Ethanolic Sodium Hydroxide Research Articles

Revisiting Staudinger and Ruzicka’s altered pyrethrolone: the cyclopentadienone dimers derived from pyrethrin I, cinerin I and jasmolin I

The reactions of pyrethrin I, cinerin I and jasmolin I with sodium hydroxide in ethanol afforded an approximately 1:1 ratio of two respective cyclopentadienone dimers, isolated in good yield. A combination of one-dimensional and two-dimensional NMR spectroscopic studies allowed determination of the structure and stereochemistry of the dimers. The dimers are formed by cycloaddition reactions of the less substituted alkene of the cyclopentadienone, and by regioisomeric endo transition states. Density functional theory calculations were in accord with the experimental findings showing the products formed by ambimodal transition states. One such transition state led to two initial products with the less stable product undergoing facile conversion to the other more stable, experimentally observed product. These studies clarify the structures of the altered pyrethrolone reported by Staudinger and Ruzicka in 1924.

Pd(II) complexes bearing NNS pincer ligands: unveiling potent cytotoxicity against breast and pancreatic cancer.

The continuously increasing rate of breast cancer is one of the major threats to female health worldwide. Recently, palladium complexes have emerged as impressive candidates with effective biocompatibility and anticancer activities. Hence, in the present study, we report a new series of palladium complexes bearing NNS pincer ligands for cytotoxicity studies. The reaction of thiophenol/4-chlorothiophenol/4-methylthiophenol/4-methoxythiophenol with 2-bromo-N-quinolin-8-yl-acetamide in the presence of sodium hydroxide in ethanol at 80 °C gave [C9H6N-NH-C(O)-CH2-S-Ar] [Ar = C6H5 (L1), C6H4Cl-4 (L2), C6H4Me-4 (L3), and C6H4-OMe-4 (L4)]. The corresponding reaction of L1-L4 with Na2PdCl4 in methanol at room temperature for 3 h resulted in complexes [(L1-H)PdCl] (C1), [(L2-H)PdCl] (C2), [(L3-H)PdCl] (C3), and [(L4-H)PdCl] (C4). All new compounds have been characterized by spectroscopic analyses. The structures of complexes C1, C3, and C4 have also been determined from single-crystal X-ray diffraction data. The cytotoxicities of L1-L4 and C1-C4 have been investigated for breast cancer 4T1 and pancreatic cancer MIA-PaCa-2 cells. The IC50 values for complexes C2 and C3 were observed to be comparable to or higher than those of cisplatin. The stressed morphology and cell death of cancerous cells were successfully observed through cellular morphology analysis and the assessment of cytoskeleton damage.

SYNTHESIS AND CHEMICAL MODIFICATION OF NEW HYDROXYBEZALDEHYDE DERIVATIVES

A high pharmacological ability of aromatic benzaldehydes makes them important intermediates for the synthesis of medicinal preparations, such as anticancer, bactericidal, antifungal, and herbicidal drugs. The purpose of this work is the synthesis of biologically active compounds, based on 4-hydroxybenzaldehyde and 4-hydroxy-3-methoxybenzaldehyde and the establishment of the structure of the synthesized compounds. Results and discussion. New carbonodithioates, based on O-aromatic systems have been synthesized by the interaction of 4-hydroxybenzaldehyde and 4-hydroxy-3-methoxybenzaldehyde with carbon disulfide in the presence of sodium hydroxide in ethanol at the room temperature. As a result of the reactions, sodium O-(4-formylphenyl)carbodithioate (86 %) and sodium O-(4-formyl-2-methoxyphenyl)carbodithioate (80%) have been isolated. The interaction of sodium xanthates with acid chlorides (4-methoxy-, 4-nitro-, 2,4-dinitrobenzoic) in chloroform has led to the formation of aromatic thioanhydrides of carbonodithioic acids in 55-80 % yields. The reactivity of hydroxybenzaldehydes and their dithiocarboxylic derivatives has been studied in the propargylation reaction. Propargylation of 4-hydroxybenzaldehyde and 4-hydroxy-3-methoxybenzaldehyde has been carried out with propargyl bromide in the presence of a 3-fold excess of K2CO3 in acetone at the temperature of 60°C. The propargylation reaction of sodium xanthate has been carried out with propargyl bromide in acetone at the room temperature. Conclusion. As a result of the reactions, carbonodithioates, thioanhydrides, acetylenic and thioacetylenic ethers have been synthesized based, on O-aromatic systems (4-hydroxybenzaldehyde and 4-hydroxy-3-methoxybenzaldehyde). The structure of the synthesized compounds has been established on the basis of elemental analysis data, IR spectra, 1Н and 13С NMR spectroscopy.

Recovery of Lithium from Simulated Nanofiltration-Treated Seawater Desalination Brine Using Solvent Extraction and Selective Precipitation

ABSTRACT The world's seas and oceans contain vast amounts of lithium, but the low concentration hereof renders solvent extraction impractical for its recovery. By contrast, seawater desalination brine, after treatment by nanofiltration, contains a roughly tenfold greater concentration of lithium than raw seawater. Hence, lithium can be effectively recovered from such streams using solvent extaction. Compared with other techniques to sequester lithium from dilute solutions, solvent extraction offers the advantages of simple operations, robust and well-established technology and high recovery yields. Thus, we propose a solvent-extraction based process to recover lithium from seawater desalination brine, treated by nanofiltration. The first step comprises the removal of magnesium and calcium using methyltrioctylammonium neodecanoate in p-cymene. This is followed by a lithium extraction step using the extractants Mextral 54–100 and Cyanex 923 in Shellsol D70 diluent. The lithium extract is then scrubbed with water and stripped with hydrochloric acid. Subsequently, residual alkaline earth metals are removed with sodium hydroxide in ethanol and finally lithium is precipitated using sodium carbonate. The solvent extraction, scrubbing and stripping steps were demonstrated on mini-pilot scale in continuous countercurrent mode (in mixer-settlers), while the precipitation steps were demonstrated in batch. The process was found to have an overall yield of 74%, affording a lithium carbonate product with a purity of 97 wt%.

SYNTHESIS, CRYSTAL STRUCTURE AND HIRSHFELD SURFACE ANALYSIS OF (E)-2-(4-METHYLBENZYLİDENE)-N-PHENYLHYDRAZİNE-1-CARBOTHİOAMİDE

(E)-2-(4-methylbenzylidene)-N-phenylhydrazine-1-carbothioamide was synthesized by reacting chalcone with phenylthiosemicarbazide in ethanolic sodium hydroxide. The resulting compound, C15H15N3S, was characterized using various spectroscopic techniques, including single-crystal X-ray diffraction, IR, 1H NMR, and 13C NMR spectroscopy. The molecule has an E configuration around the central C=N double bond and crystallizes in the triclinic system, with space group P-1. The asymmetric unit contains two independent molecules of phenylthiosemicarbazide and phenylhydrazine, both of which are non-planar. The crystal structure is stabilized by C–H···S and N–H···S hydrogen bonds, which connect the molecules to form a three-dimensional network. The availability of efficient donors and acceptors for hydrogen bonding results in a well-connected three-dimensional structure. Furthermore, Hirshfeld surface analysis was conducted to examine the potential hydrogen bonding and the location of atoms in the compound. This analysis revealed the numerical ratio of hydrogen bonding and the atoms with potential to form these Furthermore, Hirshfeld surface analysis was conducted to examine the potential hydrogen bonding and the location of atoms in the compound. This analysis revealed the numerical ratio of hydrogen bonding and the atoms with potential to form these contacts.

Molecular Docking, Multicomponent One-pot Synthesis of Pyrimidine Derivatives as Anti-mycobacterial Agents

Background: Molecular docking study is used significantly in the drug discovery process for predicting the interaction between drug and receptor. This technique has been used commonly to identify the binding affinity and orientation of drug molecules at the binding site of the target. The main objectives of docking studies include accurate modeling of molecular structure and precise prediction of the biological activity of the drug molecules. Methods: Based on this concept, a series of 2-amino-6-(substituted phenyl)-4-oxo-4,5-dihydropyrimidine-5-carbonitrile derivatives have been designed and synthesized via multi-component reaction. The synthetic protocol involves the one-pot, three-component reaction be-tween equimolar quantities of substituted benzaldehydes, ethyl cyanoacetate, and guanidine in an ethanolic sodium hydroxide solution. Results: The characterization of the titled compounds was carried out by assessing infrared spectroscopy (IR), proton nuclear magnetic resonance (1H-NMR), and mass spectrometry (MS) data. The synthesized compounds were screened for their in vitro anti-mycobacterial activity by using the luciferase reporter phage (LRP) assay method. Conclusion: The determination of anti-mycobacterial activity was carried out in terms of the percent reduction in the relative light unit (RLU). The test compounds displayed significant ac-tivity against Mycobacterium strain H37Rv in comparison to isoniazid as a standard drug.

Multicomponent one-pot synthesis, characterization and antimicrobial screening of 2 cyanoimino-6-aryl-4-(6-methoxynaphthalen-2-yl)-3,4-dihydro-1H-pyrimidines

The composite of 2-Cyanoimino-6-aryl-4-(6-methoxynaphthalen-2-yl)-3,4-dihydro-1 H-pyrimidines using 6-methoxy-2-naphthaldehyde and cyanoguanidine in the medium of aqueous sodium hydroxide in ethanol was documented. The structural designations for the aforementioned compounds were made using their spectra, which comprised Mass, FT-IR, 1H and 13C NMR. In vitro-antimicrobial testing of synthetic cyanoimino pyrimidines revealed strong antimicrobial activity against specific bacteria. The antibacterial activity data showed that compound 4 G had the strongest effect on Gram negative bacteria which is K.Pneumoniae whose minimum inhibitory concentration (MIC) is 28. Further, molecular docking studies were analyzed against synthetic cyanoimino pyrimidines to compare the experimental results. Also, produced good hydrogen bonding interactions. Availability of data and materialsAll data generated or analyzed during this study are included in this published article.

(E)-1-(5-Methyl-1-(4-nitrophenyl)-1H-1,2,3-triazol-4-yl)-3-(naphthalen-2-yl)prop-2-en-1-one

A reaction of equimolar equivalents of 2-naphthaldehyde (1) and 1-(5-methyl-1-(4-nitrophenyl)-1H-1,2,3-triazol-4-yl)ethan-1-one (2) in ethanolic sodium hydroxide at 20 °C for 4 h gave (E)-1-(5-methyl-1-(4-nitrophenyl)-1H-1,2,3-triazol-4-yl)-3-(naphthalen-2-yl)prop-2-en-1-one (3) in 92% yield. Nuclear magnetic resonance spectroscopy and single-crystal X-ray diffraction were used to establish the structure of 3.

Novel [60]fullerene polymers: Part 1: Synthesis and polymerisation processes through acrylation of N-methyl-o-hydroxy-2-phenyl fulleropyrrolidines and their monomers

This synthesis of functionalized C60 and novel fullerene polymers is described by an extended acrylation functionality via pyrrolidine substitution. The strategy employed required that first C60 was derivatised to mono-fulleropyrrolidine (6,6 ring junctions of C60) was prepared and reacted with acryloyl chloride to obtain the monomer. Addition of azomethine ylide was found to provide a versatile method for derivatization of [60]fullerene. The first step in this study was to prepare low molecular weight hydroxy fulleropyrrolidines by [3 + 2] cycloaddition of azomethine ylide to [60]fullerene through the use of N-methyl glycine in conjunction with benzaldehyde derivatives. The fulleropyrrolidine monomer was made by the reaction of an –OH group of fulleropyrrolidine with acryloyl chloride in the presence of sodium hydroxide in absolute ethanol. The monomers were characterized by UV and FT-IR techniques. Polymerisation was carried out using benzoyl peroxide as a free radical initiator and dimethylformamide was used as a solvent. DMF is an eminently suitable solvent for compounds with a high molecular weight owing to the combined action of its small molecular size. During the polymerisation process it was observed that the monomer and polymer were soluble in DMF. In addition, the higher the dilution of the reactants, the lower the polymerisation rate and the lower the molecular weight of the product.

Efficient synthesis and biological evaluation of some new series of pyridine derivatives: Promising and potent new class of anticancer agents

AbstractIn an attempt to develop potent anticancer agents, we have synthesized some substituted pyridine derivatives. Alkylation of the pyridine‐3‐carbonitrile 1a by chloroacetonitrile or methyl iodide and ethyl iodide produced the O‐alkylated nicotinonitrile derivatives (2–4), respectively. The reaction of nicotinonitrile 1a with acetic anhydride furnished the N‐acetyl derivative 5. In addition, the reaction of 1a with concentrated sulfuric acid yielded compound 6 whereas its reaction with chloroacetone gave the corresponding 2‐alkoxy‐pyridine derivative 7 which then refluxed with sodium methoxide to give compound 8. Furthermore, alkylation of 1a‐c with methyl bromoacetate and ethyl bromoacetate produced the corresponding methyl, ethyl ester derivatives 9, 10a–c, respectively. The reaction of ethyl ester 10c with a solution of sodium hydroxide in ethanol afforded the corresponding acid derivative 11. Hydrazinolysis was carried out by the reaction of ethyl ester 10a,c with hydrazine hydrate to afford the desired acetohydrazide derivative 12a,c which was used as a key intermediate for the synthesis of substituted pyridine derivatives 13–19. Chlorination of 1a with phosphorus oxychloride afforded the 2‐chloro derivative 20 which react with excess of hydrazine hydrate to yield compound 21. All synthesized compounds were characterized using IR, NMR, mass spectra, and elemental analysis. Their cytotoxic activity was evaluated against three different cancer cell lines, including breast (MCF‐7), colon (HCT‐116), and ovarian (SKOV3) cancers as well as human normal cells EA.hy 926 (human endothelial somatic cell hybrid). In general, compounds 3, 4, 5, 9, 12a, 12b, 13, 14, 15, 16, 18, 19, 21 exhibited high cytotoxicity against cancer cell lines. Besides that, the large number of synthesized compounds exhibited moderate anticancer activities.

Central Nervous System Activity of 1-aryl-2(thiomethylene benzimidazol-2-yl)-4-(phenyl/p-chlorophenyl)-imidazoles and 1-aryl-2-sulphono-[benzimidazol-2-yl]-methyl-4-(phenyl/p-chlorophenyl)-imidazoles

1-Aryl-2-mercapto-4-(phenyl/p-chlorophenyl)-imidazoles (Ia-1) were condensed with 2-chloromethyl benzimidazole (II) in presence of sodium hydroxide in ethanol to get 1-aryl-2-thiomethylene benzimidazol-2-yl-4-(phenyl/p-chlorophenyl)-imidazoles (IIIa-1). These compounds (IIIa-1) were subsequently oxidised by hydrogen peroxide to get 1-aryl-2-sulphono-[benzimidazol-2-yl]-methyl-4 and (phenyl/p-chlorophenyl)-imidazoles (Iva-1). All the compounds (IIIa-1) and (Iva-1) exhibited central nervous system depressant action on albino mice. All the compounds are non-toxic and possess some sedative activity.

An Efficient One Pot Multicomponent Synthesis of Dihydro Pyrazolyl Bisthiazole Derivatives as Potential Anticancer Agents and their Molecular Docking Studies

A novel series of dihydropyrazolyl bisthiazoles were synthesized through simple reaction conditions via one pot multicomponent reaction of 2-bromo-1-(4-methyl-2-phenyl thiazol-5-yl)ethan-1-one, thiosemicarbazide and chalcones in the presence of sodium hydroxide in ethanol under reflux condition. The reaction generates two potential five membered heterocylic pharmacophores i.e. Hantzsch thiazole and dihydropyrazole in one step through simple operation, in shorter reaction time with high yields. The newly synthesized compounds were well characterized by IR, 1H, 13C NMR and mass spectral data. All the newly synthesized compounds were evaluated for their anticancer activity against human cancer cell lines and calculated their binding energy values with respect to 3ert protein. Some of the compounds exhibited excellent activity against MCF-7 cancer cell line and studied molecular interaction of probable target protein, human estrogen receptor alpha protein (3ert.pdb) using docking simulation.

Synthesis of Some Imine, From Pyrazole -1- Carbaldehyde Compound

In this paper the synthesis of N[(1E)-1- ( 3,5.- disubstituted phenyl -4,5-dihydro-1H- pyrazol-1- yl) ethylidene or methylidene] substituted aniline [13-15] [17-19] and 1,1-{benzene- 1,4- or -1,3- diylbis [nitrilo (E) methylylidene]} bis( 4,5- dihydro -1H- pyrazole -3,5- disubstituted phenyl) [16,20] is reported. Substituted acetophenone was treated with substituted benzaldehyde to give chalcones ((2E)-1,3- disubstituted phenyl prop-2-ene-1- one) [1-4], the chalcones was treated with hydrazine hydrate in the presence of formic or acetic acid ethanol to give 1-(3,5.-disubstituted phenyl-4,5- dihydro-1H- pyrazol-1- yl) methanol or ethanone [5-12], then this products changed to imines through reaction with substituted aromatic aniline and sodium hydroxide in ethanol to give the substituted pyrazoles. Also the substituted compounds [5-12] were converted to 1-{(1E)-1-[2-(2,4-dinitrophenyl) hydrazinylidene] methyl or ethyl} – 4,5- dihydro -1H- pyrazole-3,5-disubstituted phenyl [21-28] by reaction with 2,4-dinitrophenyl hydrazine in ethanol. The synthetic compound's structure. confirmed by IR., UV. Spectra and. physical method.

Surface alcoholysis induced by alkali-activation ethanol: A novel scheme for binary flotation of polyethylene terephthalate from other plastics

Although waste plastic was defined as potential resources, heterogeneous components and low separation efficiency severely blocked plastic recycling. Based on polyesters alcoholysis, we proposed a novel surface modification process with ethanol solution and sodium hydroxide (NaOH) catalyst to assist the flotation separation of waste plastics. After surface alcoholysis, hydrophilic polyethylene terephthalate (PET), as a sinking product, was separated from the floating plastics of hydrophobic polystyrene (PS), polyvinyl chloride (PVC), and polymethyl methacrylate (PMMA). The recovery and purity of PET reached ca. 100% under optimal conditions. Then, we systematically illuminated the hydrophilization mechanism and established surface reactions for PET plastics with the aid of scanning electron microscope (SEM), Fourier transform infrared spectroscopy (FT-IR), nuclear magnetic resonance (NMR), and X-ray photoelectron spectroscopy (XPS). Exposed moieties containing oxygenated groups devoted a hydrophilic surface to PET plastics when some immobilizing segments were substituted with ethanol after surface alcoholysis. A layer of water film dissociated the hydrophilic PET surface from air bubbles, endowing its different trajectory from other hydrophobic plastics in flotation. To our knowledge, this study first proposed alkali-activation ethanol for the wettability regulation and flotation separation of plastic mixtures. Surface alcoholysis without metal and heteroatom contaminants can enrich modification operation, promote plastic flotation, and improve the recycling of waste plastics.

(E)-3-(4-Chlorophenyl)-1-(2-fluoro-4-methoxyphenyl)-2-propen-1-one

Natural products known as chalcones show promise as chemotherapeutic agents for the neglected tropical disease known as leishmaniasis. Our objective is to synthesize new targets of opportunity that may lead to better treatments of this debilitating disease. Claisen-Schmidt condensation of 4-chlorobenzaldehyde with 2′-fluoro-4′-methoxyacetophenone using aqueous sodium hydroxide in ethanol yielded the novel compound (E)-3-(4-chlorophenyl)-1-(2-fluoro-4-methoxyphenyl)-2-propen-1-one. The product was obtained in good yield and purity after recrystallization from ethyl acetate/hexane. With the known antiparasitic properties of halogenated chalcones, this novel compound is suitable for antileishmanial activity study.

Fabrication of Bioplastic from Rice Straw

<p><strong>Abstract.</strong> Oil based plastics have been proven as severe pollutants for the environments as they required years to be degraded. Thus, bioplastics are very attractive as the solution of this problem as they easier to be degraded in soil. This work was aimed to fabricate bioplastics from rice straw, with addition of carboxymethyl cellulose (CMC) and glycerol. Prior to the bioplastic fabrication, cellulose was extracted from rice straw through digestion process using ethanol solution (50% w/w) and sodium hydroxide solution (8% w/w) as catalyst. Digestion process was held for 60 minutes at temperature of 120 <sup>o</sup>C. Bioplastics were produced by blending dried pulp, carboxymethyl cellulose, and glycerol. Five grams of dried cellulose was dissolved in 100 ml of water. The amount of CMC and glycerol added to the pulp solution were varied from 1 ml to 2 ml and 0.5 to 1.5 grams, respectively. Swelling test (both in water and oil) and biodegradability test were conducted to study the performance of the bioplastics. Results showed that bioplactic dissolved easily in water. During oil swelling test, it showed that higher glycerol content increases the oil proof characteristic of the bioplastic. Meanwhile, the CMC content has no impact during the oil swelling test. The best composition of the bioplastic was achieved with the CMC and glycerol contents of 1.382% (w/w) and 1,843% (w/w), respectively, with the lowest oil swelling test result of 55%. Biodegradability of the bioplactics were lower in higher CMC and glycerol contents. The best composition with maximum weight reduction of the bioplastics was achieved by the bioplastic with 0.469% (w/w) of CMC content and 0.939% (w/w) of glycerol.</p><p><strong>Keywords:</strong> Bioplastic, Rice Straw, CMC, Glycerol, Swelling, Biodegradability</p>

A straightforward one-pot synthesis of Pd–Ag supported on activated carbon as a robust catalyst toward ethanol electrooxidation

Direct Ethanol Fuel Cells (DEFCs) have fascinated remarkable attention on account of their high current density and being environmentally friendly. Developing efficient and durable catalysts with a simple and fast method is a great challenge in the practical applications of DEFCs. To this end, the bimetallic Pd–Ag with adjustable Pd:Ag ratios were synthesized via a simple and one-pot strategy on activated carbon as a support in this study. The Pd–Ag/C catalysts with different molar ratios were synthesized by simultaneous reduction of Pd and Ag ions in the presence of the ethanolic sodium hydroxide as a green reducing agent for the first time. Several different methods, including FE-SEM, HR-TEM, XRD, XPS EDX, ICP-OES, and BET were used to confirm the structure and morphology of the catalysts. The performance of catalysts was also examined in ethanol oxidation. Obtained results of electrochemical experiments revealed that the Pd3–Ag1/C catalyst had superior catalytic activity (2911.98 mAmg−1Pd), durability, and long-stability compared to the other catalysts. The excellent catalytic characteristic can be attributed to the synergistic effect between Pd and Ag. We presume that our simple method have the chance to be utilized as a proper method for the synthesis of fuel cell catalysts.

Preparation and Characterization of New Heterocyclic Derivatives, Six and Five Ring from Acetanilide

The aim of the study synthesis of new heterocyclic derivatives (six and five ring) from acetanilide. Firstly the chalcones have been synthesized from the reaction acetanilide with aromatic aldehyde [ 2-nitrobenzaldyhade, 4- dimethylaminobenzaldehyde, 2-naphthaldehyde ] in dilute solution of ethanolic sodium hydroxide at room temperature. This reaction occurs depending on Claisen Schmidt condensation, then a new oxazine and thiazine derivatives (six ring) have been synthesized by the reaction chalcones with urea and thiourea. Finally the synthesized chalcones were reacted with hydrazine hydrate to produce new pyrazol derivatives (five ring). All derivatives were characterized by physical properties, FTIR, 1H-NMR and 13C-NMR spectra.

Preparation and Characterization of New Heterocyclic Derivatives, Six and Five Ring from Acetanilide

The aim of the study synthesis of new heterocyclic derivatives (six and five ring) from acetanilide. Firstly the chalcones have been synthesized from the reaction acetanilide with aromatic aldehyde [ 2-nitrobenzaldyhade, 4- dimethylaminobenzaldehyde, 2-naphthaldehyde ] in dilute solution of ethanolic sodium hydroxide at room temperature. This reaction occurs depending on Claisen Schmidt condensation, then a new oxazine and thiazine derivatives (six ring) have been synthesized by the reaction chalcones with urea and thiourea. Finally the synthesized chalcones were reacted with hydrazine hydrate to produce new pyrazol derivatives (five ring). All derivatives were characterized by physical properties, FTIR, 1H-NMR and 13C-NMR spectra.

Antimicrobial and antiproliferative activities of novel synthesized 6-(quinolin-2-ylthio) pyridine derivatives with molecular docking study as multi-targeted JAK2/STAT3 inhibitors.

Quinoline derivatives are attracting considerable interest due to their biological importance. In this paper, several 2-amino-4-aryl-6-(quinolin-2-ylthio)pyridine-3,5-dicarbonitrile derivatives are synthesized by adopting a one-pot reaction of quinoline-2-thione, aromatic aldehydes, and malononitrile in the presence of sodium hydroxide in absolute ethanol. The structures of these newly synthesized compounds were determined using different spectroscopic techniques, including elemental analyses, IR, 1 H NMR, and MS. The synthesized derivatives were screened for their antimicrobial and cytotoxic activities. Compounds 4a, 4b, 4d, and 4e exhibited promising antimicrobial activity compared to antibacterial and antifungal standard drugs. Additionally, 4f, 4d, and 4g showed potent cytotoxic activity against both MCF-7 and A549 cells with IC50 values (6.39-9.3μM). Our molecular docking results of compound 4f prove good binding affinity toward the three tested proteins as Jak2/STATA3 inhibition and are in accordance with the RT-PCR mRNA expressions of the compound against MCF-7 cells which downregulated the Jak2 and STAT3 genes, and this may be the proposed mode of action for anti-breast cancer activity.