Bone Mineral Density (BMD) can be determined by applying the Digital Image Processing (DIP) method using medical X-ray diagnosis. Although only the second metacarpal bone is analyzed in this approach, other parts of the body are exposed to X-ray radiation. We here propose a novel procedure in which parts of the hand surrounding the area of interest are shielded with an X-ray shielding sheet having low shielding performance. In our procedure, the main diagnostic area is not shielded, and other areas are covered with an X-ray shielding sheet with a low shielding performance. The sheet was fabricated by embedding Bi2O3 particles in resin sheet. We assessed the clinical performance of this method using three types of hand phantoms and conventional diagnostic X-ray equipment. The dose reduction for the entire hand region was evaluated by the Dose Area Product (DAPHand), which was measured with a small dosimeter, and the hand area was determined from the X-ray image. The X-ray image of the second metacarpal bone is affected by the contribution of X-rays that penetrate the object of interest and are scattered in other areas of the hand. Because our X-ray shielding sheet suppressed the generation of scattered X-rays, the pixel value of the second metacarpal bone and corresponding BMD value are varied. To address this issue, we developed a correction algorithm. We found that the X-ray shields with Dose Reduction Factor (DRF) values of 40–60% were appropriate for our methodology. Our method was estimated to have a percentage uncertainty of approximately 5% for the derivation of BMD values. Morphological information of the hand and bones could thus be clearly observed. We verified that both morphological diagnosis and quantitative determination of BMD are possible when DIP procedure is conducted using our shield.