Recent fire incidents indicated that fire-induced bridge collapse is commonly associated with local shear failures occurred in web plates. However, current studies provided failure modes only related to deflection arose from steel bridge girders, irrespective of the underlying shear mechanism. To bridge the knowledge gap, this study presents an investigation on structural behavior of horizontally curved steel box bridge girders (HCSBBGs) under the combined effects of hydrocarbon fire exposure and shear-dominant loadings. The numerical models are developed utilizing the ANSYS program, incorporating a validated thermal-structural analysis model and a shear limit analysis model that accounts for web initial imperfections. These models are further employed to examine effects of fire-shear load scenarios, curvature radius, web slenderness ratio, and aspect ratio on shear performance of HCSBBGs. Herein, deflections, degradation of shear capacity, and web out-of-plane displacement (WOPD) of the steel box bridge girders are discussed in detail. Failure modes of steel box bridge girders can be determined via moment-shear interaction diagrams as specified by Eurocode 3 (EC3). The findings indicate that decreasing web slenderness ratio and web aspect ratio can enhance shear capacity of steel box girders. Further, shear failure modes are predominant when fire occurs near side support of HCSBBGs. Current fire-resistant design practices relying on deflection or flexural limit based failure criteria, cannot be applicable in predicting fire resistance of steel box bridge girders under shear failure mode. Therefore, a failure criterion based on the ultimate web out-of-plane displacement ratio (UWOPDR), related to the web shear limit state, can be more suitable for predicting fire resistance of HCSBBGs.