Smell Sensitivity Research Articles

Evaluation of Smell Function in Patients with Childhood Epilepsy with Centrotemporal Spikes at a Pediatric Neurology Clinic—A Case–Control Study

Objective: Childhood epilepsy with centrotemporal spikes (CECTS) is associated with cognitive, behavioral, and language difficulties. These epileptic discharges predominantly occur in the temporal lobe, which is known to be involved in olfactory functions. This study aims to assess olfactory dysfunction in patients with CECTS. Methods: This study included patients diagnosed with CECTS who were attending follow-ups at the Department of Child Neurology between January 2022 and July 2023. Olfactory function was evaluated using the Sniffin’ Sticks (Burghart GmbH, Wedel, Germany) 12-point screening test, which was administered to 44 patients and 35 controls. The smell test and the final control EEGs were performed simultaneously. Results: A total of 44 patients and 35 control subjects were enrolled in this study. The smell scores were significantly lower in the patient group compared to the control group (p = 0.029). The patient group had a very high prevalence of anosmia compared to the control group. The normosmia rate in the control group was significantly higher. No significant difference was observed in the smell scores based on EEG findings or antiepileptic drug type. Conclusions: Olfactory dysfunction was identified in patients with CECTS compared to healthy controls, yielding results consistent with findings for other types of epilepsy. Olfactory dysfunction was detected in a greater frequency among the patients diagnosed with CECTS than among the healthy control group, and similar results were obtained with other types of epilepsy. It was deduced that these patients may experience problems with smell sensitivity throughout their lives. The most important result of this study is that this condition should be taken into account in regard to patients’ well-being and lives.

Sensory processing abilities in relation to motor capabilities in children with different types of cerebral palsy

Background and purpose. children with cerebral palsy have sensory processing issues as well as motor problems, which lead to severe developmental disability. In this study, we aimed to assess correlation between sensory processing abilities and motor capabilities in children with cerebral palsy and assess the effect of cerebral palsy types on sensory processing abilities and motor capabilities. Materials and methods. One hundred cerebral palsy children of both sex were included in the study; their age ranged from 4-10 years old were selected from pediatric rehabilitation out clinic of faculty of Physical Therapy Cairo University, fulfilling inclusion criteria. All children were assessed by Short sensory profile: to measure sensory processing ability, Gross Motor Function Classification System: to measure the gross motor skills and Manual Ability Classification System: to measure the fine motor skills. Result. there was a significant correlation between GMFCS, MACS and the total score of SSP as well as Low energy weak, tactile sensitivity score, taste smell sensitivity, Movement sensitivity, and Under-responsive seeks sensation (P ≤ 0.05*). There was no significant correlations between both auditory filtering and Visual-auditory sensitivity with GMFCS and MACS (P = 0.676 and 0.266, respectively). There was statistical variation among different CP types regarding SSP and motor assessment (P ≤ 0.05*). Conclusion. the study showed: sensory processing abilities effect on motor capabilities in children with cerebral palsy.

Perception of Taste and Smell in Sitting and Standing Posture among Healthy Individuals: A Cross-sectional Study

Introduction: Taste and smell are vital senses interlinked to each other that stimulate the desire to eat food. The physiological stress of a standing posture might alter taste and smell sensitivity, compelling individuals to eat more until satiety is achieved. Aim: To determine and compare the perception of taste and smell in sitting and standing postures among healthy individuals. Materials and Methods: This cross-sectional study was conducted in the physiology laboratory of Velammal Medical College, Tamil Nadu, India, over a duration of two months from February 2021 to April 2021. The study included 100 medical students (both genders) aged between 18-21 years. For taste assessment, the Sip spit rinse test was performed, where taste strips were impregnated with sweet and salty solutions of different concentrations (0.05-0.00625 g/mL). Odour threshold was measured with various dilutions of rose water (1:10000 to 1:1) using olfactometer. Taste and smell thresholds in standing and sitting postures were analysed using the Paired sample T-test and Lin’s concordance test, using Statistical Package for Social Sciences (SPSS) version 22.0 A significance level of 0.05 was used to interpret the p-value. Results: A statistically significant difference (p<0.001**) was observed for taste threshold, with a higher mean value in the standing position (0.0108) compared to the sitting position (0.0086). No statistically significant difference was observed for olfactory threshold in both sitting and standing postures (p>0.05). Additionally, no significant gender difference was found for taste and smell threshold values (p=0.418). Conclusion: Standing posture decreases taste sensitivity with no significant change in olfactory sensitivity

CTNI-66. DECODING GLIOBLASTOMA SURVIVAL: UNRAVELING THE PROGNOSTIC POTENTIAL OF OLFACTORY FUNCTION IN A PROSPECTIVE OBSERVATIONAL STUDY

Abstract BACKGROUND Olfactory impairment is a common neurologic deficit among glioblastoma patients. We have previously shown that glioblastoma patients with reduced smell sensitivity had lower overall survival rates compared to those with normal olfactory function. A notable limitation in that study was the unequal distribution of prognostic factors between the two groups, and the absence of continuous olfactory assessments during treatment to investigate if therapy-associated neurotoxicity could be a contributing factor to diminished olfactory acuity. Question: Can Olfactory Function Serve as an Independent Prognostic Indicator in Glioblastoma Patients? METHODS This prospective, multicenter study is set to recruit 64 glioblastoma patients alongside 64 healthy controls. Stratification of participants will be based on prognostically relevant variables such as resection status, MGMT promoter methylation status, radiographic involvement of olfactory brain areas, olfactory function, age, and Karnofsky performance status scale. We will utilize Sniffing Sticks to evaluate olfactory function through identification and threshold tests, and this assessment will be carried out longitudinally throughout the therapy starting from tumor diagnosis. Infiltration of the olfactory brain areas will be scrutinized using coronal T2 and T1 MRI sequences. MRI images will be independently reviewed by two board-certified radiologists from distinct institutions, who are blinded to the patients' olfactory function status. Furthermore, quality of life data, neuropsychological testing, and psychosomatic screening will be performed at specific intervals throughout the study. Also, we'll examine next-generation sequencing results to investigate potential genetic associations with hyposmia in glioblastoma patients. RESULTS The first participant was enrolled in May 2023. Plans are underway to open a second study site in 2024, with the aim to complete recruitment by December 2025. Follow-up assessments will continue until December 2027. We anticipate that the final results of the study will be available in 2028.

A supervised learning regression method for the analysis of oral sensitivity of healthy individuals and patients with chemosensory loss

The gustatory, olfactory, and trigeminal systems are anatomically separated. However, they interact cognitively to give rise to oral perception, which can significantly affect health and quality of life. We built a Supervised Learning (SL) regression model that, exploiting participants’ features, was capable of automatically analyzing with high precision the self-ratings of oral sensitivity of healthy participants and patients with chemosensory loss, determining the contribution of its components: gustatory, olfactory, and trigeminal. CatBoost regressor provided predicted values of the self-rated oral sensitivity close to experimental values. Patients showed lower predicted values of oral sensitivity, lower scores for measured taste, spiciness, astringency, and smell sensitivity, higher BMI, and lower levels of well-being. CatBoost regressor defined the impact of the single components of oral perception in the two groups. The trigeminal component was the most significant, though astringency and spiciness provided similar contributions in controls, while astringency was most important in patients. Taste was more important in controls while smell was the least important in both groups. Identifying the significance of the oral perception components and the differences between the two groups provide important information to allow for more targeted examinations supporting both patients and healthcare professionals in clinical practice.

Short Sensory Profile Assessment System for Autism Children

Autism Spectrum Disorders (ASD) are life-long neurodevelopmental disorders characterized by impairment in reciprocal social interactions, impairment in verbal and non-verbal communication skills, and restricted repetitive and stereotyped patterns of behaviour, interests and activities. Children with ASD normally shows the sensory impairment and struggles to process sensory data. Short Sensory Profile (SSP) is an assessment tool which is widely used to identify whether the autism children have exhibited the sensory disorder. There are seven parts of the questionnaire which are tactile sensitivity, taste/ smell sensitivity, movement sensitivity, under responsive/ seeks sensation, auditory filtering, low energy/ weak and visual auditory sensitivity. The problem with the current system is that the assessment is being done manually whereby it requires the therapist to spend more time and effort to get the results. Therefore, by providing a web-based SSP assessment system, it will ease the therapist to automate the manual process and receive the output easily. In addition, the profile of the patient can be stored digitally and can be referred for future reference of developing and revisit the therapy plan.

Sensory processing issues in children with cerebral palsy: a pilot study in tertiary care institute

Background: Understanding of sensory processing disorder in children with cerebral palsy is paramount to implement holistic rehabilitation and it would help in achieving highest level of function and independence. The purpose of the study was to detect sensory processing disorder in children with cerebral palsy in east zone of India. This study may help to formulate the implementation of effective therapy protocol in east zone. Methods: The study was a prospective cross-sectional study.30 children with cerebral palsy were enrolled in our study. All 30 children were spastic diplegic. Children were assessed with short sensory profile. All caretakers were given questionnaire of SSP (short sensory profile). Results: Short sensory profile can help find out the sensory processing disorder in cerebral palsy. All 30 participants showed sensory processing difficulties in at least one of the sensory processing sections. In our study, 19 children with cerebral palsy out of 30 showed sensory processing disorder. 22 children with cerebral palsy have reported sensory seeking issue and same number of kids has reported weak muscles and low endurance. Moreover, 18 of the children with cerebral palsy have reported movement sensitivity issue and 6 children reported visual auditory issues. On top of that 15 children with CP have reported auditory filtering issues, 9 children showed tactile sensitivity issues and 11 children showed taste and smell sensitivity. Conclusions: Children with spastic diplegic cerebral palsy showed difficulty in sensory processing especially in sensory seeking domain. Sensory processing disorder is present in children with cerebral palsy.

Symptoms associated with headache in youth.

To determine the underlying relationships between a broad range of headache-associated symptoms and how they relate to headache burden. Symptoms associated with head pain inform classification of headache disorders. However, many headache-associated symptoms are not included in the diagnostic criteria, which is largely based on expert opinion. Large symptom databases can assess headache-associated symptoms irrespective of pre-existing diagnostic categories. We conducted a large single-center cross-sectional study on youth (6-17 years old) assessing patient-reported outpatient headache questionnaires between June 2017 and February 2022. Multiple correspondence analysis, an exploratory factor analysis, was applied to 13 headache-associated symptoms. 6662 participants (64% female; median age 13.6 years) were included. Multiple correspondence analysis dimension 1 (25.4% of the variance) captured the absence or abundance of headache-associated symptoms. A greater number of headache-associated symptoms correlated with greater headache burden. Dimension 2 (11.0% of the variance) revealed three symptom clusters: (1) cardinal features of migraine (light, sound, and smell sensitivity, nausea, and vomiting), (2) nonspecific global neurologic dysfunction symptoms (lightheadedness, trouble thinking, blurry vision), (3) vestibular and brainstem dysfunction symptoms (vertigo, balance problems, ear ringing, double vision). Assessing a broader range of headache-associated symptoms reveals clustering of symptomatology and a strong relationship with headache burden.

Enhancement of taste by retronasal odors in patients with Wolfram syndrome and decreased olfactory function.

Wolfram syndrome is a rare disease characterized by diabetes, neurodegeneration, loss of vision, and audition. We recently found, in a young sample of participants (mean age 15 years), that Wolfram syndrome was associated with impairment in smell identification with normal smell sensitivity and whole-mouth taste function. However, these senses were assessed separately, and it is unknown whether smell-taste interactions are altered in Wolfram syndrome, which was the focus of this study. Participants with Wolfram syndrome (n = 36; 18.2 ± 6.8 years) and sex-age-equivalent healthy controls (n = 34) were assessed with a battery of sensory tests. Using sip-and-spit methods, participants tasted solutions containing gustatory and olfactory stimuli (sucrose with strawberry extract, citric acid with lemon extract, sodium chloride in vegetable broth, and coffee) with and without nose clips, and rated perceived taste and retronasal smell intensities using the generalized Labeled Magnitude Scale. Participants also completed n-butanol detection thresholds and the University of Pennsylvania Smell Identification Test (UPSIT). Retronasal smell increased taste intensity of sucrose, sodium chloride, and coffee solutions similarly in both groups (P values <0.03). Compared with the control group, participants in the Wolfram group had lower UPSIT scores and reduced smell sensitivity, retronasal intensity, and saltiness (P values <0.03), but rated other taste intensities similarly when wearing the nose clip. Despite impairments in orthonasal smell identification, odor-induced taste enhancement was preserved in participants with Wolfram syndrome who still had some peripheral olfactory function. This finding suggests that odor-induced taste enhancement may be preserved in the presence of reduced olfactory intensity.

Associations among perceived taste and smell sensitivity, gastrointestinal symptoms, and restrictive eating in a community sample of adults

Restrictive eating is associated with several poor health outcomes. Exteroceptive sensory modalities, including taste and smell, are employed while eating and disturbances in exteroceptive sensitivity may influence eating behavior. Meal-related gastrointestinal disturbances, such as early satiety and postprandial fullness, are well-documented in eating disorders and may influence eating behavior. This study examined the relationships of perceived sensitivity to taste or smell and gastrointestinal symptoms with restrictive eating, and potential interactions between gastrointestinal symptoms and perceived sensitivity to taste or smell. Adults aged 18–65 were recruited via ResearchMatch.org (N = 420) and completed questionnaires assessing restrictive eating, perceived sensitivity to taste and smell, and gastrointestinal symptom severity. There was a weak relationship between restrictive eating and perceived sensitivity to taste (r = −0.115, p = .022) and smell (r = −0.101, p = .039). There was a strong relationship between gastrointestinal symptom severity and restrictive eating (r = 0.583, p < .001). Gastrointestinal symptom severity moderated the relationship between perceived sensitivity to taste and restrictive eating, such that this relationship was strongest at lower levels of gastrointestinal symptom severity (Estimate = −0.136, p = .014). There was no observed interaction between perceived sensitivity to smell and gastrointestinal symptoms (Estimate = 0.001, p = .156). Results indicate that increased perceived sensitivity to taste, smell, and gastrointestinal symptom severity were each associated with greater restrictive eating. The relationship between perceived sensitivity to taste and restrictive eating is strongest at lower gastrointestinal symptom severity. Future research should examine whether tailoring treatments for individuals who present with elevated perceived sensitivity to taste or smell, gastrointestinal symptoms, or both is effective in reducing restrictive eating.

Assessment of Smell and Taste Disturbances among COVID-19 Convalescent Patients: A Cross-Sectional Study in Armenia.

Background and Objectives: Neurological manifestations of Coronavirus Disease 2019 (COVID-19) such as olfactory and gustatory disturbance have been reported among convalescent COVID-19 patients. However, scientific data on the prevalence of smell and taste disturbance are lacking. Therefore, we present findings on the degree of smell and taste disturbances among the Armenian population. Methods: Study participants were randomly recruited and then categorized into two groups based on their course of the disease. A cross-sectional study was performed to assess participants’ sensitivity to smell triggered by the olfactory and the trigeminal nerves; their ability to differentiate between various odors; and to evaluate their gustatory perception. Results: The smell test revealed that the degree of olfactory nerve disturbance was different by 30.7% in those participants of the early group as compared to those of the late group, and the degree of trigeminal nerve disturbance was different by 71.3% in the early group as compared to the late group. A variation of the differentiating ability among the participants of the early and late groups was detected. Gustatory disturbances for all flavors were also found to be different in both the groups. A moderate positive correlation (0.51) was found between the overall sensitivity of smell and the ability to differentiate between various odors as cumulatively stimulated by both the olfactory and trigeminal nerves. Also, a moderate positive correlation (0.33) was found between headache and smell sensitivity through the olfactory nerve and a high negative correlation (−0.71) was found between headache and smell sensitivity through the trigeminal nerve. Conclusion: Pathological changes in the olfactory and trigeminal perceptive abilities caused disturbances in smell sensation, with the trigeminal nerve being more affected. The capacity to differentiate fragrances did not improve with time and the disturbance severity of bitter taste perception was higher among the study participants.

Associations between Taste and Smell Sensitivity, Preference and Quality of Life in Healthy Aging-The NutriAct Family Study Examinations (NFSE) Cohort.

Taste and smell function decline with age, with robust impairment in the very old. Much less is known about taste and smell function in young and middle aged. We investigated taste and smell sensitivity via thresholds in a sub-sample of the NutriAct Family Study (NFS), the NFS Examinations cohort (NFSE; N = 251, age M = 62.5 years). We examined different aspects relating to taste and smell function: the degree to which taste and smell sensitivity relate to another and to taste and smell preferences, the role of gender and age, as well as effects on Quality of Life (QoL). Taste thresholds were highly correlated, but no correlation was observed between taste and smell thresholds and between thresholds and preference. Women were more sensitive for both taste and smell than men. We found no effect of age on sensitivity and no effect of sensitivity on QoL. All null findings were complemented by Bayesian statistics. Together our results indicate the independence of taste and smell despite their overlap during sensorial experiences. We found no evidence for age-related sensory decline, which could be due to our sample’s characteristics of non-clinical volunteers with good dental health and 93% non-smokers.

Smell Sensitivity in Primary Open-angle Glaucoma and Pseudoexfoliation Glaucoma.

This cross-sectional study of 20 patients with primary open-angle glaucoma (POAG), 20 with exfoliative glaucoma (XFG), 20 with exfoliation syndrome (XS) showed that exfoliative group had a significantly lower smell identification level as compared with the control groups. To investigate smell sensitivity in POAG, XFG, and XFS in comparison with healthy controls. This prospective, cross-sectional study included 20 patients with POAG, 20 with XFG, and 20 with XFS. The control group consisted of 20 age-matched and sex-matched healthy subjects with no evidence of ocular disease. The Sniffin' Sticks smell test was used to determine the, threshold values, and to assess the ability of smell identification, and differentiation in all patients One eye per patient was included for statistical purposes. One-way analysis of variance was used to compare the differences between the groups. Tukey honestly significant difference was used as a post hoc test when significant differences were detected among the 3 groups. The XFG, POAG, and control groups showed a significant difference in the odor discrimination, odor identification, and threshold discrimination identification scores. The median (minimum-maximum) smell threshold levels for the POAG, XFG, and XFS groups and healthy controls were 4.5 (0 to 7.5), 4 (0 to 7.5), 5 (4.5 to 6), and 5.5 (4 to 7.5), respectively. The smell differentiation values for the POAG, XFG, and XFS groups and healthy controls were 12 (2 to 14), 8 (0 to 13), 11 (10 to 13), and 12 (9 to 14), respectively. Smell sensitivity for the POAG, XFG, and XFS groups and healthy controls were 26 (4 to 30.5), 19 (0 to 29.5), 28.3 (22.8 to 30.5), and 29 (26.5 to 32), respectively. The smell sensitivity and differentiation were significantly different among the groups (P<0.001). The XFG group had a significantly lower smell identification level than the POAG, XFS, and control groups. Patients with XFS and XFG revealed reduced smell sensitivity and identification compared with patients with POAG and those without glaucoma. These findings provide new insights into neural degeneration and pseudoexfoliation.

Exploring sensory phenotypes in autism spectrum disorder

BackgroundAtypical reactions to the sensory environment are often reported in autistic individuals, with a high degree of variability across the sensory modalities. These sensory differences have been shown to promote challenging behaviours and distress in autistic individuals and are predictive of other functions including motor, social, and cognitive abilities. Preliminary research suggests that specific sensory differences may cluster together within individuals creating discrete sensory phenotypes. However, the manner in which these sensory differences cluster, and whether the resulting phenotypes are associated with specific cognitive and social challenges is unclear.MethodsShort sensory profile data from 599 autistic children and adults between the ages of 1 and 21 years were subjected to a K-means cluster analysis. Analysis of variances compared age, adaptive behaviour, and traits associated with autism, attention-deficit and hyperactivity disorder, and obsessive and compulsive disorder across the resultant clusters.ResultsA five-cluster model was found to minimize error variance and produce five sensory phenotypes: (1) sensory adaptive, (2) generalized sensory differences, (3) taste and smell sensitivity, (4) under-responsive and sensation seeking, and (5) movement difficulties with low energy. Age, adaptive behaviour, and traits associated with autism, attention-deficit and hyperactivity disorder, and obsessive and compulsive disorder were found to differ significantly across the five phenotypes.LimitationsThe results were based on parent-report measures of sensory processing, adaptive behaviour, traits associated with autism, attention-deficit and hyperactivity disorder, and obsessive and compulsive disorder, which may limit the generalizability of the findings. Further, not all measures are standardized, or psychometrically validated with an autism population. Autistic individuals with an intellectual disability were underrepresented in this sample. Further, as these data were obtained from established records from a large provincial database, not all measures were completed for all individuals.ConclusionsThese findings suggest that sensory difficulties in autistic individuals can be clustered into sensory phenotypes, and that these phenotypes are associated with behavioural differences. Given the large degree of heterogeneity in sensory difficulties seen in the autistic population, these sensory phenotypes represent an effective way to parse that heterogeneity and create phenotypes that may aid in the development of effective treatments and interventions for sensory difficulties.

Tracking smell loss to identify healthcare workers with SARS-CoV-2 infection.

IntroductionHealthcare workers (HCW) treating COVID-19 patients are at high risk for infection and may also spread infection through their contact with vulnerable patients. Smell loss has been associated with SARS-CoV-2 infection, but it is unknown whether monitoring for smell loss can be used to identify asymptomatic infection among high risk individuals. In this study we sought to determine if tracking smell sensitivity and loss using an at-home assessment could identify SARS-CoV-2 infection in HCW.Methods and findingsWe performed a prospective cohort study tracking 473 HCW across three months to determine if smell loss could predict SARS-CoV-2 infection in this high-risk group. HCW subjects completed a longitudinal, behavioral at-home assessment of olfaction with household items, as well as detailed symptom surveys that included a parosmia screening questionnaire, and real-time quantitative polymerase chain reaction testing to identify SARS-CoV-2 infection. Our main measures were the prevalence of smell loss in SARS-CoV-2-positive HCW versus SARS-CoV-2-negative HCW, and timing of smell loss relative to SARS-CoV-2 test positivity. SARS-CoV-2 was identified in 17 (3.6%) of 473 HCW. HCW with SARS-CoV-2 infection were more likely to report smell loss than SARS-CoV-2-negative HCW on both the at-home assessment and the screening questionnaire (9/17, 53% vs 105/456, 23%, P < .01). 6/9 (67%) of SARS-CoV-2-positive HCW reporting smell loss reported smell loss prior to having a positive SARS-CoV-2 test, and smell loss was reported a median of two days before testing positive. Neurological symptoms were reported more frequently among SARS-CoV-2-positive HCW who reported smell loss compared to those without smell loss (9/9, 100% vs 3/8, 38%, P < .01).ConclusionsIn this prospective study of HCW, self-reported changes in smell using two different measures were predictive of SARS-CoV-2 infection. Smell loss frequently preceded a positive test and was associated with neurological symptoms.

Naphthalene: irritative and inflammatory effects on the airways

ObjectiveThis cross-sectional study determined whether acute sensory irritative or (sub)chronic inflammatory effects of the eyes, nose or respiratory tract are observed in employees who are exposed to naphthalene at the workplace.MethodsThirtynine healthy and non-smoking male employees with either moderate (n = 22) or high (n = 17) exposure to naphthalene were compared to 22 male employees from the same plants with no or only rare exposure to naphthalene. (Sub)clinical endpoint measures included nasal endoscopy, smell sensitivity, self-reported work-related complaints and the intensity of naphthalene odor and irritation. In addition, cellular and soluble mediators in blood, nasal lavage fluid (NALF) and induced sputum (IS) were analysed. All measurements were carried out pre-shift on Monday and post-shift on Thursday. Personal air monitoring revealed naphthalene shift concentrations up to 11.6 mg/m3 with short-term peak concentrations up to 145.8 mg/m3 and 1- and 2-naphthol levels (sum) in post-shift urine up to 10.1 mg/L.ResultsAcute sensory irritating effects at the eyes and upper airways were reported to occur when directly handling naphthalene (e.g., sieving pure naphthalene). Generally, naphthalene odor was described as intense and unpleasant. Habituation effects or olfactory fatigue were not observed. Endoscopic examination revealed mild inflammatory effects at the nasal mucosa of exposed employees in terms of reddening and swelling and abnormal mucus production. No consistent pattern of cellular and soluble mediators in blood, NALF or IS was observed which would indicate a chronic or acute inflammatory effect of naphthalene in exposed workers.ConclusionsThe results suggest that exposure to naphthalene induces acute sensory irritative effects in exposed workers. No (sub)chronic inflammatory effects on the nasal epithelium or the respiratory tract could be observed under the study conditions described here.

Sensory Processing Disorder in Normally Developing Egyptian Children

Background: The aim of this study was to assess the sensory processing among typically developing children between 3-8 years old to follow any negative impact on their social and behavioral development.Objective: The purpose of this study was to Develop and standardize Arabic QuickSIN test that measures the signal-to-noise ratio loss.Patients and Methods: Sensory processing abilities were assessed for 190 typically developing children by using the Short Sensory Profile (SSP)caregiver questionnaire. A typical sensory performance was defined as an SSP total score of: 190-155 and the total scores of typical sensory performances for tactile sensitivity:35-30; taste/smell sensitivity:20-15; movement sensitivity: 15-13; under-responsive/seeks sensation:35-27; auditory filtering:30-23; low energy/weak:30-26; and visual/auditory sensitivity: 25-19. Below these scores shows atypical sensory performance.Results: The typically developed children showed some degree of sensory processing disorderon Under-responsive/seek sensitivity as well as Taste and smell sensitivity. Some children in this study (50.5 %) showed a degree of sensory processing impairment in the SSP total score. An increase in the tactile sensitivity was significantly associated with higher prevalence of the movement sensitivity (r=0.745, p value= <0.001). As for the Pearson correlation between the low energy/weak and the visual/auditory sensitivity is about r=0.698, which indicates that there is a moderate positive relationship between the 2 variables.Conclusion: These findings showed the types of sensory processing disorder in typically developing children and the difference between female and male children. Future studies are required on larger samples to clarify more the types of sensory impairment in typically developing children and to confirm these results.

456. Implementing an At-Home Smell Test for Early Assessment of COVID-19 in High-Risk Healthcare Workers

BackgroundSmell loss has been recognized as an important, and potentially early, sign of COVID-19. However, to date smell loss has only been assessed in retrospective, COVID+ cohorts, and largely through self-report. The objective of this study was to implement a daily standardized behavioral test of smell sensitivity in healthcare workers (HCW) to capture changes in smell sensitivity over time and to assess whether these changes occur prior to positive COVID test.MethodsThe study enrolled 500 high-risk COVID-negative HCW during the COVID-19 epidemic in Connecticut, beginning March 28, 2020 (80% F, mean age 38, 58% nurses). Initially, HCW received a daily symptom questionnaire with parosmia screening questions. On April 23 we introduced the “Jiffy”, a daily at-home psychophysical test of smell sensitivity, where olfactory stimuli are sampled and rated for perceived intensity. SARS-CoV-2 infection was tested every three days by PCR of nasopharyngeal swabs or saliva.Screening Questionnaire for Parosmia The “Jiffy” Survey and Test ResultsOf the first 500 enrolled HCW, 376 HCW (75%) completed the Jiffy 4528 times (mean 12 times/HCW). 17/500 HCW (3.4%) had a COVID+ test, of which 9/17 (53%) reported smell loss through the Jiffy or the daily symptom survey. 6/9 (67%) reported smell loss that preceded or was concurrent with a COVID+ test. 8/17 COVID+ HCW completed the Jiffy, with 5/8 (63%) reporting reductions in smell versus 42/368 (11%) COVID- HCW (OR=13, 95% CI: 2.4–85, p=.001). COVID+ HCW rated their greatest reduction in smell sensitivity as slight (40%) and severe (60%), versus slight (88%) and moderate (12%) in COVID- HCW. 16/17 COVID+ HCW completed a daily symptom survey (mean 14 times/HCW), with 8/16 (50%) ever reporting parosmia versus 90/466 (19%) of COVID- HCW (OR=4.2, 95% CI: 1.3–13, p=.007). Overall, parosmia was the first reported symptom in 3/13 (23%) COVID+ HCW who reported symptoms.Smell Changes in COVID+ and COVID- HCW Reported in the “Jiffy” Test Smell Changes in COVID+ and COVID- HCW Reported in Daily Symptom Questionnaire Smell Changes among COVID+ HCW by Day, Relative to Day of Positive PCR Test ConclusionWe conducted a prospective study of smell testing in a population at high risk for COVID-19 using two parallel approaches. Our results demonstrate the feasibility of at-home smell testing for assessing parosmia during COVID-19, in some cases even prior to a positive PCR result. Given the urgent need for widespread, low-cost, non-invasive testing for COVID-19, we are now developing an easy-to-use app to distribute this survey more widely to high-risk populations.Disclosures Julian J. Weiss, BA, Nothing to disclose

The influence of human factors on 360∘ mulsemedia QoE

Abstract Quality of Experience (QoE) is indelibly linked to the human side of the multimedia experience. Surprisingly, however, there is a paucity of research which explores the impact that human factors has in determining QoE. Whilst this is true of multimedia, it is even more starkly so as far as mulsemedia - applications that involve media engaging three or more of human senses - is concerned. Hence, in the study reported in this paper, we focus on an exciting subset of mulsemedia applications - 360∘ mulsemedia - particularly important given that the upcoming 5G technology is foreseen to be a key enabler for the proliferation of immersive Virtual Reality (VR) applications. Accordingly, we study the impact that human factors such as gender, age, prior computing experience, and smell sensitivity have on 360∘ mulsemedia QoE. Results showed insight into the potential of 360∘ mulsemedia to inspire and to enrich experiences for Generation Z - a generation empowered by rapidly advancing technology. Patterns of prior media usage and smell sensitivity play also an important role in influencing the QoE evaluation - users who have a preference for dynamic videos enjoy and find realistic the 360∘ mulsemedia experiences.

Temporal Profile of Olfactory Dysfunction in COVID-19.

ObjectiveCoronavirus disease 2019 (COVID-19) is associated with olfactory dysfunction, but the evolution of the olfactory loss and timeline to recovery are largely unknown. This study examines changes in smell sensitivity in COVID-19–positive (COVID+) and COVID-19–negative (COVID–) viral illness during the initial weeks after infection.Study DesignCross-sectional cohort comparison.SettingNational anonymous surveys.MethodsSurvey participants were queried about smell sensitivity and general health status at the time of COVID-19 testing and in the weeks that followed.ResultsIn total, 375 (174 COVID+, 201 COVID–) participants completed the survey and 132 (62 COVID+, 70 COVID–) participants completed the 2-week follow-up survey. Normal smell in the COVID+ cohort was less frequent at the time of testing and at follow up (P < .05). Dynamic changes in smell sensitivity in the COVID+ cohort were more frequent in the initial weeks (P < .001). In those with normosmia at the start of infection, 38% of the COVID+ cohort reported worsening smell compared to only 8% in the COVID– cohort (P < .05). Recovery of overall health was associated with normosmia at the time of infection and improvement of smell sensitivity within weeks of infection.ConclusionThe COVID+ cohort showed greater dynamic change in smell sensitivity and a higher rate of persistent olfactory dysfunction in the weeks after infection. Normal smell at the time of COVID-19 infection may still worsen before recovery. Overall health recovery after viral illness is associated with improvement in smell sensitivity and the absence of initial anosmia or hyposmia.