Shortage of water resources and salinization of soil are two important factors restricting the sustainable development of agriculture in Xinjiang. The current drip irrigation strategy cannot meet the high efficiency water saving and salt leaching requirement, seriously limiting sustainable development. Therefore, in 2020 and 2021, a field experiment was conducted with three leaching levels (120, 240 and 360 mm) and four alternate drip irrigation (ADI) start time (no ADI, seedling, budding and flowering). The field experiment was combined with HYDRUS to investigate the effect of water saving and salt leaching by combining ADI with leaching during the reproductive period. The results showed that the HYDRUS-2D model simulated soil moisture and salinity with high accuracy under different irrigation conditions, with R2 ranging from 0.63 to 0.93, MRE from 2.45 % to 11.66 %, and RMSE from 1.88 % to 4.41 % for soil moisture and 0.29 g kg−1 to 0.97 g kg−1 for soil salinity, respectively. Optimization of irrigation method, leaching level and ADI start time all improved water and salinity stress characteristics. Although initially high soil salinity resulted in the conversion of some severe stress to moderate due to the irrigation, these disadvantages were offset by reductions in severe stress duration and area. Water-salt production model constructed based on water and salt stress characteristics demonstrated good yield simulation performance. According to HYDRUS, water-salt production model and comprehensive evaluation, starting ADI at the 3rd irrigation event with a leaching level of 290 mm was found to be optimal considering yield, water use efficiency, soil desalination and desalination efficiency. Considering the practicability, the recommended optimum ADI leaching level was 262–318 mm, with ADI initiated between the 2nd and 4th irrigation event. The study provided a vital theoretical basis for efficient water-salt management, supporting sustainable development in saline-alkali cotton fields in Xinjiang under limited water resources.
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