Software License Research Articles

The effectiveness of endobronchial therapy in patients with chemo-resistant tuberculosis when specific process is localized in the lungs apical segments

Objective – to study the effectiveness of the additional methods of endobronchial pathology treatment in patients with chemo-resistant tuberculosis (CRTB) of lungs, that aimed to treat a specific process in bronchi when destructions are localized in the apical segments (S 1+2 ) of lungs. Materials and methods. In order to investigate effectiveness of the additional methods of endobronchial pathology treatment of bronchial mucosa 79 patients with CRTB of lungs were examined. They were divided into 3 groups: basic 1 group, which included 27 patients who were treated by using antimycobacterial drugs endobronchial introduction to S 1+2 with further implementation of intraorganic electrophoresis in S 1+2 zone in combination with systemic receiving of antimycobacterial drugs; the comparison basic 2 group 27 patients who were treated with systemic antimycobacterial therapy in combination with antituberculosis drugs inhalations; and the group included – 25 patients who received only systemic antimycobacterial therapy. Groups were compared by the severity of the process, age and gender. Tracheobronchial tree fiber-bronchoscopy in patients with CRTB of lungs was carried out on the basis of phthisiology and pulmonology department of ZSMU in communal institution Zaporizhzhia regional antituberculosis dispensary, by the author on their own. Character of bronchial mucosa was examined under anesthesia by fiber-bronchoscopes of company Olympus (Japan). Bronchial tree pathology was described according to N. V. Shesterynoy, A. N. Kaliuk (1975) classification. Results of the study were processed with modern methods of analysis on a personal computer with using the Statistical Package license software Statistica ® for Windows 6.0 (StatSoft Inc., № AXXR712 D833214FAN5). Results. The use of antimycobacterial drugs endobronchial introduction to S 1+2 with further implementation of intraorganic electrophoresis in S 1+2 zone contributed significantly increase the frequency of bacterial excretion completion in 1.6 times, the frequency of destructions healing – in 1.8 times with healing time reducing by 1.5 months. It allowed reduce incidences of S 1+2 segmental bronchi meta-tuberculosis stenosis in 4.1 times, which contributed to increase the effectiveness of treatment by 36.6 %. The using of antituberculosis drugs inhalations allowed significantly increase the frequency of bacterial excretion completion in 1.4 times and reduce incidences of S 1+2 segmental bronchi meta-tuberculosis stenosis in 2.4 times that contributed to increase the effectiveness of treatment by 28.9 %. Conclusions. When combined use of antimycobacterial drugs endobronchial introduction to S 1+2 with further implementation of intraorganic electrophoresis in S 1+2 zone in combination with systemic receiving of antimycobacterial drugs, it allows to direct the maximum drug concentration in the affected area, that increase the effectiveness of treatment by 36.6 %.

Development and Implementation of the DHAPP Military eHealth Information Network System.

As the Joint United Nations Programme on HIV/AIDS, the Global Fund, and the US President's Emergency Plan for AIDS Relief focus on reaching 90-90-90 goals, military health systems are scaling up to meet the data demands of these ambitious objectives. Since 2008, the US Department of Defense HIV/AIDS Prevention Program (DHAPP) has been working with military partners in 14 countries on implementation and adoption of a Military eHealth Information Network (MeHIN). Each country implementation plan followed a structured process using international eHealth standards. DHAPP worked with the private sector to develop a commercial-off-the-shelf (COTS) electronic medical record (EMR) for the collection of data, including patient demographic information, clinical notes for general medical care, HIV encounters, voluntary medical male circumcision, and tuberculosis screening information. The COTS software approach provided a zero-dollar software license and focused on sharing a single version of the EMR across countries, so that all countries could benefit from software enhancements and new features over time. DHAPP also worked with the public sector to modify open source disease surveillance tools and open access of HIV training materials. Important lessons highlight challenges to eHealth implementation, including a paucity of technology infrastructure, military leadership rotations, and the need for basic computer skills building. While not simple, eHealth systems can be built and maintained with requisite security, flexibility, and reporting capabilities that provide critical information to improve the health of individuals and organizations.

Cloud Storage Technology

Under the traditional model, enterprises to establish a set of IT systems not only need to buy hardware and otherinfrastructure, but also to buy software licenses, the need for specialized staff maintenance. The scale of the enterprisewill continue to upgrade the various hardware and software facilities to meet the needs. For enterprises, computers andother hardware and software itself is not what they really need, they are just to complete the work, to provide effi cienttools only. For individuals, we usually use the computer to install a lot of software, and many software is a fee, theuser is not often used to buy the software is very uneconomical. We only need to pay a small amount of 'rent' to 'rent'to these software services for us to save a lot of money to buy hardware and software. Just as we use electricity everyday, but we are not every self-generator, it is provided by the power plant; we use tap water every day, but we do nothave every well, it is provided by the water plant. This model is great enough to save resources and facilitate our lives.The face of the computer to bring us the troubles, we can like the use of water and ele

Modern clinical and epidemiological characteristic of systemic lupus erythematosus based on the data of the territorial registry

Systemic lupus erythematosus (SLE) is a severe rheumatic disease characterized by polysymptomatic clinical picture. At the present stage, there are no updated epidemiological data due to the low prevalence of the disease. The aim of the study was to examine the current clinical and epidemiological characteristics of patients with systemic lupus erythematosus based on the information contained in the territorial register, analysis of occurrence and symptoms at the early stage of the disease. This study demonstrated the epidemiological and clinical characteristics of SLE from the analysis of 107 cases during the period from 2011 to 2013 and retrospective analysis of the cases for 1980-2013. The epidemiological situation was evaluated based on extensive and intensive indicators using statistical software license. The current SLE prevalence was estimated at 5,59 per 100 000 population in 2013, the incidence between 1994 and 2003 at 0,29 per 100 000 population and between 2004 and 2013 at 0,49, with the peak in 2010 up to 1,35 per 100 000 population. The average absolute growth and growth rate of SLE in the first decade was 0,05% and 0,24%, in the second decade 0,001% and 0,006% respectively, with the female to male ratio being 9:1, mean age of the patients 37,62±11,65 years), and ethnic composition of 87 Slavs and 15 Crimean Tatars. The most common symptoms at the early (polyarthritis, fever, dermatitis) and advanced (polyarthritis, Raynaud's syndrome, carditis, myalgia) stages differed from those specified by American College of Rheumatology (1997). The difference between early and late symptoms of SLE was documented . Based on the data obtained, the division of the disease into clinical subtypes (phenotypes) is proposed.

Reply to comment by Añel on “Most computational hydrology is not reproducible, so is it really science?”

AbstractIn this article, we reply to a comment made on our previous commentary regarding reproducibility in computational hydrology. Software licensing and version control of code are important technical aspects of making code and workflows of scientific experiments open and reproducible. However, in our view, it is the cultural change that is the greatest challenge to overcome to achieve reproducible scientific research in computational hydrology. We believe that from changing the culture and attitude among hydrological scientists, details will evolve to cover more (technical) aspects over time.

Bayer, Yara sow seeds of digital farming

Bayer and fertilizer producer Yara have formed a software collaboration and licensing agreement to provide farmers with digital productivity tools. Yara will license technology to Bayer for determining the nutrient status of plants using a smartphone app. The app can be linked to Yara’s N-Sensor, a tractor-mounted device that uses the light reflectance properties of crops to adjust the amount of fertilizer being applied.

Cloud Educational Resource Datacenter Simulator

This article describes a cloud educational resource datacenter (CERD) as the means of providing an economically profitable remote access to paid and free software for educational facilities. The problem of efficient CERD scheduling for optimizing the use of cloud virtual machines and software licenses have been studied in details. We have implemented two evolutionary algorithms: simulated annealing and genetic algorithm for this problem. The simulation model of CERD is presented. The UML class diagram of CERD simulator is described. The algorithm estimation criteria are the performance time and the count of satisfied requests. The simulated annealing algorithm showed the best results by all criteria.

ALGUNOS PROBLEMAS DEL AGOTAMIENTO DE LOS DERECHOS DE PROPIEDAD INTELECTUAL RESPECTO DE LAS LICENCIAS DE SOFTWARE

La figura del agotamiento de los derechos de propiedad intelectual en relación con los contratos de licencia de software genera los mismos problemas que se pueden presentar en otros negocios jurídicos que tienen por objeto otras obras protegidas por el derecho de autor. Hoy, por ejemplo, se discute sobre cuál es el acto jurídico que puede habilitar el agotamiento de los derechos, cuáles son los derechos que se agotan mediante esta figura; incluso, respecto de la forma en que los contratos de licencia deben ser interpretados cuando hay diferencias sobre las disposiciones que pueden o no dar origen al agotamiento. Todos estos cuestionamientos son igualmente aplicables a los programas de computador y a las obras musicales o literarias. Sin embargo, el presente artículo, fruto de una ponencia del autor en la Universidad de Chile, trata en concreto dos problemas relevantes para la industria del software y los contratos de licencia allí utilizados; estos son la interpretación de los contratos y la calificación de la naturaleza de las copias objeto de descargas digitales. Los dos problemas identificados son enfrentados a la figura del agotamiento de los derechos de propiedad intelectual para concluir la necesidad de revisar los criterios de interpretación utilizados en estos contratos, y para evidenciar la necesidad de volver a categorizar las denominadas copias digitales como “bienes digitales tangibles”. <div> </div>

Investigation of sintering behavior of ZrO2 (Y) ceramic green body by means of non-isothermal dilatometry and thermokinetic analysis

Using the method of dilatometry, kinetic characteristics of compacts shrinkage manufactured from ultrafine plasmochemical ZrO2 (Y) powders and commercial Tosoh’s powders are investigated. The shrinkage curves are constructed with a DIL 402 C high-sensitivity dilatometer in a non-isothermal heating mode at different heating rates (1, 2, 5 and 10 °C min−1). It is shown that the plasmochemical powders are characterized by a lower sintering efficiency than the Tosoh’s powders. The kinetic results are processed using a Netzsch Thermokinetics license software program developed for those who make use of devices manufactured by the Netzsch-Geratebau GmbH. The kinetic characteristics of compact shrinkage are determined as a function of partial length variation using Friedman’s analysis. Considerable differences are found between the values of apparent shrinkage activation energy for plasmochemical and Tosoh’s powders in the initial and final shrinkage stages. We attribute the mentioned differences in phase composition of the powders and their degree of agglomeration. In the intermediate shrinkage stage, the values of the apparent activation energy obtained for both types of powders have only marginal differences.

A HTML5 open source tool to conduct studies based on Libet's clock paradigm.

Libet’s clock is a well-known procedure in experiments in psychology and neuroscience. Examples of its use include experiments exploring the subjective sense of agency, action-effect binding, and subjective timing of conscious decisions and perceptions. However, the technical details of the apparatus used to conduct these types of experiments are complex, and are rarely explained in sufficient detail as to guarantee an exact replication of the procedure. With this in mind, we developed Labclock Web, a web tool designed to conduct online and offline experiments using Libet’s clock. After describing its technical features, we explain how to configure specific experiments using this tool. Its degree of accuracy and precision in the presentation of stimuli has been technically validated, including the use of two cognitive experiments conducted with voluntary participants who performed the experiment both in our laboratory and via the Internet. Labclock Web is distributed without charge under a free software license (GPLv3) since one of our main objectives is to facilitate the replication of experiments and hence the advancement of knowledge in this area.

Caliko: An Inverse Kinematics Software Library Implementation of the FABRIK Algorithm

The Caliko library is an implementation of the FABRIK (Forward And Backward Reaching Inverse Kinematics) algorithm written in Java. The inverse kinematics (IK) algorithm is implemented in both 2D and 3D, and incorporates a variety of joint constraints as well as the ability to connect multiple IK chains together in a hierarchy. The library allows for the simple creation and solving of multiple IK chains as well as visualisation of these solutions. It is licensed under the MIT software license and the source code is freely available for use and modification at: https://github.com/feduni/caliko

Obtaining energy from tidal microturbines: A practical example in the Nalón River

Tidal energy has significant potential yet to be developed. Sizeable investments, operating costs and environmental impact are barriers that have to date restricted its development. However, microturbine arrays which are viable in coastal locations can help minimize the initial investment as well as operating costs and environmental impact. This paper puts forward a complete smart grid design based on tidal microturbine arrays following a methodology that includes a selection of optimal locations, the design of smart grid tidal generation and consumption components. The methodology has been applied to the estuary of the Nalón River. For the evaluation of the tidal resource and determination of the optimum locations free license software is used to simulate a one-dimensional flow. In order to achieve this, a geometrical model of the river mouth using open source geographic data and nautical information has been built. The results demonstrate high water velocities throughout the year as well as high tidal energy potential in zones that make the installation of a smart grid feasible. This smart grid includes a microturbine tidal array to generate energy and an intelligent Lighting Smart Grid system to light a promenade along the river mouth depicted as an application of the energy produced.

Electronic health records – Software licensing agreement considerations

Electronic health records – Software licensing agreement considerations

Adjusting software revenue and pricing strategies in the era of cloud computing

Recent research has recognized cloud computing as a new paradigm of servitization in which software products are offered based on service contracts. Thus, instead of selling software licenses, software vendors can rent software as a service to customers. However, it is still unclear how software providers can use software renting as a competitive strategy in the software market. Based on 37 interviews with software professionals from five case firms, this paper focuses on the connection between competitive forces and the factors influencing the selection of a pricing model. The findings indicate that servitization of the software offering makes it possible to adjust revenue and pricing strategies relative to market competition. Depending on the competitive situation in the market, firms apply mixed revenue models, or else a hybrid pricing mechanism, to protect their business against rivalry and substitutes. The software renting model has several advantages which significantly help software vendors to expand their business opportunities. However, in some cases, powerful customers are able to limit the revenue and pricing options. The findings also indicate that software renting is related to cost leadership and differentiation strategies, whereas software licensing is linked to a focus strategy.

MSAViewer: interactive JavaScript visualization of multiple sequence alignments.

Summary: The MSAViewer is a quick and easy visualization and analysis JavaScript component for Multiple Sequence Alignment data of any size. Core features include interactive navigation through the alignment, application of popular color schemes, sorting, selecting and filtering. The MSAViewer is ‘web ready’: written entirely in JavaScript, compatible with modern web browsers and does not require any specialized software. The MSAViewer is part of the BioJS collection of components.Availability and Implementation: The MSAViewer is released as open source software under the Boost Software License 1.0. Documentation, source code and the viewer are available at http://msa.biojs.net/.Supplementary information: Supplementary data are available at Bioinformatics online.Contact: msa@bio.sh

Healthcare SaaS Based on a Data Model with Built-In Security and Privacy

Cloud computing is a major technology enabler for providing efficient services at affordable costs by reducing the costs of traditional software and hardware licensing models. As it continues to evolve, it is widely being adopted by healthcare organisations. But hosting healthcare solutions on cloud is challenging in terms of security and privacy of health data. To address these challenges and to provide security and privacy to health data on the cloud, the authors present a Software-as-a-Service (SaaS) application with a data model with built-in security and privacy. This data model enhances security and privacy of the data by attaching security levels in the data itself expressed in the form of XML instead of relying entirely on application level access controls. They also present the performance evaluation of their application using this data model with different scaling indicators. To further investigate the adoption of IT and cloud computing in Indian healthcare industry they have done a survey of some major hospitals in India.

Performing Quantitative Imaging Acquisition, Analysis and Visualization Using the Best of Open Source and Commercial Software Solutions.

A challenge in any imaging laboratory, especially one that uses modern techniques, is to achieve a sustainable and productive balance between using open source and commercial software to perform quantitative image acquisition, analysis and visualization. In addition to considering the expense of software licensing, one must consider factors such as the quality and usefulness of the software's support, training and documentation. Also, one must consider the reproducibility with which multiple people generate results using the same software to perform the same analysis, how one may distribute their methods to the community using the software and the potential for achieving automation to improve productivity.

Robust structural identification via polyhedral template matching

Successful scientific applications of large-scale molecular dynamics often rely on automated methods for identifying the local crystalline structure of condensed phases. Many existing methods for structural identification, such as common neighbour analysis, rely on interatomic distances (or thresholds thereof) to classify atomic structure. As a consequence they are sensitive to strain and thermal displacements, and preprocessing such as quenching or temporal averaging of the atomic positions is necessary to provide reliable identifications. We propose a new method, polyhedral template matching (PTM), which classifies structures according to the topology of the local atomic environment, without any ambiguity in the classification, and with greater reliability than e.g. common neighbour analysis in the presence of thermal fluctuations. We demonstrate that the method can reliably be used to identify structures even in simulations near the melting point, and that it can identify the most common ordered alloy structures as well. In addition, the method makes it easy to identify the local lattice orientation in polycrystalline samples, and to calculate the local strain tensor. An implementation is made available under a Free and Open Source Software license.

The Roles of Awareness, Sanctions, and Ethics in Software Compliance

ABSTRACTMonitoring agencies continue to express concern over the use of unlicensed business software in organizations because of the ethical, legal, and financial implications of noncompliance. We constructed a multiple mediation model based on protection motivation theory in order to examine the threat and coping evaluation processes of employees regarding software license compliance. The responses of 138 organizational employees were used to empirically test the research model. The research model helps explain why compliance awareness influences compliance attitudes and behavior. The empirical findings indicate that compliance attitudes result from both consequence and coping appraisals with ethical beliefs having a stronger influence on compliance attitudes compared to the threat of sanctions. Furthermore, awareness drives the formation of threat and coping beliefs and directly influences attitude. We discuss the theoretical and practical implications of the findings that will enable organizations to meet the compliance challenge.

Netherlands: International Software License Agreement As Purchase Agreement under the CISG and the Exhaustion- Doctrine

Netherlands: International Software License Agreement As Purchase Agreement under the CISG and the Exhaustion- Doctrine