This cross-sectional study described the home tobacco environment and its association with quitting behaviors among Black/African American women caregivers who smoke cigarettes and live in rural, low-resourced areas. A baseline survey was administered to caregivers enrolled in a randomized trial from 2020 to 2022 (n = 147). Logistic regressions identified the associations between the independent variables (home cigarette smoking bans, caregiver restrictions on child cigarette access, number of people in the home who smoked around the caregiver during the past week, and who smoked in the caregiver's home) and three outcome variables: lifetime quit attempt, past-year quit attempt and use of evidence-based cessation strategies during a last quit attempt. Caregivers have multiple generations of family smoking in their homes, including caregivers' children/nieces/nephews (21%) and their parents (36%). Young family members smoking in the home was related to the caregiver's parents (p = .046) and grandparents (p = .03) smoking in the home. The number of people smoking around the caregiver was associated with lower odds of a lifetime quit attempt (odds ratio, OR = 0.63, confidence interval, CI [0.47, 0.85]; adjusted OR = 0.61, CI [0.45, 0.84]). No independent variables were significantly related to past-year quit attempts in unadjusted or adjusted models. Caregivers with young family members smoking in the home were more likely to have used evidence-based cessation strategies versus those without young family smoking (OR = 16.96, CI [1.01, 283.68]). Black/African women caregivers who smoke and live in rural, low-resourced areas are exposed to numerous family members smoking in their homes which may affect quitting. (PsycInfo Database Record (c) 2024 APA, all rights reserved).