A transient mixed thermal elastohydrodynamic lubrication model of bearing considering the thermal effect and the changes in velocity, load, and contact geometry is proposed. Based on the bearing dynamic and lubrication analysis, the effects of bearing rotational speed and start-stop conditions on the dynamic behavior and lubrication performance are studied. Results show that when the bearing rotational speed exceeds a certain critical value, the increasing speed will reduce the film thickness, especially the outer raceway. The increasing bearing acceleration can cause a higher slide-roll ratio and film temperature at the initial start-up process. Compared with the start-up process, the lubrication change in the shut-down process has a similar opposite trend, but the overall lubrication performance is better.