During the past decades, sodium borohydride has played an important role for the reduction of functional groups in modern organic synthesis. This reagent is a relatively mild reducing agent and mostly used for the reduction of aldehydes and ketones in protic solvents. In order to control the reducing power of NaBH4, hundreds of substituted boron hydrides have been made and introduced in chemical literature and many of them are now commercially available. In fact, advances in such field have been realized by replacement of one or more hydride with other substituents, change of sodium cation to other metal, quaternary ammonium and phosphonium cations, a concurrent cation and hydride exchange, ligand metal borohydrides and finally combination of the hydride transferring agents with metals, metal salts, Lewis acids and solid supports. In this context, NaBH3CN carrying an electron withdrawing cyanide group is a remarkable stable and selective reducing agent and has been found many applications in organic synthesis. It is also well known that the reducing capability of NaBH3CN in reduction reactions is greatly depended to use low pH values (3-4). In spite of the great convenience of NaBH3CN in synthetic organic chemistry, however, this reagent suffers from harsh reaction conditions (strongly acidic media), limitation to use acid-sensitive functional groups and formation of some side products. In line of the outlined strategies and our research interest to develop mild and efficient protocols for sodium cyanoborohydride reduction of functional groups in the absence of Bronsted acidic media, herein, we wish to introduce a new and convenient method for reduction of various aldoximes and ketoximes to their corresponding amines with NaBH3CN/ MoCl5/NaHSO4·H2O system in refluxing EtOH or DMF (Scheme 1). Results and Discussion