For fast-tracking climate change response, green hydrogen is key for achieving greenhouse gas neutral energy systems. Especially Sub-Saharan Africa can benefit from it enabling an increased access to clean energy through utilizing its beneficial conditions for renewable energies. However, developing green hydrogen strategies for Sub-Saharan Africa requires highly detailed and consistent information ranging from technical, environmental, economic, and social dimensions, which is currently lacking in literature. Therefore, this paper provides a comprehensive novel approach embedding the required range of disciplines to analyze green hydrogen cost-potentials in Sub-Saharan Africa. This approach stretches from a dedicated land eligibility based on local preferences, a location specific renewable energy simulation, locally derived sustainable groundwater limitations under climate change, an optimization of local hydrogen energy systems, and a socio-economic indicator-based impact analysis. The capability of the approach is shown for case study regions in Sub-Saharan Africa highlighting the need for a unified, interdisciplinary approach.