The development of efficient in-situ resource utilizsation (ISRU) processes to generate oxygen on the Moon will be essential for enabling human exploration of the Moon and the wider solar system. In this talk, we will look at electrochemical studies on two different approaches to this goal. The first approach involves the electro-deoxidation of powdered lunar regolith by a Metalysis-FFC-Cambridge approach to produce oxygen and metal alloys (Planet. Space Sci. 2020, 180, 104748; Planet. Space Sci. 2022, 211, 105408). The resulting metallic powder was found to contain only a very small percentage of oxygen (a portion of which was due to post electrolysis surface re-oxidation) and to consist primarily of Al/Fe(-Si), Fe/Si(-Ti/Al), and Ca/Si/Al(-Mg) alloys. In the second half of the talk, we will examine the efficiency of water electrolysis (and specifically of the oxygen evolving half-reaction) under reduced gravity levels, including lunar gravity, and we will discuss the prospects that these results present for performing electrolysis of water to generate oxygen on the Moon (Nat. Commun. 2022, 13, 583). Figure 1