Smoothed Nonlinear Energy Operator Research Articles

Analysing heart rate variability in preterm infants: the effect of temporal adjustment of NN peaks and missing data.

The measurement of heart rate variability (HRV) in preterm infants provides important information on function to clinicians. Measuring the underlying electrocardiogram (ECG) in the neonatal intensive care unit is a challenge and there is a trade off between extracting accurate measurements of the HRV and the amount of ECG processed due to contamination. Knowledge on the effects of 1) quantization in the time domain and 2) missing data on the calculation of HRV features will inform clinical implementation. In this paper, we studied multiple 5 minute epochs from 148 ECG recordings on 56 extremely preterm infants. We found that temporal adjustment of NN peaks improves the estimate of the NN interval resulting in HRV features (m = 9) that are better correlated with age (median percentage increase in correlation of individual features: 0.2%, IQR: 0.0 to 5.6%; correlation with age predictor and age from 0.721 to 0.787). Improved (sub-sample) quantization of the NN intervals (via interpolation) reduced the overall value of HRV features (median percentage reduction in feature value: -1.3%, IQR: -18.8 to 0.0; m = 9), primarily through a reduction in the energy of high-frequency oscillations. HRV features were also robust to missing data, with measures such as mean NN, fractal dimension and the smoothed nonlinear energy operator (SNEO) less susceptible to missing data than features such as VLF, LF, and HF. Furthermore, age predictions derived from a combination of HRV measures were more robust to missing data than individual HRV measures.Clinical Relevance-Poor quantization in time when estimating the NN peak and the presence of missing data confound HRV measures, particularly spectral measures.

Multidimensional Feature Optimization Based Eye Blink Detection Under Epileptiform Discharges.

Eye blink artifact detection in scalp electroencephalogram (EEG) of epilepsy patients is challenging due to its similar waveforms to epileptiform discharges. Developing an accurate detection method is urgent and critical. In this paper, we proposed a novel multi-dimensional feature optimization based eye blink artifact detection algorithm for EEGs containing rich epileptiform discharges. An unsupervised clustering algorithm based on smoothed nonlinear energy operator (SNEO) and variational mode extraction (VME) is proposed to detect epileptiform discharges in the frontal leads. Then, multi-dimensional time/frequency EEG features extracted from forehead electrodes (FP1 and FP2 channels) combining with the improved VME (IVME) threshold are derived for EEG representation. A variance filtering method is further applied for discriminative feature selection and a machine learning model is finally learned to perform detection. Experiments on EEGs of 16 subjects from the Children's Hospital of Zhejiang University School of Medicine (CHZU) show that our method achieves the highest average sensitivity, specificity and accuracy of 95.04, 89.52, and 93.01, respectively. That outperforms 5 recent and state-of-the-art (SOTA) eye blink detection algorithms. The proposed method is robust in eye blink artifact detection for EEGs containing high-frequency epileptiform discharges. It is also effective in dealing with individual differences in EEGs, which is usually ignored in conventional methods.

Comparison of Sneo-Based Neural Spike Detection Algorithms for Implantable Multi-Transistor Array Biosensors

Real-time neural spike detection is an important step in understanding neurological activities and developing brain-silicon interfaces. Recent approaches exploit minimally invasive sensing techniques based on implanted complementary metal-oxide semiconductors (CMOS) multi transistors arrays (MTAs) that limit the damage of the neural tissue and provide high spatial resolution. Unfortunately, MTAs result in low signal-to-noise ratios due to the weak capacitive coupling between the nearby neurons and the sensor and the high noise power coming from the analog front-end. In this paper we investigate the performance achievable by using spike detection algorithms for MTAs, based on some variants of the smoothed non-linear energy operator (SNEO). We show that detection performance benefits from the correlation of the signals detected by the MTA pixels, but degrades when a high firing rate of neurons occurs. We present and compare different approaches and noise estimation techniques for the SNEO, aimed at increasing the detection accuracy at low SNR and making it less dependent on neurons firing rates. The algorithms are tested by using synthetic neural signals obtained with a modified version of NEUROCUBE generator. The proposed approaches outperform the SNEO, showing a more than 20% increase on averaged sensitivity at 0 dB and reduced dependence on the neuronal firing rate.

FPGA Design Integration of a 32-Microelectrodes Low-Latency Spike Detector in a Commercial System for Intracortical Recordings

Numerous experiments require low latencies in the detection and processing of the neural brain activity to be feasible, in the order of a few milliseconds from action to reaction. In this paper, a design for sub-millisecond detection and communication of the spiking activity detected by an array of 32 intracortical microelectrodes is presented, exploiting the real-time processing provided by Field Programmable Gate Array (FPGA). The design is embedded in the commercially available RHS stimulation/recording controller from Intan Technologies, that allows recording intracortical signals and performing IntraCortical MicroStimulation (ICMS). The Spike Detector (SD) is based on the Smoothed Nonlinear Energy Operator (SNEO) and includes a novel approach to estimate an RMS-based firing-rate-independent threshold, that can be tuned to fine detect both the single Action Potential (AP) and Multi Unit Activity (MUA). A low-latency SD together with the ICMS capability, creates a powerful tool for Brain-Computer-Interface (BCI) closed-loop experiments relying on the neuronal activity-dependent stimulation. The design also includes: A third order Butterworth high-pass IIR filter and a Savitzky-Golay polynomial fitting; a privileged fast USB connection to stream the detected spikes to a host computer and a sub-milliseconds latency Universal Asynchronous Receiver-Transmitter (UART) protocol communication to send detections and receive ICMS triggers. The source code and the instruction of the project can be found on GitHub.

Spike detection approaches for noisy neuronal data: Assessment and comparison

Spike detection in extracellular recordings is a difficult problem, especially when there are several noise sources. In this paper, three new approaches based on fractal dimension (FD), smoothed nonlinear energy operator (SNEO) and standard deviation to detect the spikes for noisy neuronal data are proposed. These methods however do not perform well in some cases, especially when the noise level is high. To overcome these problems, we use five smoothing techniques, namely, discrete wavelet transform (DWT), Kalman filter (KF), singular spectrum analysis (SSA), Savitzgy-Golay filter, and empirical mode decomposition (EMD). Although filtering approach based on EMD is relatively slow, when SNRs>0dB, those approaches which use EMD have the best efficiency and accuracy. While SNRs<0 dB, it is demonstrated that for SSA followed by SNEO, the performance in terms of the average spikes detection accuracy and CPU time is the most desirable.

Nonstationary-epileptic-spike detection algorithm in EEG signal using SNEO

Purpose This correspondence presents the evaluation of nonstationary epileptic spike (ES) detection algorithm in the electroencephalogram (EEG) signal using the smoothed nonlinear energy operator (SNEO) based on the different time-domain window functions. However, the incorporation of adaptive threshold determination procedure enhances the performance of proposed ES detector.

Flute breakage detection during end milling using Hilbert–Huang transform and smoothed nonlinear energy operator

Real time tool condition monitoring has great significance in modern manufacturing processes. In order to prevent possible damages to the workpiece or the machine tool, reliable monitoring techniques are required to provide fast response to the unexpected tool failure. Milling is one of the most fundamental machining operations. During the milling process, the current of feed motor is weakly related to the cutter condition, the change of power consumption is not significant to identify tool condition. Thus, current of motor-based tool condition still requires some new approaches to sort out significant pattern that could be employed to indicate tool condition. In this paper, a new approach is proposed to detect end mill flute breakage via the feed-motor current signals, which implements Hilbert–Huang transform (HHT) analysis and a smoothed nonlinear energy operator (SNEO) to extract the crucial characteristics from the measured signals to indicate tool breakage. Experiments on a CNC Vertical Machining Centre are presented to show the algorithm performance. The results show that this method is feasible and can accurately and efficiently monitor the conditions of the end mill under varying cutting conditions.