This study employed quantitative methodologies to investigate the impact of a 12-week mindfulness-based Social and Emotional Learning (SEL) program on lowering stress and improving mental well-being in a sample of 300 adolescents from Jordan. The study employed a stratified random sampling strategy to choose participants from diverse urban and rural populations. Data was collected utilizing the Perceived Stress Scale (PSS) and the Strengths and Difficulties Questionnaire (SDQ). The data evaluation involved the use of descriptive statistics, paired-sample t-tests, regression analysis, and an Analysis of Covariance (ANCOVA). The results indicate a significant decrease in stress levels and positive changes in mental health outcomes following the intervention. The regression analysis revealed that age was a likely predictor of changes in stress levels, indicating that older persons saw more significant declines. The analysis of covariance (ANCOVA) indicated significant gender-specific discrepancies in the impacts of the intervention. Independent samples t-tests revealed statistically significant variations in the average rankings across specific age groups and school environments. Proposed measures include implementing mindfulness-based social and emotional learning (SEL) programs in school systems, tailoring treatments to suit different demographic groups, examining gender-specific factors, and advocating for policy integration. Performing a longitudinal study is typically advised to assess the long-term sustainability of intervention results.