Small Medical Datasets Research Articles

Evaluation of conventional and quantum computing for predicting mortality based on small early-onset colorectal cancer data

BackgroundQuantum computing integrated with machine learning (ML) offers novel solutions in various fields, including healthcare. The synergy between quantum computing and ML in classification exploits unique data patterns. Despite theoretical advantages, the empirical application and effectiveness of quantum computing on small medical datasets remains underexplored. MethodThis retrospective study from a tertiary hospital used data on early-onset colorectal cancer with 93 features and 1501 patients from 2008 to 2020 to predict mortality. We compared quantum support vector machine (QSVM) models with classical SVM models in terms of number of features, number of training sets, and outcome ratio. We evaluated the model based on the area under the curve in the receiver operating characteristic curve (AUROC). ResultsWe observed a mortality rate of 7.6 % (96 of 1253 subjects). We generated the mortality prediction model using 11 clinical variables, including cancer stage and chemotherapy history. We found that the AUROC difference between the conventional and quantum methods was the maximum for the top 11 variables. We also showed the AUROC in QSVM (mean [standard deviation], 0.863 [0.102]) outperformed all the number of trials in the conventional SVM (0.723 [0.231]). Compared to the conventional SVM, the QSVM showed robust performance, consistent with the AUROC, even in the unbalanced case. ConclusionOur study highlights the potential of quantum computing to improve predictive modeling in healthcare, especially for rare diseases with limited available data. The advantages of quantum computing, such as the exploration of Hilbert space, contributed to the superior predictive performance compared to conventional methods.

Segmentation of liver CT images based on weighted medical transformer model.

Deep convolutional neural networks have made significant strides in the field of medical image segmentation. Although existing convolutional structures enhance performance by leveraging local image information, they often lose the interdependence information between contexts. Therefore, the article utilizes the multi-attention mechanism of the Transformer structure to more comprehensively express relationships between contexts and introduced the Transformer network architecture into the field of medical image segmentation. Most models based on this Transformer structure typically require large datasets for training. However, in the medical field, the limited size of datasets makes training models with the Transformer structure challenging. To address this, the article propose a Weighted Medical Transformer (WMT) model that imposes low requirements on dataset quantity. The weighting mechanism in the WMT model aims to improve the issue of inaccurate relative positional coding when dealing with small medical datasets. Additionally, a coarse-grained and fine-grained segmentation mechanism is introduced, focusing on both the detailed aspects within image blocks and the boundary information connecting blocks. Experimental results on a liver dataset demonstrate that the model achieves F1 and IoU scores of 88.48% and 79.41%, respectively. Results on the MoNuSeg dataset show comparable high F1 and IoU scores of 79.58% and 66.19%, respectively. The model's accuracy surpasses that of U-Net++ and U-Net models. Compared to other models, this approach is applicable to scenarios with limited datasets, exhibiting high execution efficiency and accuracy.

Edge-Guided Cell Segmentation on Small Datasets Using an Attention-Enhanced U-Net Architecture

Over the past several decades, deep neural networks have been extensively applied to medical image segmentation tasks, achieving significant success. However, the effectiveness of traditional deep segmentation networks is substantially limited by the small scale of medical datasets, a limitation directly stemming from current medical data acquisition capabilities. To this end, we introduce AttEUnet, a medical cell segmentation network enhanced by edge attention, based on the Attention U-Net architecture. It incorporates a detection branch enhanced with edge attention and a learnable fusion gate unit to improve segmentation accuracy and convergence speed on small medical datasets. The AttEUnet allows for the integration of various types of prior information into the backbone network according to different tasks, offering notable flexibility and generalization ability. This method was trained and validated on two public datasets, MoNuSeg and PanNuke. The results show that AttEUnet significantly improves segmentation performance on small medical datasets, especially in capturing edge details, with F1 scores of 0.859 and 0.888 and Intersection over Union (IoU) scores of 0.758 and 0.794 on the respective datasets, outperforming both convolutional neural networks (CNNs) and transformer-based baseline networks. Furthermore, the proposed method demonstrated a convergence speed over 10.6 times faster than that of the baseline networks. The edge attention branch proposed in this study can also be added as an independent module to other classic network structures and can integrate more attention priors based on the task at hand, offering considerable scalability.

An efficient deep learning network with orthogonal softmax layer for automatic detection of tuberculosis

Tuberculosis (TB) is a persistent bacterial lung infection that affects the lungs severely. It is one of the fatal diseases among the top ten leading causes of death. Thus, early and accurate diagnosis of TB precisely has vital role in saving lives. In this work, a novel Deep Learning Network with Orthogonal SoftMax Layer (OSL) is proposed for the detection of Tuberculosis (TB) that yields admirable performance in small medical datasets. The integrated merits of deep learning-based efficient feature extraction and OSL-based classification boost the classification performance. OSL enhances discriminative feature learning capability by maintaining orthogonality among weight vectors in this layer. It is also responsible for reducing the co-adaption among parameters and making optimization easier. In addition, data augmentation is done in the training stage using a customized version of RandAugment to train the network properly, even with small medical datasets. The experimental results depict the proposed deep learning network outperforms others with the best 98.67% accuracy, 98.99% precision, 98.33% sensitivity, 99.00% specificity, and 0.9866 F1 score.

Method of Improving the Management of Cancer Risk Groups by Coupling a Features-Attention Mechanism to a Deep Neural Network

(1) Background: Lung cancers are the most common cancers worldwide, and prostate cancers are among the second in terms of the frequency of cancers diagnosed in men. Automatic ranking of the risk groups of such diseases is highly in demand, but the clinical practice has shown us that, for a sensitive screening of the clinical parameters using an artificial intelligence system, a customarily defined deep neural network classifier is not sufficient given the usually small size of medical datasets. (2) Methods: In this paper, we propose a new management method of cancer risk groups based on a supervised neural network model that is further enhanced by using a features attention mechanism in order to boost its level of accuracy. For the analysis of each clinical parameter, we used local interpretable model-agnostic explanations, which is a post hoc model-agnostic technique that outlines feature importance. After that, we applied the feature-attention mechanism in order to obtain a higher weight after training. We tested the method on two datasets, one for binary-class in cases of thoracic cancer and one for multi-class classification in cases of urological cancer, to demonstrate the wide availability and versatility of the method. (3) Results: The accuracy levels of the models trained in this way reached values of more than 80% for both clinical tasks. (4) Conclusions: Our experiments demonstrate that, by using explainability results as feedback signals in conjunction with the attention mechanism, we were able to increase the accuracy of the base model by more than 20% on small medical datasets, reaching a critical threshold for providing recommendations based on the collected clinical parameters.

SUTrans-NET: a hybrid transformer approach to skin lesion segmentation.

Melanoma is a malignant skin tumor that threatens human life and health. Early detection is essential for effective treatment. However, the low contrast between melanoma lesions and normal skin and the irregularity in size and shape make skin lesions difficult to detect with the naked eye in the early stages, making the task of skin lesion segmentation challenging. Traditional encoder-decoder built with U-shaped networks using convolutional neural network (CNN) networks have limitations in establishing long-term dependencies and global contextual connections, while the Transformer architecture is limited in its application to small medical datasets. To address these issues, we propose a new skin lesion segmentation network, SUTrans-NET, which combines CNN and Transformer in a parallel fashion to form a dual encoder, where both CNN and Transformer branches perform dynamic interactive fusion of image information in each layer. At the same time, we introduce our designed multi-grouping module SpatialGroupAttention (SGA) to complement the spatial and texture information of the Transformer branch, and utilize the Focus idea of YOLOV5 to construct the Patch Embedding module in the Transformer to prevent the loss of pixel accuracy. In addition, we design a decoder with full-scale information fusion capability to fully fuse shallow and deep features at different stages of the encoder. The effectiveness of our method is demonstrated on the ISIC 2016, ISIC 2017, ISIC 2018 and PH2 datasets and its advantages over existing methods are verified.

SW-UNet: a U-Net fusing sliding window transformer block with CNN for segmentation of lung nodules.

Medical images are information carriers that visually reflect and record the anatomical structure of the human body, and play an important role in clinical diagnosis, teaching and research, etc. Modern medicine has become increasingly inseparable from the intelligent processing of medical images. In recent years, there have been more and more attempts to apply deep learning theory to medical image segmentation tasks, and it is imperative to explore a simple and efficient deep learning algorithm for medical image segmentation. In this paper, we investigate the segmentation of lung nodule images. We address the above-mentioned problems of medical image segmentation algorithms and conduct research on medical image fusion algorithms based on a hybrid channel-space attention mechanism and medical image segmentation algorithms with a hybrid architecture of Convolutional Neural Networks (CNN) and Visual Transformer. To the problem that medical image segmentation algorithms are difficult to capture long-range feature dependencies, this paper proposes a medical image segmentation model SW-UNet based on a hybrid CNN and Vision Transformer (ViT) framework. Self-attention mechanism and sliding window design of Visual Transformer are used to capture global feature associations and break the perceptual field limitation of convolutional operations due to inductive bias. At the same time, a widened self-attentive vector is used to streamline the number of modules and compress the model size so as to fit the characteristics of a small amount of medical data, which makes the model easy to be overfitted. Experiments on the LUNA16 lung nodule image dataset validate the algorithm and show that the proposed network can achieve efficient medical image segmentation on a lightweight scale. In addition, to validate the migratability of the model, we performed additional validation on other tumor datasets with desirable results. Our research addresses the crucial need for improved medical image segmentation algorithms. By introducing the SW-UNet model, which combines CNN and ViT, we successfully capture long-range feature dependencies and break the perceptual field limitations of traditional convolutional operations. This approach not only enhances the efficiency of medical image segmentation but also maintains model scalability and adaptability to small medical datasets. The positive outcomes on various tumor datasets emphasize the potential migratability and broad applicability of our proposed model in the field of medical image analysis.

An Efficient Detection and Classification of Acute Leukemia Using Transfer Learning and Orthogonal Softmax Layer-Based Model.

For the early diagnosis of hematological disorders like blood cancer, microscopic analysis of blood cells is very important. Traditional deep CNNs lead to overfitting when it receives small medical image datasets such as ALLIDB1, ALLIDB2, and ASH. This paper proposes a new and effective model for classifying and detecting Acute Lymphoblastic Leukemia (ALL) or Acute Myelogenous Leukemia (AML) that delivers excellent performance in small medical datasets. Here, we have proposed a novel Orthogonal SoftMax Layer (OSL)-based Acute Leukemia detection model that consists of ResNet 18-based deep feature extraction followed by efficient OSL-based classification. Here, OSL is integrated with the ResNet18 to improve the classification performance by making the weight vectors orthogonal to each other. Hence, it integrates ResNet benefits (residual learning and identity mapping) with the benefits of OSL-based classification (improvement of feature discrimination capability and computational efficiency). Furthermore, we have introduced extra dropout and ReLu layers in the architecture to achieve a faster network with enhanced performance. The performance verification is performed on standard ALLIDB1, ALLIDB2, and C_NMC_2019 datasets for efficient ALL detection and ASH dataset for effective AML detection. The experimental performance demonstrates the superiority of the proposed model over other compairing models.

EP07.01-003 Metadata-Oriented Data Engineering Approach for Integration of Medical Data: A Pilot Study

Data Mining (DM) applications may benefit from artificial intelligence (AI) approaches that aim to reveal valuable information from data. The quantity and quality of data are important to receive accurate and reliable information. In recent years, research on the development of computer software programs under the title of metadata has been carried out to reach reliable data. In this study, it is aimed to evaluate the applicability of metadata-oriented data engineering methods in a relatively small medical dataset.

Improving classification results on a small medical dataset using a GAN; An outlook for dealing with rare disease datasets

For clinical decision support systems, automated classification algorithms on medical image data have become more important in the past. For such computer vision problems, deep convolutional neural networks (DCNNs) have made breakthroughs. These often require large, annotated, and privacy-cleared datasets as a prerequisite for gaining high-quality results. This proves to be difficult with rare diseases due to limited incidences. Therefore, it is hard to sensitize clinical decision support systems to identify these diseases at an early stage. It has been shown several times, that synthetic data can improve the results of clinical decision support systems. At the same time, the greatest problem for the generation of these synthetic images is the data basis. In this paper, we present four different methods to generate synthetic data from a small dataset. The images are from 2D magnetic resonance tomography of the spine. The annotation resulted in 540 healthy, 47 conspicuously non-pathological, and 106 conspicuously pathological vertebrae. Four methods are presented to obtain optimal generation results in each of these classes. The obtained generation results are then evaluated with a classification net. With this procedure, we showed that adding synthetic annotated data has a positive impact on the classification results of the original data. In addition, one of our methods is appropriate to generate synthetic image data from <50 images. Thus, we found a general approach for dealing with small datasets in rare diseases, which can be used to build sensitized clinical decision support systems to detect and treat these diseases at an early stage.

Deep learning identifies Acute Promyelocytic Leukemia in bone marrow smears

BackgroundAcute promyelocytic leukemia (APL) is considered a hematologic emergency due to high risk of bleeding and fatal hemorrhages being a major cause of death. Despite lower death rates reported from clinical trials, patient registry data suggest an early death rate of 20%, especially for elderly and frail patients. Therefore, reliable diagnosis is required as treatment with differentiation-inducing agents leads to cure in the majority of patients. However, diagnosis commonly relies on cytomorphology and genetic confirmation of the pathognomonic t(15;17). Yet, the latter is more time consuming and in some regions unavailable.MethodsIn recent years, deep learning (DL) has been evaluated for medical image recognition showing outstanding capabilities in analyzing large amounts of image data and provides reliable classification results. We developed a multi-stage DL platform that automatically reads images of bone marrow smears, accurately segments cells, and subsequently predicts APL using image data only. We retrospectively identified 51 APL patients from previous multicenter trials and compared them to 1048 non-APL acute myeloid leukemia (AML) patients and 236 healthy bone marrow donor samples, respectively.ResultsOur DL platform segments bone marrow cells with a mean average precision and a mean average recall of both 0.97. Further, it achieves high accuracy in detecting APL by distinguishing between APL and non-APL AML as well as APL and healthy donors with an area under the receiver operating characteristic of 0.8575 and 0.9585, respectively, using visual image data only.ConclusionsOur study underlines not only the feasibility of DL to detect distinct morphologies that accompany a cytogenetic aberration like t(15;17) in APL, but also shows the capability of DL to abstract information from a small medical data set, i. e. 51 APL patients, and infer correct predictions. This demonstrates the suitability of DL to assist in the diagnosis of rare cancer entities. As our DL platform predicts APL from bone marrow smear images alone, this may be used to diagnose APL in regions were molecular or cytogenetic subtyping is not routinely available and raise attention to suspected cases of APL for expert evaluation.

Brain Tumor Classification Using a Combination of Variational Autoencoders and Generative Adversarial Networks.

Brain tumors are a pernicious cancer with one of the lowest five-year survival rates. Neurologists often use magnetic resonance imaging (MRI) to diagnose the type of brain tumor. Automated computer-assisted tools can help them speed up the diagnosis process and reduce the burden on the health care systems. Recent advances in deep learning for medical imaging have shown remarkable results, especially in the automatic and instant diagnosis of various cancers. However, we need a large amount of data (images) to train the deep learning models in order to obtain good results. Large public datasets are rare in medicine. This paper proposes a framework based on unsupervised deep generative neural networks to solve this limitation. We combine two generative models in the proposed framework: variational autoencoders (VAEs) and generative adversarial networks (GANs). We swap the encoder–decoder network after initially training it on the training set of available MR images. The output of this swapped network is a noise vector that has information of the image manifold, and the cascaded generative adversarial network samples the input from this informative noise vector instead of random Gaussian noise. The proposed method helps the GAN to avoid mode collapse and generate realistic-looking brain tumor magnetic resonance images. These artificially generated images could solve the limitation of small medical datasets up to a reasonable extent and help the deep learning models perform acceptably. We used the ResNet50 as a classifier, and the artificially generated brain tumor images are used to augment the real and available images during the classifier training. We compared the classification results with several existing studies and state-of-the-art machine learning models. Our proposed methodology noticeably achieved better results. By using brain tumor images generated artificially by our proposed method, the classification average accuracy improved from 72.63% to 96.25%. For the most severe class of brain tumor, glioma, we achieved 0.769, 0.837, 0.833, and 0.80 values for recall, specificity, precision, and F1-score, respectively. The proposed generative model framework could be used to generate medical images in any domain, including PET (positron emission tomography) and MRI scans of various parts of the body, and the results show that it could be a useful clinical tool for medical experts.

A comparative analysis of eleven neural networks architectures for small datasets of lung images of COVID-19 patients toward improved clinical decisions

The 2019 novel severe acute respiratory syndrome coronavirus 2-SARS-CoV2, commonly known as COVID-19, is a highly infectious disease that has endangered the health of many people around the world. COVID-19, which infects the lungs, is often diagnosed and managed using X-ray or computed tomography (CT) images. For such images, rapid and accurate classification and diagnosis can be performed using deep learning methods that are trained using existing neural network models. However, at present, there is no standardized method or uniform evaluation metric for image classification, which makes it difficult to compare the strengths and weaknesses of different neural network models. This paper used eleven well-known convolutional neural networks, including VGG-16, ResNet-18, ResNet-50, DenseNet-121, DenseNet-169, Inception-v3, Inception-v4, SqueezeNet, MobileNet, ShuffeNet, and EfficientNet-b0, to classify and distinguish COVID-19 and non-COVID-19 lung images. These eleven models were applied to different batch sizes and epoch cases, and their overall performance was compared and discussed. The results of this study can provide decision support in guiding research on processing and analyzing small medical datasets to understand which model choices can yield better outcomes in lung image classification, diagnosis, disease management and patient care.

Value Analysis of Using Urinary Microalbumin in Artificial Intelligence Medical Institutions to Detect Early Renal Damage in Diabetes.

As the scale and depth of artificial intelligence network models continue to increase, their accuracy in albumin recognition tasks has increased rapidly. However, today's small medical datasets are the main reason for the poor recognition of artificial intelligence techniques in this area. The sample size in this article is based on the data analysis and research on urine albumin detection of diabetes in the EI database. It is assumed that the observation group has at least 20 mg UAER difference from the control group, and the standard deviation of the UAER change from baseline to 12 weeks is 30 mg. Therefore, the sample size of the two groups is 77 cases. Assuming that the rate of loss to follow-up during the follow-up period is 20%, at least 92 patients are needed. The final enrollment in this study is 100 patients. Studies have shown that DR is used as an indicator to diagnose NDRD, and its OR value is as high as 28.198, indicating that non-DR can be used as an indicator to distinguish DN from NDRD. The meta-analysis found that DR has a sensitivity of 0.65 and a specificity of 0.75 in distinguishing DN from NDRD in patients with type 2 diabetes, and it is emphasized that PDR is highly specific in the diagnosis of DN. Using a meta-analysis to systematically analyze 45 studies, it was found that the sensitivity of DR to diagnose DN was 0.67, the specificity was 0.78, and the specificity of PDR to predict DN was 0.99, indicating that DR is a good indicator for predicting DN, and the team's latest research has also verified this point of view. They have established a new model for diagnosing DN. In addition to including traditional proteinuria, glycosylated hemoglobin, FR, blood pressure, and other indicators into the diagnostic model, it will also include the presence or absence of DR. The final external verification accuracy rate of this model is 0.875.

Deep Learning Based HPV Status Prediction for Oropharyngeal Cancer Patients

Simple SummaryDetermination of human papillomavirus (HPV) status for oropharyngeal cancer patients depicts a essential diagnostic factor and is important for treatment decisions. Current histological methods are invasive, time consuming and costly. We tested the ability of deep learning models for HPV status testing based on routinely acquired diagnostic CT images. A network trained for sports video clip classification was modified and then fine tuned for HPV status prediction. In this way, very basic information about image structures is induced into the model before training is started, while still allowing for exploitation of full 3D information in the CT images. Usage of this approach helps the network to cope with a small number of training examples and makes it more robust. For comparison, two other models were trained, one not relying on a pre-training task and another one pre-trained on 2D Data. The pre-trained video model preformed best.Infection with the human papillomavirus (HPV) has been identified as a major risk factor for oropharyngeal cancer (OPC). HPV-related OPCs have been shown to be more radiosensitive and to have a reduced risk for cancer related death. Hence, the histological determination of HPV status of cancer patients depicts an essential diagnostic factor. We investigated the ability of deep learning models for imaging based HPV status detection. To overcome the problem of small medical datasets, we used a transfer learning approach. A 3D convolutional network pre-trained on sports video clips was fine-tuned, such that full 3D information in the CT images could be exploited. The video pre-trained model was able to differentiate HPV-positive from HPV-negative cases, with an area under the receiver operating characteristic curve (AUC) of for an external test set. In comparison to a 3D convolutional neural network (CNN) trained from scratch and a 2D architecture pre-trained on ImageNet, the video pre-trained model performed best. Deep learning models are capable of CT image-based HPV status determination. Video based pre-training has the ability to improve training for 3D medical data, but further studies are needed for verification.

Agile convolutional neural network for pulmonary nodule classification using CT images.

To distinguish benign from malignant pulmonary nodules using CT images is critical for their precise diagnosis and treatment. A new Agile convolutional neural network (CNN) framework is proposed to conquer the challenges of a small-scale medical image database and the small size of the nodules, and it improves the performance of pulmonary nodule classification using CT images. A hybrid CNN of LeNet and AlexNet is constructed through combining the layer settings of LeNet and the parameter settings of AlexNet. A dataset with 743 CT image nodule samples is built up based on the 1018 CT scans of LIDC to train and evaluate the Agile CNN model. Through adjusting the parameters of the kernel size, learning rate, and other factors, the effect of these parameters on the performance of the CNN model is investigated, and an optimized setting of the CNN is obtained finally. After finely optimizing the settings of the CNN, the estimation accuracy and the area under the curve can reach 0.822 and 0.877, respectively. The accuracy of the CNN is significantly dependent on the kernel size, learning rate, training batch size, dropout, and weight initializations. The best performance is achieved when the kernel size is set to [Formula: see text], the learning rate is 0.005, the batch size is 32, and dropout and Gaussian initialization are used. This competitive performance demonstrates that our proposed CNN framework and the optimization strategy of the CNN parameters are suitable for pulmonary nodule classification characterized by small medical datasets and small targets. The classification model might help diagnose and treat pulmonary nodules effectively.

Handling limited datasets with neural networks in medical applications: A small-data approach.

Single-centre studies in medical domain are often characterised by limited samples due to the complexity and high costs of patient data collection. Machine learning methods for regression modelling of small datasets (less than 10 observations per predictor variable) remain scarce. Our work bridges this gap by developing a novel framework for application of artificial neural networks (NNs) for regression tasks involving small medical datasets. In order to address the sporadic fluctuations and validation issues that appear in regression NNs trained on small datasets, the method of multiple runs and surrogate data analysis were proposed in this work. The approach was compared to the state-of-the-art ensemble NNs; the effect of dataset size on NN performance was also investigated. The proposed framework was applied for the prediction of compressive strength (CS) of femoral trabecular bone in patients suffering from severe osteoarthritis. The NN model was able to estimate the CS of osteoarthritic trabecular bone from its structural and biological properties with a standard error of 0.85MPa. When evaluated on independent test samples, the NN achieved accuracy of 98.3%, outperforming an ensemble NN model by 11%. We reproduce this result on CS data of another porous solid (concrete) and demonstrate that the proposed framework allows for an NN modelled with as few as 56 samples to generalise on 300 independent test samples with 86.5% accuracy, which is comparable to the performance of an NN developed with 18 times larger dataset (1030 samples). The significance of this work is two-fold: the practical application allows for non-destructive prediction of bone fracture risk, while the novel methodology extends beyond the task considered in this study and provides a general framework for application of regression NNs to medical problems characterised by limited dataset sizes.

A fuzzy-based data transformation for feature extraction to increase classification performance with small medical data sets

Medical data sets are usually small and have very high dimensionality. Too many attributes will make the analysis less efficient and will not necessarily increase accuracy, while too few data will decrease the modeling stability. Consequently, the main objective of this study is to extract the optimal subset of features to increase analytical performance when the data set is small. This paper proposes a fuzzy-based non-linear transformation method to extend classification related information from the original data attribute values for a small data set. Based on the new transformed data set, this study applies principal component analysis (PCA) to extract the optimal subset of features. Finally, we use the transformed data with these optimal features as the input data for a learning tool, a support vector machine (SVM). Six medical data sets: Pima Indians' diabetes, Wisconsin diagnostic breast cancer, Parkinson disease, echocardiogram, BUPA liver disorders dataset, and bladder cancer cases in Taiwan, are employed to illustrate the approach presented in this paper. This research uses the t-test to evaluate the classification accuracy for a single data set; and uses the Friedman test to show the proposed method is better than other methods over the multiple data sets. The experiment results indicate that the proposed method has better classification performance than either PCA or kernel principal component analysis (KPCA) when the data set is small, and suggest creating new purpose-related information to improve the analysis performance. This paper has shown that feature extraction is important as a function of feature selection for efficient data analysis. When the data set is small, using the fuzzy-based transformation method presented in this work to increase the information available produces better results than the PCA and KPCA approaches.

Mining a Small Medical Data Set by Integrating the Decision Tree and t-test

Although several researchers have used statistical methods to prove that aspiration followed by the injection of 95% ethanol left in situ (retention) is an effective treatment for ovarian endometriomas, very few discuss the different conditions that could generate different recovery rates for the patients. Therefore, this study adopts the statistical method and decision tree techniques together to analyze the postoperative status of ovarian endometriosis patients under different conditions. Since our collected data set is small, containing only 212 records, we use all of these data as the training data. Therefore, instead of using a resultant tree to generate rules directly, we use the value of each node as a cut point to generate all possible rules from the tree first. Then, using t -test, we verify the rules to discover some useful description rules after all possible rules from the tree have been generated. Experimental results show that our approach can find some new interesting knowledge about recurrent ovarian endometriomas under different conditions.

Adaptive local hyperplane algorithm for learning small medical data sets

Abstract: It is not unique that only a few samples from medical studies are available for knowledge discovery. Hence, a suitable classifier for the small data set learning problem is very interesting in medical work. In this paper, we experiment with the adaptive local hyperplane algorithm on small medical data sets. The experimental results on two cancer data sets demonstrate that the proposed classifier outperforms, on average, all the other four benchmarking classifiers for learning small data sets.