthesis of peptide amides on a polystyrene support using fluorenylmethoxycarbonyl protecting groups

ChemInform Abstract: A Gradative Deprotection Strategy for the Solid-Phase Synthesis of Peptide Amides Using p-(Acyloxy)benzhydrylamine Resin and the SN2 Deprotection Method.

Chemischer InformationsdienstVolume 17, Issue 21 Natural Products ChemInform Abstract: A Gradative Deprotection Strategy for the Solid-Phase Synthesis of Peptide Amides Using p-(Acyloxy)benzhydrylamine Resin and the SN2 Deprotection Method. J. P. TAM, J. P. TAMSearch for more papers by this author J. P. TAM, J. P. TAMSearch for more papers by this author First published: May 27, 1986 https://doi.org/10.1002/chin.198621298AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat No abstract is available for this article. Volume17, Issue21May 27, 1986 RelatedInformation

A p-methylbenzhydrylamine resin for improved solid-phase synthesis of peptide amides

A p-methylbenzhydrylamine-resin, alpha-(p-tolyl)-amino-aminomethyl-functionalized copoly(styrene-1%-dvinylbenzene), was prepared for the improved solid-phase synthesis of peptide alpha-carboxamides. Following a Friedel-Crafts acylation of polymer beads, the resulting ketone resin was reductively aminated via the Leuckart reaction. A comparison of the relative acid stability of the p-methylbenzhydrylamine-(MBHA)-, benzhydrylamine (BHA)- and alpha-phenyethylamine-resins indicated that the p-methylbenzhydrylamine-resin provided the best yields of the model peptide carboxamides.