Considering the complex attitude dynamics of Rigid-Liquid-Flexible Coupling Spacecraft, especially when the large amplitude sloshing of liquid exists in rapid attitude maneuver, the conventional control design method based on the linearized model is not suitable for the significant coupling and strong nonlinearity. By contrast, Active Disturbance Rejection Control is model-independent and easy to design and implement. In this paper, the three main components of Active Disturbance Rejection Control, Tracking Differentiator, Extended State Observer and Nonlinear State Error Feedback are comprehensively applied to the attitude tracking control of Rigid-Liquid-Flexible Coupling Spacecraft. Firstly, two cascaded Tracking Differentiators are used to arrange the transition process of the attitude command, which not only reduces overshoot and oscillation of the tracking process, but also obtains the angular acceleration information of attitude trajectory for feed-forward compensation. Secondly, the total disturbance caused by liquid sloshing and flexible vibration is observed by Extended State Observer and compensated synchronously. Finally, the Nonlinear State Error Feedback is used to further improve the transient behavior and steady-state quality of the control system. The simulation results show that the tracking accuracy of the attitude and angular velocity using the Active Disturbance Rejection Control are about 3 to 27 times and 6 to 115 times that of the PID control, respectively. The convergence time, overshooting are also significantly less than the PID control.