Skin Contact Research Articles

Facts about Wildlife Diseases: Warts in White-tailed deer (Cutaneous Fibromas).

Deer warts, or cutaneous fibromas, are skin tumors caused by papillomavirus infection that affect white-tailed deer and other deer. These growths are generally benign, but in rare cases may proliferate and impede functions like sight, movement, or feeding. Deer immune systems usually eradicate the infection over time. Found exclusively on the skin, usually around the eyes, neck, face, and forelegs, warts may be diverse in appearance and size, ranging from small fleshy nodules to larger, pendulous masses or clusters. Transmission mechanisms are suspected to involve skin contact or possibly insect vectors but remain unclear. Diagnosis is by visual examination and histopathological analysis of the wart tissue. Wild deer populations usually do not require treatment, but surgical removal is an option for captive herds. Vaccine development remains plausible but has not yet been pursued extensively.

How to Make the Skin Contact Area Controllable by Optical Calibration in Wearable Tactile Displays of Softness.

Virtual reality systems may benefit from wearable (fingertip-mounted) haptic displays capable of rendering the softness of virtual objects. According to neurophysiological evidence, the easiest reliable way to render a virtual softness is to generate purely tactile (as opposed to kinaesthetic) feedback to be delivered via a finger-pulp-interfaced deformable surface. Moreover, it is necessary to control not only the skin indentation depth by applying quasi-static (non-vibratory) contact pressures, but also the skin contact area. This is typically impossible with available devices, even with those that can vary the contact area, because the latter cannot be controlled due to the complexity of sensing it at high resolutions. This causes indetermination on an important tactile cue to render softness. Here, we present a technology that allows the contact area to be open-loop controlled via personalised optical calibrations. We demonstrate the solution on a modified, pneumatic wearable tactile display of softness previously described by us, consisting of a small chamber containing a transparent membrane inflated against the finger pulp. A window on the device allowed for monitoring the skin contact area with a camera from an external unit to generate a calibration curve by processing photos of the skin membrane interface at different pressures. The solution was validated by comparisons with an ink-stain-based method. Moreover, to avoid manual calibrations, a preliminary automated procedure was developed. This calibration strategy may be applied also to other kinds of displays where finger pulps are in contact with transparent deformable structures.

In the arm-in-cage test, topical repellents activate mosquitoes to disengage upon contact instead of repelling them at distance

Topical repellents provide protection against mosquito bites and their efficacy is often assessed using the arm-in-cage test. The arm-in-cage test estimates the repellent’s protection time by exposing a repellent-treated forearm to host-seeking mosquitoes inside a cage at regular intervals until the first confirmed mosquito bite. However, the test does not reveal the repellents’ behavioural mode of action. To understand how mosquitoes interact with topical repellents in the arm-in-cage test, we used a 3D infrared video camera system to track individual Aedes aegypti and Anopheles stephensi females during exposure to either a repellent-treated or an untreated forearm. The repellents tested were 20% (m/m) ethanolic solutions of N, N-diethyl-meta-toluamide, p-menthane-3,8-diol, icaridin and ethyl butylacetylaminopropionate. All four repellents substantially reduced the number of bites compared to an untreated forearm, while the flight trajectories indicate that the repellents do not prevent skin contact as the mosquitoes made multiple brief contacts with the treated forearm. We conclude that, in the context of the arm-in-cage test, topical repellents activate mosquitoes to disengage from the forearm with undirected displacements upon contact rather than being repelled at distance by volatile odorants.

Contact dermatitis secondary to povidone-iodine: A systematic review.

Cutaneous reactions to povidone (PVP)-iodine are widely reported; however, distinction between allergic and irritant reactions can be challenging. Free iodine is responsible for irritant reactions and is released when PVP-iodine is in a liquid state. The aim of this study was to review the clinical presentation and results of patch testing in patients with PVP-iodine contact dermatitis. A systematic review was conducted by searching Pubmed, MEDLINE, and Google Scholar databases for reports of contact dermatitis secondary to PVP-iodine. Data were collated including study design, patient age and gender identity, iodine exposure, skin biopsy findings, and patch test methodology and results. The search revealed 187 reports with 38 eligible studies; 30 case reports/case series and 8 retrospective cohort studies. Overall, there were 223 patients with PVP-iodine contact dermatitis. The commonest reaction was irritant contact dermatitis (51%), followed by allergic contact dermatitis (40%) and contact dermatitis not further specified (9%). Irritant reactions were characterised by burn-like morphology and, when due to surgical skin disinfectant, were often distant from the surgical incision site. Patch testing was most often performed with a 10% PVP-iodine aqueous solution; however, irritant reactions in controls occur. Various testing methods including iodine in petrolatum, ethanol, dried powder, and open application testing were described. Most reactions to PVP-iodine are irritant and patch testing using a closed-chamber method yields inconsistent results due to risk of irritation from free iodine release over the 2-day occlusion time. Surgeons should be aware of the risk of prolonged skin contact with wet iodine solution.

Touch: A Review of the Infant-Caregiver Relationship in the Neonatal Field

Touch is a domain of enormous importance with implications in development, from birth, and across the lifespan. This work aims to review touch implications within infant-caregiver interaction. A non-systematic review of the literature was performed to assess the relevance of touch in the neonatal period, on attachment, and in child development. The review was conducted on PubMed database, in May 2023 using the following keywords: “infant”, “child”, “baby”, “newborn”, “neonatal”, “touch”, “contact”, “tactile”, and “attachment”. In the neonatal period, close skin contact facilitates caregiver sensitivity and responsiveness, promotes parent-infant reciprocity, reduces psychological distress both in caregiver and infants, and regulates the infant’s physiological systems (circadian rhythm, autonomic regulation). Touch also plays a crucial role in attachment by contributing to synchrony and self-regulation abilities, since secure attachment promotes learning of emotional regulation, social skills, and behavioural organization. Early sensory experiences are critical to developmental dimensions such as cognitive, motor, and socio-emotional, and influence physical growth rate. Concluding, in neonatal care services, touch should be systematically addressed in routine appointments. Within the field of infant-caregiver interactions, there is an urgent need to create a reliable tool for tactile assessment, allowing clear interpretations and the development of target interventions.

Edukasi Pemanfaatan Minyak Jelantah Dan Daun Kelor Menjadi Sabun Batang Sebagai Upaya Pencegahan Paparan Logam Berat Dari Pewarna Sintetis Dan Pestisida di Desa Tlingsing, Cawas, Klaten

Oxidative stress induced in cells by the generation of reactive oxygen species (ROS) is a toxic effect of heavy metals that exceed the threshold if they enter the body and can cause health threats. Apart from heavy metals that can cause oxidative stress are pesticides. The impact of oxidative stress will disrupt health because it has damaging properties on proteins, DNA and lipids. Exposure to heavy metals by workers and pesticides by farmers through skin contact, inhalation or respiration, to reduce the impact of inhalation or contact on the skin, in this service workers and farmers are given PHBS education, and one of them is by maintaining cleanliness after contact with colors or pesticides by means of wash your hands using soap. Community service is provided through counseling methods, health checks in the form of MCU, and making Moringa leaf soap which contains antioxidants

A Novel Wearable Sensor for Measuring Respiration Continuously and in Real Time.

In this work, a flexible textile-based capacitive respiratory sensor, based on a capacitive sensor structure, that does not require direct skin contact is designed, optimised, and evaluated using both computational modelling and empirical measurements. In the computational study, the geometry of the sensor was examined. This analysis involved observing the capacitance and frequency variations using a cylindrical model that mimicked the human body. Four designs were selected which were then manufactured by screen printing multiple functional layers on top of a polyester/cotton fabric. The printed sensors were characterised to detect the performance against phantoms and impacts from artefacts, normally present whilst wearing the device. A sensor that has an electrode ratio of 1:3:1 (sensor, reflector, and ground) was shown to be the most sensitive design, as it exhibits the highest sensitivity of 6.2% frequency change when exposed to phantoms. To ensure the replicability of the sensors, several batches of identical sensors were developed and tested using the same physical parameters, which resulted in the same percentage frequency change. The sensor was further tested on volunteers, showing that the sensor measures respiration with 98.68% accuracy compared to manual breath counting.

Characteristics, Source Apportionment, and Health Risk of Heavy Metals in the Soils of Peri-urban Shanghai Chongming Island.

Heavy metals resulting from human activities pose significant threats to human health and the soil ecosystem. In the current study, 917 soil samples from Chongming Island in Shanghai, China, were examined for eight heavy metals. The sources of contamination were identified by using a Positive Matrix Factorization (PMF) model. Meanwhile, spatial interpolation and Moran's I index were applied to validate the model in terms of spatial linkages. The results revealed that the average concentrations of As, Cd, Hg, Pb, Cr, Cu, Zn, and Ni in the soil were 8.87, 0.19, 0.06, 28.75, 76.01, 37.74, 88.93, and 30.33 mg kg-1, respectively. The PMF analysis proved that heavy metals in the soil of the study area are mainly influenced by traffic sources (Cr and Pb), industrial sources (Zn, Cd, and Cu), station sources (Hg), and natural sources (As and Ni), with contribution rates of 22.23, 26.25, 36.38, and 15.14%, respectively. The combination of Moran's index and the spatial analysis method not only verified the analytical results of the receptor model on the one hand but also served as a supplementary explanation for the sources of heavy metals in the soil. The health risk assessment indicated that noncarcinogenic values were below the threshold values. The total carcinogenic risk (R T) of different heavy metals has a descending order of Cr > As > Ni > Cd. The R T values of multiple heavy metals for children and adults were 5.28 × 10-04 and 4.10 × 10-05, respectively, which were close to the risk threshold. Therefore, attention should be paid to the health risks, especially for children's skin contact, which is the main exposure pathway.

Flower-like boron-doped zinc single-atom nanozymes for colorimetric sensing and smartphone-assisted detection of Cr(VI)

With the development of electronics, electroplating, printing, and dyeing industries, environmental pollution caused by hexavalent chromium (Cr(VI)) has become increasingly prominent. Skin contact with Cr (VI) can cause allergies or genetic defects, and inhalation can cause cancer, which is a lasting danger to the environment and the human body. Developing effective strategies to monitor Cr(VI) in environmental water or industrial wastewater can evaluate the degree of water pollution and risk warning, thus helping to prevent the spread of Cr(VI) pollution, promote the protection of water resources and the ecological environment, and ensure human safety and sustainable development. On the basis of the regulation of dopamine, boron-doped zinc single-atom nanozymes (Zn/B-NC SAzymes) with three-dimensional nanoflower morphology were controlled in this work. The introduction of B in Zn/B-NC SAzymes and the high metal loading of Zn (6.5 wt%) led to the formation of more active sites, resulting in the material showing excellent enzyme-like activity. H2O2 decomposed to generate superoxide radicals under the catalysis of Zn/B-NC SAzymes, which then oxidized the substrate 3,3′,5,5′-tetramethylbenzidine (TMB) to generate blue oxTMB. When Cr(VI) was introduced into the sensor system, the color of blue oxTMB is deepened, and the colorimetric method of Cr(VI) was constructed. The linear range is 0.2–40 μM, LOD is 59 nM, and the visual detection of Cr (VI) is performed with the aid of the smartphone. This work not only provides experimental and theoretical guidance for understanding the active centers of Zn-SAzymes and their catalytic processes, but also provides a promising and alternative detection strategy for the rapid and even visual on-site detection of Cr(VI) in aquatic environments, which is of great significance for the control of Cr(VI) pollution in the environment and industrial wastewater.

Health and Environmental Risk Assessment of Heavy Metals Contamination from Medical Wastes Ash of Baghdad Hospitals

Abstract One of the complex problems that many countries suffer from is how to deal with medical waste because of its harmful and devastating effects on humans and the environment. Hospitals around the world use and consume many different products. These products are composed of various materials, and many of them contain heavy metals in their production and manufacturing, which are ultimately emitted into the environment, posing a major danger and risk to human health. This work focused on assessing the contamination levels of medical waste ash after the incineration process. Ash samples were collected from major hospitals in the capital, Baghdad. The health risks resulting from heavy metal pollution were calculated. Medical waste ash was collected at different times from three major hospitals within the capital, Baghdad, and tested for contamination with heavy metals. To measure the bottom ash samples, X-ray spectroscopy (XRF) technology was used to determine heavy metal concentrations. The results showed the presence of more than twenty elements in the ash of medical waste, including the heavy metals found in Baghdad hospitals. Work was done on eight of these heavy metals due to their high concentrations. These selected elements are considered highly toxic and dangerous if exposed to them, including zinc (Zn), lead (Pb), arsenic (As), cobalt (Co), and copper. (Cu), nickel (Ni), chromium (Cr), and mercury (Hg). To evaluate the health risks of this pollution. All of these elements are a major problem if exposed to them. The amount of contamination was calculated using the contamination factor (CF). The results showed that the percentage of As, Cd, Hg, Zn, Pb, and Cu was very high. Meanwhile, the concentrations of Co and Ni were moderate values in medical waste ash. Adult health risks were calculated using the non-cancer health risk ratio (HL). The calculated values show values higher than the safe level in Imam Ali Central Hospital, indicating a potential high health risk. Meanwhile, other hospitals (Sheikh Zayed and Dhari Al Fayyad) recorded risk values below the safe level, indicating no health risks. The health risk assessment indicated that there are three main routes of human exposure: “ingestion, inhalation, and skin contact.” The cancer risk index (Risk) was also calculated. The values obtained were within the acceptable range. An analysis of the metal pollution index was also conducted, and it was found that heavy metals pose a non-cancerous risk. But the harmful effects of pollution from ash disposal have been particularly serious because they may contain high concentrations of heavy metals.

Percutaneous Absorption of Two Bisphenol A Analogues, BPAF and TGSA: Novel In Vitro Data from Human Skin

Bisphenol AF (BPAF) and TGSA are analogues of Bisphenol A (BPA). BPAF is used in polymer synthesis, while TGSA is applied in thermal papers. The EU classifies BPAF as toxic to reproduction and TGSA as a skin sensitizer. However, TGSA's other health effects remain unclear. BPAF contamination has been noted among electronic waste workers, and TGSA exposure is documented in various professions. Despite the significance of skin contact, data on skin permeation rates for BPAF and TGSA are limited. This study aimed to generate percutaneous absorption data for BPAF and TGSA following OECD guidelines.[14C]-labelled BPAF or TGSA was applied to human skin samples in vitro using Franz diffusion cells for 20 and 40 h, respectively. Key parameters such as steady-state flux, lag time, and skin permeability coefficient (Kp) were calculated. Furthermore, the distribution of the dose across different compartments, particularly within the skin, was evaluated at the conclusion of the experiment. Sequential strippings and epidermis-dermis separation were conducted for BPAF to predict the potential absorption of the remaining dose present within the skin.The permeability coefficients for BPAF and TGSA were found to be 1.9 E-03 and 1.6 E-03 cm/h, with 22% and 23% of the applied doses absorbed, respectively. Both chemicals are classified as "fast" penetrants based on their Kp values. These findings suggest that BPAF and TGSA are absorbed through the skin, highlighting potential occupational risks through dermal exposure. The new percutaneous absorption data will enhance the assessment of the occupational risks.

Cartap Poisoning with Paroxysmal Supraventricular Tachycardia: A Case Report

Cartap, a nereistoxin derivative from the marine annelid Lumbriconeresis heteropoda, is widely used as a pesticide, targeting pests like caterpillars. While the WHO classifies it as moderately hazardous, with a recommended daily intake of 0.05 mg/kg, human toxicity reports are limited. A 34-year-old female was admitted after consuming an unknown poison. She reported epigastric pain, burning sensations, sweating, vomiting, dyspnea, palpitations, and restlessness, compounded by alcohol intake. Initially treated for organophosphate poisoning, her cholinesterase level was 8.91. It was later confirmed she ingested 100 ml of 50% concentration cartap. Treatment included amiodarone for supraventricular tachycardia and intravenous N-acetylcysteine, magnesium sulfate, and midazolam for general tonic clonic seizure. Cartap, toxic through ingestion and skin contact, can cause symptoms such as vomiting, convulsions, and cardiac issues like supraventricular tachycardia. Supportive care is crucial, and awareness of its risks is necessary.

The Effect of Sub-Acute Inhalation Exposure to Polyethylene and Polyvinyl Chloride Micro-Nano Plastics on the Superoxide Dismutase (SOD) Level and Malondialdehyde (MDA) Level in Rat Ovary

Plastic is a synthetic or semi-synthetic organic polymer that is widely used in daily life and in industrial production. Microplastics are widespread contaminants and can enter the human body through the consumption of foods containing microplastics, inhalation of microplastics in the air, and skin contact with microplastic particles present in products. Microplastics can enter the ovaries as foreign bodies and can cause inflammation, oxidative stress, and even ovarian granulosa cell death. Polyethylene plastic shards generally have a higher ability to absorb environmental toxins than other types of plastic. Polyvinyl chloride (PVC) is one of the oldest thermoplastic polymers that is often used as water pipes. PVC has carcinogenic monomers and some harmful additives. This study aims to determine the effect of subacute exposure to micro-nanoplastics per inhalation on SOD and MDA levels in rat ovaries. The research method used is a true experimental design with a Randomize Post Test Only Group Design research design. This study used the ovarian organs of female white rats that had been exposed to PVC and PE for 28 days. The number of samples used in this study amounted to 18 female rats. Subacute exposure to micro-nanoplastics per inhalation can lower SOD levels and significantly increase MDA levels in rat ovaries. This study is expected to provide knowledge and an overview for future research on the mechanism of toxicity of micro-nanoplastic exposure that has an impact on female infertility through free radicals in the ovaries.

Does static friction information predict the onset of sliding for soft material?

Friction behavior between soft and hard materials has long been a question of great interest in the fields of artificial joints, human skin contact, robotic grippers, and others. In this study, we presented a combination of theoretical and experimental analyses to investigate the friction behavior of soft materials. Using some geometric and stick–slip features in the early stage of static friction, the friction property of the interface between a soft material and a hard material is determined. Moreover, the onset of slip, the threshold force at which a friction interface begins to slide, is also predicted by a theoretical model. The predictive ability of this model may provide insights for improving interaction property recognition, as well as for developing fine tactile feedback and dexterous operation of robotic grasping.

Nanoscale Strategies for Enhancing the Performance of Adhesive Dry Electrodes for the Skin.

High-quality electrophysiological monitoring requires electrodes to maintain a compliant and stable skin contact. This necessitates low impedance, good skin compliance, and strong adhesion to ensure continuous and stable contact under dynamic conditions. In this context, adhesive epidermal dry electrodes are advancing rapidly, which is promising for long-term applications in clinical diagnosis, wearable health monitoring, and human-machine interfaces. However, challenges persist, as conventional technologies usually fall short of meeting the high standards required for electrophysiological electrodes. This Perspective discusses four key aspects for high-performance epidermal electrodes from an adhesive perspective: initial adhesion, water resistance, dynamic stability, and removal simplicity. We review recent nanoscale strategies addressing these issues, providing a comprehensive guideline to enhance the application performance of epidermal dry electrodes. Additionally, we explore key nanoscale strategies and their associated functions, future technology roadmaps, and prospects for dry adhesive epidermal electrodes.

Weaving Fiber-based Triboelectric Nanogenerators and Yarn-based Sweat-activated Batteries for Dry-wet Bimodal Power Supply in Textile Electronics

Textile-based energy systems, which can provide sustainable power in both dry and wet conditions, are ideal for wearable devices, especially electronic textiles used for motion monitoring, and have attracted much interest in recent years. In this work, we developed a hybrid energy fabric woven with fiber-based triboelectric nanogenerators (F-TENGs) and yarn-based sweat-activated batteries (Y-SABs) to achieve a dry-wet bimodal power supply. Single-electrode core-sheath F-TENGs were fabricated as dry-state energy harvesters, which could respond sensitively to repeated skin contact to produce transient spikes of open-circuit voltage and short-circuit current at 30V and 2µA, respectively. Since the wetting of the F-TENGs could result in a remarkable degradation of the triboelectric performance, coaxial Y-SABs with the output voltage of 0.6V (external load=2 kΩ) were manufactured to supply power in the wet state sustainably. Both devices withstood 1,500 times bending/twisting and 20 times machine washing. The F-TENGs and the Y-SABs were integrated with the conventional weaving technique to obtain a plain structured fabric, in which the TENG and SAB regions could successively generate electricity to power electronic devices under repeated skin contacts in the dry state and NaCl-solution activation in the wet state, respectively, without affecting each other. The hybrid energy fabric was further integrated into a shoe insole and a T-shirt for the on-body trials. During the volunteer’s running process, the system could provide electricity to charge a capacitor or illuminate LEDs in sweatless and sweaty conditions, demonstrating its great potential as a reliable and sustainable dry-wet bimodal power source in wearable applications.

Dermatoses among athletes

Introduction: Dermatoses are a common problem among athletes due to exposure to various chemical substances, close skin contact with other individuals and higher risk of abrasions and skin trauma. Dermatoses affecting athletes may be divided to inflammatory, infectious and mechanical dermatoses. Due to various presentations, athletes should not neglect any lesions on their skin and should seek medical help. Physicians must remember about thorough examination including skin, to check if athletes can exercise and participate in sport events. Purpose of work: The aim of this article is to emphasize the association between dermatoses and sport activities, including the necessity of their proper diagnosis and treatment. Materials and methods: Articles in Pubmed database were researched using following keywords: dermatoses among athletes, sport dermatoses, infections among athletes, exercise-induced anaphylaxis. Conclusions: Skin diseases may affect athletes’ performance and require them to cease professional training and close contact with other athletes. Physicians must remember the necessity of an accurate diagnosis and prompt initiation of the treatment to avoid delay in practice, team training and competitions.

Acute gastrointestinal symptoms associated with oil spill exposures among U.S. coast guard responders to the Deepwater Horizon oil spill

PurposeResearch investigating gastrointestinal (GI) symptoms from oil spill-related exposures is sparse. We evaluated prevalent GI symptoms among U.S. Coast Guard responders deployed to the Deepwater Horizon oil spill cleanup. MethodsCrude oil (via skin contact, inhalation, or ingestion routes), combined crude oil/oil dispersant exposures, other deployment exposures, deployment characteristics, demographics, and acute GI symptoms during deployment (i.e., nausea/vomiting, diarrhea, stomach pain, and constipation) were ascertained cross-sectionally via a post-deployment survey (median time between deployment end and survey completion 185 days) (N = 4885). Log-binomial regression analyses were employed to calculate prevalence ratios (PRs) and 95 % confidence intervals (CI). Effect modification was evaluated. ResultsIn adjusted models, responders in the highest (versus lowest) tertile of self-reported degree of skin contact to crude oil were more than twice as likely to report nausea/vomiting (PR=2.45; 95 %CI, 1.85–3.23), diarrhea (PR=2.40; 95 %CI, 2.00–2.88), stomach pain (PR=2.51; 95 %CI, 2.01–3.12), and constipation (PR=2.21; 95 %CI, 1.70–2.89). Tests for trend were statistically significant (p < 0.05). Results were similar for crude oil exposure via inhalation and ingestion. Higher PRs for all symptoms were found with combined crude oil/dispersant exposure than with crude oil exposure alone. ConclusionsThese results indicate positive associations between self-reported crude oil and combined crude oil/oil dispersant exposures and acute GI symptoms.

Polyethylene Micro/Nanoplastics Exposure Induces Epithelial-Mesenchymal Transition in Human Bronchial and Alveolar Epithelial Cells.

Micro/nanoplastics (MNPs), which are widely spread in the environment, have gained attention because of their ability to enter the human body mainly through ingestion, inhalation, and skin contact, thus representing a serious health threat. Several studies have reported the presence of MNPs in lung tissue and the potential role of MNP inhalation in triggering lung fibrosis and tumorigenesis. However, there is a paucity of knowledge regarding the cellular response to MNPs composed of polyethylene (PE), one of the most common plastic pollutants in the biosphere. In this study, we investigated the effects of low/high concentrations of PE MNPs on respiratory epithelial cell viability and migration/invasion abilities, using MTT, scratch, and transwell assays. Morphological and molecular changes were assessed via immunofluorescence, Western blot, and qRT-PCR. We demonstrated that acute exposure to PE MNPs does not induce cellular toxicity. Instead, cells displayed visible morphological changes also involving actin cytoskeleton reorganization. Our data underlined the role of epithelial-mesenchymal transition (EMT) in triggering this process. Moreover, a remarkable increase in migration potential was noticed, in absence of a significant alteration of the cell's invasive capacity. The present study highlights the potential impact of PE MNPs inhalation on the human respiratory epithelium, suggesting a possible role in carcinogenesis.

Calcium chloride poisoning: an autopsy case report and histologic features.

Calcium chloride, which is commonly used in de-icing agents and desiccants, is known for the potential harm it can cause through skin contact, oral ingestion, or intravenous administration. The current paper reports on an autopsy case of a 68-year-old woman who died after ingesting an unknown substance. Histopathological examination revealed coagulative necrosis in the esophagus and ionized blood calcium levels that were significantly higher than normal. Calcium chloride was detected in the contents of the water bottle collected at the scene. These results are expected to make a significant contribution to the limited literature on fatal outcomes from calcium chloride ingestion, while emphasizing the need for heightened awareness and education about the risks of commonly available chemicals.