You have accessJournal of UrologyCME1 Apr 2023MP46-11 LONG-TERM ONCOLOGIC OUTCOMES OF ROBOT-ASSISTED RADICAL CYSTECTOMY: UPDATE SERIES FROM A HIGH-VOLUME ROBOTIC CENTER BEYOND 10 YEARS OF FOLLOW-UP Angelo Mottaran, Carlo Bravi, Adele Piro, Luca Sarchi, Marco Paciotti, Maria Peraire Lores, Eleonora Balestrazzi, Luigi Nocera, Federico Piramide, Ruben De Groote, Frederiek D'hondt, Alberto Briganti, Francesco Montorsi, and Alexandre Mottrie Angelo MottaranAngelo Mottaran More articles by this author , Carlo BraviCarlo Bravi More articles by this author , Adele PiroAdele Piro More articles by this author , Luca SarchiLuca Sarchi More articles by this author , Marco PaciottiMarco Paciotti More articles by this author , Maria Peraire LoresMaria Peraire Lores More articles by this author , Eleonora BalestrazziEleonora Balestrazzi More articles by this author , Luigi NoceraLuigi Nocera More articles by this author , Federico PiramideFederico Piramide More articles by this author , Ruben De GrooteRuben De Groote More articles by this author , Frederiek D'hondtFrederiek D'hondt More articles by this author , Alberto BrigantiAlberto Briganti More articles by this author , Francesco MontorsiFrancesco Montorsi More articles by this author , and Alexandre MottrieAlexandre Mottrie More articles by this author View All Author Informationhttps://doi.org/10.1097/JU.0000000000003292.11AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: Long-term oncologic data on patients undergoing robot-assisted radical cystectomy (RARC) for non-metastatic bladder cancer (BCa) are limited. We here assessed long-term oncologic outcomes of patients receiving robotic radical cystectomy at a high-volume European Institution. METHODS: We analyzed data of 107 patients treated with RARC between 2003 and 2012 at a high-volume robotic center (OLV Hospital, Aalst, Belgium). All surgeries were performed by two high-volume surgeons. Clinical, pathologic, and survival data at the latest follow-up were collected. Clinical recurrence (CR)-free survival, cancer-specific mortality (CSM)-free survival, and overall survival (OS) were plotted using Kaplan-Meier survival curves. Cox proportional hazards models investigated predictors of CR and CSM. Competing risk regressions were utilized to depict cumulative incidences of death from BCa and death from other causes after RARC at long-term. RESULTS: Pathologic nonorgan-confined BCa was found in 40% of patients, and 7 (7%) patients had positive soft tissue surgical margins. Median (interquartile range [IQR]) number of nodes removed was 11 (6, 14), and 26% of patients had pN+ disease. Median (IQR) follow-up for survivors was 123 (117, 149) months. The 12-year CR-free, CSM-free and overall survival were 55% (95% confidence interval [CI]: 44%, 65%), 62% (95%CI: 50%, 72%), and 34% (95%CI: 24%, 44%) respectively. On multivariable competing risk analysis, nodal involvement at final pathology was associated with higher risk of both CR (hazards ratio [HR]: 1.82; 95%CI: 1.06, 3.13, p=0.030) and CSM (HR: 1.70, 95%CI 1.30, 2.22; p<0.0001). The cumulative incidence of non-cancer death exceeded that of death from BCa after approximately ten years after RARC (Figure 1). CONCLUSIONS: We provided relevant data on the oncologic outcomes of RARC at a high-volume robotic center, with acceptable rates of clinical recurrence and cancer-specific survival at long-term. In patients treated with RARC, the cumulative incidence of death from causes other than BCa is non-negligible, and should be taken into consideration for post-operative follow-up. Source of Funding: None © 2023 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 209Issue Supplement 4April 2023Page: e635 Advertisement Copyright & Permissions© 2023 by American Urological Association Education and Research, Inc.MetricsAuthor Information Angelo Mottaran More articles by this author Carlo Bravi More articles by this author Adele Piro More articles by this author Luca Sarchi More articles by this author Marco Paciotti More articles by this author Maria Peraire Lores More articles by this author Eleonora Balestrazzi More articles by this author Luigi Nocera More articles by this author Federico Piramide More articles by this author Ruben De Groote More articles by this author Frederiek D'hondt More articles by this author Alberto Briganti More articles by this author Francesco Montorsi More articles by this author Alexandre Mottrie More articles by this author Expand All Advertisement PDF downloadLoading ...