The infiltration of solid particles (fines) into a reservoir during drilling or water reinjection is a long-standing problem in the petroleum industry because of the associated production decline or injectivity loss. Solid particle infiltration is also an active area of research in other fields such as waste water treatment and fines migration in clay-rich reservoirs.In this work, we perform experiments to study particle infiltration into sintered glass bead core plugs and measure the changes in porosity and permeability using computed tomography (CT) scanning and pressure transducers, respectively. Suspensions of prescribed bimodal particle sizes, concentrations, and flowrates are flooded through the core plugs. Permeability changes are measured continuously over time, and the porosity change is measured after flowing a fixed mass of invaded particles.A dual pore-scale numerical model approach (a combination of a direct pore-scale discrete element method (DEM) and a pore-scale network model) is used to predict permeability reduction by particle filtration in porous media. Large particle deposition is modeled using the DEM in a disordered sphere pack geometry; the result is a prediction of deposition as a function of large particle concentration. Small particle deposition is modeled using the network model; the result is a prediction of deposition as a function of small particle concentration. Crucially, the geometry of the network model depends on the amount of large particles deposited. In this way, the deposition of large and small sized particles is coupled together.The permeability and porosity reduction of the network due to the deposition of small and large particles are then calculated from the functions above. We compare the experimental results with simulation predictions and find that the dual pore-scale model is capable of predicting the permeability of the invaded core in the regions away from the injection face. Permeability prediction in the region adjacent to the injection face is improved by incorporating the influence of the external filter cake.