Small Package Research Articles

Design of high voltage power supply for SINEW mask

Abstract. Electrostatic Precipitation (ESP) is an effective method of removing particulates from the air. It is currently used in many large-scale industrial applications but sees little to no use in smaller-scale use-cases due to the difficulty of generating high voltage in small packages and safety concerns. This paper presents the motivation, design, and evaluation of a miniature DC high voltage (HVDC) power supply for application in small-scale ESP systems. The power supply's potential for portable ESP application is tested on The Smart, Individualized, Noncontact, Extended-Wear (SINEW) mask. The results show that the power supply operates with acceptable efficiency and generates the necessary high voltages and power necessary to drive ESP even on non-optimized geometries.

Unlocking the potential of Extracellular Vesicles in Nephrology – what does MISEV2023 add?

Extracellular vesicles, small membrane-bound packages secreted by virtually all cells of the body, have become a focus of interest in Nephrology over the recent years. After the first characterization of their proteomic and transcriptomic content, the scientific attention shifted towards their potential as biomarkers for kidney diseases both as diagnostic and monitoring tools. More recently, researchers have begun exploring whether extracellular vesicles mediate intercellular signaling inside the nephron and between the kidney and other organs throughout the body. Nevertheless, the field of extracellular vesicle research has struggled to translate major findings to the clinical context due to numerous methods to separate extracellular vesicles yielding fractions of different sizes and varying purity, unclear terminology, and, hence, limitations concerning reproducibility. The International Society of Extracellular Vesicles, therefore, has striven to reduce these barriers by an ongoing initiative to increase rigor and standardization of extracellular vesicle research. The “Minimal information for studies of extracellular vesicles” MISEV-guideline is the result of this initiative and, in its now 3rd iteration, provides the most concise suggestions for investigating extracellular vesicles to date. This mini review illustrates the advances made in extracellular vesicle research in nephrology so far using informative examples, outlines the advances made by the former MISEV guidelines and what potential utilizing the latest iteration holds.

Wire Bond Ability Enhancement of 8 Leads Small Outline Integrated Circuit and 14 Leads Thin Shrink Small Outline Package Using AuPd Coated Cu Wire Bonding for Automotive Devices

Paper present a study enhancement of wire bonding process in the integrated circuit package with 2N AuPd coated Cu wire (2N-AuPdCu) for Automotive devices. Wire bonding is the electrical connection between pad and leadframe. In present, Au wire is recently use for interconnection while the gold price still exorbitant and caused concern to the wire bonding cost. Cu wire is a lower price and considered to be an alternative for the interconnection but still concern in term of corrosion and reliability. Recently, 4N AuPd coated Cu wire (4N-AuPdCu) material have been introduced for automotive device but still encounter the reliability problem. The 2N AuPd coated Cu wire was developed version for more reliability enhancement and consider to use for alternative wire of automotive device. In the experiment, Au wire, 4NAuPdCu wire and 2N AuPd coated Cu wire were used for wire bonding process on 8 leads Small Outline Integrated Circuit Package (8L-SOIC) and 14 leads Thin Shrink Small Outline Package (14L-TSSOP) to compare wire bond ability. Analysis, this package tested wire bond ability and reliability. The results performed well in wire bond ability and reliability for 2N AuPd coated Cu wire when comparing with Au wire and 4N AuPd coated Cu wire. Therefore, 2N AuPd coated Cu wire can enhance the quality and reliability for 8L-SOIC package and 14L-TSSOP package for automotive device.

Delivering large genes using adeno-associated virus and the CRE-lox DNA recombination system.

Adeno-associated virus (AAV) is a safe and efficient gene delivery vehicle for gene therapies. However, its relatively small packaging capacity limits its use as a gene transfer vector. Here, we describe a strategy to deliver large genes that exceed the AAV's packaging capacity using up to four AAV vectors and the CRE-lox DNA recombination system. We devised novel lox sites by combining non-compatible and reaction equilibrium-modifying lox site variants. These lox sites facilitate sequence-specific and near-unidirectional recombination of AAV vector genomes, enabling efficient reconstitution of up to 16kb of therapeutic genes in a pre-determined configuration. Using this strategy, we have developed AAV gene therapy vectors to deliver IFT140, PCDH15, CEP290, and CDH23 and demonstrate efficient production of full-length proteins in cultured mammalian cells and mouse retinas. Notably, AAV-IFT140 gene therapy vectors ameliorated retinal degeneration and preserved visual functions in an IFT140-associated retinitis pigmentosa mouse model. The CRE-lox approach described here provides a simple, flexible, and effective platform for generating AAV gene therapy vectors beyond AAV's packaging capacity.

Evaluating Reduced-Order Urban Wind Models for Simulating Flight Dynamics of Advanced Aerial Mobility Aircraft

Advanced Aerial Mobility (AAM) platforms are poised to begin high-density operations in urban areas nationwide. This new category of aviation platforms spans a broad range of sizes, from small package delivery drones to passenger-carrying vehicles. Unlike traditional aircraft, AAM vehicles operate within the urban boundary layer, where large structures, such as buildings, interrupt the flow. This study examines the response of a package delivery drone, a general aviation aircraft, and a passenger-carrying urban air mobility aircraft through an urban wind field generated using Large Eddy Simulations (LES). Since it is burdensome to simulate flight dynamics in real-time using the full-order solution, reduced-order wind models are created. Comparing trajectories for each aircraft platform using full-order or reduced-order solutions reveals little difference; reduced-order wind representations appear sufficient to replicate trajectories as long as the spatiotemporal wind field is represented. However, examining control usage statistics and time histories creates a stark difference between the wind fields, especially for the lower wing-loading package delivery drone where control saturation was encountered. The control saturation occurrences were inconsistent across the full-order and reduced-order winds, advising caution when using reduced-order models for lightly wing-loaded aircraft. The results presented demonstrate the effectiveness of using a simulation environment to evaluate reduced-order models by directly comparing their trajectories and control activity metrics with the full-order model. This evaluation provides designers valuable insights for making informed decisions for disturbance rejection systems. Additionally, the results indicate that using Reynolds-averaged Navier–Stokes (RANS) solutions to represent urban wind fields is inappropriate. It was observed that the mean wind field trajectories fall outside the 95% confidence intervals, a finding consistent with the authors’ previous research.

A Paradigm Shift in Cross-Border E-Commerce Regulatory Compliance: Evidence From Brazil

Cross-border e-commerce data quality and taxation pose a challenge for customs administrations worldwide. The increased volume of transactions involving small packages addressed to individuals has led to more precise controls, imposing a new dynamic in the need to receive accurate data. Globalisation has reached individuals actively participating in international trade as direct importers and exporters, made scalable by the platform-type digital business model. This study uses a qualitative approach to analyse Brazil’s Programa Remessa Conforme (Compliant Shipment Program), implemented by companies that treat small parcels in Brazil. It illustrates the program’s contribution to improving data quality, controls, and better allocation of human and technological resources in risk management, stimulating good practices and contributing to tax collection. Our findings also hold practical applications that can be used by other emerging markets facing similar issues in managing the risk associated with small packages.

Development of an Extremely Small Power Chip Size Package for Wide Bandgap Power Semiconductors and Its Evaluation and Analysis

Development of an Extremely Small Power Chip Size Package for Wide Bandgap Power Semiconductors and Its Evaluation and Analysis

Research on performance of porous scaffold-based getter activated by induction heating and its application in MEMS device

Non-evaporable getter (NEG) is widely used in vacuum packaging. However, there are two main contradictions. Firstly, the contradiction between bonding temperature of the device and activation temperature of the getter results in the getter being activated first and then packaged, and cannot be repeatedly activated, which seriously reduces the adsorption capacity and life of the getter. Secondly, the contradiction between the small package volume and the large adsorption capacity, how to integrate large adsorption capacity getter in a small space is a tricky problem. In view of the above contradictions, a porous scaffold-based getter activated by induction heating was proposed in this paper, results show that when nickel plating is used as the induction heating layer, the temperature can quickly rise to 700 °C within 10 s, and 1 μm Ti getter can be fully activated for 7 min. The good periodicity of the temperature curves proved that the nickel layer has good repeatable heating characteristics. In addition, the adsorption performance of the getter was tested and characterized at device level. The device level characterization of optical deflection method proves the effectiveness of induction heating to activate getter, which lays a foundation for the application of getter on MEMS devices.

Drivers of Pharmaceutical Compounding: Regional Experience Analysis Using Irkutsk Pharmacy Organisations as a Case Study

INTRODUCTION. National pharmacy compounding is a priority for providing the population with medicinal products, particularly the medicinal products lacking in the Russian Federation. Investigating opportunities to improve the operation of compounding pharmacies in the Russian Federation remains essential, especially in the context of the developing personalised approach to treatment, growing practice of orphan drug development, and import substitution needs.AIM. This study aimed to identify the factors driving the development of compounding pharmacies under the current conditions.MATERIALS AND METHODS. The study focused on the Russian regulatory framework for pharmacy compounding, as well as the range of dosage forms and administration routes of the medicinal products that had been produced and packaged by the compounding pharmacies in Irkutsk in 2021–2023.RESULTS. This study showed a demand for compounded medicinal products among both healthcare providers and patients. These medicinal products covered a traditional range of compounded medicines, including custom formulae, medicines for paediatrics and geriatrics, stock preparations, and pharmacy-packaged items. In 2021–2023, the mean annual production of Irkutsk pharmacy organisations amounted to ~500,000 units of compounded medicinal products, with a variety of doses and dosage forms. The medicinal products were compounded using ~100 different active substances and over 20 approved medicinal products. This study examined the evolution of Russian pharmacy compounding legislation. The key aspects included the establishment of a pharmaceutical quality system for compounded medicinal products, the extension of shelf life for specific dosage forms, and the authorisation to use medicinal products approved in the Eurasian Economic Union in compounding. The study showed that the main factors driving the operation of compounding pharmacies were the ongoing regulatory framework transformation and the transition from standardised treatment to personalised medicine. The main impediments for compounding pharmacies included the lack of state support, the ban on compounding medicinal products produced by pharmaceutical companies, the shortage of skilled staff, the inadequate supply of equipment (first of all, production machinery), the poor availability of active substances and excipients in small packages, and the challenges associated with regulatory control and oversight over the quality of compounded medicinal products.CONCLUSIONS. Further stimulation of the active development of compounding pharmacies requires further investigation into their operation in other regions, which will help to develop legal arrangements for the federal and regional state support of compounding pharmacies, procure up-to-date materials and equipment, and train the staff for compounding pharmacies.

The therapeutic implications of all-in-one AAV-delivered epigenome-editing platform in neurodegenerative disorders

Safely and efficiently controlling gene expression is a long-standing goal of biomedical research, and CRISPR/Cas system can be harnessed to create powerful tools for epigenetic editing. Adeno-associated-viruses (AAVs) represent the delivery vehicle of choice for therapeutic platform. However, their small packaging capacity isn’t suitable for large constructs including most CRISPR/dCas9-effector vectors. Thus, AAV-based CRISPR/Cas systems have been delivered via two separate viral vectors. Here we develop a compact CRISPR/dCas9-based repressor system packaged in AAV as a single optimized vector. The system comprises the small Staphylococcus aureus (Sa)dCas9 and an engineered repressor molecule, a fusion of MeCP2’s transcription repression domain (TRD) and KRAB. The dSaCas9-KRAB-MeCP2(TRD) vector platform repressed robustly and sustainably the expression of multiple genes-of-interest, in vitro and in vivo, including ApoE, the strongest genetic risk factor for late onset Alzheimer’s disease (LOAD). Our platform broadens the CRISPR/dCas9 toolset available for transcriptional manipulation of gene expression in research and therapeutic settings.

Ultrathin Small Outline Package Key Techniques for High-Speed Chips with Multi-Leads.

The key technologies for the ultrathin small outline package (TSOP) of large-sized high-speed chips have been designed and developed in this paper. The designing techniques, such as a 25 µm precise positioning dice attaching technique, a lead frame unit structure without a base island, and a lead co-plane layout inside the frame, were developed. The TSO package outline with a large number of leads, a frame unit arrangement, and a frame distribution with a base island and without one were improved. The technological problems, including the reduction in thickness, wafer cutting, chip sticking bonding, and plastic sealing, were successfully solved. The designed large-sized package products have many advantages, such as high availability, low cost, high reliability, and a short production cycle. This package technique can be widely used in various intellectual application regions.

Deciphering Factors Contributing to Cost-Effective Medicine Using Machine Learning.

This study uses machine learning to identify critical factors influencing the cost-effectiveness of over-the-counter (OTC) medications. By developing a novel cost-effectiveness rating (CER) based on user ratings and prices, we analyzed data from Amazon. The findings indicate that Flexible Spending Account (FSA)/Health Savings Account (HSA) eligibility, symptom treatment range, safety warnings, special effects, active ingredients, and packaging size significantly impact cost-effectiveness across cold, allergy, digestion, and pain relief medications. Medications eligible for FSA or HSA funds, treating a broader range of symptoms, and having smaller packaging are perceived as more cost-effective. Cold medicines with safety warnings were cost-effective due to their lower average price and effective ingredients like phenylephrine and acetaminophen. Allergy medications with kid-friendly features showed higher cost-effectiveness, and ingredients like calcium, famotidine, and magnesium boosted the cost-effectiveness of digestion medicines. These insights help consumers make informed purchasing decisions and assist manufacturers and retailers in enhancing product competitiveness. Overall, this research supports better decision-making in the pharmaceutical industry by highlighting factors that drive cost-effective medication purchases.

Application of material flow cost accounting (MFCA) in waste reduction: a case study on small and medium-scaled enterprise (SME) corrugation packages industry

Application of material flow cost accounting (MFCA) in waste reduction: a case study on small and medium-scaled enterprise (SME) corrugation packages industry

The Little Book of Trees

From the publisher: Packed with surprising facts, this delightful and gorgeously designed book will beguile any nature lover. Expertly written and beautifully illustrated throughout with color photographs and original color artwork, The Little Book of Trees is an accessible and enjoyable mini-reference about the world’s trees, with examples drawn from across the globe. It fits an astonishing amount of information in a small package, covering a wide range of topics—from tree anatomy, diversity, and architecture to habitat and conservation. It also includes curious facts and a section on trees in myths, folklore, and modern culture from around the world. The result is an irresistible guide to the amazing lives of trees.

Transport Service Website

Abstract— ShipEx Transport is an awesome website that offers a wide range of shipping services.They specialize in transporting goods by ship, providing efficient and reliable solutions for both domestic and international shipping needs. Whether you need to transport large cargo or small packages, ShipEx has got you covered. Their website provides all the information you need about their services, including rates, tracking options, and customer reviews. It’s a convenient and trustworthy platform for all your shipping needs.

TRANSPORT SERVICE WEBSITE

Abstract: Transport is an awesome website that offers a wide range of shipping services. They specialize in transporting goods by ship, providing efficient and reliable solutions for both domestic and international shipping needs. Whether you need to transport large cargo or small packages, ShipEx has got you covered. Their website provides all the information you need about their services, including rates, tracking options, and customer reviews. It’s a convenient and trustworthy platform for all your shipping needs. Online transportation service has become a means of transportation development which able to attract people’s interest. This research explores the development and implementation of an intelligent transportation services website aimed at optimizing transportation services. Leveraging advanced algorithms, real-time data integration, and user-centric design, our platform facilitates seamless connections between various transportation modes, providing users with personalized, efficient, and sustainable goods transport options. Our findings highlight the positive impact of inclusive design on user satisfaction, accessibility, and overall usability, contributing to the broader discourse on creating equitable transportation solutions. This research explores the integration of augmented reality (AR) to improve user experience on transportation services websites. By overlaying real-time information onto the physical environment, our AR-enhanced platform provides users with intuitive navigation and enhanced situational awareness. We will ensure interactions and experience is top notch for the users. Index Term-: Management Processes, Transport Services, Strategic Functions, HTML, CSS, PHP.

Contraband detection of millimeter wave image for postal security checks using a spatial transformer-feature fusion network

The image resolution and contraband object detection accuracy are the two key factors for security checks based on millimeter wave imaging techniques. In this paper, a homemade real-time millimeter imaging system for small package security inspection is used to obtain about 400 raw images of envelopes containing multi-contraband objects like guns and knives. After pre-processing, spatial transformer-feature fusion (ST-FF) adapted single-shot multi-box detector (SSD) networks are used to detect the contraband objects of postal packages. The experiments reveal that the spatial-transformed-feature fusion deep learning networks demonstrate better mean average precision (mAP) performance than traditional single networks in detecting contraband objects of different scales, orientations, and distortions, and prove the great potential for security checks based on millimeter wave imaging.

Hot gas impingement and radiation on neighboring surfaces from venting and combustion in a package of 18650 cells

A quasi-steady, CFD-based modeling approach is employed to investigate the heat loading within a small package of twenty-five 18650 Li-ion cells. The quasi-steady approach allows for computationally efficient simulations to capture the compressible and turbulent flow field through the safety vent structure and out into the space surrounding a failing cell. Combustion of vent gases leads to high heat loading on neighboring cells and nearby surfaces. Heat transfer mechanisms within the enclosure include convection from hot gases, radiation from the participating medium, and radiation exchange between surfaces. Simulations provide insight into the magnitude of each heat transfer mechanism, and the spatial distribution of heat flux on nearby cells and surfaces within the pack. The complex geometry of the safety vent geometry resulted in an asymmetric jet flow pattern, which induces highly localized impingement heat transfer on specific cells within the enclosure. Radiation from hot surfaces was more significant than radiation from hot gases and soot to neighboring cells. The quasi-steady simulations may be used in the future to develop reduced-order heat transfer models that include the effects of venting and combustion on propagating failure.

Vertical Takeoff and Landing for Distribution of Parcels to Hospitals: A Case Study about Industry 5.0 Application in Israel’s Healthcare Arena

To gain a sustained competitive advantage, organizations such as UPS, Fedex, Amazon, etc., began to seek for industry 5.0 innovative autonomous delivery options for the last mile. Autonomous unmanned aerial vehicles are a promising alternative for the logistics industry. The fact that drones are propelled by green renewable energy source fits the companies’ need to become sustainable, replacing their fuel truck fleets, especially for traveling to remote rural locations to deliver small packages, but a major obstacle is the necessity for charging stations which is well documented in the literature. Therefore, the current research embarks on devising a novel yet practical piece of technology adopting the simplicity approach of direct flights to destinations. The analysis showcases the application for a network of warehouses and hospitals in Israel while controlling costs. Given the products in the case study are medical, direct flight has the potential to save lives when every moment counts. Hydrogen cell technology allows long-range flying without refueling, and it is both vibration-free which is essential for sensitive medical equipment and environmentally friendly in terms of air pollution and silence in urban areas. Importantly, hydrogen cells are lighter, with higher energy density than batteries, which makes them ideal for drone usage to reduce weight, maintain a longer life, and enable faster charging, all of which minimize downtime. Also, hydrogen sourcing is low-cost and unlimited compared to lithium-ion material which needs to be mined. The case study investigates an Israeli entrepreneurial company, Gadfin, which builds a vertical takeoff-and-landing-type of drone with folded wings that enable higher speed for the delivery of refrigerated medical cargo, blood, organs for transplant, and more to hospitals in partnership with the Israeli medical logistic conglomerate, SAREL. An analysis of shipping optimization (concerning the number and type of drone) is conducted using a mixed-integer linear programming technique based on various types of constraints such as traveling distance, parcel weight, the amount of flight controllers and daily number of flights allowed in order to not overcrowd the airspace. Importantly, the discussion assesses the ecosystem’s variety of risks and commensurate safety mechanisms for advancing a newly shaped landscape of drones in an Israeli tight airspace to establish a network of national routes for drone traffic. The conclusion of this research cautions limitations to overcome as the utilization of drones expand and offers future research avenues.

A compact self-powered inductor-less piezoelectric energy harvesting circuit using gyrator

In traditional low-frequency energy harvesting circuits, a large matched inductor with a large size is unavoidable. To reduce the size of the circuit, this paper proposes a compact self-powered inductor-less high-efficiency piezoelectric energy harvesting circuit using a low-power-consumption gyrator. A self-powered floating gyrator inductor is used in place of an inductor in the proposed circuit, and the required phasor response is acquired by using its voltage–current (V–I) relationship. The proposed circuit offers easy adjustability and performance benefits in small integrated circuits packages. The proposed circuit can be cost-effective and provide reduced area advantages in autonomous self-powered Internet-of-Things and wireless sensor nodes applications. Regarding harvested energy, the proposed circuit with a storage capacitor of 0.24 F can obtain 320% improved performance than standard energy harvesting along with the lowest power consumption of 0.25 µW in self-powered operation. The proposed technique can also be applied to similar piezoelectric energy harvesting strategies with large inductors.