In the telehealth and Internet of Things (IoT) context, the development of wearable biosensors has become increasingly necessary to remotely monitor chemical and biological markers anytime, anywhere via a smartphone. To achieve a "burdenless" wearing experience, these devices should ideally be soft and thin, seamlessly integrating with human skin. Electrochemical signal transduction is a promising approach due to its ability to facilitate miniaturization and integration with state-of-the-art technology. However, traditional electrochemical devices, including biosensors and supercapacitors, are often constructed using rigid, planar bulk electrodes with limited electroactive surface areas.In this presentation, I will introduce our innovative skin-like electronic skins and tattoos that utilize standing enokitake mushroom-like vertically aligned gold nanowires as electrochemical electrodes. These soft and three-dimensional electrodes possess high surface areas for efficient electrochemical reactions. Gold is an ideal material due to its biocompatibility, chemical inertness, ease of synthesis/surface functionalization, and band-gap-matching with many semiconductor materials. We will discuss our gold nanowire-based soft biosensing platform in the form of patches, fibers, and tattoos for wireless detection of glucose, lactate, pH, and cationic ions.