This paper introduces a novel hybrid control strategy for quadrotor UAVs inspired by neural dynamics. Our approach effectively addresses two common issues: the velocity jump problem in traditional backstepping control and the control signal chattering in conventional sliding mode control. The proposed system combines an outer-loop bioinspired backstepping controller with an inner-loop bioinspired sliding mode controller, ensuring smooth trajectory tracking even under external disturbances. We rigorously analyzed the system’s stability using Lyapunov stability theory. To validate our algorithm’s effectiveness, we conducted trajectory tracking experiments in both disturbance-free and step-disturbance conditions, comparing it with the traditional backstepping control, conventional sliding mode control, and saturated sliding mode control. The results demonstrate that our algorithm not only tracks trajectories more effectively but also significantly outperforms these methods in suppressing velocity jumps and signal chattering.