Small Animal Medicine Research Articles

Epidemiology of Canine Wei Syndrome and Its Hemorheology Characteristics.

Canine paraplegia is a common condition in small animal medicine, referred to as Wei Syndrome (WS) in Traditional Chinese Veterinary Medicine (TCVM). Common clinical manifestations encompass hind limb paralysis, motor dysfunction, muscle atrophy, and the absence of pain perception. WS is considered a difficult-to-treat disease in small animal practice. The objective of this study was to investigate the epidemiology of canine WS and the characteristics of hemorheology. A total of 53 dogs with WS and 53 healthy dogs were included in this study. A retrospective case-controlled study design was employed. Data regarding the gender, season of WS occurrence, breed, and age of dogs with WS, as well as hemorheology from dogs with WS and healthy dogs, were collected and analyzed using SPSS 27.0. The study findings revealed that male dogs were more susceptible to WS (77.36%, 41/53). WS cases occurred more frequently in Winter (33.96%, 18/53), and were commonly found in Poodle breeds (43.40%, 23/53). The most affected age of WS was between 3 and 6 years old (54.72%, 29/53). Except for plasma viscosity and fibrinogen, the hemorheology indices of canine WS were significantly higher than those of healthy dogs (p < 0.05), especially in male dogs, Poodles and Bulldogs, those between 3 to 10 years, and in Autumn and Winter. This study provides evidence that male Poodles and Bulldogs aged 3 to 6 years are more prone to developing WS, with Winter being the season of high disease incidence. Abnormal hemorheology is a characteristic feature in dogs with WS, which should be considered during the treatment of WS.

Awareness of Antimicrobial Resistance and Antimicrobial Drugs Prescription Pattern in Small Animal Clinical Practice in Ogun State, Nigeria

Antimicrobial resistance (AMR) is a global health challenge in veterinary and human health, leading to monitoring of resistance and promotion of responsible antimicrobial use. This survey assessed the use of antimicrobials among government veterinarians in Ogun state, Nigeria. Clinicians were requested to fill questionnaires designed to extract information on the frequency of antibiotics use, antibiotic prescription patterns and evaluation of perception on AMR and use of antibiotics with compromised efficacy in veterinary practice in the last three years. Fifty-two (52) questionnaires were administered and duly completed upon return. Data analysis showed 100% awareness of AMR with 80.8% (42/52) agreeing to have encountered AMR in the course of managing small animal cases. The tetracycline class of antibiotics 49(94.2%) was the most prescribed, followed by aminoglycosides 40(76.9%) and fluoroquinolones 35(67.3%). Empirical therapy (34/52) 65.4% is the most common treatment option among clinicians while 18 (34.6%) out of 52 clinicians performed antibiotic susceptibility testing along with laboratory diagnosis as treatment guide. Furthermore, 75.0% of the respondents affirmed administering antibiotics formulated for human use in small animal treatment. Thirty-three (63.5%) respondents administered human antimicrobials in animals according to the recommended dosage in humans. This survey identified that AMR was common in small animals in the state studied and this may be due to the irrational use of antibiotics. Promoting antimicrobial stewardship in small animal medicine therefore is paramount to mitigating antimicrobial resistance and data obtained from this study will contribute to developing evidence-based policy on the rational use of antibiotics in small animal practice in Nigeria.

Zoonoses-specific resources, collaborative networks, and enhanced communication can help US veterinarians tackle zoonotic diseases: results from a national survey.

Increased incidence of zoonoses, coupled with veterinarians' occupational exposure, led to this study examining the knowledge of licensed US veterinarians on zoonoses and their disease prevention practices. This online survey supported by the National Association of State Public Health Veterinarians received 466 responses from 36 US states; 67% of the respondents were female, and 72.5% were small animal medicine practitioners. The One Health concept was familiar among 82% of respondents, 51.3% knew of continuing education training on zoonoses, and 68% had attended such a training in the last 5 years. Respondents were unaware of which zoonoses to report to public health departments. For 3 out of 8 questions on standard operating procedures, statistically significant differences in protocols followed among small, large, and mixed animal medicine practitioners were observed. Most respondents believed they play a critical role in zoonoses prevention but would like more information on zoonotic diseases. Results indicate that assisting veterinarians with regularly updated information on zoonoses, providing targeted education and training to adhere to standardized infection control measures, and increasing communication with public health agencies and physicians may help prevent and reduce incidence of zoonoses.

Insulinoma in a Boxer- A case report

A nine-year-old female Boxer was presented to the Small Animal Medicine outpatient unit of Teaching Veterinary Hospital, Madras Veterinary College with the complaint of weakness and occasional ataxia. The general clinical, physical and neurological examinations were found to be normal except for the history of weakness and ataxia. The complete blood count was normal. Serum biochemistry revealed hypoglycemia and the amended insulin to glucose ratio was 187.4. Abdominal ultrasonography and radiography examination were unrewarding. Contrast CT revealed presence of multiple nodular lesions over the pancreas suggestive of insulinoma. The hypoglycemic episodes were managed with dextrose solution followed by dietary management, prednisolone and octreotide. The animal responded to treatment with an improvement in blood glucose level.

FLASC – Fast Localized Abdominal Scan in Cattle

Rapid ultrasound examination has been used in human emer­gency medicine and adapted to small animal (FAST) and equine medicine (FLASH) for assessment of trauma or colic. Fast Lo­calized Abdominal Scan in Cattle (FLASC) is a focused assess­ment using the ultrasound that I have adapted to assist with all of my examinations when I do not have a clear idea what is causing clinical signs. This exam is tailored toward the most common things I find in beef cattle, but can be useful with all classes of cattle to assist in diagnosis.

From ultrasound to microscopy: Actualities in thyroid investigation in cattle.

Thyroid ultrasonography examination is widely used in human and small animal medicine. However, it has rarely been applied in cattle. The aim of this study was to determine whether the measurements of the thyroid gland by ultrasound examination correlate to those taken during post-mortem examination. A sample of 22 cows and 23 calves was selected for thyroid gland evaluation. An ultrasound scan was performed ante-mortem, followed by euthanasia (for medical reasons) or slaughtered in the food chain and the dissection of the thyroid gland was therefore performed. Post-mortem, the gland was weighed and its dimensions and volume measured. The volume and weight measurements were compared with the predicted ones on US using the formulas available in the literature. Finally, histological examination was performed on thyroid glands. The dimensions of the thyroid gland measured by ultrasonography were significantly different (p<0.05) from those observed post-mortem, except for lobe lengths in calves (p>0.1). However, in calves, there was no systematic bias between the ultrasound and post-mortem examination of the thyroid gland, which were concordant (with an average error of 18%). Cystic lesions were observed on ultrasound in 9/22 cows and could be found on histological examination in 7 of these. Other lesions, such as follicular hypoplasia and hyperplasia, were seen on histological examination but not on ultrasound. Although the ultrasound measurements did not significantly correlate with those taken post-mortem, this examination may allow to differentiate non-standard thyroids in the case of hyperplastic goiter, as demonstrated in other species. This study also describes and illustrates interesting lesions of the thyroid gland in cattle. These findings are innovative in the description of the use of thyroid ultrasound in cattle, although further studies are needed to allow deeper conclusions.

Medical management of cutaneous lymphoma and associated ileus in a labrador dog

A 6-year-old male Labrador dog was presented to the Small Animal Medicine unit of the Veterinary Clinical Complex, Veterinary College and Research Institute, Orathanadu with a history of hair loss and multiple skin lumps all over the body. The dog was treated for atopic dermatitis past three weeks. Clinical examination revealed generalized alopecia, lymphadenopathy and nodule-like skin lumps were noticed all over the body. Hemato-biochemical analysis revealed anaemia, lymphocytosis and hypoproteinemia. FNAC of skin lump revealed cutaneous lymphoma. Radiography and ultrasonography examination revealed no evidence of metastasis. The dog was treated with modified Wisconsin Madison protocol. On the 15th week of protocol dog showed a distended abdomen and constipation, further abdominal ultrasonography revealed a distended loop and ileus. Hence the present case was diagnosed as vincristine-associated ileus in a dog. Neostigmine was administered to restore the intestinal motility. The dog showed uneventful recovery from cutaneous lymphoma and as well as vincristine-associated ileus.

Cabergoline therapy against hyperadrenocorticism in a dog

A 9-year-old male Labrador dog was presented to Small Animal Medicine Unit of Veterinary Clinical Complex, Veterinary College and Research Institute, Orathanadu with a history of chronic skin infection for the past 6 months. Clinical examination revealed alopecia, skin thinning, calcinosis cutis and comedone with pendulous abdomen. Laboratory examination revealed increased ALP and hyperglycemia. Hepatomegaly and bilateral adrenal gland hyperplasia were noticed on ultrasonography. Based on clinical and ultrasonographic findings it was diagnosed as hyperadrenocorticism. The dog was treated with Cabergoline @ 0.07 mg/kg P.O every 3 days for 3 months. The clinical signs were gradually subsided and animal recovered uneventfully with 3 months of treatment. Cabergoline found to be an alternative treatment of choice for the management of hyperadrenocorticism in dogs.

Evaluation of Canine Neonatal Health by Breeders: A Prospective Questionnaire Study on the Association between Neonatal Scores (Modified APGAR), Parturition, Birth Weight, Growth, and Puppy Mortality

Mortality of neonatal puppies is a widespread problem in small animal medicine. Neonatal monitoring, according to standardized protocols, can be useful for identifying puppies that are at risk of mortality. Prompt intervention on weak puppies could increase survival rates. Apgar scoring adapted for puppies has been demonstrated to be associated with mortality and is usually performed by trained veterinary staff. The majority of puppies, however, are born in a home or kennel environment and not at a veterinary clinic. Our aims were, therefore, to evaluate if a modified protocol for neonatal monitoring would be usable by breeders in a home environment. We wanted to evaluate potential associations between modified Apgar scores, birth weights, delivery times, growth rates, and puppy mortality. Modified Apgar scores were related to the viability of live-born puppies (p &lt; 0.0013). The viability and expulsion time of each puppy were significantly related (p = 0.010 with all puppies included and p = 0.038 with only live-born puppies included). Viability was significantly related to relative birthweight (p &lt; 0.01). Puppies with a negative growth rate the first two days after parturition did not have a significantly higher risk of mortality. In conclusion, a modified and simplified Apgar scoring performed by breeders approximately 5 min after birth was associated with puppy mortality.

A retrospective study on epidemiology and management of canine cystine uroliths in one part of Norway from 2015 to 2020

BackgroundUrinary tract problems are a common complaint in small animal medicine and urolithiasis is considered to be an important cause of urinary tract disease in dogs. In this study the main aim was to investigate whether the occurrence of cystine urolithiasis increased during a five-year period. A second aim was to evaluate possible risk-factors as breed, age and gender. This study also evaluated how urine specific gravity, pH and level of cystine in urine responded to preventive strategies. Medical records of dogs with urolithiasis presented at nine Norwegian animal clinics and one animal hospital between 2015 and 2020 were retrospectively reviewed.ResultsThe incidence of cystine uroliths increased significantly during the five study years (R2 = 0.72, P = 0.0199). Dogs with cystine uroliths were significantly younger (5.0 years (n = 84, 95% CI [4.4–5.6])) when they were diagnosed with cystine uroliths compared to dogs with other types of uroliths (8.1 years (n = 255, 95% CI[7.8-8.5]) P < < 0.0001). Cystine levels in urine were increased in 93% of the dogs with cystine urolithiasis. Cystinuria decreased significantly after neutering (P < 0.0001). Breeds most commonly affected with cystine urolithiasis in this study were Staffordshire bull terrier, Danish Swedish farmdog and Chihuahua.ConclusionsThe results from this study supports a suggested genetic basis for cystine urolithiasis as described in previous studies. Neutering is considered an important part of preventing reoccurrence since cystine values decreased significantly after neutering.

Microbiome Responses to Fecal Microbiota Transplantation in Cats with Chronic Digestive Issues.

There is growing interest in the application of fecal microbiota transplants (FMTs) in small animal medicine, but there are few published studies that have tested their effects in the domestic cat (Felis catus). Here we use 16S rRNA gene sequencing to examine fecal microbiome changes in 46 domestic cats with chronic digestive issues that received FMTs using lyophilized stool that was delivered in oral capsules. Fecal samples were collected from FMT recipients before and two weeks after the end of the full course of 50 capsules, as well as from their stool donors (N = 10), and other healthy cats (N = 113). The fecal microbiomes of FMT recipients varied with host clinical signs and dry kibble consumption, and shifts in the relative abundances of Clostridium, Collinsella, Megamonas, Desulfovibrio and Escherichia were observed after FMT. Overall, donors shared 13% of their bacterial amplicon sequence variants (ASVs) with FMT recipients and the most commonly shared ASVs were classified as Prevotella 9, Peptoclostridium, Bacteroides, and Collinsella. Lastly, the fecal microbiomes of cats with diarrhea became more similar to the microbiomes of age-matched and diet-matched healthy cats compared to cats with constipation. Overall, our results suggest that microbiome responses to FMT may be modulated by the FMT recipient's initial presenting clinical signs, diet, and their donor's microbiome.

The Effects of Photobiomodulation Therapy on the Healing of Eastern Box Turtle (Terrapene carolina) Shells

Photobiomodulation therapy (cold laser or low-level laser therapy) has been evaluated in human and small animal medicine; however, there is a lack of knowledge about the role photobiomodulation therapy could play in reptile rehabilitation and release. This study used a quantifiable unit, Hounsfield units (bone density measurement), in computed tomography (CT) to evaluate if photobiomodulation therapy showed a significant healing difference between groups treated with photobiomodulation and those that were not. This study included 20 eastern box turtles (Terrapene carolina) presented to a rehabilitation center that sustained shell fractures without penetrating the coelom. They all received similar medical treatments, except that the photobiomodulation group received 250 Hz of red light laser for three minutes three times a week for eight weeks. The turtles were evaluated over the course of two months of therapy. Computed tomography scans were performed prior to therapy, at the midpoint of treatment (one month postinjury), and at the end of the study (two months postinjury). The average Hounsfield units of the fractures were evaluated using nonparametric means, the Wilcoxon/Kruskal–Wallis tests (ranked sums), and found that there were no significant differences in shell density between the photobiomodulation and control groups amongst the scans. This study did find that there was a significant difference (p = 0.0455) between the two groups in regard to the width of the fracture between pre- and post-treatment scans. This study found that the photobiomodulation group had a significantly decreased width of the fracture site between pre-treatment and post-treatment measurements, showing that photobiomodulation could be a relatively easy and effective treatment to promote healing of fractured turtle shells.

Prevalence of mental health symptoms and potential risk factors among Austrian veterinary medicine students

Although the poor mental health of veterinarians has been reported in different countries, no data exist on mental health in Austrian veterinary students. This study aimed to provide first data on a broad range of mental health indicators in Austrian veterinary students, compare these data with the Austrian general population, and explore factors associated with poor mental health. A total of 29.1% (n = 430; 85.8% female; mean age: 23.14 ± 3.69 years) of the total Austrian veterinary student population (N = 1477 students; 82.1% females) took part in an online survey conducted from November 2022 to January 2023. Indicators of mental health were symptoms of depression (PHQ-9), anxiety (GAD-7), insomnia (ISI-7), stress (PSS-4), alcohol abuse (CAGE) and disordered eating (SCOFF). Compared to the general Austrian population a higher proportion of veterinary students exceeded the cut-offs for clinically relevant mental health symptoms (P < 0.05). A total of 55.3% of participating veterinary students exceeded the cut-off for moderate depressive symptoms, 52.6% for moderate anxiety symptoms, 20.9% for clinically relevant insomnia symptoms, 79.3% for high-stress symptoms, 22.8% for symptoms of alcohol abuse and 38.6% for symptoms of disordered eating. Multivariable logistic regression including several sociodemographic, health behavior, and study-related variables as predictors revealed that mental health symptoms in veterinary students were associated with female gender, older age, low physical activity, high smartphone usage, and desired specification in small animal or wildlife medicine. In conclusion, Austrian veterinary students experience a high mental health burden. The teaching of coping skills and strategies to improve mental hygiene should be implemented in the curricula of veterinary education to improve mental health in the veterinary profession.

Explainable automated pain recognition in cats

Manual tools for pain assessment from facial expressions have been suggested and validated for several animal species. However, facial expression analysis performed by humans is prone to subjectivity and bias, and in many cases also requires special expertise and training. This has led to an increasing body of work on automated pain recognition, which has been addressed for several species, including cats. Even for experts, cats are a notoriously challenging species for pain assessment. A previous study compared two approaches to automated ‘pain’/‘no pain’ classification from cat facial images: a deep learning approach, and an approach based on manually annotated geometric landmarks, reaching comparable accuracy results. However, the study included a very homogeneous dataset of cats and thus further research to study generalizability of pain recognition to more realistic settings is required. This study addresses the question of whether AI models can classify ‘pain’/‘no pain’ in cats in a more realistic (multi-breed, multi-sex) setting using a more heterogeneous and thus potentially ‘noisy’ dataset of 84 client-owned cats. Cats were a convenience sample presented to the Department of Small Animal Medicine and Surgery of the University of Veterinary Medicine Hannover and included individuals of different breeds, ages, sex, and with varying medical conditions/medical histories. Cats were scored by veterinary experts using the Glasgow composite measure pain scale in combination with the well-documented and comprehensive clinical history of those patients; the scoring was then used for training AI models using two different approaches. We show that in this context the landmark-based approach performs better, reaching accuracy above 77% in pain detection as opposed to only above 65% reached by the deep learning approach. Furthermore, we investigated the explainability of such machine recognition in terms of identifying facial features that are important for the machine, revealing that the region of nose and mouth seems more important for machine pain classification, while the region of ears is less important, with these findings being consistent across the models and techniques studied here.

Reversible control of reproduction in tom cats: medical options for manipulating libido and fertility.

There has been a growing interest in alternatives to surgery for controlling reproduction in tom cats, and the resultant medical options add to a practitioner's toolbox when handling these cases in clinical practice. It is important, however, that when suggesting these drugs, veterinarians have a good understanding of their mode of action, and their correct use and dosage. Breeders increasingly wish to be able to switch on/off the reproductive ability of their tom cats in a controlled manner. In addition, in small animal medicine, there has been concern from some academics, and a growing number of pet cat owners, about potential long-term effects of surgical sterilisation. Further, for some cats surgical castration may not be possible due to health conditions that mean anaesthesia is unsafe. In all of these scenarios, medical alternatives to surgery can prove useful. No special equipment or technical skills are required. A good knowledge of the medical alternatives to surgical sterilisation for controlling reproduction in a tom, and making sure the patient is a suitable candidate, are, however, important for ensuring the cat's health during and after treatment and the owner's satisfaction. This review is aimed principally (but not exclusively) at veterinary practitioners working with cat breeders who seek a temporary arrest in their tom cat's reproduction. It may also help practitioners with clients who would like an alternative to surgery or with cats where anaesthesia for surgical castration is not possible. Advances in reproductive feline medicine have resulted in improved knowledge of medical contraception. This review draws on scientific evidence-based papers that report on the mode of action, length of efficacy and potential side effects of different methods of medical contraception, as well as the authors' own clinical experience.

Successful Resuscitation of Neonatal Kittens Delivered by a Perimortem Cesarean Section Following Maternal Cardiopulmonary Arrest.

A 9 yr old, unknown weight, intact female domestic shorthair presented for evaluation of dystocia with dyspnea. En route to the hospital for treatment, the owners noted the queen stopped breathing. On presentation, cardiopulmonary arrest was confirmed. The exact cause was unknown but suspected to be secondary to acute fulminant congestive heart failure or acute respiratory distress syndrome due to a large volume of serosanguineous fluid within the mouth and nose. Cardiopulmonary resuscitation (CPR) was immediately started. After 2 min of CPR without return of spontaneous circulation, the owners consented to perimortem Cesarean section. Two kittens were removed via emergency hysterotomy within 3-4 min. Both kittens were successfully resuscitated. CPR efforts were continued on the queen for 2 min after delivery of the kittens, at which time the owners elected to stop further resuscitative efforts. Both kittens were discharged from the hospital and were alive at last follow-up, 2 yr and 4 mo after birth. There are no previous reports regarding the use of a perimortem Cesarean section to deliver neonates in small animal medicine. Therefore, this report represents a novel treatment approach that can be considered in the case of maternal arrest during dystocia.

Removal of lower urinary tract stones by percutaneous cystolithotomy in domestic male ferrets (Mustela putorius furo): four cases (2017–2020)

BackgroundUrinary tract stones are a common cause of clinical signs and urinary tract obstruction in male ferrets (Mustela putorius furo). Traditionally, stone removal is accomplished by cystotomy in ferrets while minimally invasive approaches, considered standard of care in human and small animal medicine, are not described. MethodsFour male ferrets presented with obstructive urethral stones. Percutaneous cystolithotomy (PCCL) successfully relieved the obstruction in all 4 ferrets. In one ferret, the technique was used following an unsuccessful surgical cystotomy. ResultsThe ferrets presented depression, dehydration, and lower urinary tract signs including dysuria, stranguria, pollakiuria or complete urethral obstruction, and bladder distention. Clinicopathologic findings were compatible with urinary obstruction and radiographs confirmed bladder or urethral stones in all ferrets. Among the 4 cases, 3 underwent the procedure without any intraprocedural complications. Postoperative radiographs confirmed the removal of all lower urinary tract stones and the ferrets were discharged within 24 hours after surgery. The remaining ferret, unfortunately, died during anesthetic recovery. All uroliths were found to be composed of 100% cystine. Conclusions and clinical relevanceThe success of PCCL in these 4 cases suggests that this approach is easily adapted to the ferret's smaller urinary tract anatomy. It provides excellent visualization of the urethra and bladder with minimal soft tissue trauma and rapid recovery. In some cases, it may be useful as an adjunct to cystotomy. Additional studies evaluating the efficacy and the safety of PCCL in a larger number of ferrets are warranted.

Veterinary Naturopathy and Complementary Medicine: A Survey among Homepages of German Veterinary Practitioners

Background: The use and interest in veterinary naturopathy and complementary medicine are increasing and modes of treatment are diverse. To this point, only a few data on the German situation in small animal medicine exist. Material and Methods: An online research of 1,083 German veterinary homepages for contents of veterinary naturopathy and complementary medicine was performed in September and October 2017. “Veterinarian” and “Chamber of Veterinary Surgeons” were used as search items. Homepages of small animal medicine were included. They were surveyed for modes of complementary and naturopathic treatments and corresponding qualifications of the offering veterinarian. Data were collected and processed using Excel 2013 Version 15.0. Afterward, a descriptive data analysis was performed. Results: 60.7% (n = 657) of homepages showed contents of veterinary naturopathy and complementary medicine. The highest percentage was found in the Chamber of Veterinary Surgeons of Saarland (91.7%, n = 11 out of 12). Homeopathy was cited most frequently (58%, n = 381). Out of all homepages with relevant content, 31.4% (n = 206) gave information about user qualifications, with continuous education programs named most frequently (52.9%, n = 109). Conclusion: The given data illustrate the high number of German veterinary homepages with contents of veterinary naturopathy and complementary medicine, corresponding to actual data of a high usage in veterinary and human medicine. Therefore, further scientific research in this field seems reasonable. Modes of treatment and qualifications are highly diverse and despite of controversial public discussions, homeopathy was the most frequently cited treatment modality on German veterinary homepages.

Acral Lick Dermatitis (Lick granuloma) in an Adult Male Labrador Retriever Dog

Introduction: Acral lick dermatitis is a skin injury commonly noticed in dogs with obsessive licking behavior. The lesions are usually noticed on the distal extremities which become raised, thickened, and plaque-like. &#x0D; Case report: A five-year-old male Labrador retriever dog was presented to the Small Animal Medicine Unit of Veterinary Clinical Complex (VCC), Rajiv Gandhi Institute of Veterinary Education and Research (RIVER), Puducherry, India, with a history of a superficial wound on the metatarsal region of the right hind limb with bleeding and continuous licking since a month. Clinical examination of the lesion showed a nodular eczematous lesion of 2 cm thickness, while other vital parameters were normal. Based on the licking behavior and other investigations, the skin lesions were diagnosed as acral lick dermatitis. Treatment included the application of Ointment Triamcinolone acetonide (topically) for a month. The licking was controlled using E-collar, and the dog was engaged in playful activities to overcome boredom. The lesion regressed completely within a month and hence was treated uneventfully.&#x0D; Conclusion: Diagnosis and identifying the root cause of the skin disorder can determine the course of treatment. Topical application of corticosteroids (triamcinolone acetonide) and methods, such as E-collar, to control the licking behavior, helped the animal’s recovery.

Baclofen Toxicity in Dogs

Introduction: Baclofen is a centrally-acting skeletal muscle relaxant used to control spasticity and pain in humans. In an overdose situation, the onset of clinical signs, such as vocalization, vomiting, ataxia, disorientation, salivation, coma, weakness, recumbency, and seizures, is usually noticed.&#x0D; Case report: Case 1- A two-month-old female Spitz pup weighing 5 kg was brought to the Small Animal Medicine unit of Veterinary Clinical. Complex (VCC), Rajiv Gandhi Institute of Veterinary Education and Research (RIVER), Puducherry, India, with a history of vomiting, vocalization, and restlessness for the past hour. After recording the history, it was revealed that the dog had accidentally consumed four Baclofen tablets (10 mg each). The animal was immediately treated with fluids, activated charcoal, and Kaolin mixed with water (orally). The gradual reduction in clinical signs was noticed by the lower of 12 hours, and a dramatic improvement was noticed the day after, and the pup recovered completely. Case 2- A six-month-old male Labrador dog weighing 20 kg was brought to the Small Animal Medicine unit of VCC, RIVER, Puducherry, India, with a history of vocalization, restlessness, and salivation for the past two hours. After considering the history, it was revealed that the dog had accidentally ingested eight Baclofen tablets of 10 mg. The animal was immediately treated with fluids (Injection) Atropine sulfate and activated charcoal mixed with water (orally). The gradual reduction of clinical signs was noticed in less than 12 hours, dramatic improvement was noticed the next day, and the dog recovered completely.&#x0D; Conclusion: Timely diagnosis and proper management of the toxicity with drugs can eliminate the clinical signs, and fluid therapy can help the animal’s recovery.