Smart Patch Research Articles

Noggin-Loaded PLA/PCL Patch Inhibits BMP-Initiated Reactive Astrogliosis.

Myelomeningocele (MMC) is a congenital birth defect of the spine and spinal cord, commonly treated clinically through prenatal or postnatal surgery by repairing the unclosed spinal canal. Having previously developed a PLA/PCL polymer smart patch for this condition, we aim to further expand the potential therapeutic options by providing additional cellular and biochemical support in addition to its mechanical properties. Bone morphogenetic proteins (BMPs) are a large class of secreted factors that serve as modulators of development in multiple organ systems, including the CNS. We hypothesize that our smart patch mitigates the astrogenesis induced, at least partly, by increased BMP activity during MMC. To test this hypothesis, neural stem or precursor cells were isolated from rat fetuses and cultured in the presence of Noggin, an endogenous antagonist of BMP action, with recombinant BMPs. We found that the developed PLA/PCL patch not only serves as a biocompatible material for developing neural stem cells but was also able to act as a carrier for BMP-Notch pathway inhibitor Noggin, effectively minimizing the effect of BMP2 or BMP4 on NPCs cultured with the Noggin-loaded patch.

Magnetic Liquid Gating Valve Terminal for Patterned Droplet Generation and Transportation of Highly Viscous Bioactive Fluids.

As an open microfluidic technology with excellent anti-fouling and energy-saving properties, liquid gating technology can selectively separate or transfer multiphase fluids, which has shown great application value in the field of biomedical engineering. However, no study has demonstrated that liquid gating technology has the ability to transfer high-viscosity fluids and biologically active substances, and current liquid gating valves are unable to realize smart-responsive pulsed-patterned transfer, which severely limits their application scope. In this paper, liquid gating technology is combined with magnetically responsive materials to prepare a liquid-based magnetic porous membrane (LMPM) with excellent magnetostatic deformation capability and antifouling properties. On this basis, a magnetic liquid gating valve terminal (MLGVT) with patterning transfer capability is developed, and the feasibility of liquid gating technology for transferring high-viscosity fluids and hydrogel bioinks is explored. Meanwhile, a flexible MLGVT is prepared and realized for targeted drug delivery. This study expands the potential of liquid gating technology for drug delivery, cellular transport and smart patches.

Embedding Ethics in the Implementation of a Vital Sign Monitoring Technology.

The implementation of wireless continuous vital sign monitoring (CVSM) technologies changes daily care practices of healthcare professionals, which gives rise to unknown new roles and responsibilities. In this paper we present a study on how we combine the disciplines of medical informatics and ethics in the implementation of the Philips Healthdot, a smart patch for remote CVSM. The aim of this study is to investigate experiences and perspectives on the support levels and roles and responsibilities associated with the integration of smart patches, by conducting interviews with nurses. This interdisciplinary study gives insights into the technological, organizational, and ethical concerns surrounding the implementation of CVSM in healthcare. The findings and analytical approach may provide valuable insights for researching the appropriate implementation of digital health technologies.

Healthcare and the Internet of Medical Things: Applications, Trends, Key Challenges, and Proposed Resolutions

In recent years, the Internet of medical things (IoMT) has become a significant technological advancement in the healthcare sector. This systematic review aims to identify and summarize the various applications, key challenges, and proposed technical solutions within this domain, based on a comprehensive analysis of the existing literature. This review highlights diverse applications of the IoMT, including mobile health (mHealth) applications, remote biomarker detection, hybrid RFID-IoT solutions for scrub distribution in operating rooms, IoT-based disease prediction using machine learning, and the efficient sharing of personal health records through searchable symmetric encryption, blockchain, and IPFS. Other notable applications include remote healthcare management systems, non-invasive real-time blood glucose measurement devices, distributed ledger technology (DLT) platforms, ultra-wideband (UWB) radar systems, IoT-based pulse oximeters, accident and emergency informatics (A&EI), and integrated wearable smart patches. The key challenges identified include privacy protection, sustainable power sources, sensor intelligence, human adaptation to sensors, data speed, device reliability, and storage efficiency. The proposed mitigations encompass network control, cryptography, edge-fog computing, and blockchain, alongside rigorous risk planning. The review also identifies trends and advancements in the IoMT architecture, remote monitoring innovations, the integration of machine learning and AI, and enhanced security measures. This review makes several novel contributions compared to the existing literature, including (1) a comprehensive categorization of IoMT applications, extending beyond the traditional use cases to include emerging technologies such as UWB radar systems and DLT platforms; (2) an in-depth analysis of the integration of machine learning and AI in IoMT, highlighting innovative approaches in disease prediction and remote monitoring; (3) a detailed examination of privacy and security measures, proposing advanced cryptographic solutions and blockchain implementations to enhance data protection; and (4) the identification of future research directions, providing a roadmap for addressing current limitations and advancing the scientific understanding of IoMT in healthcare. By addressing current limitations and suggesting future research directions, this work aims to advance scientific understanding of the IoMT in healthcare.

Electrically Conducting Hydrogels for Health care: Concept, Fabrication Methods, and Applications.

Electrically conducting hydrogels are gaining increasing attention due to their potential application in smart patches, biosensors, functional tissue engineering scaffolds, wound management, and implants. The current review focuses on these novel materials, their synthesis routes, and their composites. Special attention is paid to fabrication routes to produce functional composites with organic and inorganic components. The design of conductive hydrogels leads to inheritance of the advantages of each component and offers new features from the synergistic effects between the components, thus opening new application areas. The review also discusses the emerging role of 3D printing as an advanced approach toward new design, functionality, and material combination possibilities. The issue of lack of the spatial control with current techniques is highlighted, and possible new routes to solve it are discussed. The review will provide readers with knowledge tool to select appropriate methodology for designing desired hydrogel material composites.

Reliability and Validity of Running Step Rate Derived From a Novel Wearable Smart Patch

Reliability and Validity of Running Step Rate Derived From a Novel Wearable Smart Patch

Kirigami triboelectric spider fibroin microneedle patches for comprehensive joint management

Joint injuries are among the leading causes of disability. Present concentrations were focused on oral drugs and surgical treatment, which brings severe and unnecessary difficulties for patients. Smart patches with high flexibility and intelligent drug control-release capacity are greatly desirable for efficient joint management. Herein, we present a novel kirigami spider fibroin-based microneedle triboelectric nanogenerator (KSM-TENG) patch with distinctive features for comprehensive joint management. The microneedle patch consists of two parts: the superfine tips and the flexible backing base, which endow it with great mechanical strength to penetrate the skin and enough flexibility to fit different bends. Besides, the spider fibroin-based MNs served as a positive triboelectric material to generate electrical stimulation, thereby forcing drug release from needles within 720 min. Especially, kirigami structures could also transform the flat patch into three dimensions, which could impart the patch with flexible properties to accommodate the complicated processes produced by joint motion. Benefiting from these traits, the KSM-TENG patch presents excellent performance in inhibiting the inflammatory response and promoting wound healing in mice models. The results indicated that the mice possessed only 2% wound area and the paw thickness was reduced from 10.5 mm to 6.2 mm after treatment with the KSM-TENG patch, which further demonstrates the therapeutic effect of joints in vivo. Thus, it is believed that the proposed novel KSM-TENG patch is valuable in the field of comprehensive treatments and personalized clinical applications.

Numerical study of free vibration of laminated curved beam with magnetostrictive patches

The present study analyzes the vibrations of a curved laminated beam with magnetostrictive layers and patches for vibration suppression. Hamilton's Principle is used to establish the equations of motion. An analytical solution examines a beam with simply-supported boundaries (H-H), while the finite element method (FEM) considers various boundary conditions (H-H, C-C, and C-F). The analytical solutions incorporate magnetostrictive layers as active controllers, while the FE formulation includes smart patches for wider application. The study also investigates the in-plane stress of a laminate composite layer. Finally, a parametric study demonstrates the accuracy and practicality of the derived formulations.

Smart Patch for Non-Invasive Blood Pressure Monitoring in Epileptic Seizure Patients via the Sole

Epileptic seizures can cause sudden blood pressure changes, requiring continuous monitoring. However, traditional blood pressure monitoring methods are often invasive and uncomfortable for the patient. In addition, it is difficult to measure blood pressure during seizures. This research aims to design a non-invasive, comfortable device to monitor blood pressure during epileptic seizures continuously. Photoplethysmography (PPG) signals from the sole of the patient's foot were used to extract blood pressure data. A smart patch was designed to be worn comfortably on foot for continuous monitoring during seizures. The results show that the average systolic and diastolic blood pressure errors were 2.838 and 4.494 mmHg during epileptic seizures, respectively. These blood pressure changes could be related to the onset of seizures, suggesting that the device and methodology could be combined with other measures to analyze and predict seizure activity. This research offers a non-invasive and comfortable solution for continuous blood pressure monitoring during seizures, which may affect seizure prediction and management.

Smart Patch repair solution for cure monitoring of bonded repairs in composite aircraft structures

Composite repair solutions are applied to recover the strength and functionality of composite structures in service without having to replace the whole structural part which is impractical for large sections. However, such bonded repairs are still not implemented in primary aircraft structures given the inability to provide repeatable results, ensure uniform bondline and the absence of nondestructive testing methods for detecting poor bond. In this paper, a dielectric-based technique is proposed to monitor the curing of composite bonded repairs based on Impedance Spectroscopy using smart patches embedded in the laminate by relying on drop-on-demand inkjet printed circuits which provided indicators of the polymer's curing stage whilst introducing minimal thickness in the bondline. The inkjet printed circuit is bonded to the composite plates using a newly developed procedure for high-level applications. The experimental campaign followed a building block approach to iteratively upscale the information from single printed IDTs in polymeric films to large circuits bonded to repaired composite parts with multiple tracks and IDTs. Numerous parameters were explored with the respective influence on the cure monitoring procedure of the thermoset adhesive layer, like the IDT design, the presence of imperfections at the bondline and instrumentation noise. Finally, the embedded smart patch was successfully employed for the detection of multiple impact damages and respective severity on the repair patch.

Swift 4D printing of thermoresponsive shape-memory polymers using vat photopolymerization

Shape-memory polymers (SMPs) are smart materials that have gained significant attention in recent years owing to their widespread application in smart structures and devices. Digital light processing (DLP), a vat-photopolymerization-based technique, is a significantly faster technology for printing a complete layer in a single step. The current study reports a facile and fast method for the 3D printing of SMP-based smart structures using a DLP 3D printer and a customized resin. A liquid crystal (LC, RM257) was combined with the resin to introduce shape-memory properties. The combination of LCs in photocurable resin provides the opportunity to directly 3D-print thermoresponsive structures, avoiding the complexity of SMP resin preparation. The structures were printed with different geometries, and the shape-memory response was measured. Lattice structures were fabricated and programmed to obtain tunable mechanical properties. Furthermore, the strain-sensing response was measured to demonstrate the utility of these lattice structures as smart patches for joint-movement sensing. The SMPs can be prepared conveniently and can potentially be used for various applications, such as smart tools, toys, and meta-material sensors.

Fully Printed Flexible Zinc Oxide Patch for Wearable UV Light Sensing

AbstractMetal oxide materials are widely adopted in UV sensing due to their advantages of reliability, stability, and high sensitivity. However, the fabrication of metal oxide films on flexible substrates using micro/nano printing techniques still poses challenges. Notably, inks containing oxide nanoparticles often lead to nozzle clogging during the printing process. In addition, methods relying on precursor solutions typically require high post‐processing temperatures that conventional flexible substrates cannot withstand. In this study, a novel precursor ink based on zinc amine hydroxide complexes is proposed, enabling post‐processing at a low temperature of 250 °C. Through a fully printed approach, a wearable UV sensor based on a zinc oxide nanofilm on a flexible substrate is successfully fabricated. The sensor exhibits outstanding sensitivity and rapid response characteristics. By incorporating silver nanoparticles into the ink, the baseline resistance of the sensitive material is adjusted. Furthermore, a smart patch utilizing the NFC communication protocol is developed, allowing for wireless, passive, and wearable UV detection. In this study, a process paradigm for fabricating metal oxide films on flexible substrates using micro/nano printing techniques is introduced, showcasing significant potential in the field of micro/nano sensor fabrication.

Incorporating Wireless Strategies to Wearable Devices Enabled by Photocurable Hydrogel for Monitoring Pressure Information.

Advances in emerging technologies for wireless collection and the timely analysis of various information captured by wearable devices are of growing interest. Herein, we propose a crosslinked ionic hydrogel prepared by a facile photocuring process, that allows wearable devices to be further incorporated into two wireless integrated systems for pressure monitoring applications. The device exhibits a simplified structure by effectively sharing functional layers, rather than conventional two separate combinations, offering the salient performance of iontronic sensing and electrochromic properties to simultaneously quantify and visualize pressure. The developed smart patch system was demonstrated to monitor physiological signals in real-time using the user interface of remote portable equipment with Bluetooth protocol and on-site electrochromic displays. Moreover, a passive wireless system based on the magnetic coupling effect was designed, which could operate free from the battery and simultaneously acquire multiple pressure information. It is envisioned that the strategies would hold enormous potential for flexible electronics, versatile sensing platforms and wireless on-body networks. This article is protected by copyright. All rights reserved.

ELSAH (electronic smart patch system for wireless monitoring of molecular biomarkers for healthcare and wellbeing): definition of possible use cases.

The ELSAH (electronic smart patch system for wireless monitoring of molecular biomarkers for healthcare and wellbeing) project has received funding from EU's Horizon 2020 research and innovation program (grant agreement no. 825549). Its aim is to develop a wearable smart patch-based microneedle sensor system that can simultaneously measure several biomarkers in users' dermal interstitial fluid. This system could have several use cases based on continuous glucose and lactate monitoring: early detection of (pre-) diabetes mellitus, increasing physical performance through optimal carbohydrate intake, achieving a healthier lifestyle through behavioral changes based on the interpretation of glucose data, performance diagnostics (lactate threshold test), control of optimal training intensities corresponding with certain lactate levels, or warning of diseases/health threats, such as the metabolic syndrome or sepsis associated with increased lactate levels. The ELSAH patch system has a high potential of increasing health and wellbeing in users.

Supercooled Liquid Ga Stretchable Electronics

AbstractBy controlling the properties of its medium, supercooled liquid Ga (SLGa) based stretchable remains stretchable at −22 °C, i.e., 52 °C below its thermodynamic melting point of Ga. Thus far, our oldest deposited SLGa circuit and film have remained liquids for 2 years at room temperature. The study investigates the crystallization of SLGa triggered by the surface energy of nucleation agents, temperature, circuit cross‐section, and mechanical impact. Based on these parameters, a method is presented to integrate electronic components with SLGa circuits without compromising its supercooling effect. Further, the large stiffness variation induced by phase transition is demonstrated in different applications. For the desired stiffness variation, the crystallization rate can be controlled by varying the temperature and cross‐section area. Finally, spray‐printing an ink of microscale SLGa microscale particles can conformally pattern Ga on a rough surface, e.g., to fabricate a stretchable array of SLGa microelectrodes. A smart patch with stretchable SLGa electrode arrays records human electrocardiogram signals in cold water and does not stain the skin after use. Its low and stable impedance in water will enable novel applications in wearable electronics.

Use of smart patches by athletes: A concise SWOT analysis.

OPINION article Front. Physiol., 22 March 2023Sec. Exercise Physiology Volume 14 - 2023 | https://doi.org/10.3389/fphys.2023.1055173

A Novel Snore Detection and Suppression Method for a Flexible Patch With MEMS Microphone and Accelerometer

Sleep apnea impacts more and more people all over the world, and obstructive sleep apnea of which is the most frequent. Hence, research on snoring detection and related suppression methods is extremely urgent. In this article, a novel low-cost flexible patch with MEMS microphone and accelerometer is developed to detect snore event and sleeping posture, and a small vibration motor embedded in the patch is designed to suppress snoring. Theoretical analyses of short-time energy, piecewise average filtering (PAF), and Mel-frequency cepstral coefficients (MFCCs) processing are described in detail, and the improved MFCCs are put forward and used as the input of the convolutional neural network (CNN). Furthermore, the snore recognition method based on the combination of similarity analysis and CNN analysis is presented, followed by the snoring suppression method. Experimental results demonstrate that the main features of the sound signals can be extracted effectively by PAF and MFCCs processing, and the data compression ratio is about 99.41%. Besides, the locations of the eigenvectors can be found accurately based on short-time energy analysis. The numbers of high similarity of snoring signals within 30 s are larger than 3, while those of non-snoring signals are often less than 3. If the preliminary screening with similarity analysis is passed, CNN analysis will be conducted to judge whether there are snoring events. The accuracy of snore recognition with CNN analysis is calculated to be as high as 99.25%. Finally, the average snoring time measured by the smart patch with snoring suppression is reduced to 15 from 135 min, which indicates that the proposed snore recognition and suppression methods are effective.

Ultralight Smart Patch with Reduced Sensing Array Based on Reduced Graphene Oxide for Hand Gesture Recognition

Flexible sensors for hand gesture recognition and human–machine interface (HMI) applications have witnessed tremendous advancements during the last decades. Current state‐of‐the‐art sensors placed on fingers or embedded into gloves are incapable of fully capturing all hand gestures and are often uncomfortable for the wearer. Herein, a flake‐sphere hybrid structure of reduced graphene oxide (rGO) doped with polystyrene (PS) spheres is fabricated to construct the highly sensitive, fast response, and flexible piezoresistive sensor array, which is ultralight in the weight of only 2.8 g and possesses the remarkable curved‐surface conformability. The flexible wrist‐worn device with a five‐sensing array is used to measure pressure distribution around the wrist for accurate and comfortable hand gesture recognition. The intelligent wristband is able to classify 12 hand gestures with 96.33% accuracy for five participants using a machine learning algorithm. To showcase our wristband, a real‐time system is developed to control a robotic hand via the classification results, which further demonstrates the potential of this work for HMI applications.

Exosomes of mesenchymal stem cells delivered from methacrylated hyaluronic acid patch improve the regenerative properties of endothelial and dermal cells.

Wound care management urgently needs the development of innovative smart wound dressings. The complexity of the wound often requires the use of personalized medication and the advent of three-dimensional (3D) bioprinting fits strongly with this need. In this view, in the present work a methacrylated hyaluronic acid (MeHA) bioink was tested for the fabrication of advanced smart patches as a delivery system of exosomes derived from human mesenchymal stem cells (hMSC-EXOs) suitable for wound healing purposes. MeHA patches were realized by 3D bioprinting technique and they were loaded with hMSC-EXOs. The 3D printed MeHA patches revealed improved mechanical performance, appropriate swelling ratio, extended degradation time, and suitable biocompatibility. Furthermore, MeHA patches loaded with hMSC-EXOs improved the proliferation, migration, angiogenic ability, and expression of specific markers related to wound healing process in human fibroblasts and human endothelial cells.

Lasered Graphene Microheaters Modified with Phase-Change Composites: New Approach to Smart Patch Drug Delivery.

The combination of paraffin wax and O,O′-bis(2-aminopropyl) polypropylene glycol–block–polyethylene glycol–block–polypropylene glycol was used as a phase-change material (PCM) for the controlled delivery of curcumin. The PCM was combined with a graphene-based heater derived from the laser scribing of polyimide film. This assembly provides a new approach to a smart patch through which release can be electronically controlled, allowing repetitive dosing. Rather than relying on passive diffusion, delivery is induced and terminated through the controlled heating of the PCM with transfer only occurring when the PCM transitions from solid to liquid. The material properties of the device and release characteristics of the strategy under repetitive dosing are critically assessed. The delivery yield of curcumin was found to be 3.5 µg (4.5 µg/cm2) per 3 min thermal cycle.