Bubble aeration is a significant consumer of energy in wastewater treatment processes. Optimizing oxygen transfer, from an energy usage perspective, is crucial in the development of clean production techniques and for the stimulation of the circular economy. Although large efforts have been made in enhancing this process, particularly in ameliorating bubble diffusers, a main problem lies in energy wastage due to over-pursuing ultra-fine bubble generation. In this study, a dynamic model, that integrated both bubble expansion and detachment at submerged orifices, and consequential oxygen utilization during the uprising, was developed in order to better facilitate energy savings during the control of bubble generation. We demonstrate through calibrated models that bubble formation is governed by many factors including gas flow rate, orifice radius, surface tension, liquid viscosity, and surface wettability. Small bubbles are more prone to form when subjected to conditions of high wettability, small orifice size and low flow rate, since the bubbles are easily detached by the increasing upward forces in these scenarios. The oxygen transfer during the rising process was calculated as a function of bubble size, gas type and water depth. Bubbles with a radius smaller than a threshold value can shrink and collapse while below the water surface and thus provide 100% oxygen utilization. The threshold values of bubble radius are determined to be 150 μm and 250 μm at 5 m and 15 m initial water depth, respectively. The parameter set for bubble generation in order to obtain the desired bubble size may then be inversely determined by our bubble formation model, and it's considered as optimal aeration strategy to realize precise aeration. With these results, our study highlights the viability of the approach employing the proposed model in order to direct energy-efficient bubble generation.