Although research including biological concepts and variables has gained more prominence in sociology, progress assimilating the organ of experience, the brain, has been theoretically and technically challenging. Formal uptake and assimilation have thus been slow. Within psychology and neuroscience, the traditional brain, which has made brief appearances in sociological research, is a “bottom–up” processor in which sensory signals are passed up the neural hierarchy where they are eventually cognitively and emotionally processed, after which actions and responses are generated. In this paper, we introduce the Active Inference Framework (AIF), which casts the brain as a Bayesian “inference engine” that tests its “top–down” predictive models against “bottom–up” sensory error streams in its attempts to resolve uncertainty and make the world more predictable. After assembling and presenting key concepts in the AIF, we describe an integrated neuro-bio-social model that prioritizes the microsociological assertion that the scene of action is the situation, wherein brains enculturate. Through such social dynamics, enculturated brains share models of the world with one another, enabling collective realities that disclose the actions afforded in those times and places. We conclude by discussing this neuro-bio-social model within the context of exemplar sociological research areas, including the sociology of stress and health, the sociology of emotions, and cognitive cultural sociology, all areas where the brain has received some degree of recognition and incorporation. In each case, sociological insights that do not fit naturally with the traditional brain model emerge intuitively from the predictive AIF model, further underscoring the interconnections and interdependencies between these areas, while also providing a foundation for a probabilistic sociology.
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